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The map label for this gene is cysK [H]

Identifier: 103487377

GI number: 103487377

Start: 1992079

End: 1993059

Strand: Reverse

Name: cysK [H]

Synonym: Sala_1893

Alternate gene names: 103487377

Gene position: 1993059-1992079 (Counterclockwise)

Preceding gene: 103487379

Following gene: 103487376

Centisome position: 59.58

GC content: 65.34

Gene sequence:

>981_bases
ATGACCATTGCCAGAACCAGCCTGGACCTGATCGGCAACACGCCGCTCGTCCTGCTCAAGGGCCCCAGCGAAGCGACCGG
CTGCGAAATCTGGGGCAAATGCGAATATGCCAATCCCGGCGGATCGGTAAAGGATCGCGCGGCGCTCTATATCGTCCGCG
ATGCCGAAGCGACCGGCAGCCTGCGCCCCGGCGGCACGATCGTCGAGGGCACGGCGGGCAACACCGGTATCGGGCTTGCG
CTCGTCGGCAATGCACTTGGTTACAAGACGATCATCGTCATGCCCGACAATCAGAGCGCCGAGAAGATGGCGACGATCCG
GGCCTTGGGTGCCGAGCTGGTGCTCGTGCCGCCCGCGCCCTTTGCCAACCCCGGCCATTTCGTTCACACCTCGCGCCGCA
TCGCCGAGGAAACCGACAATGCAATCTGGGCCAACCAGTTCGACAATATCGCCAACCGCAAGGCGCATATCTCTGGCACC
GCCGAGGAAATCTGGGCCCAGATGGGGGGGCGGATCGACGGCTTCACCTGCGCCGCGGGGACGGGCGGGACGATCGCCGG
GACGGGGCTGGGGCTGAAAGCCAGGGATCCCGCCATCACCATCGCGCTGACCGACCCGCACGGCGCGGGCCTTTACAATT
ATTACCAGTGCGGCGAGCTGAAAGCCGAGGGATCGAGCGTCGCCGAAGGCATCGGGCAGAATCGCATCACCGCGAACCTC
GAAGGCGCGCCGATCGACACGCAGTTCCGCATTTCGGATGCCGAGGGTCTCGCGGTCGTGCGCCGCCTGCTCGACGAGGA
GGGGCTGTGCCTTGGTCTCTCGTCGGGGATCAACGTCGCGGGTGCGATGGCGCTGGCGCGGCAATTGGGGCCGGGCAAGC
GCATCGCAACCATTTTGTGCGACAGCGGGTTTCGCTATCTCTCGACGCTTTACAACCCCGAGTGGCTGGCCGCCAGGGGA
CTGGGTGAGGCAAAGGGATGA

Upstream 100 bases:

>100_bases
TGGTCGGCGCCGAACGGCTGTTCGTCGACAAAGGCCGATCATCGGCCAGGCAAGCGAAGCTGTCTTGCGGCGTCCGGAAC
GCCGCCCTAGATCATGACGC

Downstream 100 bases:

>100_bases
ACATGCGTATCGATAGCGGTTCGCCCCCGCCGCCGGGGCAACAACCCGCGCCGCCGTCGCCACCGCCGGTACACGACACG
ATGCGCCGTCTGCAGATCGG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTIARTSLDLIGNTPLVLLKGPSEATGCEIWGKCEYANPGGSVKDRAALYIVRDAEATGSLRPGGTIVEGTAGNTGIGLA
LVGNALGYKTIIVMPDNQSAEKMATIRALGAELVLVPPAPFANPGHFVHTSRRIAEETDNAIWANQFDNIANRKAHISGT
AEEIWAQMGGRIDGFTCAAGTGGTIAGTGLGLKARDPAITIALTDPHGAGLYNYYQCGELKAEGSSVAEGIGQNRITANL
EGAPIDTQFRISDAEGLAVVRRLLDEEGLCLGLSSGINVAGAMALARQLGPGKRIATILCDSGFRYLSTLYNPEWLAARG
LGEAKG

Sequences:

>Translated_326_residues
MTIARTSLDLIGNTPLVLLKGPSEATGCEIWGKCEYANPGGSVKDRAALYIVRDAEATGSLRPGGTIVEGTAGNTGIGLA
LVGNALGYKTIIVMPDNQSAEKMATIRALGAELVLVPPAPFANPGHFVHTSRRIAEETDNAIWANQFDNIANRKAHISGT
AEEIWAQMGGRIDGFTCAAGTGGTIAGTGLGLKARDPAITIALTDPHGAGLYNYYQCGELKAEGSSVAEGIGQNRITANL
EGAPIDTQFRISDAEGLAVVRRLLDEEGLCLGLSSGINVAGAMALARQLGPGKRIATILCDSGFRYLSTLYNPEWLAARG
LGEAKG
>Mature_325_residues
TIARTSLDLIGNTPLVLLKGPSEATGCEIWGKCEYANPGGSVKDRAALYIVRDAEATGSLRPGGTIVEGTAGNTGIGLAL
VGNALGYKTIIVMPDNQSAEKMATIRALGAELVLVPPAPFANPGHFVHTSRRIAEETDNAIWANQFDNIANRKAHISGTA
EEIWAQMGGRIDGFTCAAGTGGTIAGTGLGLKARDPAITIALTDPHGAGLYNYYQCGELKAEGSSVAEGIGQNRITANLE
GAPIDTQFRISDAEGLAVVRRLLDEEGLCLGLSSGINVAGAMALARQLGPGKRIATILCDSGFRYLSTLYNPEWLAARGL
GEAKG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=39.7476340694006, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=39.7476340694006, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=39.7476340694006, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=37.7049180327869, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788754, Length=303, Percent_Identity=37.6237623762376, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=38.6581469648562, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI32566674, Length=307, Percent_Identity=38.7622149837134, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=36.9281045751634, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17561720, Length=307, Percent_Identity=38.7622149837134, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17534315, Length=332, Percent_Identity=37.0481927710843, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=338, Percent_Identity=35.5029585798817, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI115535073, Length=313, Percent_Identity=36.4217252396166, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=221, Percent_Identity=33.4841628959276, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71996324, Length=345, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=40, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6321594, Length=326, Percent_Identity=35.2760736196319, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=39.1849529780564, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=39.1849529780564, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33893; Mature: 33762

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIARTSLDLIGNTPLVLLKGPSEATGCEIWGKCEYANPGGSVKDRAALYIVRDAEATGS
CCEECCCHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCC
LRPGGTIVEGTAGNTGIGLALVGNALGYKTIIVMPDNQSAEKMATIRALGAELVLVPPAP
CCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEECCCC
FANPGHFVHTSRRIAEETDNAIWANQFDNIANRKAHISGTAEEIWAQMGGRIDGFTCAAG
CCCCCCEEEHHHHHHHHCCCCEEHHHHHHHHCCEEECCCCHHHHHHHHCCCCCCEEEECC
TGGTIAGTGLGLKARDPAITIALTDPHGAGLYNYYQCGELKAEGSSVAEGIGQNRITANL
CCCCEEECCCCCEECCCEEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEEEC
EGAPIDTQFRISDAEGLAVVRRLLDEEGLCLGLSSGINVAGAMALARQLGPGKRIATILC
CCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGFRYLSTLYNPEWLAARGLGEAKG
CCCHHHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure 
TIARTSLDLIGNTPLVLLKGPSEATGCEIWGKCEYANPGGSVKDRAALYIVRDAEATGS
CEECCCHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCC
LRPGGTIVEGTAGNTGIGLALVGNALGYKTIIVMPDNQSAEKMATIRALGAELVLVPPAP
CCCCCEEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEECCCC
FANPGHFVHTSRRIAEETDNAIWANQFDNIANRKAHISGTAEEIWAQMGGRIDGFTCAAG
CCCCCCEEEHHHHHHHHCCCCEEHHHHHHHHCCEEECCCCHHHHHHHHCCCCCCEEEECC
TGGTIAGTGLGLKARDPAITIALTDPHGAGLYNYYQCGELKAEGSSVAEGIGQNRITANL
CCCCEEECCCCCEECCCEEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHCCCCCEEEEC
EGAPIDTQFRISDAEGLAVVRRLLDEEGLCLGLSSGINVAGAMALARQLGPGKRIATILC
CCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGFRYLSTLYNPEWLAARGLGEAKG
CCCHHHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA