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The map label for this gene is nadB [H]

Identifier: 103487796

GI number: 103487796

Start: 2443609

End: 2445195

Strand: Reverse

Name: nadB [H]

Synonym: Sala_2315

Alternate gene names: 103487796

Gene position: 2445195-2443609 (Counterclockwise)

Preceding gene: 103487797

Following gene: 103487793

Centisome position: 73.1

GC content: 65.47

Gene sequence:

>1587_bases
ATGGCCGCTGATTCTTCCCACGACGTCATCATCATCGGCTCAGGCGCTGCCGGTCTCACCGCCGCCATCGCGCTCGCCGA
TCATTGTCGTGTGCTCGTGCTCGCGAAGGGCGATCTGACTGGCGGGTCAACGGCCTGGGCGCAGGGCGGCATCGCCGCGG
TGCTCGACGCGGGCGACACATTCGACAATCATATCGAGGACACGATGGTCGCGGGGGCGGGATTGAGCCGGCGCGAGACG
GTCGAGTTCGTGATTGAAAATGCCCCGCGAGCGATCGAACGGCTCGCCCGGATGGGCGTGCCCTTCAACATGGAAGAAGG
CGGGTTGCACCTCACCCGCGAGGGTGGCCATTCGCACCGCCGCATCGTCCATGTCGACGACGCGACCGGCTGGGCGGTGC
AGGCGGCGCTGCTCAAGACCGCCGAGGCGCATCCGAACATCACGCTGCTGCCGGGGCAGGCGTGCATCGACCTCATCACC
GGGCGGCACGAAGCGCGCTATTCGGGGTCGGGGCGCGTATGGGGCGTCTATGCGCTCGACGAGGCGAGCGGCACGGTCCA
CGCGCATGTCGGCCGCGCGACAATCCTTGCGAGCGGCGGCGCGGGGCGCGTCTATCAATTTTCGACCGCGCCGCGCGGCG
CGACCGGCGATGGCATCGCGATGGCCTGGCGCGCGGGCGCGCGCGTCAGCAACATGGAAATGATGCAGTTCCACCCGACC
TGCCTGTTCAACCTCGACGTCAAGAATTTCCTGATCACCGAGGCGGTGCGCGGCGAGGGCGGGATTTTGAAGCATCCCGA
AACCGGGCACCGCTACATGCCCGATTACGATCCGCGCGCCGAACTGGCGCCGCGCGACGTGGTGGCGCGCGCGAACGACG
ACCAGATCAAGCGTTACGGCCTCGATTATGTCCACCTCGACATCAGCCATCAGGACCCCGATTTCGTCGCAGGCCATTTC
CCCAACATCTACGACAAGCTGCTCGGCCTCGGCATCGACATGACGAAGCAGCCGATCCCGGTGGTCCCGGCGCAGCATTA
TACCTGCGGCGGGGTGCTGATCGACCTTGCGGGTCGCACCGACCTGCCGGGGCTGTACGCGGCGGGCGAATGCTCCGAAA
GCGGACTGCACGGCGCGAACCGCCTTGCGTCGAACAGCCTGCTCGAATGTTTCGTGTTCGGCGAGGCGGCGGCGAAGGAC
ATCATCGCGCGCTGGGACCAGCTCGAACCGCCCCCCGCGATCCGCGCGTGGGACGAAAGCCGCGTCACCGATTCCGACGA
AGAGGTCGTCATCAAGCAGAACTGGACCGAAATCCGCCGCTTCATGTGGAATTATGTCGGTATCGTGCGCACGACCAAGC
GCCTCGAACGTGCCCGGCATCGCATCGCCTTGTTGCGGCATGAAGTGCATGAATATTATTCGCAATTCCGCGTGACCACC
GACCTGATCGAACTGCGCAACCTCATTGAAACCGCCGATCTGATCGTCCGCAGCGCGCTCCACCGCAAGGAAAGCCGCGG
GCTGCATTATACGCTCGACTATCCCGGGATGCTGCCGCAGGCGGTGGATACGGTGCTGGTGCCGTGA

Upstream 100 bases:

>100_bases
AACCCCGGTTCCCGTCCGTGTCGAGCGGAGTCGAGACACCCATAAGGACAGCGCAAGGCCGAGGGGCATCTCGACTTCGC
TCGATACGAACGGAAATTTG

Downstream 100 bases:

>100_bases
GGTTGGGGTAAGAAAATCTCACGCAAAGGCGTGAAGGCGCAAGGACGAAGACATCCCAAACGCGATGGTCGTTGGCGATG
CGACGAACGCCTTTGCGTGA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MAADSSHDVIIIGSGAAGLTAAIALADHCRVLVLAKGDLTGGSTAWAQGGIAAVLDAGDTFDNHIEDTMVAGAGLSRRET
VEFVIENAPRAIERLARMGVPFNMEEGGLHLTREGGHSHRRIVHVDDATGWAVQAALLKTAEAHPNITLLPGQACIDLIT
GRHEARYSGSGRVWGVYALDEASGTVHAHVGRATILASGGAGRVYQFSTAPRGATGDGIAMAWRAGARVSNMEMMQFHPT
CLFNLDVKNFLITEAVRGEGGILKHPETGHRYMPDYDPRAELAPRDVVARANDDQIKRYGLDYVHLDISHQDPDFVAGHF
PNIYDKLLGLGIDMTKQPIPVVPAQHYTCGGVLIDLAGRTDLPGLYAAGECSESGLHGANRLASNSLLECFVFGEAAAKD
IIARWDQLEPPPAIRAWDESRVTDSDEEVVIKQNWTEIRRFMWNYVGIVRTTKRLERARHRIALLRHEVHEYYSQFRVTT
DLIELRNLIETADLIVRSALHRKESRGLHYTLDYPGMLPQAVDTVLVP

Sequences:

>Translated_528_residues
MAADSSHDVIIIGSGAAGLTAAIALADHCRVLVLAKGDLTGGSTAWAQGGIAAVLDAGDTFDNHIEDTMVAGAGLSRRET
VEFVIENAPRAIERLARMGVPFNMEEGGLHLTREGGHSHRRIVHVDDATGWAVQAALLKTAEAHPNITLLPGQACIDLIT
GRHEARYSGSGRVWGVYALDEASGTVHAHVGRATILASGGAGRVYQFSTAPRGATGDGIAMAWRAGARVSNMEMMQFHPT
CLFNLDVKNFLITEAVRGEGGILKHPETGHRYMPDYDPRAELAPRDVVARANDDQIKRYGLDYVHLDISHQDPDFVAGHF
PNIYDKLLGLGIDMTKQPIPVVPAQHYTCGGVLIDLAGRTDLPGLYAAGECSESGLHGANRLASNSLLECFVFGEAAAKD
IIARWDQLEPPPAIRAWDESRVTDSDEEVVIKQNWTEIRRFMWNYVGIVRTTKRLERARHRIALLRHEVHEYYSQFRVTT
DLIELRNLIETADLIVRSALHRKESRGLHYTLDYPGMLPQAVDTVLVP
>Mature_527_residues
AADSSHDVIIIGSGAAGLTAAIALADHCRVLVLAKGDLTGGSTAWAQGGIAAVLDAGDTFDNHIEDTMVAGAGLSRRETV
EFVIENAPRAIERLARMGVPFNMEEGGLHLTREGGHSHRRIVHVDDATGWAVQAALLKTAEAHPNITLLPGQACIDLITG
RHEARYSGSGRVWGVYALDEASGTVHAHVGRATILASGGAGRVYQFSTAPRGATGDGIAMAWRAGARVSNMEMMQFHPTC
LFNLDVKNFLITEAVRGEGGILKHPETGHRYMPDYDPRAELAPRDVVARANDDQIKRYGLDYVHLDISHQDPDFVAGHFP
NIYDKLLGLGIDMTKQPIPVVPAQHYTCGGVLIDLAGRTDLPGLYAAGECSESGLHGANRLASNSLLECFVFGEAAAKDI
IARWDQLEPPPAIRAWDESRVTDSDEEVVIKQNWTEIRRFMWNYVGIVRTTKRLERARHRIALLRHEVHEYYSQFRVTTD
LIELRNLIETADLIVRSALHRKESRGLHYTLDYPGMLPQAVDTVLVP

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=512, Percent_Identity=33.0078125, Blast_Score=210, Evalue=3e-54,
Organism=Escherichia coli, GI1788928, Length=530, Percent_Identity=55.6603773584906, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1790597, Length=513, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1786942, Length=532, Percent_Identity=32.1428571428571, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17550100, Length=533, Percent_Identity=31.7073170731707, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17505833, Length=534, Percent_Identity=31.0861423220974, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71986328, Length=466, Percent_Identity=27.8969957081545, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322701, Length=561, Percent_Identity=33.5115864527629, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322416, Length=558, Percent_Identity=32.9749103942652, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322511, Length=476, Percent_Identity=26.2605042016807, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=25.6673511293634, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137288, Length=558, Percent_Identity=32.078853046595, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24655642, Length=558, Percent_Identity=32.078853046595, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24655647, Length=558, Percent_Identity=32.078853046595, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24663005, Length=554, Percent_Identity=31.4079422382672, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 57741; Mature: 57610

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADSSHDVIIIGSGAAGLTAAIALADHCRVLVLAKGDLTGGSTAWAQGGIAAVLDAGDT
CCCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCCCEEEEEECCCC
FDNHIEDTMVAGAGLSRRETVEFVIENAPRAIERLARMGVPFNMEEGGLHLTREGGHSHR
CHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC
RIVHVDDATGWAVQAALLKTAEAHPNITLLPGQACIDLITGRHEARYSGSGRVWGVYALD
EEEEECCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCEECCCCCEEEEEEEE
EASGTVHAHVGRATILASGGAGRVYQFSTAPRGATGDGIAMAWRAGARVSNMEMMQFHPT
CCCCEEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCE
CLFNLDVKNFLITEAVRGEGGILKHPETGHRYMPDYDPRAELAPRDVVARANDDQIKRYG
EEEECCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHEECCCCHHHHHHC
LDYVHLDISHQDPDFVAGHFPNIYDKLLGLGIDMTKQPIPVVPAQHYTCGGVLIDLAGRT
CCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
DLPGLYAAGECSESGLHGANRLASNSLLECFVFGEAAAKDIIARWDQLEPPPAIRAWDES
CCCCCEECCCCCCCCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCC
RVTDSDEEVVIKQNWTEIRRFMWNYVGIVRTTKRLERARHRIALLRHEVHEYYSQFRVTT
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIELRNLIETADLIVRSALHRKESRGLHYTLDYPGMLPQAVDTVLVP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure 
AADSSHDVIIIGSGAAGLTAAIALADHCRVLVLAKGDLTGGSTAWAQGGIAAVLDAGDT
CCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHCCCEEEEEECCCC
FDNHIEDTMVAGAGLSRRETVEFVIENAPRAIERLARMGVPFNMEEGGLHLTREGGHSHR
CHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCC
RIVHVDDATGWAVQAALLKTAEAHPNITLLPGQACIDLITGRHEARYSGSGRVWGVYALD
EEEEECCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCEECCCCCEEEEEEEE
EASGTVHAHVGRATILASGGAGRVYQFSTAPRGATGDGIAMAWRAGARVSNMEMMQFHPT
CCCCEEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCE
CLFNLDVKNFLITEAVRGEGGILKHPETGHRYMPDYDPRAELAPRDVVARANDDQIKRYG
EEEECCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCHHHEECCCCHHHHHHC
LDYVHLDISHQDPDFVAGHFPNIYDKLLGLGIDMTKQPIPVVPAQHYTCGGVLIDLAGRT
CCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
DLPGLYAAGECSESGLHGANRLASNSLLECFVFGEAAAKDIIARWDQLEPPPAIRAWDES
CCCCCEECCCCCCCCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCC
RVTDSDEEVVIKQNWTEIRRFMWNYVGIVRTTKRLERARHRIALLRHEVHEYYSQFRVTT
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLIELRNLIETADLIVRSALHRKESRGLHYTLDYPGMLPQAVDTVLVP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737518; 10984043; 7961421 [H]