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The map label for this gene is pepA [H]

Identifier: 103487246

GI number: 103487246

Start: 1855377

End: 1856822

Strand: Reverse

Name: pepA [H]

Synonym: Sala_1761

Alternate gene names: 103487246

Gene position: 1856822-1855377 (Counterclockwise)

Preceding gene: 103487248

Following gene: 103487245

Centisome position: 55.51

GC content: 67.36

Gene sequence:

>1446_bases
ATGGACATTCAGTTTGTCGCGCAAATCGACGCGTCTGCCGACGTCGTCGCTTTCCCCGTCCGCAAGGGCGAGGCGGGGGC
GCTTGGCGCGCTGCTCGGCGCCGCCGCGGCGCAGGCGCGCTTCGACGGGGCGGCGGGCACGATCGCCGAGACCGCGGCGA
TCGACGGCGAGCAGGCCAAGCGCCTGCTGCTGGTCGGCATCGGCGAGGGCAGCGAGCACGACCTCGAACGCGGCGGCGCG
GCGCTGACGGCGAAACTCCAGACGAGCGGCGCCACCCAGGTCCATGTCGATTTCGCGAGCACGGGGCCGAGCGACGCCGA
CGATGTGCTGGCCTTTGCCATGGGCGCGCGTCTTCGAGGCTGGCGGCTCGACACCTATCGCACGCGCCTTGCCGACAAGG
CGAAACCGACGCTGAAGACGGTGACGATCGCCTCGCCGCACAGCGATCTGTCGGCGCGCTGGGCCGCGAACGAAGCGATT
GCGGAGGGCGTCGCCTTCACCCAGACGCTTGTCGCGGAGCCGCCGAACATCCTCTATCCCGAAAGCTTCGTCGAACGCTG
CCAGCATCTCGCCGATCTCGGCGTCGAGCTTGAAGTGCTCGACGAACGGCAGATGAAGGCGCTCGGCATGGGCGCGCTGC
TCGGCGTCGCGCAGGGGTCGACGCGCCCGCCGCGCCTCCTTGCGATGCGCTGGAACGGCGGCAATGCCGGCGACGCGCCC
GTCGTGTTCATCGGCAAGGGCGTCACCTTCGACACCGGCGGCATCAGCCTGAAACCGGGGCCGGGCATGGACATGATGAA
ATGGGATATGGGCGGCGCGGGCGCCGTCGCGGGCGCGATGAAGGCGATCGCAGGGCGCAAGGCCAGGGCCAATGTCGTCG
GCGTCGTCGGCCTTGTCGAAAACATGCCCGACGGTAATGCGATGCGCCCCGGCGACATCGTCACCACCATGTCGGGGCAG
ACGGTCGAGGTGCTCAACACCGACGCCGAGGGTCGGCTGGTCCTTTGCGATGCGATCAGCTGGGCGCAAAAGGTCTATGA
TCCCAAGGTGATCGTTGATCTCGCGACGCTGACTGGTGCAATGGTGATCTCGCTCGGCCATGAATATGCCGGCATGTTCG
CGAATGACGAGGCCCTCGCCGCCGACCTCATCGCCGCGGGCGAGGCGTCGAACAACAAGCTGTGGCGCTTCCCGTTGTCA
CCGGCTTATGACAAGCTGATCGACAGCCCGATCGCCGACATGAAGAATATCGGCCCGCGCGAGGGCGGGTCGATCACCGC
GGCCCAGTTCCTGAAACGCTTTGTGAATGACGGCGTCGCCTGGGCGCATCTCGACATCGCGGGTATGGCATGGGCTGACA
AGGATGGTCCGGTCTACGCCAAGGGCGCGACCGGCTATGGCGTACGCCTGCTCGACCGCTATATCGCGGCCAAGCACGAG
GGGTGA

Upstream 100 bases:

>100_bases
TTTCCCGGCTTGGACCGGCCGCTTTGTTTTTGCAACTCGCAGGCGAAACCCCTATCGGTCCGCCACGTTCCAATCAATCA
TTGCATAAGAAGGTTAAGGC

Downstream 100 bases:

>100_bases
TGGTCTGATGCTCGTCATTGCGAGGAGCGAAGCGACGCAGCAATCTCCAGCCATCGGCCTTGTGCAAGGTTGCGGGCTGA
AGATTGCTTCCCCCGGATCA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MDIQFVAQIDASADVVAFPVRKGEAGALGALLGAAAAQARFDGAAGTIAETAAIDGEQAKRLLLVGIGEGSEHDLERGGA
ALTAKLQTSGATQVHVDFASTGPSDADDVLAFAMGARLRGWRLDTYRTRLADKAKPTLKTVTIASPHSDLSARWAANEAI
AEGVAFTQTLVAEPPNILYPESFVERCQHLADLGVELEVLDERQMKALGMGALLGVAQGSTRPPRLLAMRWNGGNAGDAP
VVFIGKGVTFDTGGISLKPGPGMDMMKWDMGGAGAVAGAMKAIAGRKARANVVGVVGLVENMPDGNAMRPGDIVTTMSGQ
TVEVLNTDAEGRLVLCDAISWAQKVYDPKVIVDLATLTGAMVISLGHEYAGMFANDEALAADLIAAGEASNNKLWRFPLS
PAYDKLIDSPIADMKNIGPREGGSITAAQFLKRFVNDGVAWAHLDIAGMAWADKDGPVYAKGATGYGVRLLDRYIAAKHE
G

Sequences:

>Translated_481_residues
MDIQFVAQIDASADVVAFPVRKGEAGALGALLGAAAAQARFDGAAGTIAETAAIDGEQAKRLLLVGIGEGSEHDLERGGA
ALTAKLQTSGATQVHVDFASTGPSDADDVLAFAMGARLRGWRLDTYRTRLADKAKPTLKTVTIASPHSDLSARWAANEAI
AEGVAFTQTLVAEPPNILYPESFVERCQHLADLGVELEVLDERQMKALGMGALLGVAQGSTRPPRLLAMRWNGGNAGDAP
VVFIGKGVTFDTGGISLKPGPGMDMMKWDMGGAGAVAGAMKAIAGRKARANVVGVVGLVENMPDGNAMRPGDIVTTMSGQ
TVEVLNTDAEGRLVLCDAISWAQKVYDPKVIVDLATLTGAMVISLGHEYAGMFANDEALAADLIAAGEASNNKLWRFPLS
PAYDKLIDSPIADMKNIGPREGGSITAAQFLKRFVNDGVAWAHLDIAGMAWADKDGPVYAKGATGYGVRLLDRYIAAKHE
G
>Mature_481_residues
MDIQFVAQIDASADVVAFPVRKGEAGALGALLGAAAAQARFDGAAGTIAETAAIDGEQAKRLLLVGIGEGSEHDLERGGA
ALTAKLQTSGATQVHVDFASTGPSDADDVLAFAMGARLRGWRLDTYRTRLADKAKPTLKTVTIASPHSDLSARWAANEAI
AEGVAFTQTLVAEPPNILYPESFVERCQHLADLGVELEVLDERQMKALGMGALLGVAQGSTRPPRLLAMRWNGGNAGDAP
VVFIGKGVTFDTGGISLKPGPGMDMMKWDMGGAGAVAGAMKAIAGRKARANVVGVVGLVENMPDGNAMRPGDIVTTMSGQ
TVEVLNTDAEGRLVLCDAISWAQKVYDPKVIVDLATLTGAMVISLGHEYAGMFANDEALAADLIAAGEASNNKLWRFPLS
PAYDKLIDSPIADMKNIGPREGGSITAAQFLKRFVNDGVAWAHLDIAGMAWADKDGPVYAKGATGYGVRLLDRYIAAKHE
G

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=328, Percent_Identity=39.9390243902439, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI47155554, Length=318, Percent_Identity=35.5345911949685, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790710, Length=471, Percent_Identity=40.1273885350318, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87082123, Length=327, Percent_Identity=36.697247706422, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=323, Percent_Identity=32.1981424148607, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=162, Percent_Identity=35.1851851851852, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355725, Length=315, Percent_Identity=35.8730158730159, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20129969, Length=464, Percent_Identity=30.3879310344828, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24661038, Length=315, Percent_Identity=35.5555555555556, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI161077148, Length=370, Percent_Identity=30.8108108108108, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20130057, Length=370, Percent_Identity=30.8108108108108, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24662227, Length=395, Percent_Identity=29.620253164557, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI21355645, Length=396, Percent_Identity=29.7979797979798, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24662223, Length=396, Percent_Identity=29.7979797979798, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129963, Length=398, Percent_Identity=30.9045226130653, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19922386, Length=398, Percent_Identity=31.1557788944724, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=35.1097178683386, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=35.1097178683386, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=35.1097178683386, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646701, Length=254, Percent_Identity=29.5275590551181, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646703, Length=254, Percent_Identity=29.5275590551181, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358201, Length=254, Percent_Identity=29.5275590551181, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50252; Mature: 50252

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQFVAQIDASADVVAFPVRKGEAGALGALLGAAAAQARFDGAAGTIAETAAIDGEQAK
CCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCC
RLLLVGIGEGSEHDLERGGAALTAKLQTSGATQVHVDFASTGPSDADDVLAFAMGARLRG
EEEEEEECCCCCHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCC
WRLDTYRTRLADKAKPTLKTVTIASPHSDLSARWAANEAIAEGVAFTQTLVAEPPNILYP
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ESFVERCQHLADLGVELEVLDERQMKALGMGALLGVAQGSTRPPRLLAMRWNGGNAGDAP
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCHHHHEECCCCCCCCEEEEEEECCCCCCCCC
VVFIGKGVTFDTGGISLKPGPGMDMMKWDMGGAGAVAGAMKAIAGRKARANVVGVVGLVE
EEEEECCEEECCCCEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHH
NMPDGNAMRPGDIVTTMSGQTVEVLNTDAEGRLVLCDAISWAQKVYDPKVIVDLATLTGA
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEECHHHHHHHHCCCEEEEEHHHHHHH
MVISLGHEYAGMFANDEALAADLIAAGEASNNKLWRFPLSPAYDKLIDSPIADMKNIGPR
HHEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHCCCC
EGGSITAAQFLKRFVNDGVAWAHLDIAGMAWADKDGPVYAKGATGYGVRLLDRYIAAKHE
CCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCC
G
C
>Mature Secondary Structure
MDIQFVAQIDASADVVAFPVRKGEAGALGALLGAAAAQARFDGAAGTIAETAAIDGEQAK
CCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCC
RLLLVGIGEGSEHDLERGGAALTAKLQTSGATQVHVDFASTGPSDADDVLAFAMGARLRG
EEEEEEECCCCCHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCC
WRLDTYRTRLADKAKPTLKTVTIASPHSDLSARWAANEAIAEGVAFTQTLVAEPPNILYP
EECHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ESFVERCQHLADLGVELEVLDERQMKALGMGALLGVAQGSTRPPRLLAMRWNGGNAGDAP
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCHHHHEECCCCCCCCEEEEEEECCCCCCCCC
VVFIGKGVTFDTGGISLKPGPGMDMMKWDMGGAGAVAGAMKAIAGRKARANVVGVVGLVE
EEEEECCEEECCCCEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHH
NMPDGNAMRPGDIVTTMSGQTVEVLNTDAEGRLVLCDAISWAQKVYDPKVIVDLATLTGA
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEECHHHHHHHHCCCEEEEEHHHHHHH
MVISLGHEYAGMFANDEALAADLIAAGEASNNKLWRFPLSPAYDKLIDSPIADMKNIGPR
HHEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHCCCC
EGGSITAAQFLKRFVNDGVAWAHLDIAGMAWADKDGPVYAKGATGYGVRLLDRYIAAKHE
CCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA