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The map label for this gene is merR [H]

Identifier: 103487914

GI number: 103487914

Start: 2574002

End: 2574409

Strand: Reverse

Name: merR [H]

Synonym: Sala_2435

Alternate gene names: 103487914

Gene position: 2574409-2574002 (Counterclockwise)

Preceding gene: 103487922

Following gene: 103487913

Centisome position: 76.96

GC content: 66.91

Gene sequence:

>408_bases
TTGCGTGACATGACCATCGGCCAGCTTGCCCGGCAGGGCGGCGTCAATGTCGAGACGATCCGCTATTACCAACGCCGCGG
CCTGTTGCCCGTTCCGCCTCAGTCGGCCAGCGCCCCGTCGGAAGGCCGAGTCCGGCGTTACGACGAGGCGGTTCTGCGCC
GTCTGCGCTTCATCAAATCGGCACAGGCAGCGGGATTTACGCTCACCGAGATCGCCGAACTGCTCGAACTCGACGCGTCG
AGCGATCGCGCGCGAGCGCGCGAACTGGCCGACGCGCGCATCGCGGCGATCGAAAAGACGATCGCCGAACTCGATGTGGC
GCGGCGCGCGCTCATGGGCCTGTCGCGCCAATGCGCTGCCGCCGACACGCTCCACTGCCCGATCATAGCGGCGTTCGAGC
AGATCTAG

Upstream 100 bases:

>100_bases
TCGTTCGCGCGCTGAACCTGCATATTCATCGATTCGCCTTTCTTGATTCCCGATCGCTTCCCGCTATATAGGCTCCGTAC
CATAGTACGGAGTCAAGGCC

Downstream 100 bases:

>100_bases
CCCGACTGGTCTTGGGGGCGGATGGTGCTGACGGCCCGTCTCACCTCCCTCAAACTGGTGTCAATCGGTCGCAAATGGTT
CCAGCATCCCGGCTACAAGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MRDMTIGQLARQGGVNVETIRYYQRRGLLPVPPQSASAPSEGRVRRYDEAVLRRLRFIKSAQAAGFTLTEIAELLELDAS
SDRARARELADARIAAIEKTIAELDVARRALMGLSRQCAAADTLHCPIIAAFEQI

Sequences:

>Translated_135_residues
MRDMTIGQLARQGGVNVETIRYYQRRGLLPVPPQSASAPSEGRVRRYDEAVLRRLRFIKSAQAAGFTLTEIAELLELDAS
SDRARARELADARIAAIEKTIAELDVARRALMGLSRQCAAADTLHCPIIAAFEQI
>Mature_135_residues
MRDMTIGQLARQGGVNVETIRYYQRRGLLPVPPQSASAPSEGRVRRYDEAVLRRLRFIKSAQAAGFTLTEIAELLELDAS
SDRARARELADARIAAIEKTIAELDVARRALMGLSRQCAAADTLHCPIIAAFEQI

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=32.8125, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14908; Mature: 14908

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDMTIGQLARQGGVNVETIRYYQRRGLLPVPPQSASAPSEGRVRRYDEAVLRRLRFIKS
CCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AQAAGFTLTEIAELLELDASSDRARARELADARIAAIEKTIAELDVARRALMGLSRQCAA
HHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTLHCPIIAAFEQI
HCCCCCHHHHHHHCC
>Mature Secondary Structure
MRDMTIGQLARQGGVNVETIRYYQRRGLLPVPPQSASAPSEGRVRRYDEAVLRRLRFIKS
CCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AQAAGFTLTEIAELLELDASSDRARARELADARIAAIEKTIAELDVARRALMGLSRQCAA
HHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADTLHCPIIAAFEQI
HCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]