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The map label for this gene is proC [H]

Identifier: 107021806

GI number: 107021806

Start: 264790

End: 265602

Strand: Reverse

Name: proC [H]

Synonym: Bcen_0246

Alternate gene names: 107021806

Gene position: 265602-264790 (Counterclockwise)

Preceding gene: 107021807

Following gene: 107021799

Centisome position: 8.06

GC content: 72.45

Gene sequence:

>813_bases
ATGAAAATCGCATTCATCGGCGGCGGCAACATGGCCGCGGCCCTGATCGGCGGCCTGATCAAGCGCGGCGTCGCCGCGGA
CTGCCTGTATGCCATCGACGTCAACGAAGACGTCCGCGCGCGCGCCGCGCAGCAGTTCGGCATCCGGACCGGCGCGGCCA
TCGACGCGACGCTCGCCGACTACGACGCGATCGTGCTCGCGGTGAAGCCGCAGGTGCTGCACGACGTCGCGCAGGCGCTC
GCGCCGCACCTGAAGTCGCAGCTCGTGATCAGCATCGCGGCCGGCATCCGCGGCACGGATCTCGCCCGCTGGCTCGGCGG
CTACGCGCGCGTCGTGCGCACGATGCCGAACACGCCCGCGCTGGTCGGCATGGGCGTGACGGGCCTGGCCGCGCTGCCGG
GCGTCGATGCGGCGGGCCGCGAACTCGCGTCGAGCGTGCTCGGCGCGGTCGGCGAGATCGTATGGTTCGACGACGAAGCG
CAGCTCGACGCGGTCACCGCGATTTCGGGCAGCGGCCCCGCATACGTGTTCTATTTCATCGAAGCGCTGCAGGAAGCCGC
GCGCCGCCTCGGCATGAACGACGAGCAGGGCCGCGCGCTCGCGGTCGCGACGTTCACGGGCGCCGCGCAACTGGCCGCGC
AGTCGGGCGAACCGGCGAGCGTGCTGCGCGAACGCGTGACGTCGAAGGGCGGCACGACGGCCGCCGCGCTCGCGGCGTTC
GACGCGCAGGGCGTGAAGGAAGCGATCGTGCGCGGCGCGCTCGCGGCCGAAGCGCGCGCGAAGGAAATGGGCGACGAGCT
CGGCCGCGCGTAA

Upstream 100 bases:

>100_bases
TGCGCGTCGGCACCGCGATCTTCGGCGCGCGCGATTACGCGCACTGAACGCCGCGCCCTTTTCCGCCTTTCCGTTCACTC
ACTCGCTCATTCCCGACATC

Downstream 100 bases:

>100_bases
GCGCGACGGCGGCGCCGGTCGTGCCGGCGCGAGACGTAAAAAAAGCGACCGTCAGGTCGCTTTTTCGTTGGCGCCGCGCG
CAAGTACGCGCGGTGTGCCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADCLYAIDVNEDVRARAAQQFGIRTGAAIDATLADYDAIVLAVKPQVLHDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASSVLGAVGEIVWFDDEA
QLDAVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAAF
DAQGVKEAIVRGALAAEARAKEMGDELGRA

Sequences:

>Translated_270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADCLYAIDVNEDVRARAAQQFGIRTGAAIDATLADYDAIVLAVKPQVLHDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASSVLGAVGEIVWFDDEA
QLDAVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAAF
DAQGVKEAIVRGALAAEARAKEMGDELGRA
>Mature_270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADCLYAIDVNEDVRARAAQQFGIRTGAAIDATLADYDAIVLAVKPQVLHDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYARVVRTMPNTPALVGMGVTGLAALPGVDAAGRELASSVLGAVGEIVWFDDEA
QLDAVTAISGSGPAYVFYFIEALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAAF
DAQGVKEAIVRGALAAEARAKEMGDELGRA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=32.9545454545455, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=28.6245353159851, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=28.6245353159851, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=26.7657992565056, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=34.3173431734317, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=34.2007434944238, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=28.3687943262411, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=28.6713286713287, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=34.8484848484849, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=29.8561151079137, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=37.2781065088757, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27599; Mature: 27599

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAADCLYAIDVNEDVRARAAQQFGIRTGAAIDATLAD
CEEEEECCCHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHC
YDAIVLAVKPQVLHDVAQALAPHLKSQLVISIAAGIRGTDLARWLGGYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLAALPGVDAAGRELASSVLGAVGEIVWFDDEAQLDAVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHEEEECCCCCCHHHHHH
EALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAAF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHH
DAQGVKEAIVRGALAAEARAKEMGDELGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAADCLYAIDVNEDVRARAAQQFGIRTGAAIDATLAD
CEEEEECCCHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHC
YDAIVLAVKPQVLHDVAQALAPHLKSQLVISIAAGIRGTDLARWLGGYARVVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLAALPGVDAAGRELASSVLGAVGEIVWFDDEAQLDAVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHEEEECCCCCCHHHHHH
EALQEAARRLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALAAF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHH
DAQGVKEAIVRGALAAEARAKEMGDELGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]