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The map label for this gene is ribB [H]

Identifier: 103488458

GI number: 103488458

Start: 3124219

End: 3125493

Strand: Direct

Name: ribB [H]

Synonym: Sala_2981

Alternate gene names: 103488458

Gene position: 3124219-3125493 (Clockwise)

Preceding gene: 103488457

Following gene: 103488459

Centisome position: 93.39

GC content: 67.45

Gene sequence:

>1275_bases
ATGACCATCCAGCTCATCGATCGCATCCGCGCCATCGTCGCCGACGGCACCATGTCGCGTTCGGGCCTCGCGCGCGCCGC
GGGGCTTCACGCCAACAGCCTGCGCGACCTCGACTCGCCCGGCTGGAACCCGACCGCCGAAACGCTGCGCAAGCTCGAAA
ACTGGCTCGCCAACGGCAGCGACCTGTCGCCGATGGCGAGCCCCGAAGAGATCATCGCCGAGGCGCGCAACGGCCGCATG
TTCATCCTCGTCGACGACGAGGATCGCGAAAATGAGGGCGACCTTGTCATTCCCGCGCAGATGGCCACCCCCGACGCGAT
CAATTTCATGGCGACGCACGGCCGCGGGCTCATCTGCCTGACGCTGACCAGGGCGCGCGTCGATGCGCTGGGCCTCGAGC
TGATGAGCCGCAACAATGGCACGCGGCACGAAACGGCCTTCACCACCTCGATCGAAGCGCGCGAAGGCGTGACGACGGGC
ATTTCGGCGGGGGACCGGGCGCGCACGGTGGCGGTGGCGATCGATGCGAGCAAGGGGCGCGACGATATCGTCACGCCGGG
GCATGTCTTTCCCCTCATCGCGCGCGACGGCGGCGTGCTCGTCCGCGCGGGCCATACCGAGGCGTCGGTCGACATCGCGC
GCCTTGCCGGACTCAATCCGTCGGGGGTGATCTGCGAGATCATGAACGACGATGGCACCATGGCGCGCCTCGACGACCTC
ATCCCCTTCGCGCGGCGCCACGGGCTCAAGATCGGTACGATCGCCGACCTCATCGCCTATCGCAACCGCAGCGACCGGCT
GGTCGAATGCGTTGCCGACGAACCGTTCGAATCGGATTATGGCGGCGAGTGGCGGCTTAAATCCTATCGCAACAAGATCG
ACGGCAGCGTCAATCTGGTGCTGCAAAAGGGGCCGGTCGATCCCGATGGCGTGACATTGGTGCGGATGCACCCCGTGTCG
ATCTTCGACGATATCATGGGGCGTCCCGGCCCCCGCAAGCGCCGCCTGCAACGGTCGATGGACGCGATCGGCGAAGCGGG
TGCGGGGGTCATCGTCCTGCTCATGCGCCCGCTCCCCGGATCGGCCGACGCCGAGGCGCTGCCGCCGCCGACCGGCGGCA
TGGACCTGCGCACCTACGGCATCGGCGCGCAGATCCTCGCCGACCTCGGCGTTCACGCGATGGAACTGCTCACCCCCACC
CACAGCAATATCGTCGGGCTCGAAGGCTATGGCCTGTCGGTCGTCGGCGAACGCCCCATTCCCGGAGAAGCCTGA

Upstream 100 bases:

>100_bases
GATGCGCCCAAGCGCGAATATGGGCCGACCTTTGGCCCCAATTAACGTTGAATGTGATTGATGGATTGACGATCACATTA
TGATGTGAGATATGGCTGGC

Downstream 100 bases:

>100_bases
TGGCGCACGTCCTGATCGTCGAAGCGCGTTTCTACAGCCATTTGAACGACATGCTGCTCGATGGCGTGCGCAGCGCGCTC
GATGCCGAAGGGCATAGCCA

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTIQLIDRIRAIVADGTMSRSGLARAAGLHANSLRDLDSPGWNPTAETLRKLENWLANGSDLSPMASPEEIIAEARNGRM
FILVDDEDRENEGDLVIPAQMATPDAINFMATHGRGLICLTLTRARVDALGLELMSRNNGTRHETAFTTSIEAREGVTTG
ISAGDRARTVAVAIDASKGRDDIVTPGHVFPLIARDGGVLVRAGHTEASVDIARLAGLNPSGVICEIMNDDGTMARLDDL
IPFARRHGLKIGTIADLIAYRNRSDRLVECVADEPFESDYGGEWRLKSYRNKIDGSVNLVLQKGPVDPDGVTLVRMHPVS
IFDDIMGRPGPRKRRLQRSMDAIGEAGAGVIVLLMRPLPGSADAEALPPPTGGMDLRTYGIGAQILADLGVHAMELLTPT
HSNIVGLEGYGLSVVGERPIPGEA

Sequences:

>Translated_424_residues
MTIQLIDRIRAIVADGTMSRSGLARAAGLHANSLRDLDSPGWNPTAETLRKLENWLANGSDLSPMASPEEIIAEARNGRM
FILVDDEDRENEGDLVIPAQMATPDAINFMATHGRGLICLTLTRARVDALGLELMSRNNGTRHETAFTTSIEAREGVTTG
ISAGDRARTVAVAIDASKGRDDIVTPGHVFPLIARDGGVLVRAGHTEASVDIARLAGLNPSGVICEIMNDDGTMARLDDL
IPFARRHGLKIGTIADLIAYRNRSDRLVECVADEPFESDYGGEWRLKSYRNKIDGSVNLVLQKGPVDPDGVTLVRMHPVS
IFDDIMGRPGPRKRRLQRSMDAIGEAGAGVIVLLMRPLPGSADAEALPPPTGGMDLRTYGIGAQILADLGVHAMELLTPT
HSNIVGLEGYGLSVVGERPIPGEA
>Mature_423_residues
TIQLIDRIRAIVADGTMSRSGLARAAGLHANSLRDLDSPGWNPTAETLRKLENWLANGSDLSPMASPEEIIAEARNGRMF
ILVDDEDRENEGDLVIPAQMATPDAINFMATHGRGLICLTLTRARVDALGLELMSRNNGTRHETAFTTSIEAREGVTTGI
SAGDRARTVAVAIDASKGRDDIVTPGHVFPLIARDGGVLVRAGHTEASVDIARLAGLNPSGVICEIMNDDGTMARLDDLI
PFARRHGLKIGTIADLIAYRNRSDRLVECVADEPFESDYGGEWRLKSYRNKIDGSVNLVLQKGPVDPDGVTLVRMHPVSI
FDDIMGRPGPRKRRLQRSMDAIGEAGAGVIVLLMRPLPGSADAEALPPPTGGMDLRTYGIGAQILADLGVHAMELLTPTH
SNIVGLEGYGLSVVGERPIPGEA

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=48.5294117647059, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=39.9038461538462, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 45436; Mature: 45305

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQLIDRIRAIVADGTMSRSGLARAAGLHANSLRDLDSPGWNPTAETLRKLENWLANGS
CCHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
DLSPMASPEEIIAEARNGRMFILVDDEDRENEGDLVIPAQMATPDAINFMATHGRGLICL
CCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHEEEEECCCCEEEE
TLTRARVDALGLELMSRNNGTRHETAFTTSIEAREGVTTGISAGDRARTVAVAIDASKGR
EEEHHHHHHHHHHHHHCCCCCCCCEEEEEECHHCCCCCCCCCCCCCCEEEEEEEECCCCC
DDIVTPGHVFPLIARDGGVLVRAGHTEASVDIARLAGLNPSGVICEIMNDDGTMARLDDL
CCCCCCCCEEEEEECCCCEEEEECCCCHHEEHHHHCCCCCCCEEEEEECCCCCHHHHHHH
IPFARRHGLKIGTIADLIAYRNRSDRLVECVADEPFESDYGGEWRLKSYRNKIDGSVNLV
HHHHHHCCCEEHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCEEEHHHHHHCCCEEEEE
LQKGPVDPDGVTLVRMHPVSIFDDIMGRPGPRKRRLQRSMDAIGEAGAGVIVLLMRPLPG
EECCCCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
SADAEALPPPTGGMDLRTYGIGAQILADLGVHAMELLTPTHSNIVGLEGYGLSVVGERPI
CCCCCCCCCCCCCCEEEEECCHHHHHHHHCHHHHHHHCCCCCCEEEECCCCEEEEECCCC
PGEA
CCCC
>Mature Secondary Structure 
TIQLIDRIRAIVADGTMSRSGLARAAGLHANSLRDLDSPGWNPTAETLRKLENWLANGS
CHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
DLSPMASPEEIIAEARNGRMFILVDDEDRENEGDLVIPAQMATPDAINFMATHGRGLICL
CCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHEEEEECCCCEEEE
TLTRARVDALGLELMSRNNGTRHETAFTTSIEAREGVTTGISAGDRARTVAVAIDASKGR
EEEHHHHHHHHHHHHHCCCCCCCCEEEEEECHHCCCCCCCCCCCCCCEEEEEEEECCCCC
DDIVTPGHVFPLIARDGGVLVRAGHTEASVDIARLAGLNPSGVICEIMNDDGTMARLDDL
CCCCCCCCEEEEEECCCCEEEEECCCCHHEEHHHHCCCCCCCEEEEEECCCCCHHHHHHH
IPFARRHGLKIGTIADLIAYRNRSDRLVECVADEPFESDYGGEWRLKSYRNKIDGSVNLV
HHHHHHCCCEEHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCEEEHHHHHHCCCEEEEE
LQKGPVDPDGVTLVRMHPVSIFDDIMGRPGPRKRRLQRSMDAIGEAGAGVIVLLMRPLPG
EECCCCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
SADAEALPPPTGGMDLRTYGIGAQILADLGVHAMELLTPTHSNIVGLEGYGLSVVGERPI
CCCCCCCCCCCCCCEEEEECCHHHHHHHHCHHHHHHHCCCCCCEEEECCCCEEEEECCCC
PGEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]