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The map label for this gene is dxr [H]

Identifier: 103487438

GI number: 103487438

Start: 2061228

End: 2062391

Strand: Reverse

Name: dxr [H]

Synonym: Sala_1954

Alternate gene names: 103487438

Gene position: 2062391-2061228 (Counterclockwise)

Preceding gene: 103487439

Following gene: 103487437

Centisome position: 61.65

GC content: 69.16

Gene sequence:

>1164_bases
ATGACGCGCCGTCTCTCCCTCTTCGGCGCCACGGGATCGGTCGGGCAATCGACGCTCGACCTTGTCCGCCGCGACCGCGA
GGCGTGGCGCGTCGGGGTGCTGACGGCCAATTGCGACGTCCAGGAACTGGCGCGGCTCGCCATCGAGTTCCGGCCCGATG
TCGCGGTGGTCGCCGATGAAAGCTGTTATGGCTATCTCAAGGCCGCGCTCGCGGGGCAGGGGATCGAATGTGCGGCGGGC
GCGGCGGCGCTCGTCGAAGCCGCCGAACGGCGGGCCGATCTCGTCATGGCCGCGATCGTCGGCACCGCGGGGCTGGCGCC
GACGATGACGGCACTGGCGGCGGGGCACGACGTTGCGCTCGCCAACAAGGAAGCGCTGGTGTCGGCCGGCGAGCTGATGA
CCGCCGCAGCGCGCGCGTCGGGCGCGACGATCCTCCCGGTCGACAGCGAACATAATGCGATCTTTCAATGCCTCGCGGGC
GGGCGGATCGACCAGGTGCGGCGCATCATCCTGACCGCGAGCGGCGGCCCGTTCCGCACCATGAGCGCCGCCGACATGGC
CGCGGTGACCCCGGCGCAGGCGGTCGCGCATCCCAATTGGTCGATGGGCGCCAAGATCAGCGTCGATTCGGCAACGATGA
TGAACAAGGGCCTCGAACTCATCGAGGCGCATCATCTTTTCCCTGTCGGGCTCGACCGGATCGAGATCCTCGTCCACCCG
CAATCGGTGATCCACAGCCTCGTCGAATATATCGACTGCTCGACGCTCGCACAGCTCGGTTCGCCCGACATGCGCATCCC
GATCGCGTCGGCGCTCGCCTGGCCGCAGCGGATGGCGACGCCGTGCGCGCCGCTCGACCTGGCGGCGATTTCGCGGCTCG
ATTTCGAGGCGCCCGACGAAGAGCGCTTCCCCGCGACCGCGCTCTGCCGCGCCGCGATCGCGGCGGGCGGCGCGCGCCCG
GCGCAGCTCAATGCCGCGAACGAGGTGGCGGTCGCCGCCTTCCTCGCGGGCCGCATTTCCTTCCCCGCGATCGTCGATAC
GGTACGGCGGGTGGTCGACGCGGCGGAACCTGCGGCTCCGTCCTCGCTTCAGGACATATTCAGCGTCGATACCGCATCGC
GGGCGGCTGCGCTGCGCTTTGTGGAACAATATGAACATGCTTGA

Upstream 100 bases:

>100_bases
GGCCACGGCGGCCTGTTCGATCGCGTCGACGGTTTGCTGCCGGTCGCGCTGCTGCTCGGCGCGCTGGCGTTCGCGGGCCA
GATCGGGGCGCGCGGCTGAC

Downstream 100 bases:

>100_bases
GACGCCCGGTTTCGGATTCACGATCCTTGCCTTCCTGCTCGTGCTGGGGCCGCTCGTGTTCGTCCACGAATATGGCCATT
ATATCGTCGGCCGCTGGTGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTRRLSLFGATGSVGQSTLDLVRRDREAWRVGVLTANCDVQELARLAIEFRPDVAVVADESCYGYLKAALAGQGIECAAG
AAALVEAAERRADLVMAAIVGTAGLAPTMTALAAGHDVALANKEALVSAGELMTAAARASGATILPVDSEHNAIFQCLAG
GRIDQVRRIILTASGGPFRTMSAADMAAVTPAQAVAHPNWSMGAKISVDSATMMNKGLELIEAHHLFPVGLDRIEILVHP
QSVIHSLVEYIDCSTLAQLGSPDMRIPIASALAWPQRMATPCAPLDLAAISRLDFEAPDEERFPATALCRAAIAAGGARP
AQLNAANEVAVAAFLAGRISFPAIVDTVRRVVDAAEPAAPSSLQDIFSVDTASRAAALRFVEQYEHA

Sequences:

>Translated_387_residues
MTRRLSLFGATGSVGQSTLDLVRRDREAWRVGVLTANCDVQELARLAIEFRPDVAVVADESCYGYLKAALAGQGIECAAG
AAALVEAAERRADLVMAAIVGTAGLAPTMTALAAGHDVALANKEALVSAGELMTAAARASGATILPVDSEHNAIFQCLAG
GRIDQVRRIILTASGGPFRTMSAADMAAVTPAQAVAHPNWSMGAKISVDSATMMNKGLELIEAHHLFPVGLDRIEILVHP
QSVIHSLVEYIDCSTLAQLGSPDMRIPIASALAWPQRMATPCAPLDLAAISRLDFEAPDEERFPATALCRAAIAAGGARP
AQLNAANEVAVAAFLAGRISFPAIVDTVRRVVDAAEPAAPSSLQDIFSVDTASRAAALRFVEQYEHA
>Mature_386_residues
TRRLSLFGATGSVGQSTLDLVRRDREAWRVGVLTANCDVQELARLAIEFRPDVAVVADESCYGYLKAALAGQGIECAAGA
AALVEAAERRADLVMAAIVGTAGLAPTMTALAAGHDVALANKEALVSAGELMTAAARASGATILPVDSEHNAIFQCLAGG
RIDQVRRIILTASGGPFRTMSAADMAAVTPAQAVAHPNWSMGAKISVDSATMMNKGLELIEAHHLFPVGLDRIEILVHPQ
SVIHSLVEYIDCSTLAQLGSPDMRIPIASALAWPQRMATPCAPLDLAAISRLDFEAPDEERFPATALCRAAIAAGGARPA
QLNAANEVAVAAFLAGRISFPAIVDTVRRVVDAAEPAAPSSLQDIFSVDTASRAAALRFVEQYEHA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=48.2142857142857, Blast_Score=324, Evalue=7e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40453; Mature: 40322

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRLSLFGATGSVGQSTLDLVRRDREAWRVGVLTANCDVQELARLAIEFRPDVAVVADE
CCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHCCCCEEEEECC
SCYGYLKAALAGQGIECAAGAAALVEAAERRADLVMAAIVGTAGLAPTMTALAAGHDVAL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
ANKEALVSAGELMTAAARASGATILPVDSEHNAIFQCLAGGRIDQVRRIILTASGGPFRT
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCHHHEEEEEEEECCCCCEE
MSAADMAAVTPAQAVAHPNWSMGAKISVDSATMMNKGLELIEAHHLFPVGLDRIEILVHP
CCHHHHHHCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
QSVIHSLVEYIDCSTLAQLGSPDMRIPIASALAWPQRMATPCAPLDLAAISRLDFEAPDE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCCCHHHHHHHHCCCCCCCC
ERFPATALCRAAIAAGGARPAQLNAANEVAVAAFLAGRISFPAIVDTVRRVVDAAEPAAP
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
SSLQDIFSVDTASRAAALRFVEQYEHA
HHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRRLSLFGATGSVGQSTLDLVRRDREAWRVGVLTANCDVQELARLAIEFRPDVAVVADE
CCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHCCCCEEEEECC
SCYGYLKAALAGQGIECAAGAAALVEAAERRADLVMAAIVGTAGLAPTMTALAAGHDVAL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEE
ANKEALVSAGELMTAAARASGATILPVDSEHNAIFQCLAGGRIDQVRRIILTASGGPFRT
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCHHHEEEEEEEECCCCCEE
MSAADMAAVTPAQAVAHPNWSMGAKISVDSATMMNKGLELIEAHHLFPVGLDRIEILVHP
CCHHHHHHCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
QSVIHSLVEYIDCSTLAQLGSPDMRIPIASALAWPQRMATPCAPLDLAAISRLDFEAPDE
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHCCCCCCHHHHHHHHCCCCCCCC
ERFPATALCRAAIAAGGARPAQLNAANEVAVAAFLAGRISFPAIVDTVRRVVDAAEPAAP
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
SSLQDIFSVDTASRAAALRFVEQYEHA
HHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11004410 [H]