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The map label for this gene is copA [H]

Identifier: 103487902

GI number: 103487902

Start: 2559314

End: 2561095

Strand: Reverse

Name: copA [H]

Synonym: Sala_2422

Alternate gene names: 103487902

Gene position: 2561095-2559314 (Counterclockwise)

Preceding gene: 103487903

Following gene: 103487901

Centisome position: 76.56

GC content: 64.7

Gene sequence:

>1782_bases
ATGGCCGCATGGTTCCCGGCCTGGGCCCAGTCGGTGTCGTCCGGCATCACCGCGCCGCTTCCGACCGTATCCGGCAATGA
CATAACGCTGCGCATCGCCCGGCAGACGATGCGGATCGACGGCAAGGTCAGCCGCGCGATCGGGATCAACGGCACCGTGC
CCGCGCCGCTCGTCCGTCTAAAGGAAGGGCAGACAGCGCGCCTGACCGTCGTCAACGATCTCGACGAGGACAGCTCGATC
CACTGGCACGGGCTGATCCTGCCGTTCCAGATGGACGGCGTGCCCGGCGTCAGCTTCCCCGGCATCAAACCGCGATCGCA
GTTCGTGTATGAGTTTCCCGTCGTCCAGTCGGGGACCTATTGGTATCACAGCCATTCGGGGCTGCAGGAACAGCTGGGCC
ACTACGGCCCGATCGTCATCGATCCCGCGGGCGCCGACCCGATCGGCTACGATCGCGAGCATGTCGTCGTCCTGTCCGAC
CACAGTCAATTGTCGCCCGAGGCGATCTTCCGCAAGCTCAAGGTCAATCCCGGCCATTTCAACATGCAGCGCCAGACGCT
GGCGGGCCTGCTCGCCGGCAAGGATCAACCGCTCAAGGAGCGGATCGATTGGGGCAAGATGCGGATGGACCCGACCGACG
TCGCCGACGTCAATGGTTCGACATACACCTTCCTCGTCAACGGCCATGGTCCGCGCGACAACTGGACCGCGCTCTTCAGC
CCGGGCGAGCGGGTGCGCCTGCGTATCGTCAATGCGTCGGCGATGACGATCTTCAACGTCCGCATCCCGGGCCTCAGGAT
GACCGTGGTGCAGGCCGACGGCCTCAATGTCGTGCCGACCGAGATCGACGAGTTCCAGATCGCGGTCGCCGAAACCTATG
ACGTCATCGTGACCCCGGTCGAGGACCGTGCTTATACGCTCGTTGCCGAGGCCAATGACCGCTCGGGCATGGGACGCGCG
ACGCTCGCACCGCGCGCTGGCATGGTCGCCGAGGTGCCGCCGCTCCGCGAACGGCCGCTCGCGACCATGAAGGACATGGG
CATGGGCGACATGTCGGGCGGCGCGATGGCGGGTATGGACCATTCGGGCGGCGATATGGGCGCCATGCCCATGCCGGCGA
GCGACCCTTCTTGTCCTCCCGAACATGCCAAGATGGGCCATTGTACGCCAGCGGGGGAAAGCGGCGCGATGGCGGGCATG
GATCATGGATCTGGCGGAGGCATGCAGCACAGCATGCGCGACTTCAGTGTCGCGCCGCAGGTCAAGCGCGATCCCAGCGT
TCAGACGATCTCGCCGATGCCGATGGATCGCATGGGCGAGCCGGGGCAGGGACTGGAGAATGTCGGGCACAAGGTGCTGA
CCTACCATGACCTTGTCGCGCTCGAGCGCAACCCCGATACCCGCGCCGCCTCGCGCTCGCTCGACATCCATCTGACCGGC
AATATGGAACGCTTCATGTGGTCGTTCGACGGCATCAAGATGTCCGACTATCACGAGCCCATCCCCTTCATCGAGGGAGA
GCGCGTGCGGATCAACCTCATCAACGATTCGATGATGAGCCACCCCATCCACCTCCACGGCCATTTTTTCGAACTGGTGA
CGGGCAAGGGCGACCGGTCGCCGCGCAAGCATACGGTGCTTGTCCAGCCGGGCGGCATCGCGAGCTTCGATTTCACCGCC
GACGCGCTCGGCGACTGGGCGTTCCATTGCCACCTTCTCTATCACATGCACGCGGGGATGATGCGCGTCGTCAGCGTCCG
TCCGAAGGGAGACGGCGAATGA

Upstream 100 bases:

>100_bases
CGTATAGCTTTAGGAACAGTCAGTAACGGTCGGAAAGAATATGCAGATGGAAAGGCGTCGGTTCGTCAGTGGAGCTTTGG
GTGGAGGGGCTGCTGCGGCG

Downstream 100 bases:

>100_bases
CCCGGGTCGCGCTTCTCCTCGCGGGTATCGCCCCGCTGGCCTTTGCTGTGCCCGCCGCGGCGCAGTCGATGGATCATTCG
ATGCATGGTGCGGCGCCCGC

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MAAWFPAWAQSVSSGITAPLPTVSGNDITLRIARQTMRIDGKVSRAIGINGTVPAPLVRLKEGQTARLTVVNDLDEDSSI
HWHGLILPFQMDGVPGVSFPGIKPRSQFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVIDPAGADPIGYDREHVVVLSD
HSQLSPEAIFRKLKVNPGHFNMQRQTLAGLLAGKDQPLKERIDWGKMRMDPTDVADVNGSTYTFLVNGHGPRDNWTALFS
PGERVRLRIVNASAMTIFNVRIPGLRMTVVQADGLNVVPTEIDEFQIAVAETYDVIVTPVEDRAYTLVAEANDRSGMGRA
TLAPRAGMVAEVPPLRERPLATMKDMGMGDMSGGAMAGMDHSGGDMGAMPMPASDPSCPPEHAKMGHCTPAGESGAMAGM
DHGSGGGMQHSMRDFSVAPQVKRDPSVQTISPMPMDRMGEPGQGLENVGHKVLTYHDLVALERNPDTRAASRSLDIHLTG
NMERFMWSFDGIKMSDYHEPIPFIEGERVRINLINDSMMSHPIHLHGHFFELVTGKGDRSPRKHTVLVQPGGIASFDFTA
DALGDWAFHCHLLYHMHAGMMRVVSVRPKGDGE

Sequences:

>Translated_593_residues
MAAWFPAWAQSVSSGITAPLPTVSGNDITLRIARQTMRIDGKVSRAIGINGTVPAPLVRLKEGQTARLTVVNDLDEDSSI
HWHGLILPFQMDGVPGVSFPGIKPRSQFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVIDPAGADPIGYDREHVVVLSD
HSQLSPEAIFRKLKVNPGHFNMQRQTLAGLLAGKDQPLKERIDWGKMRMDPTDVADVNGSTYTFLVNGHGPRDNWTALFS
PGERVRLRIVNASAMTIFNVRIPGLRMTVVQADGLNVVPTEIDEFQIAVAETYDVIVTPVEDRAYTLVAEANDRSGMGRA
TLAPRAGMVAEVPPLRERPLATMKDMGMGDMSGGAMAGMDHSGGDMGAMPMPASDPSCPPEHAKMGHCTPAGESGAMAGM
DHGSGGGMQHSMRDFSVAPQVKRDPSVQTISPMPMDRMGEPGQGLENVGHKVLTYHDLVALERNPDTRAASRSLDIHLTG
NMERFMWSFDGIKMSDYHEPIPFIEGERVRINLINDSMMSHPIHLHGHFFELVTGKGDRSPRKHTVLVQPGGIASFDFTA
DALGDWAFHCHLLYHMHAGMMRVVSVRPKGDGE
>Mature_592_residues
AAWFPAWAQSVSSGITAPLPTVSGNDITLRIARQTMRIDGKVSRAIGINGTVPAPLVRLKEGQTARLTVVNDLDEDSSIH
WHGLILPFQMDGVPGVSFPGIKPRSQFVYEFPVVQSGTYWYHSHSGLQEQLGHYGPIVIDPAGADPIGYDREHVVVLSDH
SQLSPEAIFRKLKVNPGHFNMQRQTLAGLLAGKDQPLKERIDWGKMRMDPTDVADVNGSTYTFLVNGHGPRDNWTALFSP
GERVRLRIVNASAMTIFNVRIPGLRMTVVQADGLNVVPTEIDEFQIAVAETYDVIVTPVEDRAYTLVAEANDRSGMGRAT
LAPRAGMVAEVPPLRERPLATMKDMGMGDMSGGAMAGMDHSGGDMGAMPMPASDPSCPPEHAKMGHCTPAGESGAMAGMD
HGSGGGMQHSMRDFSVAPQVKRDPSVQTISPMPMDRMGEPGQGLENVGHKVLTYHDLVALERNPDTRAASRSLDIHLTGN
MERFMWSFDGIKMSDYHEPIPFIEGERVRINLINDSMMSHPIHLHGHFFELVTGKGDRSPRKHTVLVQPGGIASFDFTAD
ALGDWAFHCHLLYHMHAGMMRVVSVRPKGDGE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=337, Percent_Identity=24.0356083086053, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321067, Length=604, Percent_Identity=22.1854304635762, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323703, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18859919, Length=590, Percent_Identity=23.3898305084746, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24650186, Length=596, Percent_Identity=21.9798657718121, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574104, Length=303, Percent_Identity=28.0528052805281, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 64749; Mature: 64618

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAWFPAWAQSVSSGITAPLPTVSGNDITLRIARQTMRIDGKVSRAIGINGTVPAPLVRL
CCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEECCCCCCCCCEEEE
KEGQTARLTVVNDLDEDSSIHWHGLILPFQMDGVPGVSFPGIKPRSQFVYEFPVVQSGTY
CCCCEEEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEECEEECCEE
WYHSHSGLQEQLGHYGPIVIDPAGADPIGYDREHVVVLSDHSQLSPEAIFRKLKVNPGHF
EEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCC
NMQRQTLAGLLAGKDQPLKERIDWGKMRMDPTDVADVNGSTYTFLVNGHGPRDNWTALFS
CCHHHHHHHHHCCCCCCHHHHCCCCCEECCCCCCEECCCCEEEEEEECCCCCCCCEEEEC
PGERVRLRIVNASAMTIFNVRIPGLRMTVVQADGLNVVPTEIDEFQIAVAETYDVIVTPV
CCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCCEECCCCCCCEEEEEEEEEEEEEEEC
EDRAYTLVAEANDRSGMGRATLAPRAGMVAEVPPLRERPLATMKDMGMGDMSGGAMAGMD
CCCEEEEEEECCCCCCCCCEEECCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCEEECCC
HSGGDMGAMPMPASDPSCPPEHAKMGHCTPAGESGAMAGMDHGSGGGMQHSMRDFSVAPQ
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
VKRDPSVQTISPMPMDRMGEPGQGLENVGHKVLTYHDLVALERNPDTRAASRSLDIHLTG
CCCCCCCEEECCCCHHHCCCCCCCHHHHCCEEEEEEEEEEEECCCCCCHHCCEEEEEECC
NMERFMWSFDGIKMSDYHEPIPFIEGERVRINLINDSMMSHPIHLHGHFFELVTGKGDRS
CHHHEEEEECCEEECCCCCCCCCCCCCEEEEEEECCHHHCCCEEEEEEEEEEEECCCCCC
PRKHTVLVQPGGIASFDFTADALGDWAFHCHLLYHMHAGMMRVVSVRPKGDGE
CCCCEEEECCCCCEEECCCHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCC
>Mature Secondary Structure 
AAWFPAWAQSVSSGITAPLPTVSGNDITLRIARQTMRIDGKVSRAIGINGTVPAPLVRL
CCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEECCCCCCCCCEEEE
KEGQTARLTVVNDLDEDSSIHWHGLILPFQMDGVPGVSFPGIKPRSQFVYEFPVVQSGTY
CCCCEEEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEECEEECCEE
WYHSHSGLQEQLGHYGPIVIDPAGADPIGYDREHVVVLSDHSQLSPEAIFRKLKVNPGHF
EEECCCCHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCC
NMQRQTLAGLLAGKDQPLKERIDWGKMRMDPTDVADVNGSTYTFLVNGHGPRDNWTALFS
CCHHHHHHHHHCCCCCCHHHHCCCCCEECCCCCCEECCCCEEEEEEECCCCCCCCEEEEC
PGERVRLRIVNASAMTIFNVRIPGLRMTVVQADGLNVVPTEIDEFQIAVAETYDVIVTPV
CCCEEEEEEEECCEEEEEEEECCCEEEEEEECCCCEECCCCCCCEEEEEEEEEEEEEEEC
EDRAYTLVAEANDRSGMGRATLAPRAGMVAEVPPLRERPLATMKDMGMGDMSGGAMAGMD
CCCEEEEEEECCCCCCCCCEEECCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCEEECCC
HSGGDMGAMPMPASDPSCPPEHAKMGHCTPAGESGAMAGMDHGSGGGMQHSMRDFSVAPQ
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCC
VKRDPSVQTISPMPMDRMGEPGQGLENVGHKVLTYHDLVALERNPDTRAASRSLDIHLTG
CCCCCCCEEECCCCHHHCCCCCCCHHHHCCEEEEEEEEEEEECCCCCCHHCCEEEEEECC
NMERFMWSFDGIKMSDYHEPIPFIEGERVRINLINDSMMSHPIHLHGHFFELVTGKGDRS
CHHHEEEEECCEEECCCCCCCCCCCCCEEEEEEECCHHHCCCEEEEEEEEEEEECCCCCC
PRKHTVLVQPGGIASFDFTADALGDWAFHCHLLYHMHAGMMRVVSVRPKGDGE
CCCCEEEECCCCCEEECCCHHHHCCHHHHHHHHHHHHCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]