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The map label for this gene is hisG

Identifier: 103487510

GI number: 103487510

Start: 2139279

End: 2139950

Strand: Reverse

Name: hisG

Synonym: Sala_2027

Alternate gene names: 103487510

Gene position: 2139950-2139279 (Counterclockwise)

Preceding gene: 103487512

Following gene: 103487509

Centisome position: 63.97

GC content: 65.48

Gene sequence:

>672_bases
ATGTGCGCGACGCTTATGCCCGAACCGATCATCTTTGCCATCCCCAAGGGACGCATCCTCGACGAGGCGCTGCCGCTGCT
CGCGCGCGTCGGGATCGAGCCGGCGGCGGATTTCTTTGACAAGAAGAGCCGCGCGCTGGTGTTCGGGACGAACCAGTCGC
ACATCTCGCTGATCCGCGTCCGCGCCTTCGACGTCGCGACCTTTGTGGCGCATGGTGCAGCGCAGCTCGGCATCGTCGGG
TCGGACGTCGTCGACGAGTTCGATTACAGCGAGTTGTATGCGCCGGTCGATCTGGGCATCGGCCATTGCCGCCTGTCGCT
CGCGGGGCCGGAGGGCGGCGCGCCGCCGGGGCTGGGCGAAAGCCATATCCGCGTCGCGACCAAATATCCCGCGACGACGC
GGCGATGGTTCGCGGCGCAGGGCATCCAGGCCGAGTGCATCAAGCTGAATGGGGCGATGGAGATTGCCCCGAAGCTGGGG
CTCGCCTCGCACATCGTCGATCTGGTATCGACGGGGCGCACGCTGGTCGAAAATGCGCTCGCCGAACAAAAGATAATCAG
CGAGGTATCGGCGCGGCTGATCGTCAATCGCGCTGCGTTCAAACTCAATTCGGCCGAAGTGCCTGCGCTCGTCGAGCGCT
TCCGTCAGGCGGTGGGCGATGCGGCGGCTTGA

Upstream 100 bases:

>100_bases
ACTTGATTTGCGAAGGCAGCGCGCACAGCGCCTTTCCCGGTGGCGCCGATTCCGGCGGGCTGGATACGCTCGCTCATTGC
CCTTTTTCCCTTCGCCGCCT

Downstream 100 bases:

>100_bases
CGCCTCGGCGCCCGGCTTTGCGGCTCAGTTCGACGCGCTGGTCAATGACCGGCGCGAGAGTGCGTCCGACGTGTCGGCGG
ATGTCGCGGCGATCATCGCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MCATLMPEPIIFAIPKGRILDEALPLLARVGIEPAADFFDKKSRALVFGTNQSHISLIRVRAFDVATFVAHGAAQLGIVG
SDVVDEFDYSELYAPVDLGIGHCRLSLAGPEGGAPPGLGESHIRVATKYPATTRRWFAAQGIQAECIKLNGAMEIAPKLG
LASHIVDLVSTGRTLVENALAEQKIISEVSARLIVNRAAFKLNSAEVPALVERFRQAVGDAAA

Sequences:

>Translated_223_residues
MCATLMPEPIIFAIPKGRILDEALPLLARVGIEPAADFFDKKSRALVFGTNQSHISLIRVRAFDVATFVAHGAAQLGIVG
SDVVDEFDYSELYAPVDLGIGHCRLSLAGPEGGAPPGLGESHIRVATKYPATTRRWFAAQGIQAECIKLNGAMEIAPKLG
LASHIVDLVSTGRTLVENALAEQKIISEVSARLIVNRAAFKLNSAEVPALVERFRQAVGDAAA
>Mature_223_residues
MCATLMPEPIIFAIPKGRILDEALPLLARVGIEPAADFFDKKSRALVFGTNQSHISLIRVRAFDVATFVAHGAAQLGIVG
SDVVDEFDYSELYAPVDLGIGHCRLSLAGPEGGAPPGLGESHIRVATKYPATTRRWFAAQGIQAECIKLNGAMEIAPKLG
LASHIVDLVSTGRTLVENALAEQKIISEVSARLIVNRAAFKLNSAEVPALVERFRQAVGDAAA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=187, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=211, Percent_Identity=28.436018957346, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SPHAL (Q1GRI4)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617071.1
- ProteinModelPortal:   Q1GRI4
- SMR:   Q1GRI4
- GeneID:   4079925
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2027
- NMPDR:   fig|317655.9.peg.1958
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   SALA317655:SALA_2027-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23725; Mature: 23725

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCATLMPEPIIFAIPKGRILDEALPLLARVGIEPAADFFDKKSRALVFGTNQSHISLIRV
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCEEEEEE
RAFDVATFVAHGAAQLGIVGSDVVDEFDYSELYAPVDLGIGHCRLSLAGPEGGAPPGLGE
HHHHHHHHHHCCHHHCCCCCHHHHHHCCHHHHCCCHHCCCCEEEEEECCCCCCCCCCCCC
SHIRVATKYPATTRRWFAAQGIQAECIKLNGAMEIAPKLGLASHIVDLVSTGRTLVENAL
CCEEEEEECCCHHHHHHHHCCCCEEEEEECCCEEEHHHCCHHHHHHHHHHCCHHHHHHHH
AEQKIISEVSARLIVNRAAFKLNSAEVPALVERFRQAVGDAAA
HHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MCATLMPEPIIFAIPKGRILDEALPLLARVGIEPAADFFDKKSRALVFGTNQSHISLIRV
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCEEEEEE
RAFDVATFVAHGAAQLGIVGSDVVDEFDYSELYAPVDLGIGHCRLSLAGPEGGAPPGLGE
HHHHHHHHHHCCHHHCCCCCHHHHHHCCHHHHCCCHHCCCCEEEEEECCCCCCCCCCCCC
SHIRVATKYPATTRRWFAAQGIQAECIKLNGAMEIAPKLGLASHIVDLVSTGRTLVENAL
CCEEEEEECCCHHHHHHHHCCCCEEEEEECCCEEEHHHCCHHHHHHHHHHCCHHHHHHHH
AEQKIISEVSARLIVNRAAFKLNSAEVPALVERFRQAVGDAAA
HHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA