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The map label for this gene is ispA [C]

Identifier: 103487675

GI number: 103487675

Start: 2305825

End: 2306745

Strand: Reverse

Name: ispA [C]

Synonym: Sala_2194

Alternate gene names: 103487675

Gene position: 2306745-2305825 (Counterclockwise)

Preceding gene: 103487676

Following gene: 103487674

Centisome position: 68.96

GC content: 69.49

Gene sequence:

>921_bases
GTGGCGTCGGTGGGCGGCGACAATGCGCGCGGCGCCGAGTTGCTCCGCGCGACCCAGGCCGAAGTCGCCGAGGGGATCGA
CGCGCTGTTCGACCAATTGCTCGCCGTCCCCGCCGACCCACGCGGGCCGCTTTACGAAGCGATGCGTTATGCCGCGATCG
CGGGAGGGAAAAGGCTGCGCCCCTTGCTTGTTCGCGCCGCCGGCGACCTGTTCCACGTCGATCGCGCGCTCACCCTGCGC
GTCGGCGCTGCGGTCGAGGCGATGCACGTCTATTCGCTGATCCACGACGATCTGCCGTGCATGGACGACGACGATATGCG
CCGCGGCAAGCCGACCACCCACAAGGCCTTCGGCGAGGCGACCGCGGTGCTCGCGGGCGATTCGCTCCATGCGCTCGCTT
TTGAATGGCTGTGCGATCCGGCGACGAGCGCCGATCCCTTCGTGCGCGCCGAGCTGTGCTGTGAACTGGCGCGCGCTGCG
GGCCCGGCAGGCATGGCGGGCGGGCAGATGATGGATCTTGCTGCCGAAACGTCCGATTTCGACCTGCCGACCGTGACGCG
GCTGCAACAGCTCAAGACCGGCGCGCTGATCGCCTTTTCGGTGGAGGCGGGGGCGATCCTCGCGCGCATCCCCGCCGAGG
GCCGCCGACCGCTGCGCGGCTATGCCCGCGACATCGGCCTCGCCTTCCAGATCGCCGACGACATCATGGATGTCGAGGGC
GACGAGGCGCTGGCGGGCAAGGCGCTGCACAAGGATGAAGCGGCGGGCAAGGCGACCTTCGTGACGCTGATGGGGCTGGA
TCGCGCGCGCGACCAGGCGACGCTGCTCGTCGAACAGGCGATCGCTCATCTCGGCGGCTTCGGCGACGAAGCCGCGCTGC
TCCGCGCGATCGCGCGCTATGTCGTGGAAAGGGACCGGTAA

Upstream 100 bases:

>100_bases
GGCGCGGCTCGCCGCGGCGCAGGCGCGGATCGAGCAGGTCAGCCTGGCCGCCGATGGTCGGCCGGCGGGAACCACGCCCT
TCGGCGAGGGCTGAGCGGGC

Downstream 100 bases:

>100_bases
TGCGGGTGGGGGTTTATCCGGGGACGTTCGATCCGATCACGCTTGGCCATATGGACATCATCCGGCGCGGCGCGAAGCTC
GTCGACCGGCTGGTGATCGG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MASVGGDNARGAELLRATQAEVAEGIDALFDQLLAVPADPRGPLYEAMRYAAIAGGKRLRPLLVRAAGDLFHVDRALTLR
VGAAVEAMHVYSLIHDDLPCMDDDDMRRGKPTTHKAFGEATAVLAGDSLHALAFEWLCDPATSADPFVRAELCCELARAA
GPAGMAGGQMMDLAAETSDFDLPTVTRLQQLKTGALIAFSVEAGAILARIPAEGRRPLRGYARDIGLAFQIADDIMDVEG
DEALAGKALHKDEAAGKATFVTLMGLDRARDQATLLVEQAIAHLGGFGDEAALLRAIARYVVERDR

Sequences:

>Translated_306_residues
MASVGGDNARGAELLRATQAEVAEGIDALFDQLLAVPADPRGPLYEAMRYAAIAGGKRLRPLLVRAAGDLFHVDRALTLR
VGAAVEAMHVYSLIHDDLPCMDDDDMRRGKPTTHKAFGEATAVLAGDSLHALAFEWLCDPATSADPFVRAELCCELARAA
GPAGMAGGQMMDLAAETSDFDLPTVTRLQQLKTGALIAFSVEAGAILARIPAEGRRPLRGYARDIGLAFQIADDIMDVEG
DEALAGKALHKDEAAGKATFVTLMGLDRARDQATLLVEQAIAHLGGFGDEAALLRAIARYVVERDR
>Mature_305_residues
ASVGGDNARGAELLRATQAEVAEGIDALFDQLLAVPADPRGPLYEAMRYAAIAGGKRLRPLLVRAAGDLFHVDRALTLRV
GAAVEAMHVYSLIHDDLPCMDDDDMRRGKPTTHKAFGEATAVLAGDSLHALAFEWLCDPATSADPFVRAELCCELARAAG
PAGMAGGQMMDLAAETSDFDLPTVTRLQQLKTGALIAFSVEAGAILARIPAEGRRPLRGYARDIGLAFQIADDIMDVEGD
EALAGKALHKDEAAGKATFVTLMGLDRARDQATLLVEQAIAHLGGFGDEAALLRAIARYVVERDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=273, Percent_Identity=46.8864468864469, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789578, Length=238, Percent_Identity=29.4117647058824, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=214, Percent_Identity=28.0373831775701, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651612, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32503; Mature: 32372

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVGGDNARGAELLRATQAEVAEGIDALFDQLLAVPADPRGPLYEAMRYAAIAGGKRLR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
PLLVRAAGDLFHVDRALTLRVGAAVEAMHVYSLIHDDLPCMDDDDMRRGKPTTHKAFGEA
HHHHHHHCCHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHCCE
TAVLAGDSLHALAFEWLCDPATSADPFVRAELCCELARAAGPAGMAGGQMMDLAAETSDF
EEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
DLPTVTRLQQLKTGALIAFSVEAGAILARIPAEGRRPLRGYARDIGLAFQIADDIMDVEG
CCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHEEHHHHHCCCC
DEALAGKALHKDEAAGKATFVTLMGLDRARDQATLLVEQAIAHLGGFGDEAALLRAIARY
CHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VVERDR
HHHCCC
>Mature Secondary Structure 
ASVGGDNARGAELLRATQAEVAEGIDALFDQLLAVPADPRGPLYEAMRYAAIAGGKRLR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
PLLVRAAGDLFHVDRALTLRVGAAVEAMHVYSLIHDDLPCMDDDDMRRGKPTTHKAFGEA
HHHHHHHCCHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHCCE
TAVLAGDSLHALAFEWLCDPATSADPFVRAELCCELARAAGPAGMAGGQMMDLAAETSDF
EEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
DLPTVTRLQQLKTGALIAFSVEAGAILARIPAEGRRPLRGYARDIGLAFQIADDIMDVEG
CCHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHEEHHHHHCCCC
DEALAGKALHKDEAAGKATFVTLMGLDRARDQATLLVEQAIAHLGGFGDEAALLRAIARY
CHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VVERDR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]