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The map label for this gene is purH [H]

Identifier: 103488598

GI number: 103488598

Start: 3274335

End: 3275993

Strand: Reverse

Name: purH [H]

Synonym: Sala_3123

Alternate gene names: 103488598

Gene position: 3275993-3274335 (Counterclockwise)

Preceding gene: 103488599

Following gene: 103488596

Centisome position: 97.93

GC content: 67.69

Gene sequence:

>1659_bases
TTGCTCTTGGGGAGTGACCCGACTAGGGGAGCCGCGTCTTTCCCGTCTCGCAAAAGGCCGCCCTCCATGACCGACCTGAT
TCCCGTCCGCCGCGCGCTCTTGTCCGTCAGCGACAAGGCGGGGCTTGCCGATCTGGCCGCGGCGCTCGTCCGCCACGGGG
TCGAACTGGTGTCGACCGGGGGGACTGCGAAGGCATTGCGCGAGGCGGGTCATAGCGTGCTCGATGTCGCCGATTTGACC
GGCTTTCCCGAGATGATGGACGGCCGCGTCAAGACGCTGCACCCGGCGGTGCATGGCGGCATATTGGCGGTGCGCGACGA
CGAGCGCCACGTCGCCGCGATGGACGCGCACGGGATCGGCGCGATCGATCTGGTCGTCGTCAATCTCTACCCCTTCGCCG
CGACCGTCGCGAAGGGCGCGGCGCGCGACGAGATCATCGAAAATATAGACATCGGCGGCCCCGCGATGGTGCGCTCGGCA
GCGAAGAACCATGCGTTCGTCGGCATCGTCACCGAGCCCGAGGATTATGCCGCGGTGATCGCGGAGATGGACGCCAACGG
CGGCGCGATGACGCTGGACCTGCGCAAGCGGCTCGCCGCGACCGCCTTTGCCCACACCGCCACCTATGACGGGACGATCG
CGAGCTGGTTCGCCTTTGCCGACCAGGGCAAGCTGTTTCCCGACACGCTGCCGCTGACCGCCAAGCTGTCGGCCGAACTG
CGCTATGGCGAAAATCCGCACCAAAAGGCCGCGCTTTACCTGCCCGCCGGTCCCGCCGGGCGCGGGATAGCGCAAGCCGA
ACAGGTGCAGGGCAAGGAACTCAGCTACAACAATATCAACGACGCCGATGCCGCGCTCGAACTCGTCGCGGAGTTTCGCG
AGGCCGATCCGACCTGCGTGATCGTCAAGCACGCCAATCCGTGCGGCGTCGCGACCGCCGCGAGTTTGAGCCAGGCCTAT
GACGCGGCGCTGAAATGCGACGATGTGTCGGCGTTCGGCGGGATCATCGCGGTCAACCGACCACTCGACGGGCCGACGGC
GGAGGCGATCAGCGGCATTTTCACCGAGGTCGTCTGCGCCCCCGACGCCGATGCCGATGCCCGTGCGGTGTTCGCGAAGA
AGAAGAACCTCCGCCTGCTGCTCACCGGCGACTTGCCCGATCCGGCGCGCGGCGGGTTGATGCTGAAGACGATCGCCGGC
GGCTGGCTCGCGCAGAGCCGCGACAACGGCCGCATCACCCGCGCCGACCTGAAGGTCGTGACCGACCGCGCGCCGACCGA
GGAAGAACTGGCCGACGCGCTATTCGCGTGGACGGTTGCCAAGCATGTGAAGTCGAACGCGATCGTCTATGCCAAGGGCG
GCGCAACCGCGGGCATCGGCGCGGGGCAGATGAACCGCCGCGACAGCGCGCGCATTGCCGCGGCGAAAGCGCGCGAAGCG
GCCGAATCCCATGGCTGGGCAAGCCCGCGCACCATTGGCAGCGCGGTCGCCAGCGACGCCTTCTTCCCCTTTGCCGACGG
GTTGCTCGCGGCGGTCGAGGCGGGCGCGACCTGCGTGATCCAGCCCGGCGGATCGATCCGCGACGATGAGGTGATCGCAG
CCGCGAACAAAGCCGGGCTGGCGATGGTCTTCACCGGAATGCGGCATTTCCGGCATTGA

Upstream 100 bases:

>100_bases
TAAATCGTCGTTCCCGCACAGGCGGGGGCCGCAATCGGTTTGAAGCGGCGAGGCCGGAATAGACCGACAGCGGCCCCTGC
CTGTGCGGGGGCAACGATGC

Downstream 100 bases:

>100_bases
CCGCGCGCCCGGCGGCAACCAGTCTGTCAGCTTCGCGTCGGCAATCGTAGCGGAGCCCTGGTTCGCGGCAGAAATCAGGC
CAGCGATTCTCGCGCCGCCA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MLLGSDPTRGAASFPSRKRPPSMTDLIPVRRALLSVSDKAGLADLAAALVRHGVELVSTGGTAKALREAGHSVLDVADLT
GFPEMMDGRVKTLHPAVHGGILAVRDDERHVAAMDAHGIGAIDLVVVNLYPFAATVAKGAARDEIIENIDIGGPAMVRSA
AKNHAFVGIVTEPEDYAAVIAEMDANGGAMTLDLRKRLAATAFAHTATYDGTIASWFAFADQGKLFPDTLPLTAKLSAEL
RYGENPHQKAALYLPAGPAGRGIAQAEQVQGKELSYNNINDADAALELVAEFREADPTCVIVKHANPCGVATAASLSQAY
DAALKCDDVSAFGGIIAVNRPLDGPTAEAISGIFTEVVCAPDADADARAVFAKKKNLRLLLTGDLPDPARGGLMLKTIAG
GWLAQSRDNGRITRADLKVVTDRAPTEEELADALFAWTVAKHVKSNAIVYAKGGATAGIGAGQMNRRDSARIAAAKAREA
AESHGWASPRTIGSAVASDAFFPFADGLLAAVEAGATCVIQPGGSIRDDEVIAAANKAGLAMVFTGMRHFRH

Sequences:

>Translated_552_residues
MLLGSDPTRGAASFPSRKRPPSMTDLIPVRRALLSVSDKAGLADLAAALVRHGVELVSTGGTAKALREAGHSVLDVADLT
GFPEMMDGRVKTLHPAVHGGILAVRDDERHVAAMDAHGIGAIDLVVVNLYPFAATVAKGAARDEIIENIDIGGPAMVRSA
AKNHAFVGIVTEPEDYAAVIAEMDANGGAMTLDLRKRLAATAFAHTATYDGTIASWFAFADQGKLFPDTLPLTAKLSAEL
RYGENPHQKAALYLPAGPAGRGIAQAEQVQGKELSYNNINDADAALELVAEFREADPTCVIVKHANPCGVATAASLSQAY
DAALKCDDVSAFGGIIAVNRPLDGPTAEAISGIFTEVVCAPDADADARAVFAKKKNLRLLLTGDLPDPARGGLMLKTIAG
GWLAQSRDNGRITRADLKVVTDRAPTEEELADALFAWTVAKHVKSNAIVYAKGGATAGIGAGQMNRRDSARIAAAKAREA
AESHGWASPRTIGSAVASDAFFPFADGLLAAVEAGATCVIQPGGSIRDDEVIAAANKAGLAMVFTGMRHFRH
>Mature_552_residues
MLLGSDPTRGAASFPSRKRPPSMTDLIPVRRALLSVSDKAGLADLAAALVRHGVELVSTGGTAKALREAGHSVLDVADLT
GFPEMMDGRVKTLHPAVHGGILAVRDDERHVAAMDAHGIGAIDLVVVNLYPFAATVAKGAARDEIIENIDIGGPAMVRSA
AKNHAFVGIVTEPEDYAAVIAEMDANGGAMTLDLRKRLAATAFAHTATYDGTIASWFAFADQGKLFPDTLPLTAKLSAEL
RYGENPHQKAALYLPAGPAGRGIAQAEQVQGKELSYNNINDADAALELVAEFREADPTCVIVKHANPCGVATAASLSQAY
DAALKCDDVSAFGGIIAVNRPLDGPTAEAISGIFTEVVCAPDADADARAVFAKKKNLRLLLTGDLPDPARGGLMLKTIAG
GWLAQSRDNGRITRADLKVVTDRAPTEEELADALFAWTVAKHVKSNAIVYAKGGATAGIGAGQMNRRDSARIAAAKAREA
AESHGWASPRTIGSAVASDAFFPFADGLLAAVEAGATCVIQPGGSIRDDEVIAAANKAGLAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=485, Percent_Identity=39.1752577319588, Blast_Score=265, Evalue=1e-70,
Organism=Escherichia coli, GI1790439, Length=543, Percent_Identity=57.2744014732965, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI71985564, Length=610, Percent_Identity=33.9344262295082, Blast_Score=275, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI71985574, Length=309, Percent_Identity=29.4498381877023, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=37.3949579831933, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323056, Length=475, Percent_Identity=37.4736842105263, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24649832, Length=472, Percent_Identity=38.9830508474576, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 57516; Mature: 57516

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLGSDPTRGAASFPSRKRPPSMTDLIPVRRALLSVSDKAGLADLAAALVRHGVELVSTG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECC
GTAKALREAGHSVLDVADLTGFPEMMDGRVKTLHPAVHGGILAVRDDERHVAAMDAHGIG
CHHHHHHHCCCCEEEHHHHCCCHHHHCCCHHEECHHHHCCEEEEECCCCEEEEECCCCCC
AIDLVVVNLYPFAATVAKGAARDEIIENIDIGGPAMVRSAAKNHAFVGIVTEPEDYAAVI
EEEEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCHHEEEE
AEMDANGGAMTLDLRKRLAATAFAHTATYDGTIASWFAFADQGKLFPDTLPLTAKLSAEL
EEECCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
RYGENPHQKAALYLPAGPAGRGIAQAEQVQGKELSYNNINDADAALELVAEFREADPTCV
ECCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IVKHANPCGVATAASLSQAYDAALKCDDVSAFGGIIAVNRPLDGPTAEAISGIFTEVVCA
EEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHEEEC
PDADADARAVFAKKKNLRLLLTGDLPDPARGGLMLKTIAGGWLAQSRDNGRITRADLKVV
CCCCCCHHEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCHHCCCCCCCCEEEEEEEEE
TDRAPTEEELADALFAWTVAKHVKSNAIVYAKGGATAGIGAGQMNRRDSARIAAAKAREA
ECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AESHGWASPRTIGSAVASDAFFPFADGLLAAVEAGATCVIQPGGSIRDDEVIAAANKAGL
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCC
AMVFTGMRHFRH
HHHHHHHHHHCC
>Mature Secondary Structure
MLLGSDPTRGAASFPSRKRPPSMTDLIPVRRALLSVSDKAGLADLAAALVRHGVELVSTG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECC
GTAKALREAGHSVLDVADLTGFPEMMDGRVKTLHPAVHGGILAVRDDERHVAAMDAHGIG
CHHHHHHHCCCCEEEHHHHCCCHHHHCCCHHEECHHHHCCEEEEECCCCEEEEECCCCCC
AIDLVVVNLYPFAATVAKGAARDEIIENIDIGGPAMVRSAAKNHAFVGIVTEPEDYAAVI
EEEEEEEEHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCHHEEEE
AEMDANGGAMTLDLRKRLAATAFAHTATYDGTIASWFAFADQGKLFPDTLPLTAKLSAEL
EEECCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
RYGENPHQKAALYLPAGPAGRGIAQAEQVQGKELSYNNINDADAALELVAEFREADPTCV
ECCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IVKHANPCGVATAASLSQAYDAALKCDDVSAFGGIIAVNRPLDGPTAEAISGIFTEVVCA
EEECCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHEEEC
PDADADARAVFAKKKNLRLLLTGDLPDPARGGLMLKTIAGGWLAQSRDNGRITRADLKVV
CCCCCCHHEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCHHCCCCCCCCEEEEEEEEE
TDRAPTEEELADALFAWTVAKHVKSNAIVYAKGGATAGIGAGQMNRRDSARIAAAKAREA
ECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AESHGWASPRTIGSAVASDAFFPFADGLLAAVEAGATCVIQPGGSIRDDEVIAAANKAGL
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCC
AMVFTGMRHFRH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA