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The map label for this gene is hisE

Identifier: 103487861

GI number: 103487861

Start: 2503512

End: 2503841

Strand: Direct

Name: hisE

Synonym: Sala_2380

Alternate gene names: 103487861

Gene position: 2503512-2503841 (Clockwise)

Preceding gene: 103487852

Following gene: 103487862

Centisome position: 74.84

GC content: 69.09

Gene sequence:

>330_bases
ATGAGCAAGGCAATGGGCGAAACGCTGGGACGGCTCGAGGCGGTCATCCACGACCGGCTCGCCGCGGGCGAAGCCGAAGC
CTCCTATGTCGCGAGTCTCGCCGCCAAGGGCCGCGGCAAGATCGCGCAGAAGCTGGGCGAAGAAGCCGTCGAGGCGGTGA
TCGCCGCGGTGAGCGAAGACGATCCCGCGCTGATCGGCGAGGCGAGCGATCTCGTCTTTCACCTCTCGATCCTGCTCGCG
GAGCGCGGCCTGACGTGGGACGCGATCGCCGCCGAACTCGACCGCCGCCACGGCACTTCGGGCCACACCGAAAAAGCCGC
CCGCGCGTGA

Upstream 100 bases:

>100_bases
CCGAGGCGTTTCAATATGGTTGACGCGGCGGTAAGTTTTTCAGCGGCGCTTGCCCGCGCGGCGCGGCGGCGGTAGGCACG
GCGCCGAAAGGATCGGCGCG

Downstream 100 bases:

>100_bases
AAGTCCGTCCAGCCCGTTTCTTCACCACATCCGTCATCCCGGCGAAGGCCGGGATCTCGCCGGTGCGTCAATCCGATTGG
GTGAGATCCCGGCCTTCGCC

Product: phosphoribosyl-ATP pyrophosphohydrolase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSKAMGETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGEASDLVFHLSILLA
ERGLTWDAIAAELDRRHGTSGHTEKAARA

Sequences:

>Translated_109_residues
MSKAMGETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGEASDLVFHLSILLA
ERGLTWDAIAAELDRRHGTSGHTEKAARA
>Mature_108_residues
SKAMGETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGEASDLVFHLSILLAE
RGLTWDAIAAELDRRHGTSGHTEKAARA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=102, Percent_Identity=41.1764705882353, Blast_Score=71, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_SPHAL (Q1GQI3)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617422.1
- ProteinModelPortal:   Q1GQI3
- SMR:   Q1GQI3
- GeneID:   4080820
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2380
- NMPDR:   fig|317655.9.peg.2303
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- BioCyc:   SALA317655:SALA_2380-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11376; Mature: 11245

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAMGETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSED
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
DPALIGEASDLVFHLSILLAERGLTWDAIAAELDRRHGTSGHTEKAARA
CCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure 
SKAMGETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSED
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
DPALIGEASDLVFHLSILLAERGLTWDAIAAELDRRHGTSGHTEKAARA
CCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA