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The map label for this gene is acdA [H]

Identifier: 103488529

GI number: 103488529

Start: 3203208

End: 3204353

Strand: Direct

Name: acdA [H]

Synonym: Sala_3053

Alternate gene names: 103488529

Gene position: 3203208-3204353 (Clockwise)

Preceding gene: 103488528

Following gene: 103488530

Centisome position: 95.76

GC content: 63.7

Gene sequence:

>1146_bases
ATGACCGACCAGTTCCAGCTTACCGAAGACCAGCTCGCCATTCAGGACATGGCGCGCAAGTTCACCGCCGATCGCATCAC
GCCCTTCGCGGCCGAATGGGACGAGGCAAGCCATTATCCCGTCGATGTGTGGAAGGCGGCGGGCGAGCTTGGCTTCGGCG
CGATCTATGTGGCCGAGGAATCGGGCGGCATCGGGCTCGGCAGGCTCGAGGCGGCGCTGATCATGGAGGCGATGGCCTAT
GGCTGCCCTGCGACCAGCGCGTACATCTCGATCCACAATATGGCGACGTGGATGATAGACCGCTTCGGCGGCGCCGAAAT
CAAGGCGCGTTTTCTGCCCGCGCTCGTCAGCATGGACAAGATCGCCAGCTATTGCCTGACCGAGCCGGGCTCGGGCTCCG
ACGCCGCGGCGCTCAAGACGACCGCGAAAAGGGATGGCGACCATTATGTGCTGAATGGCACCAAGCAGTTCATCTCGGGC
GCGGGCTATAACGACATCTATGTCTGCATGGTCCGCACCGGCGAGGAAAAGGCCAAAGGCATCAGCTGCCTCGTCGTCGA
AAAGGACACGCCGGGACTCAGCTTCGGCGCGCCCGAAAAGAAGCTCGGCTGGAACGCCTCCCCCACCGCGCAAGTGATTT
TCGAGGATTGCCGCGTGCCGGTCGAGAATCGCGTCGGGGCGGAGGGCGACGGCTTCCGCTTCGCGATGGCGGGGCTCGAC
GGCGGCCGCCTCAACATCGGCGCCTGCTCGCTGGGGGGCGCGCAGCGATGCCTCGACGAAGCGATCACCTACACCAGGGA
CCGCCAGCAGTTCGGGCAACCGGTCGCCGATTTCCAGAACACCCAGTTCATGCTCGCCGACATGGCGACCGACCTCGAAG
CCGCGCGCGCGCTGCTCTATATGGCGGCGGCGAAAGTCACTGCGAACGCCCCCGACAAGTCACGCTTCTCGGCGATGGCC
AAGCGGCTCGCGACCGACAATGGCAGCAGGATCGTCAACGATGCGCTTCAGCTGTTCGGGGGCTATGGCTATTTGAAGGA
TTATCCGATCGAGCGGTTCTGGCGCGATCTGCGCGTCCATTCGATCCTCGAGGGCACCAATCAGGTGATGCGGATGATCG
TCGGAAGGGATTTGCTGCGCCAATAG

Upstream 100 bases:

>100_bases
ACATCCGCCCGGCATCGACGATGATCGTGATACCCGCGCTCATCCGTCCCGAATGGAAGGTCGAAATCGAGGCCGAAGCC
ATCATCATCGAGAAGAGCGC

Downstream 100 bases:

>100_bases
ATTTCCCCCTCTCCCGTCGGGAGAGGGTTGCGAAGACTTGCCAGCTCGCTGGCTAGTCGAAGCTGGGTGAGGGGCGGTGC
GCTATCGGTACGGCGGATTC

Product: Acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTDQFQLTEDQLAIQDMARKFTADRITPFAAEWDEASHYPVDVWKAAGELGFGAIYVAEESGGIGLGRLEAALIMEAMAY
GCPATSAYISIHNMATWMIDRFGGAEIKARFLPALVSMDKIASYCLTEPGSGSDAAALKTTAKRDGDHYVLNGTKQFISG
AGYNDIYVCMVRTGEEKAKGISCLVVEKDTPGLSFGAPEKKLGWNASPTAQVIFEDCRVPVENRVGAEGDGFRFAMAGLD
GGRLNIGACSLGGAQRCLDEAITYTRDRQQFGQPVADFQNTQFMLADMATDLEAARALLYMAAAKVTANAPDKSRFSAMA
KRLATDNGSRIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQ

Sequences:

>Translated_381_residues
MTDQFQLTEDQLAIQDMARKFTADRITPFAAEWDEASHYPVDVWKAAGELGFGAIYVAEESGGIGLGRLEAALIMEAMAY
GCPATSAYISIHNMATWMIDRFGGAEIKARFLPALVSMDKIASYCLTEPGSGSDAAALKTTAKRDGDHYVLNGTKQFISG
AGYNDIYVCMVRTGEEKAKGISCLVVEKDTPGLSFGAPEKKLGWNASPTAQVIFEDCRVPVENRVGAEGDGFRFAMAGLD
GGRLNIGACSLGGAQRCLDEAITYTRDRQQFGQPVADFQNTQFMLADMATDLEAARALLYMAAAKVTANAPDKSRFSAMA
KRLATDNGSRIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQ
>Mature_380_residues
TDQFQLTEDQLAIQDMARKFTADRITPFAAEWDEASHYPVDVWKAAGELGFGAIYVAEESGGIGLGRLEAALIMEAMAYG
CPATSAYISIHNMATWMIDRFGGAEIKARFLPALVSMDKIASYCLTEPGSGSDAAALKTTAKRDGDHYVLNGTKQFISGA
GYNDIYVCMVRTGEEKAKGISCLVVEKDTPGLSFGAPEKKLGWNASPTAQVIFEDCRVPVENRVGAEGDGFRFAMAGLDG
GRLNIGACSLGGAQRCLDEAITYTRDRQQFGQPVADFQNTQFMLADMATDLEAARALLYMAAAKVTANAPDKSRFSAMAK
RLATDNGSRIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQ

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=55.4089709762533, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=36.9393139841689, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=36.9393139841689, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=40.5835543766578, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.6310160427808, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.7765957446808, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4501857, Length=365, Percent_Identity=33.4246575342466, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=34.8571428571429, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=34.8082595870207, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI76496475, Length=393, Percent_Identity=32.0610687022901, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557235, Length=393, Percent_Identity=32.0610687022901, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI7669494, Length=359, Percent_Identity=28.4122562674095, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI48976061, Length=337, Percent_Identity=29.9703264094956, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI211971008, Length=339, Percent_Identity=30.3834808259587, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=27.6595744680851, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=30, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=29.3963254593176, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082384, Length=270, Percent_Identity=29.2592592592593, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=50.132625994695, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=39.6325459317585, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=39.5778364116095, Blast_Score=287, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=38.5224274406332, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=38.7096774193548, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=36.6120218579235, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17538396, Length=389, Percent_Identity=32.9048843187661, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=32.9512893982808, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=33.2439678284182, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=34.4, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=326, Percent_Identity=36.1963190184049, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=42.7312775330396, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=32.3636363636364, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=281, Percent_Identity=32.7402135231317, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17534353, Length=378, Percent_Identity=29.3650793650794, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=30.4721030042918, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=321, Percent_Identity=26.4797507788162, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=325, Percent_Identity=26.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=325, Percent_Identity=26.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531913, Length=168, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=38.6243386243386, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=36.604774535809, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=35.4838709677419, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.2340425531915, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=34.5646437994723, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=32.0209973753281, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41552; Mature: 41420

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQFQLTEDQLAIQDMARKFTADRITPFAAEWDEASHYPVDVWKAAGELGFGAIYVAEE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHCCCCCCEEEEEEEC
SGGIGLGRLEAALIMEAMAYGCPATSAYISIHNMATWMIDRFGGAEIKARFLPALVSMDK
CCCCCHHHHHHHHHHHHHHHCCCCCHHHEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IASYCLTEPGSGSDAAALKTTAKRDGDHYVLNGTKQFISGAGYNDIYVCMVRTGEEKAKG
HHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHHHCCCCCCCEEEEEEECCCHHHCC
ISCLVVEKDTPGLSFGAPEKKLGWNASPTAQVIFEDCRVPVENRVGAEGDGFRFAMAGLD
EEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCEEEEECCC
GGRLNIGACSLGGAQRCLDEAITYTRDRQQFGQPVADFQNTQFMLADMATDLEAARALLY
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHH
MAAAKVTANAPDKSRFSAMAKRLATDNGSRIVNDALQLFGGYGYLKDYPIERFWRDLRVH
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SILEGTNQVMRMIVGRDLLRQ
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDQFQLTEDQLAIQDMARKFTADRITPFAAEWDEASHYPVDVWKAAGELGFGAIYVAEE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHHHHHCCCCCCEEEEEEEC
SGGIGLGRLEAALIMEAMAYGCPATSAYISIHNMATWMIDRFGGAEIKARFLPALVSMDK
CCCCCHHHHHHHHHHHHHHHCCCCCHHHEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IASYCLTEPGSGSDAAALKTTAKRDGDHYVLNGTKQFISGAGYNDIYVCMVRTGEEKAKG
HHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHHHCCCCCCCEEEEEEECCCHHHCC
ISCLVVEKDTPGLSFGAPEKKLGWNASPTAQVIFEDCRVPVENRVGAEGDGFRFAMAGLD
EEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCEEEEECCC
GGRLNIGACSLGGAQRCLDEAITYTRDRQQFGQPVADFQNTQFMLADMATDLEAARALLY
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHH
MAAAKVTANAPDKSRFSAMAKRLATDNGSRIVNDALQLFGGYGYLKDYPIERFWRDLRVH
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SILEGTNQVMRMIVGRDLLRQ
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]