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The map label for this gene is pepP [H]

Identifier: 107021771

GI number: 107021771

Start: 224724

End: 226109

Strand: Reverse

Name: pepP [H]

Synonym: Bcen_0211

Alternate gene names: 107021771

Gene position: 226109-224724 (Counterclockwise)

Preceding gene: 107021773

Following gene: 107021770

Centisome position: 6.86

GC content: 71.14

Gene sequence:

>1386_bases
ATGAATGCGCCCCTCGATACCGCCATCGCCGTCGACGTCTACCGCCAGCGCCGTGAACGCGTGCTTGCCGCACTGCGTGC
CGCGGGCGGCGGCGTCGCCATCGTCCCCACCGCGCCGGAAATGCTGCGCAACCGCGATACGGCCTACCCGTACCGGTTCG
ACAGCTACTTCCATTACCTGACGGGCTTCACCGAGCCGGATGCCGTGCTCGTGCTGAACGCGGCCGCGCCGCACGGCGCG
CCGGAATCGATCCTGTTCTGCCGCGCCAGGAACGTCGACCGCGAGATCTGGGAAGGCTTTCACTACGGCCCCGACGCCGC
GCGCGACGCGTTCGGCTTCGACGCGGCCTTCGCGACCGACGTGATCGACACCGAGATGCCGCGCCTGCTCGCCGATGCGG
GCACCGTGCACTACCGGTTCGGCGCATCGGCCGACTTCGAGCGCCAGCTCGCCGGCTGGATCGACGCGGTGCGCGCGCAG
GCACGCGCGGGCGTCGCCGCACCGGACGCGCTGCTCGACCTCACGCCGCTGCTCGACGACATGCGGCTCGTGAAGGACGA
ACACGAACTCGCGATCATGATGCGCGCCGCGCACATCTCCGCGCTCGCGCACCGCCGCGCGATGCAGGTGTGCCGCCCGG
GCATCCGCGAATACGAGCTCGAGGCCGAGCTGCTGTACCTGTTCCGCAAGCACGGCGCGCAGGCGCCCGCGTACGGCTCG
ATCGTCGCGGCCGGCGCGAATGCGTGCGTGCTGCACTACCCGGCCGGCAACGCGGCCGCGCGGGACGGCGACCTGATCCT
GATCGACGCCGCGTGCGAACTCGACGGCTATGCGTCGGACATCACGCGCACGTTCCCGGCCAACGGCCGCTTCTCGCCCG
CGCAGCGCACGCTGTACGACATCGTGCTCGCCGCGCAGCAGGCTGCGATCGATGCGACGCGCGCGGGCGTGCCGTTCGAG
GCACCGCACGACGCGGCCGTACGCGTGCTCGCGCAGGGGCTGCTCGACACCGGCATCATCCCGAAAACGCGCTTCTCGAA
CGTCGACGACGTGATTGCCGAGCGCGCGTACACGCGCTTCTACATGCACCGCACGGGCCACTGGCTCGGAATGGACGTGC
ACGACTGCGGCGACTACCGCGAACGGCTCGCCGCGCGCGACGCCAACGGCGCGCTGCCGTGGCGCACGCTGAAGCCCGGC
ATGACGCTCACCGTCGAGCCCGGCCTGTACGTGCGCGCGGCCGACGACGTGCCGCCCGAGTACTGGAACATCGGCATCCG
CATCGAGGACGACGCGATCGTACGCGAGCACGGCTGCGAGCTGATCACGCGCGGCGTGCCGGTCGCGGCCGACGAGATCG
AGGCGCTGATGCGCGCGGACGCATGA

Upstream 100 bases:

>100_bases
GGCCTGTGGATGGTTTGCAACAGCCGCCGCGCGGGACTTGGCCGGTGCGGCTTCGGGCCCTGCTCTCACGCACCGCGTCG
CGCGGCGCTACAATCGCACG

Downstream 100 bases:

>100_bases
CCGGGCGCCGACCGTTACCTCCGTTTCACGAATCAAGATGACGACCGCTTCCTCCCCGGCCACGCCGGATTACGATCTCG
CCATCGTCGGCGCCGGCCCC

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEMLRNRDTAYPYRFDSYFHYLTGFTEPDAVLVLNAAAPHGA
PESILFCRARNVDREIWEGFHYGPDAARDAFGFDAAFATDVIDTEMPRLLADAGTVHYRFGASADFERQLAGWIDAVRAQ
ARAGVAAPDALLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQVCRPGIREYELEAELLYLFRKHGAQAPAYGS
IVAAGANACVLHYPAGNAAARDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERLAARDANGALPWRTLKPG
MTLTVEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRADA

Sequences:

>Translated_461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEMLRNRDTAYPYRFDSYFHYLTGFTEPDAVLVLNAAAPHGA
PESILFCRARNVDREIWEGFHYGPDAARDAFGFDAAFATDVIDTEMPRLLADAGTVHYRFGASADFERQLAGWIDAVRAQ
ARAGVAAPDALLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQVCRPGIREYELEAELLYLFRKHGAQAPAYGS
IVAAGANACVLHYPAGNAAARDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERLAARDANGALPWRTLKPG
MTLTVEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRADA
>Mature_461_residues
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEMLRNRDTAYPYRFDSYFHYLTGFTEPDAVLVLNAAAPHGA
PESILFCRARNVDREIWEGFHYGPDAARDAFGFDAAFATDVIDTEMPRLLADAGTVHYRFGASADFERQLAGWIDAVRAQ
ARAGVAAPDALLDLTPLLDDMRLVKDEHELAIMMRAAHISALAHRRAMQVCRPGIREYELEAELLYLFRKHGAQAPAYGS
IVAAGANACVLHYPAGNAAARDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYDIVLAAQQAAIDATRAGVPFE
APHDAAVRVLAQGLLDTGIIPKTRFSNVDDVIAERAYTRFYMHRTGHWLGMDVHDCGDYRERLAARDANGALPWRTLKPG
MTLTVEPGLYVRAADDVPPEYWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRADA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=452, Percent_Identity=29.8672566371681, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI149589008, Length=493, Percent_Identity=29.6146044624746, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI260593665, Length=311, Percent_Identity=35.6913183279743, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI260593663, Length=326, Percent_Identity=33.1288343558282, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1789275, Length=453, Percent_Identity=41.7218543046358, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1788728, Length=329, Percent_Identity=30.3951367781155, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790282, Length=318, Percent_Identity=29.874213836478, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=479, Percent_Identity=30.8977035490605, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=378, Percent_Identity=27.7777777777778, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=421, Percent_Identity=27.0783847980998, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6321118, Length=438, Percent_Identity=28.7671232876712, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19920384, Length=448, Percent_Identity=33.4821428571429, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI21357079, Length=500, Percent_Identity=30, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50526; Mature: 50526

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEMLRNRDTAYPYRFDSYFHYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCEEHHHHHHHH
TGFTEPDAVLVLNAAAPHGAPESILFCRARNVDREIWEGFHYGPDAARDAFGFDAAFATD
CCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHCCCCHHHHHH
VIDTEMPRLLADAGTVHYRFGASADFERQLAGWIDAVRAQARAGVAAPDALLDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMMRAAHISALAHRRAMQVCRPGIREYELEAELLYLFRKHGAQAPAYGS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IVAAGANACVLHYPAGNAAARDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIPKTRFSNVDDVIAERAYTRF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERLAARDANGALPWRTLKPGMTLTVEPGLYVRAADDVPPE
HHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRADA
CEEEEEEECCCHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNAPLDTAIAVDVYRQRRERVLAALRAAGGGVAIVPTAPEMLRNRDTAYPYRFDSYFHYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCEEHHHHHHHH
TGFTEPDAVLVLNAAAPHGAPESILFCRARNVDREIWEGFHYGPDAARDAFGFDAAFATD
CCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHCCCCHHHHHH
VIDTEMPRLLADAGTVHYRFGASADFERQLAGWIDAVRAQARAGVAAPDALLDLTPLLDD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MRLVKDEHELAIMMRAAHISALAHRRAMQVCRPGIREYELEAELLYLFRKHGAQAPAYGS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
IVAAGANACVLHYPAGNAAARDGDLILIDAACELDGYASDITRTFPANGRFSPAQRTLYD
EEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCHHHHHHHH
IVLAAQQAAIDATRAGVPFEAPHDAAVRVLAQGLLDTGIIPKTRFSNVDDVIAERAYTRF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERLAARDANGALPWRTLKPGMTLTVEPGLYVRAADDVPPE
HHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCEEEEECCCCCCC
YWNIGIRIEDDAIVREHGCELITRGVPVAADEIEALMRADA
CEEEEEEECCCHHHHHHCCHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]