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The map label for this gene is prs [H]

Identifier: 103488419

GI number: 103488419

Start: 3085178

End: 3086113

Strand: Reverse

Name: prs [H]

Synonym: Sala_2942

Alternate gene names: 103488419

Gene position: 3086113-3085178 (Counterclockwise)

Preceding gene: 103488425

Following gene: 103488418

Centisome position: 92.26

GC content: 65.38

Gene sequence:

>936_bases
ATGAAACTCATCTCCGGCAACAGCAACCTGCCGCTGGCCCGCGCGATCGCCGATTATCTCGAGCTGCCGCTGACCGACAC
CAGCGTGCGCCGCTTCGCCGACGAAGAGGTTTTCGTCGAAATCCACGAAAATGTCCGCGGGCAGGATGTTTTCGTCGTTC
AGCCGACCAATTTCCCCGCGAACGACAATCTGATGGAATTGCTCATCATCAACGACGCGCTGCGCCGCGCGTCGGCGAAG
CGCATCACCGCGGTCGTTCCCTATTTCGGCTATGCGCGGCAGGATCGCAAACCCGGCCCGCGCACGCCGATCTCGGCAAA
GCTGGTCGCGAACCTCATCACCACCTCGGGCGCCGACCGCGTGCTCGCGATCGACCTGCACGCCGGGCAGATCCAGGGCT
TCTTCGACATCCCGACCGACAATCTCTATGCCGCGCCGGTGATGAGCGCCGACATCCAGGCGCGCTTCGGCGACAAGAAT
CTGATGGTCGTGTCGCCCGACGTCGGCGGCGTCGTGCGCGCCCGCGCGCTCGCCAAGCGGCTCGACAACGCGCCGCTCGC
CATCGTCGACAAGCGCCGCGAGCGCGCGGGCGAATCGGAAGTGATGAACATCATCGGCGACGTCGCGGGTCGCTTCTGCA
TCCTCATCGACGATATCGTCGATTCGGCGGGAACGCTGTGCAATGCCGCCGGGGCGCTGAAGGCCGCAGGCGCCGAAGGC
GTCGTCGCCTATTGCACCCATGGCGTGCTGTCGGGCGGCGCCGTCGCCCGCGTCAATGCGAGCGAGCTCACCGAACTCGT
CATCACCGATTCGATCCAGCCGACCGACGCGGTGAACGACAGCGCCAAGGTTCGCACGCTTACCGTCGCGCCGCTGCTCG
GCGAGGCGATCAAGCGGATTGCCGACGAAACGAGCGTCTCCTCGCTCTTTGACTGA

Upstream 100 bases:

>100_bases
GGCGACGGGGACCGATCGCCTCCTTTAACCCCTTCCCCTCATGGCCATCGCTGGCTAAGGGGCGCGCAATCCCATCCGCC
GCGAAAGGGCCCTGCACCCC

Downstream 100 bases:

>100_bases
AAGCCGCGACGGGGACGGGAAAAATGCTGCGCAGGCTGGCGGCGCGAACCCGGCTGCGCTAGCGCAACGTCATGTCGATC
GTGTCAGACCTTGCACTCGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKLISGNSNLPLARAIADYLELPLTDTSVRRFADEEVFVEIHENVRGQDVFVVQPTNFPANDNLMELLIINDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITTSGADRVLAIDLHAGQIQGFFDIPTDNLYAAPVMSADIQARFGDKN
LMVVSPDVGGVVRARALAKRLDNAPLAIVDKRRERAGESEVMNIIGDVAGRFCILIDDIVDSAGTLCNAAGALKAAGAEG
VVAYCTHGVLSGGAVARVNASELTELVITDSIQPTDAVNDSAKVRTLTVAPLLGEAIKRIADETSVSSLFD

Sequences:

>Translated_311_residues
MKLISGNSNLPLARAIADYLELPLTDTSVRRFADEEVFVEIHENVRGQDVFVVQPTNFPANDNLMELLIINDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITTSGADRVLAIDLHAGQIQGFFDIPTDNLYAAPVMSADIQARFGDKN
LMVVSPDVGGVVRARALAKRLDNAPLAIVDKRRERAGESEVMNIIGDVAGRFCILIDDIVDSAGTLCNAAGALKAAGAEG
VVAYCTHGVLSGGAVARVNASELTELVITDSIQPTDAVNDSAKVRTLTVAPLLGEAIKRIADETSVSSLFD
>Mature_311_residues
MKLISGNSNLPLARAIADYLELPLTDTSVRRFADEEVFVEIHENVRGQDVFVVQPTNFPANDNLMELLIINDALRRASAK
RITAVVPYFGYARQDRKPGPRTPISAKLVANLITTSGADRVLAIDLHAGQIQGFFDIPTDNLYAAPVMSADIQARFGDKN
LMVVSPDVGGVVRARALAKRLDNAPLAIVDKRRERAGESEVMNIIGDVAGRFCILIDDIVDSAGTLCNAAGALKAAGAEG
VVAYCTHGVLSGGAVARVNASELTELVITDSIQPTDAVNDSAKVRTLTVAPLLGEAIKRIADETSVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=45.9807073954984, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=45.6310679611651, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=45.1923076923077, Blast_Score=276, Evalue=1e-74,
Organism=Homo sapiens, GI28557709, Length=311, Percent_Identity=45.016077170418, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=32.3615160349854, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=32.6241134751773, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=32.6241134751773, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=32.6241134751773, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=32.6241134751773, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=54.1666666666667, Blast_Score=337, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17554702, Length=311, Percent_Identity=44.3729903536978, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25149168, Length=311, Percent_Identity=44.3729903536978, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=311, Percent_Identity=44.3729903536978, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.336569579288, Blast_Score=276, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=33.2344213649852, Blast_Score=187, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=43.9102564102564, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=44.408945686901, Blast_Score=252, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=42.443729903537, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=39.2857142857143, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=87, Percent_Identity=45.9770114942529, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355239, Length=311, Percent_Identity=45.016077170418, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=41.9161676646707, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=32.1022727272727, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651462, Length=200, Percent_Identity=37, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24651464, Length=200, Percent_Identity=37, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552010, Length=200, Percent_Identity=37, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33179; Mature: 33179

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISGNSNLPLARAIADYLELPLTDTSVRRFADEEVFVEIHENVRGQDVFVVQPTNFPA
CEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHEEEECCCCCCCEEEEECCCCCCC
NDNLMELLIINDALRRASAKRITAVVPYFGYARQDRKPGPRTPISAKLVANLITTSGADR
CCCEEEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VLAIDLHAGQIQGFFDIPTDNLYAAPVMSADIQARFGDKNLMVVSPDVGGVVRARALAKR
EEEEEEECCCCCEEEECCCCCEEECCCCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHH
LDNAPLAIVDKRRERAGESEVMNIIGDVAGRFCILIDDIVDSAGTLCNAAGALKAAGAEG
HCCCCEEEEECHHHHCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCC
VVAYCTHGVLSGGAVARVNASELTELVITDSIQPTDAVNDSAKVRTLTVAPLLGEAIKRI
EEHHHHHHHHCCCEEEEECHHHHHEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
ADETSVSSLFD
HHHHHHHHHCC
>Mature Secondary Structure
MKLISGNSNLPLARAIADYLELPLTDTSVRRFADEEVFVEIHENVRGQDVFVVQPTNFPA
CEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHEEEECCCCCCCEEEEECCCCCCC
NDNLMELLIINDALRRASAKRITAVVPYFGYARQDRKPGPRTPISAKLVANLITTSGADR
CCCEEEEEEEHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VLAIDLHAGQIQGFFDIPTDNLYAAPVMSADIQARFGDKNLMVVSPDVGGVVRARALAKR
EEEEEEECCCCCEEEECCCCCEEECCCCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHH
LDNAPLAIVDKRRERAGESEVMNIIGDVAGRFCILIDDIVDSAGTLCNAAGALKAAGAEG
HCCCCEEEEECHHHHCCHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCC
VVAYCTHGVLSGGAVARVNASELTELVITDSIQPTDAVNDSAKVRTLTVAPLLGEAIKRI
EEHHHHHHHHCCCEEEEECHHHHHEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH
ADETSVSSLFD
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]