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The map label for this gene is ada [H]

Identifier: 103487763

GI number: 103487763

Start: 2405311

End: 2406348

Strand: Reverse

Name: ada [H]

Synonym: Sala_2282

Alternate gene names: 103487763

Gene position: 2406348-2405311 (Counterclockwise)

Preceding gene: 103487764

Following gene: 103487762

Centisome position: 71.93

GC content: 68.21

Gene sequence:

>1038_bases
ATGAGCCGCCACCTGCTGATGACCGACGACGAATGCTGGCGGGCGGTTCAGGCGCGTGACAAGGCGTTCGACGGGCGTTT
CGTCACCGGCGTGCTGACGACCGGCATCTATTGCCGGCCGAGCTGCGCCGCGCGGCATCCGCGGCGCGAGAATGTGCGCT
TTTTTGCCGATGGCGCCGCGGCGCGCAGGGCGGGCTTGCGTCCGTGCAAGCGCTGCCTGCCCGACGATGTCGCGCGCGAC
GAAAGCGCGGTGATCAAGGCGATCGCCGCGATCAAGCAGAGCGAGGAACCGCTCGCGCTCGCCGACCTCGCCGCGCGCAC
CGGCTATTCGCCGACGCATTTCCAGCGCGTCTTTACCCGCCACACCGGCCTGTCGCCCGCCGCTTACGCCCGCGCGCTTC
GCGACGAACGCGCGCGGCGGGCGCTGAGCGAGGGGGCGCGGGTGACCGACGCGATTTACGACGCGGGCTTTTCGGGGCCG
TCGCGTTTTTATGACAATATGGAGGGACGCATGGGGATGACGGCATCGGCCTGGGTGAACGGCGGCAGGGGCGTGACGAT
CCATTGGGCGGTCGTGCCGACCAGCCTTGGCGACATGCTGGTCGCGGCAACCGACAAGGGCGTGTGCCGACTGAGCTTTG
CCGAGGGGCGCGAGGCGCTCGAGGAACGCTTCCCCGCCGCAACGCTGGTCGAGGGCGGCGAAGATTTCGCCGCGCTTCTG
TCGCAGGTAGTTGCCGCGGTCGAGGCGCCGACGCACGGTTTCGACCATATCCCGATCGACGTGAAAGGGACTGCGTTTCA
GGAGGCGGTGTGGCGTGAATTGCGCAGGATCCCGGCGGGCGAGACGCGCAGCTATGCCGACATCGCCGCCGCGGTCGGCA
AGCCCAAGGCGGTGCGTGCGGCGGGAAGCGCGAACGGTGCGAACAATGTCGCGGTGCTCATCCCGTGCCACCGCGTGGTG
CGCAGCGACGGCTCGCTCGGCGGCTATGCCTATGGCCTGCCGATCAAGGAAGAATTGCTCAAAAGGGAAGTGAAATGA

Upstream 100 bases:

>100_bases
CTGCAATCCGTTCCCTGTTCGCCGACCCTGCGATTGCCTATATCCACGCACAATATGCGACGAACGGCTGTTTCGCCGCG
CGGATCGAAAGGGACGAGCC

Downstream 100 bases:

>100_bases
CCGACGACAAAATTGCCCGTTTCCGTGCGCTGCACGTCCCCGGCGACCCGCTGATTCTCGTCAACATCTGGGATGCGGGG
AGCGCGAAGGCGGTTGCCGC

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSRHLLMTDDECWRAVQARDKAFDGRFVTGVLTTGIYCRPSCAARHPRRENVRFFADGAAARRAGLRPCKRCLPDDVARD
ESAVIKAIAAIKQSEEPLALADLAARTGYSPTHFQRVFTRHTGLSPAAYARALRDERARRALSEGARVTDAIYDAGFSGP
SRFYDNMEGRMGMTASAWVNGGRGVTIHWAVVPTSLGDMLVAATDKGVCRLSFAEGREALEERFPAATLVEGGEDFAALL
SQVVAAVEAPTHGFDHIPIDVKGTAFQEAVWRELRRIPAGETRSYADIAAAVGKPKAVRAAGSANGANNVAVLIPCHRVV
RSDGSLGGYAYGLPIKEELLKREVK

Sequences:

>Translated_345_residues
MSRHLLMTDDECWRAVQARDKAFDGRFVTGVLTTGIYCRPSCAARHPRRENVRFFADGAAARRAGLRPCKRCLPDDVARD
ESAVIKAIAAIKQSEEPLALADLAARTGYSPTHFQRVFTRHTGLSPAAYARALRDERARRALSEGARVTDAIYDAGFSGP
SRFYDNMEGRMGMTASAWVNGGRGVTIHWAVVPTSLGDMLVAATDKGVCRLSFAEGREALEERFPAATLVEGGEDFAALL
SQVVAAVEAPTHGFDHIPIDVKGTAFQEAVWRELRRIPAGETRSYADIAAAVGKPKAVRAAGSANGANNVAVLIPCHRVV
RSDGSLGGYAYGLPIKEELLKREVK
>Mature_344_residues
SRHLLMTDDECWRAVQARDKAFDGRFVTGVLTTGIYCRPSCAARHPRRENVRFFADGAAARRAGLRPCKRCLPDDVARDE
SAVIKAIAAIKQSEEPLALADLAARTGYSPTHFQRVFTRHTGLSPAAYARALRDERARRALSEGARVTDAIYDAGFSGPS
RFYDNMEGRMGMTASAWVNGGRGVTIHWAVVPTSLGDMLVAATDKGVCRLSFAEGREALEERFPAATLVEGGEDFAALLS
QVVAAVEAPTHGFDHIPIDVKGTAFQEAVWRELRRIPAGETRSYADIAAAVGKPKAVRAAGSANGANNVAVLIPCHRVVR
SDGSLGGYAYGLPIKEELLKREVK

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=162, Percent_Identity=33.9506172839506, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788542, Length=351, Percent_Identity=41.5954415954416, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1787596, Length=90, Percent_Identity=44.4444444444444, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115533070, Length=129, Percent_Identity=37.984496124031, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533068, Length=126, Percent_Identity=38.0952380952381, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320001, Length=88, Percent_Identity=46.5909090909091, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137554, Length=172, Percent_Identity=31.9767441860465, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 37311; Mature: 37180

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHLLMTDDECWRAVQARDKAFDGRFVTGVLTTGIYCRPSCAARHPRRENVRFFADGAA
CCCCEECCCHHHHHHHHHHHHHCCCCEEHHHHHCCCEECCCHHHCCCCCCCCEEEECCHH
ARRAGLRPCKRCLPDDVARDESAVIKAIAAIKQSEEPLALADLAARTGYSPTHFQRVFTR
HHHHCCCHHHHCCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
HTGLSPAAYARALRDERARRALSEGARVTDAIYDAGFSGPSRFYDNMEGRMGMTASAWVN
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHCC
GGRGVTIHWAVVPTSLGDMLVAATDKGVCRLSFAEGREALEERFPAATLVEGGEDFAALL
CCCCEEEEEEEECCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCEECCCCHHHHHHH
SQVVAAVEAPTHGFDHIPIDVKGTAFQEAVWRELRRIPAGETRSYADIAAAVGKPKAVRA
HHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEEE
AGSANGANNVAVLIPCHRVVRSDGSLGGYAYGLPIKEELLKREVK
CCCCCCCCCEEEEEECHHHHHCCCCCCCEEECCCHHHHHHHHCCC
>Mature Secondary Structure 
SRHLLMTDDECWRAVQARDKAFDGRFVTGVLTTGIYCRPSCAARHPRRENVRFFADGAA
CCCEECCCHHHHHHHHHHHHHCCCCEEHHHHHCCCEECCCHHHCCCCCCCCEEEECCHH
ARRAGLRPCKRCLPDDVARDESAVIKAIAAIKQSEEPLALADLAARTGYSPTHFQRVFTR
HHHHCCCHHHHCCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
HTGLSPAAYARALRDERARRALSEGARVTDAIYDAGFSGPSRFYDNMEGRMGMTASAWVN
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHCC
GGRGVTIHWAVVPTSLGDMLVAATDKGVCRLSFAEGREALEERFPAATLVEGGEDFAALL
CCCCEEEEEEEECCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCEECCCCHHHHHHH
SQVVAAVEAPTHGFDHIPIDVKGTAFQEAVWRELRRIPAGETRSYADIAAAVGKPKAVRA
HHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHEEE
AGSANGANNVAVLIPCHRVVRSDGSLGGYAYGLPIKEELLKREVK
CCCCCCCCCEEEEEECHHHHHCCCCCCCEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1904855; 11677609 [H]