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The map label for this gene is hisD [H]

Identifier: 103487509

GI number: 103487509

Start: 2138000

End: 2139292

Strand: Reverse

Name: hisD [H]

Synonym: Sala_2026

Alternate gene names: 103487509

Gene position: 2139292-2138000 (Counterclockwise)

Preceding gene: 103487510

Following gene: 103487508

Centisome position: 63.95

GC content: 68.91

Gene sequence:

>1293_bases
ATGCGGCGGCTTGACGCCTCGGCGCCCGGCTTTGCGGCTCAGTTCGACGCGCTGGTCAATGACCGGCGCGAGAGTGCGTC
CGACGTGTCGGCGGATGTCGCGGCGATCATCGCGCGCGTCAAGGCCGAGGGCGACGCGGCGCTTGCCGACTATACCGCAA
AGTTCGACCGCTTCGACCTCGATGCGCGCGGGTGGAGCATCGCGAAGAAGGATTGCGCGACGGCCTATCAGGCGCTGGCG
CCCGACCTGCGCGACGCGCTGAACCTCGCTGCCGACCGCATCGGTGCCTATCATGCGGCGCAATTGCCCGAGGATCGCGA
CTATCGCGATGCGACGGGCGCGCGGCTGGGTGCGCGCTGGAACGCGGTCGATGCCGCGGGGGTCTATGTCCCCGGCGGAC
GCGCCGCCTATCCCTCGTCGGTGCTCATGAACATCCTGCCCGCGAAGGTCGCGGGGGTGGGGCGCATCGTGATGGTAACG
CCGACGCCCGACGGCCAGGTCAATCCGGTCGTGATGGCTGCGGCGCATATCGGCGGCGTCGATGAAATCTGGCGCGTCGG
CGGCGCGCAGGCGATCGCCGCGCTGGCCCATGGGACCGATCGGATCGCACCGGTCGATGTCGTCACCGGCCCCGGCAATG
CGTGGGTCGCCGAGGCGAAGCGCCAGCTGTATGGCGTCGTCGGCATCGACATGGTAGCGGGGCCGAGCGAGATCGTCATC
GTTGCCGACAACAAGAATGCGCCGCACGTCATCGCCGCCGACCTTTTGAGCCAGGCCGAGCATGATCCGACGAGCCAGTC
GATCCTGTTCACCGACGACGGCGATTTCGCCGATGCCGTCGCAGCCGCGGTCGCAGACGTCATCCCGACGCTCGCCACCG
CGGCGACGATGCTGGCGAGCTGGACCGACAATGGCGTTGTGATCGTCGTGCCGACGCTCGCCGATGCGATCCCGCTCTGC
GACCGGCTGGCGCCCGAACATCTCGAACTCGCGGTCGATCCGGCCGAGGCCGATGCGCTCTTCGCCAGGGTGCGCCACGC
CGGATCGGTCTTCCTCGGTCGCCAGACACCCGAGGCGATCGGCGATTATGTCGCGGGACCGAACCACGTCCTTCCCACCG
GGCGCCGCGCGCGCTTTTCGAGCGGATTGTCGGTTACCGACTTCATGAAGCGCACCAGCTTCCTTGCGCTCGACGAGGCG
AGCCTTGCGGCCATCGGTCCCGCGGCCGTCGCGCTCGCGGGCGCCGAGGGGCTTCCCGCCCATGCGCTCAGCGTGCAGAA
TCGTCTGAAGTAG

Upstream 100 bases:

>100_bases
AGCGAGGTATCGGCGCGGCTGATCGTCAATCGCGCTGCGTTCAAACTCAATTCGGCCGAAGTGCCTGCGCTCGTCGAGCG
CTTCCGTCAGGCGGTGGGCG

Downstream 100 bases:

>100_bases
AAATGTCATGAACAAACGCGCCCAGTCCCGTTCCGCCGCCCGCCTTGCCGCCGTGCAGGCGCTCTATCAGCACGAGATGG
AGGCGACGCCGGTAGCTCAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MRRLDASAPGFAAQFDALVNDRRESASDVSADVAAIIARVKAEGDAALADYTAKFDRFDLDARGWSIAKKDCATAYQALA
PDLRDALNLAADRIGAYHAAQLPEDRDYRDATGARLGARWNAVDAAGVYVPGGRAAYPSSVLMNILPAKVAGVGRIVMVT
PTPDGQVNPVVMAAAHIGGVDEIWRVGGAQAIAALAHGTDRIAPVDVVTGPGNAWVAEAKRQLYGVVGIDMVAGPSEIVI
VADNKNAPHVIAADLLSQAEHDPTSQSILFTDDGDFADAVAAAVADVIPTLATAATMLASWTDNGVVIVVPTLADAIPLC
DRLAPEHLELAVDPAEADALFARVRHAGSVFLGRQTPEAIGDYVAGPNHVLPTGRRARFSSGLSVTDFMKRTSFLALDEA
SLAAIGPAAVALAGAEGLPAHALSVQNRLK

Sequences:

>Translated_430_residues
MRRLDASAPGFAAQFDALVNDRRESASDVSADVAAIIARVKAEGDAALADYTAKFDRFDLDARGWSIAKKDCATAYQALA
PDLRDALNLAADRIGAYHAAQLPEDRDYRDATGARLGARWNAVDAAGVYVPGGRAAYPSSVLMNILPAKVAGVGRIVMVT
PTPDGQVNPVVMAAAHIGGVDEIWRVGGAQAIAALAHGTDRIAPVDVVTGPGNAWVAEAKRQLYGVVGIDMVAGPSEIVI
VADNKNAPHVIAADLLSQAEHDPTSQSILFTDDGDFADAVAAAVADVIPTLATAATMLASWTDNGVVIVVPTLADAIPLC
DRLAPEHLELAVDPAEADALFARVRHAGSVFLGRQTPEAIGDYVAGPNHVLPTGRRARFSSGLSVTDFMKRTSFLALDEA
SLAAIGPAAVALAGAEGLPAHALSVQNRLK
>Mature_430_residues
MRRLDASAPGFAAQFDALVNDRRESASDVSADVAAIIARVKAEGDAALADYTAKFDRFDLDARGWSIAKKDCATAYQALA
PDLRDALNLAADRIGAYHAAQLPEDRDYRDATGARLGARWNAVDAAGVYVPGGRAAYPSSVLMNILPAKVAGVGRIVMVT
PTPDGQVNPVVMAAAHIGGVDEIWRVGGAQAIAALAHGTDRIAPVDVVTGPGNAWVAEAKRQLYGVVGIDMVAGPSEIVI
VADNKNAPHVIAADLLSQAEHDPTSQSILFTDDGDFADAVAAAVADVIPTLATAATMLASWTDNGVVIVVPTLADAIPLC
DRLAPEHLELAVDPAEADALFARVRHAGSVFLGRQTPEAIGDYVAGPNHVLPTGRRARFSSGLSVTDFMKRTSFLALDEA
SLAAIGPAAVALAGAEGLPAHALSVQNRLK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=39.0243902439024, Blast_Score=252, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6319819, Length=416, Percent_Identity=33.8942307692308, Blast_Score=216, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44637; Mature: 44637

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLDASAPGFAAQFDALVNDRRESASDVSADVAAIIARVKAEGDAALADYTAKFDRFDL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
DARGWSIAKKDCATAYQALAPDLRDALNLAADRIGAYHAAQLPEDRDYRDATGARLGARW
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCC
NAVDAAGVYVPGGRAAYPSSVLMNILPAKVAGVGRIVMVTPTPDGQVNPVVMAAAHIGGV
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHCCCH
DEIWRVGGAQAIAALAHGTDRIAPVDVVTGPGNAWVAEAKRQLYGVVGIDMVAGPSEIVI
HHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCEEEE
VADNKNAPHVIAADLLSQAEHDPTSQSILFTDDGDFADAVAAAVADVIPTLATAATMLAS
EECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WTDNGVVIVVPTLADAIPLCDRLAPEHLELAVDPAEADALFARVRHAGSVFLGRQTPEAI
CCCCCEEEEECCHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHCCCEEECCCCHHHH
GDYVAGPNHVLPTGRRARFSSGLSVTDFMKRTSFLALDEASLAAIGPAAVALAGAEGLPA
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEEEECCCCHHHCCHHHHEEECCCCCCH
HALSVQNRLK
HHHHHHHHCC
>Mature Secondary Structure
MRRLDASAPGFAAQFDALVNDRRESASDVSADVAAIIARVKAEGDAALADYTAKFDRFDL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
DARGWSIAKKDCATAYQALAPDLRDALNLAADRIGAYHAAQLPEDRDYRDATGARLGARW
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCC
NAVDAAGVYVPGGRAAYPSSVLMNILPAKVAGVGRIVMVTPTPDGQVNPVVMAAAHIGGV
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHCCCH
DEIWRVGGAQAIAALAHGTDRIAPVDVVTGPGNAWVAEAKRQLYGVVGIDMVAGPSEIVI
HHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCEEEE
VADNKNAPHVIAADLLSQAEHDPTSQSILFTDDGDFADAVAAAVADVIPTLATAATMLAS
EECCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
WTDNGVVIVVPTLADAIPLCDRLAPEHLELAVDPAEADALFARVRHAGSVFLGRQTPEAI
CCCCCEEEEECCHHHHHHHHHHCCCCHHEEEECCHHHHHHHHHHHHCCCEEECCCCHHHH
GDYVAGPNHVLPTGRRARFSSGLSVTDFMKRTSFLALDEASLAAIGPAAVALAGAEGLPA
HHHCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHEEEECCCCHHHCCHHHHEEECCCCCCH
HALSVQNRLK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA