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The map label for this gene is cobQ

Identifier: 103488233

GI number: 103488233

Start: 2905222

End: 2906679

Strand: Direct

Name: cobQ

Synonym: Sala_2756

Alternate gene names: 103488233

Gene position: 2905222-2906679 (Clockwise)

Preceding gene: 103488232

Following gene: 103488235

Centisome position: 86.85

GC content: 69.41

Gene sequence:

>1458_bases
ATGGCCGCGCTGATGCTGCAAGGCACCGGCTCCGACGTCGGCAAGTCGGTGCTCGTCGCCGGGCTGTGCCGGGCGCTTGC
CAATCGCGGGCTCCGCGTGCGCCCGTTCAAGCCGCAGAATATGTCGAACAATGCCGCGGTCACGATCGACGGCGGCGAAA
TCGGTCGCGCGCAGGCGTTGCAGGCGCTCGCGTGCCGCACCCCGCCGCACAGCGACATGAACCCGGTGCTGTTGAAGCCG
CAGGCCGACCGGACGTCGCAACTCATCGTCCACGGGCGCGTGCGCGGCACGCTGGGCAGCGGCAATTTTCGCGCAGGACG
CGGCGCCCTGCTCCCCGACGTGCTCGAAAGCTATGGCCGGCTGCGCCGCCAGTGTGACATCGTCATTGTCGAAGGCGCGG
GATCGCCCGCCGAAATCAACCTGCGCGCGGGCGATATCGCCAACATGGGCTTTGCCCGCGCCGCGCGCGTCCCGGTGGTT
CTGGTCGGTGACATCGACCGCGGCGGGGTGATCGCGGCAATCGTCGGTACCCGGACCGTGATCGACGCAGAGGATGCGGC
GATGATCAAGGGCTTTGTCATCAACAAGTTTCGCGGCGATCCGGCGCTGTTCGACGATGGCTATCGCGCGATTGCGGAGC
GCAGCGGCTGGCCGGGGCTGGGGGTCGTTCCCTGGCTCGCGGCGGCGGCGCGTCTGCCAAGCGAGGATGCGGTGATCCTC
GAACGCCGCGCCGATGCGCGCGAGGGCCGCCGGATCGTCGCCTGCCCGATCCTGCCGCGCATCGCCAATTTCGACGACCT
CGACCCGCTGAAACAGGAACCCGGCGTCGAACTGCTGATGGTCCCGCCGGGGCAGCCGATCCCCGCGGAGGCAGCGATCA
TCGTCCTGCCGGGATCAAAAGCGACGATCGCCGACCTTGCCGCGCTCCGCCGCGAAGGCTGGGACATCGACATCAAGGCG
CATCACCGCCGCGGCGGGCTGATCCTGGGCCTCTGCGGCGGCTATCAGATGCTGGGGACGCGCATCGCCGATCCGCTGGG
GATCGAAGGGGCGGCATCGGAGGTGGAGGGGCTGGGCCTGCTCGACGTCACCACCGAACTGGCTCCCGCCAAGACGCTCC
GCGAAGTGACCGGAACCGCATGGAACAGTCCGGTCGCGGGATATGAGATGCACATGGGCGCGACCGTCGGCACCGACACG
GCGCGCCCCTTTGCGCGGATCGACGGCGGCGGGGGGGAAGGTGCGATCAACGCCGCGGGCAATGTGATCGGAACCTATAT
CCACGGCCTGCTCGCGTCGCCCGCCCTGCGCAGCGCGCTGCTGGCCAAGATCGGCGTCGCCGGGAACGGGCGCGACCATG
GCGCCGATGTCGACGCCGCGCTCGACGACATCGCCGCCGAACTGGCAATCCATATCGACATCGGCGCGCTGCTGCGCATC
GCCGCTCATCCGGTGTAG

Upstream 100 bases:

>100_bases
ATGAGCGCCGAGCCCGAAATGCTCGTTCCCGACCGGCCGAGCGCGGCGCAGCGCGAACTCCCCGGTCTGTTCTGACGACG
GCAATCGACGGGAGCAGCGC

Downstream 100 bases:

>100_bases
AGCGCGATGACATGATATTGACCCACCGTGACGGAGGCGATTTTGGCCGAGTGCGAGGCGCGAGGAGCGGCGCGATGCGG
GACATCGCGCCCGACGAGCA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MAALMLQGTGSDVGKSVLVAGLCRALANRGLRVRPFKPQNMSNNAAVTIDGGEIGRAQALQALACRTPPHSDMNPVLLKP
QADRTSQLIVHGRVRGTLGSGNFRAGRGALLPDVLESYGRLRRQCDIVIVEGAGSPAEINLRAGDIANMGFARAARVPVV
LVGDIDRGGVIAAIVGTRTVIDAEDAAMIKGFVINKFRGDPALFDDGYRAIAERSGWPGLGVVPWLAAAARLPSEDAVIL
ERRADAREGRRIVACPILPRIANFDDLDPLKQEPGVELLMVPPGQPIPAEAAIIVLPGSKATIADLAALRREGWDIDIKA
HHRRGGLILGLCGGYQMLGTRIADPLGIEGAASEVEGLGLLDVTTELAPAKTLREVTGTAWNSPVAGYEMHMGATVGTDT
ARPFARIDGGGGEGAINAAGNVIGTYIHGLLASPALRSALLAKIGVAGNGRDHGADVDAALDDIAAELAIHIDIGALLRI
AAHPV

Sequences:

>Translated_485_residues
MAALMLQGTGSDVGKSVLVAGLCRALANRGLRVRPFKPQNMSNNAAVTIDGGEIGRAQALQALACRTPPHSDMNPVLLKP
QADRTSQLIVHGRVRGTLGSGNFRAGRGALLPDVLESYGRLRRQCDIVIVEGAGSPAEINLRAGDIANMGFARAARVPVV
LVGDIDRGGVIAAIVGTRTVIDAEDAAMIKGFVINKFRGDPALFDDGYRAIAERSGWPGLGVVPWLAAAARLPSEDAVIL
ERRADAREGRRIVACPILPRIANFDDLDPLKQEPGVELLMVPPGQPIPAEAAIIVLPGSKATIADLAALRREGWDIDIKA
HHRRGGLILGLCGGYQMLGTRIADPLGIEGAASEVEGLGLLDVTTELAPAKTLREVTGTAWNSPVAGYEMHMGATVGTDT
ARPFARIDGGGGEGAINAAGNVIGTYIHGLLASPALRSALLAKIGVAGNGRDHGADVDAALDDIAAELAIHIDIGALLRI
AAHPV
>Mature_484_residues
AALMLQGTGSDVGKSVLVAGLCRALANRGLRVRPFKPQNMSNNAAVTIDGGEIGRAQALQALACRTPPHSDMNPVLLKPQ
ADRTSQLIVHGRVRGTLGSGNFRAGRGALLPDVLESYGRLRRQCDIVIVEGAGSPAEINLRAGDIANMGFARAARVPVVL
VGDIDRGGVIAAIVGTRTVIDAEDAAMIKGFVINKFRGDPALFDDGYRAIAERSGWPGLGVVPWLAAAARLPSEDAVILE
RRADAREGRRIVACPILPRIANFDDLDPLKQEPGVELLMVPPGQPIPAEAAIIVLPGSKATIADLAALRREGWDIDIKAH
HRRGGLILGLCGGYQMLGTRIADPLGIEGAASEVEGLGLLDVTTELAPAKTLREVTGTAWNSPVAGYEMHMGATVGTDTA
RPFARIDGGGGEGAINAAGNVIGTYIHGLLASPALRSALLAKIGVAGNGRDHGADVDAALDDIAAELAIHIDIGALLRIA
AHPV

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_SPHAL (Q1GPG1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617794.1
- ProteinModelPortal:   Q1GPG1
- GeneID:   4080241
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2756
- NMPDR:   fig|317655.9.peg.2621
- HOGENOM:   HBG302271
- OMA:   RGDIANM
- ProtClustDB:   PRK00784
- BioCyc:   SALA317655:SALA_2756-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 50450; Mature: 50319

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 332-332 ACT_SITE 428-428

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALMLQGTGSDVGKSVLVAGLCRALANRGLRVRPFKPQNMSNNAAVTIDGGEIGRAQAL
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHHHHH
QALACRTPPHSDMNPVLLKPQADRTSQLIVHGRVRGTLGSGNFRAGRGALLPDVLESYGR
HHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHH
LRRQCDIVIVEGAGSPAEINLRAGDIANMGFARAARVPVVLVGDIDRGGVIAAIVGTRTV
HHHCCCEEEEECCCCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCCCEEEEEECCCEE
IDAEDAAMIKGFVINKFRGDPALFDDGYRAIAERSGWPGLGVVPWLAAAARLPSEDAVIL
ECCCCHHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEE
ERRADAREGRRIVACPILPRIANFDDLDPLKQEPGVELLMVPPGQPIPAEAAIIVLPGSK
EECCCHHHCCEEEEECCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCEEEEEECCCC
ATIADLAALRREGWDIDIKAHHRRGGLILGLCGGYQMLGTRIADPLGIEGAASEVEGLGL
CHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCEE
LDVTTELAPAKTLREVTGTAWNSPVAGYEMHMGATVGTDTARPFARIDGGGGEGAINAAG
EEHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCCEEECCCCCCCEECCCC
NVIGTYIHGLLASPALRSALLAKIGVAGNGRDHGADVDAALDDIAAELAIHIDIGALLRI
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHEEEEEEHHHHHHH
AAHPV
HCCCC
>Mature Secondary Structure 
AALMLQGTGSDVGKSVLVAGLCRALANRGLRVRPFKPQNMSNNAAVTIDGGEIGRAQAL
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHHHHH
QALACRTPPHSDMNPVLLKPQADRTSQLIVHGRVRGTLGSGNFRAGRGALLPDVLESYGR
HHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHH
LRRQCDIVIVEGAGSPAEINLRAGDIANMGFARAARVPVVLVGDIDRGGVIAAIVGTRTV
HHHCCCEEEEECCCCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCCCEEEEEECCCEE
IDAEDAAMIKGFVINKFRGDPALFDDGYRAIAERSGWPGLGVVPWLAAAARLPSEDAVIL
ECCCCHHHHHEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEE
ERRADAREGRRIVACPILPRIANFDDLDPLKQEPGVELLMVPPGQPIPAEAAIIVLPGSK
EECCCHHHCCEEEEECCCCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCEEEEEECCCC
ATIADLAALRREGWDIDIKAHHRRGGLILGLCGGYQMLGTRIADPLGIEGAASEVEGLGL
CHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCEE
LDVTTELAPAKTLREVTGTAWNSPVAGYEMHMGATVGTDTARPFARIDGGGGEGAINAAG
EEHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCCEEECCCCCCCEECCCC
NVIGTYIHGLLASPALRSALLAKIGVAGNGRDHGADVDAALDDIAAELAIHIDIGALLRI
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHEEEEEEHHHHHHH
AAHPV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA