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The map label for this gene is pip [H]

Identifier: 103487489

GI number: 103487489

Start: 2115059

End: 2116153

Strand: Reverse

Name: pip [H]

Synonym: Sala_2006

Alternate gene names: 103487489

Gene position: 2116153-2115059 (Counterclockwise)

Preceding gene: 103487493

Following gene: 103487488

Centisome position: 63.26

GC content: 65.21

Gene sequence:

>1095_bases
ATGGTCATGGATTTTTCGCGGCTTCAGGCGTCGAGCAAGATCGGCGAGCAGTGGGTCTATCCGCAGCCCGCCTGCCTCAA
TTTCGGGTGGCTGGAGGTCGACCGCGATCCCGCGCACCGCCTTTACTGGGAGGAATATGGCAATCCCGCGGGCGAGCCGG
TGATGGTCCTGCACGGCGGCCCCGGCGGCGCGTGCGCGCCGGTGATGGCGCGCTTTTTCGATCCGAAGCGATACCGGGTG
ATCCTGTTCGACCAGCGCGGGTGCGGCAAGAGCGAGCCCAATGTCGCGTCGGCCGGGCCGGCGGTCGCGCTGGCCAAAAA
CACCACCGCCGACCTGATCGGCGACATCGAGAAATTGCGCGATCATCTGGCGATTGCGGGGCCGATGCACGTCTTTGGCG
GCAGCTGGGGCAGCACGCTGGCCATGGCCTATGCGATCCAGCATCCCGCGCACTGCGCCAGCCTGATCCTGCGCGGCATC
TTTCTGGGCGCGGCGGAGGATCTGCTTTACCTCTATCAGGGCAATGCCGCGACGTGGGGAGACGACCCGTTCGCGCTGAC
CGCGCCCGGCGCCTATATCAAATATCCCGACCAATGGGCGGCGCTGCTCTCGGTGCTGAGCGCCGACGAGCGGCGCGATG
TCATGGCGTCGTACAAGGCGATTTTCGATATGGTGCCGGCGAATGCGGCGGAGAAGGAGCGGCAGCTGAACGCCGCGCTC
ACCTGGTCGCTATGGGAAGGGGTGATTTCCAACATGATCCCCGAGACGGCCGACACGGGCAAGTTCGGCGAGGCCGATTT
CGCGCTGTGCTTCGCGCAGATCGAGGCGCATTATTTCGCCAACGACCTGTTCCTGCCCGCGGGCCATTTTTTCGACCATA
TCGACATACTGGCGTCGATCCCCATCCACATCGTCCACGGCCGTTTCGACGAAGTCTGCCCGCTGACACAGGCATCGCGG
CTGGTCGCCGCGCTGCGCGCCGCGGGGGCGGAGCCGGTGTCCTATGTCGTCACCAATGCGGGGCACAGCGCGATGGAGCG
CGAGAATGCGCTGGCGCTGACGGCGGTGATGGATGGGTTGGGGAGGATTGTATAA

Upstream 100 bases:

>100_bases
GGCCGACAGGCCCCACCCCACTACGACTAGGCAGCAAGCTGCCAAGTCTTCGTTGCCCCTCCCCTGAAGGGGAGGGGCTT
ACTGGGGAGCGGATGGGGTT

Downstream 100 bases:

>100_bases
CCATATAGGTTATTTTTGTTGACATCGTCACGCTGATGTGGCACACGAGTCACATCATGAAGAATTGCGAGTCGGGCCGG
CGCCTTTCGGGGCGGTCGGC

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MVMDFSRLQASSKIGEQWVYPQPACLNFGWLEVDRDPAHRLYWEEYGNPAGEPVMVLHGGPGGACAPVMARFFDPKRYRV
ILFDQRGCGKSEPNVASAGPAVALAKNTTADLIGDIEKLRDHLAIAGPMHVFGGSWGSTLAMAYAIQHPAHCASLILRGI
FLGAAEDLLYLYQGNAATWGDDPFALTAPGAYIKYPDQWAALLSVLSADERRDVMASYKAIFDMVPANAAEKERQLNAAL
TWSLWEGVISNMIPETADTGKFGEADFALCFAQIEAHYFANDLFLPAGHFFDHIDILASIPIHIVHGRFDEVCPLTQASR
LVAALRAAGAEPVSYVVTNAGHSAMERENALALTAVMDGLGRIV

Sequences:

>Translated_364_residues
MVMDFSRLQASSKIGEQWVYPQPACLNFGWLEVDRDPAHRLYWEEYGNPAGEPVMVLHGGPGGACAPVMARFFDPKRYRV
ILFDQRGCGKSEPNVASAGPAVALAKNTTADLIGDIEKLRDHLAIAGPMHVFGGSWGSTLAMAYAIQHPAHCASLILRGI
FLGAAEDLLYLYQGNAATWGDDPFALTAPGAYIKYPDQWAALLSVLSADERRDVMASYKAIFDMVPANAAEKERQLNAAL
TWSLWEGVISNMIPETADTGKFGEADFALCFAQIEAHYFANDLFLPAGHFFDHIDILASIPIHIVHGRFDEVCPLTQASR
LVAALRAAGAEPVSYVVTNAGHSAMERENALALTAVMDGLGRIV
>Mature_364_residues
MVMDFSRLQASSKIGEQWVYPQPACLNFGWLEVDRDPAHRLYWEEYGNPAGEPVMVLHGGPGGACAPVMARFFDPKRYRV
ILFDQRGCGKSEPNVASAGPAVALAKNTTADLIGDIEKLRDHLAIAGPMHVFGGSWGSTLAMAYAIQHPAHCASLILRGI
FLGAAEDLLYLYQGNAATWGDDPFALTAPGAYIKYPDQWAALLSVLSADERRDVMASYKAIFDMVPANAAEKERQLNAAL
TWSLWEGVISNMIPETADTGKFGEADFALCFAQIEAHYFANDLFLPAGHFFDHIDILASIPIHIVHGRFDEVCPLTQASR
LVAALRAAGAEPVSYVVTNAGHSAMERENALALTAVMDGLGRIV

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 39508; Mature: 39508

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMDFSRLQASSKIGEQWVYPQPACLNFGWLEVDRDPAHRLYWEEYGNPAGEPVMVLHGG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEEECC
PGGACAPVMARFFDPKRYRVILFDQRGCGKSEPNVASAGPAVALAKNTTADLIGDIEKLR
CCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
DHLAIAGPMHVFGGSWGSTLAMAYAIQHPAHCASLILRGIFLGAAEDLLYLYQGNAATWG
HHHHHCCCHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCC
DDPFALTAPGAYIKYPDQWAALLSVLSADERRDVMASYKAIFDMVPANAAEKERQLNAAL
CCCEEEECCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TWSLWEGVISNMIPETADTGKFGEADFALCFAQIEAHYFANDLFLPAGHFFDHIDILASI
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
PIHIVHGRFDEVCPLTQASRLVAALRAAGAEPVSYVVTNAGHSAMERENALALTAVMDGL
CEEEEECCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHH
GRIV
HCCC
>Mature Secondary Structure
MVMDFSRLQASSKIGEQWVYPQPACLNFGWLEVDRDPAHRLYWEEYGNPAGEPVMVLHGG
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEEECC
PGGACAPVMARFFDPKRYRVILFDQRGCGKSEPNVASAGPAVALAKNTTADLIGDIEKLR
CCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
DHLAIAGPMHVFGGSWGSTLAMAYAIQHPAHCASLILRGIFLGAAEDLLYLYQGNAATWG
HHHHHCCCHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCC
DDPFALTAPGAYIKYPDQWAALLSVLSADERRDVMASYKAIFDMVPANAAEKERQLNAAL
CCCEEEECCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TWSLWEGVISNMIPETADTGKFGEADFALCFAQIEAHYFANDLFLPAGHFFDHIDILASI
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
PIHIVHGRFDEVCPLTQASRLVAALRAAGAEPVSYVVTNAGHSAMERENALALTAVMDGL
CEEEEECCCHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHH
GRIV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]