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The map label for this gene is merR1 [H]

Identifier: 103487949

GI number: 103487949

Start: 2610216

End: 2610632

Strand: Reverse

Name: merR1 [H]

Synonym: Sala_2470

Alternate gene names: 103487949

Gene position: 2610632-2610216 (Counterclockwise)

Preceding gene: 103487950

Following gene: 103487948

Centisome position: 78.04

GC content: 61.87

Gene sequence:

>417_bases
ATGGGAAGCTACAAGATCGGAAAGCTCGCCGAAGCCGCGGGCGTGGGGCGCGATACGATACGCTATTATGAGCGGACGGG
CTTGCTACCGGCCCCGGGCCGTACCGCGGCCGGCTATCGCCTTTACAGCGACGGGGACCTTGAGCGGCTCAACTTCATTC
GCGCGTCGCAGGAACTCGGATTCACGCTCGAACAGGCGCGCCAGCTTCTCACCCTCAAGGCATCGGATACCGCCACCGCG
GCGGCCGTGCTTGCGATCACGCTCGACAAGGTTCGGGAGGCCGAAACGCGGGTCAGGAAGCTGACTGAGATTCGGGATGT
GCTGCAGGACCTCGCCGACAATTGCCCGCGAGAGGCGCCGGTCTCCGACTGCAACATAATCGCATTCTTGGCGGAAAAAC
GAAGACCAAAAAAATAG

Upstream 100 bases:

>100_bases
GGACCCGCGTTGGAGGCATGAACCGGCAATAGCCCGCCTCCAATGCCGAATGTCTCTTGACCTTGGACCATGGTCCAACC
TGCACAAGCGAGCGGATGTC

Downstream 100 bases:

>100_bases
CGTTCGCAGGGGAACATATTACAACATTGAAAATAGGGGATTTTTATGAAGAAATATTCCATTTTGTTGCTCACCCCCGC
GCTCCTTCTCGGAGGCTGCG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 137

Protein sequence:

>138_residues
MGSYKIGKLAEAAGVGRDTIRYYERTGLLPAPGRTAAGYRLYSDGDLERLNFIRASQELGFTLEQARQLLTLKASDTATA
AAVLAITLDKVREAETRVRKLTEIRDVLQDLADNCPREAPVSDCNIIAFLAEKRRPKK

Sequences:

>Translated_138_residues
MGSYKIGKLAEAAGVGRDTIRYYERTGLLPAPGRTAAGYRLYSDGDLERLNFIRASQELGFTLEQARQLLTLKASDTATA
AAVLAITLDKVREAETRVRKLTEIRDVLQDLADNCPREAPVSDCNIIAFLAEKRRPKK
>Mature_137_residues
GSYKIGKLAEAAGVGRDTIRYYERTGLLPAPGRTAAGYRLYSDGDLERLNFIRASQELGFTLEQARQLLTLKASDTATAA
AVLAITLDKVREAETRVRKLTEIRDVLQDLADNCPREAPVSDCNIIAFLAEKRRPKK

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=131, Percent_Identity=38.9312977099237, Blast_Score=95, Evalue=2e-21,
Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=35.4330708661417, Blast_Score=79, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15270; Mature: 15138

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSYKIGKLAEAAGVGRDTIRYYERTGLLPAPGRTAAGYRLYSDGDLERLNFIRASQELG
CCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
FTLEQARQLLTLKASDTATAAAVLAITLDKVREAETRVRKLTEIRDVLQDLADNCPREAP
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VSDCNIIAFLAEKRRPKK
CCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
GSYKIGKLAEAAGVGRDTIRYYERTGLLPAPGRTAAGYRLYSDGDLERLNFIRASQELG
CCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
FTLEQARQLLTLKASDTATAAAVLAITLDKVREAETRVRKLTEIRDVLQDLADNCPREAP
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VSDCNIIAFLAEKRRPKK
CCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]