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The map label for this gene is tdcB [H]

Identifier: 103487326

GI number: 103487326

Start: 1935505

End: 1936755

Strand: Reverse

Name: tdcB [H]

Synonym: Sala_1842

Alternate gene names: 103487326

Gene position: 1936755-1935505 (Counterclockwise)

Preceding gene: 103487331

Following gene: 103487325

Centisome position: 57.9

GC content: 66.59

Gene sequence:

>1251_bases
ATGACCGATCACCTTACCCTGACCTCCGCGGCCGATTTTCCGGCGATCACATTGGACGATGTGCGCGCGGCGGCGGGGCG
AATTAACGGCGCGGTGGTGCGCACGCCGACGCTCCATTCGCAGACGCTGTCCGAGCTGGTCGGCGCCGAGGTGTGGCTGA
AGTTCGAGAATCTGCAATTCACCGCGGCCTACAAGGAACGCGGGGCATTGAACGCGCTGCTGCTGCTCAGCGAAGAAGCC
AGGGCGCGCGGCGTGATCGCGGCGTCGGCGGGCAATCATGCGCAGGGGCTGGCCTATCACGGCAAAAGGCTGGGCGTGCC
CGTCACCATCGTGATGCCCAGCACGACGCCGCAGGTGAAGGTGTCGCAGACCGCGGGCCACGGCGCGACGATCGTGCTGC
ACGGCGAAAAGTTCGACGACGCCTATGCCCATGCGCGCGAGCTGGAAGAGGAACGCGGGCTTACCTTTGTCCACCCCTTC
GACCATCCGCACGTCGCGGCGGGGCAGGGGACGGTGGCGCTCGAAATGCTTGAGGATGTGCCTGAACTCGACACGCTGAT
CGTGCCGATCGGCGGCGGCGGGCTGCTCGCGGGCATGGGCACCGCGGCGCGCGGGATCAAGAACGACATGCGCCTCGTCG
GCGTGCAGGCCGAGCTTTATCCCTCGATGTACGCCGAGCTGAACGGCGTCGACATGGCGTGCGAGGGCGATACGCTGGCC
GAGGGCATCGCGGTCAAGGAACCGGGGAGCTATACGCGCAAGCTCGTCGCCGAGCTCAACGACGACATCGTGCTCGTCGC
CGAACGGCATCTGGAGCGCGCGGTGAGCCTGTTGCTCCAGATCGAAAAAACGGTCGTCGAGGGCGCGGGCGCCGCGGGCC
TCGCGGCGATGCTCGCGCACCCCGACGAGTTCGCCGGGCGCAAGGTCGGACTGGTGCTCACCGGCGGCAATATCGACACG
CGCCTCCTCGCGAACGTGCTGCTGCGCGACCTTGCGCGATCGGGCCGCATCGCGCGGCTGCGCATCCGCTTGCAGGACCG
CCCCGGCGCGCTGTTCAAGGTGATGAAGCTGTTCGACGAGAAACAGGTCAACATCATCGAAATCTATCACCAGCGCATCT
TCACGACGCTCCCCGCGAAAGGGCTGATCACCGACATCGAATGCGAAGCGCGCGACCGCGAGCATCTCGACAGCCTCGTC
ACCGCTCTGCGCGACGCGGGCTATATGGTGACGACGGTCGAGCTGGCTTAG

Upstream 100 bases:

>100_bases
CCCTAGGCAGCAAGCTACCAAGTTTCGCTGCCCTCCCCTGAAGGGGAGGGCGCAAGAAGGCCTTTCCCTTCGCTACCCTT
GCCGTTAGGGCCGCAACGCT

Downstream 100 bases:

>100_bases
CCTCCGTTCCGTCGTCATTGCGAGGAGCCGACGCGGCAATCTAAAGCCATCGGGCCAGCGCGATCGCGATGGCCGGAGAT
TGCTTCGCTCCGCTCGCAAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTDHLTLTSAADFPAITLDDVRAAAGRINGAVVRTPTLHSQTLSELVGAEVWLKFENLQFTAAYKERGALNALLLLSEEA
RARGVIAASAGNHAQGLAYHGKRLGVPVTIVMPSTTPQVKVSQTAGHGATIVLHGEKFDDAYAHARELEEERGLTFVHPF
DHPHVAAGQGTVALEMLEDVPELDTLIVPIGGGGLLAGMGTAARGIKNDMRLVGVQAELYPSMYAELNGVDMACEGDTLA
EGIAVKEPGSYTRKLVAELNDDIVLVAERHLERAVSLLLQIEKTVVEGAGAAGLAAMLAHPDEFAGRKVGLVLTGGNIDT
RLLANVLLRDLARSGRIARLRIRLQDRPGALFKVMKLFDEKQVNIIEIYHQRIFTTLPAKGLITDIECEARDREHLDSLV
TALRDAGYMVTTVELA

Sequences:

>Translated_416_residues
MTDHLTLTSAADFPAITLDDVRAAAGRINGAVVRTPTLHSQTLSELVGAEVWLKFENLQFTAAYKERGALNALLLLSEEA
RARGVIAASAGNHAQGLAYHGKRLGVPVTIVMPSTTPQVKVSQTAGHGATIVLHGEKFDDAYAHARELEEERGLTFVHPF
DHPHVAAGQGTVALEMLEDVPELDTLIVPIGGGGLLAGMGTAARGIKNDMRLVGVQAELYPSMYAELNGVDMACEGDTLA
EGIAVKEPGSYTRKLVAELNDDIVLVAERHLERAVSLLLQIEKTVVEGAGAAGLAAMLAHPDEFAGRKVGLVLTGGNIDT
RLLANVLLRDLARSGRIARLRIRLQDRPGALFKVMKLFDEKQVNIIEIYHQRIFTTLPAKGLITDIECEARDREHLDSLV
TALRDAGYMVTTVELA
>Mature_415_residues
TDHLTLTSAADFPAITLDDVRAAAGRINGAVVRTPTLHSQTLSELVGAEVWLKFENLQFTAAYKERGALNALLLLSEEAR
ARGVIAASAGNHAQGLAYHGKRLGVPVTIVMPSTTPQVKVSQTAGHGATIVLHGEKFDDAYAHARELEEERGLTFVHPFD
HPHVAAGQGTVALEMLEDVPELDTLIVPIGGGGLLAGMGTAARGIKNDMRLVGVQAELYPSMYAELNGVDMACEGDTLAE
GIAVKEPGSYTRKLVAELNDDIVLVAERHLERAVSLLLQIEKTVVEGAGAAGLAAMLAHPDEFAGRKVGLVLTGGNIDTR
LLANVLLRDLARSGRIARLRIRLQDRPGALFKVMKLFDEKQVNIIEIYHQRIFTTLPAKGLITDIECEARDREHLDSLVT
ALRDAGYMVTTVELA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=34.2857142857143, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=35.4166666666667, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33469958, Length=275, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789505, Length=319, Percent_Identity=40.7523510971787, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1790207, Length=334, Percent_Identity=37.4251497005988, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=392, Percent_Identity=37.5, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17537387, Length=379, Percent_Identity=35.3562005277045, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=30.379746835443, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=40.7523510971787, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=341, Percent_Identity=34.8973607038123, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=205, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355833, Length=396, Percent_Identity=39.6464646464646, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24645328, Length=300, Percent_Identity=35, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44717; Mature: 44586

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHLTLTSAADFPAITLDDVRAAAGRINGAVVRTPTLHSQTLSELVGAEVWLKFENLQF
CCCCEEEECCCCCCEEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCEEEEEEECEEE
TAAYKERGALNALLLLSEEARARGVIAASAGNHAQGLAYHGKRLGVPVTIVMPSTTPQVK
EEEHHHCCCCEEEEEEECCHHHCEEEEECCCCCCCCCEECCCCCCCEEEEEECCCCCCEE
VSQTAGHGATIVLHGEKFDDAYAHARELEEERGLTFVHPFDHPHVAAGQGTVALEMLEDV
EEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCHHHHHHCC
PELDTLIVPIGGGGLLAGMGTAARGIKNDMRLVGVQAELYPSMYAELNGVDMACEGDTLA
CCCCEEEEEECCCCHHHCCCHHHHCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCCHHH
EGIAVKEPGSYTRKLVAELNDDIVLVAERHLERAVSLLLQIEKTVVEGAGAAGLAAMLAH
CCEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
PDEFAGRKVGLVLTGGNIDTRLLANVLLRDLARSGRIARLRIRLQDRPGALFKVMKLFDE
CHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCC
KQVNIIEIYHQRIFTTLPAKGLITDIECEARDREHLDSLVTALRDAGYMVTTVELA
CCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEC
>Mature Secondary Structure 
TDHLTLTSAADFPAITLDDVRAAAGRINGAVVRTPTLHSQTLSELVGAEVWLKFENLQF
CCCEEEECCCCCCEEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCEEEEEEECEEE
TAAYKERGALNALLLLSEEARARGVIAASAGNHAQGLAYHGKRLGVPVTIVMPSTTPQVK
EEEHHHCCCCEEEEEEECCHHHCEEEEECCCCCCCCCEECCCCCCCEEEEEECCCCCCEE
VSQTAGHGATIVLHGEKFDDAYAHARELEEERGLTFVHPFDHPHVAAGQGTVALEMLEDV
EEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCHHHHHHCC
PELDTLIVPIGGGGLLAGMGTAARGIKNDMRLVGVQAELYPSMYAELNGVDMACEGDTLA
CCCCEEEEEECCCCHHHCCCHHHHCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCCHHH
EGIAVKEPGSYTRKLVAELNDDIVLVAERHLERAVSLLLQIEKTVVEGAGAAGLAAMLAH
CCEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
PDEFAGRKVGLVLTGGNIDTRLLANVLLRDLARSGRIARLRIRLQDRPGALFKVMKLFDE
CHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCC
KQVNIIEIYHQRIFTTLPAKGLITDIECEARDREHLDSLVTALRDAGYMVTTVELA
CCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA