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The map label for this gene is manC [H]

Identifier: 103487078

GI number: 103487078

Start: 1669207

End: 1670280

Strand: Direct

Name: manC [H]

Synonym: Sala_1593

Alternate gene names: 103487078

Gene position: 1669207-1670280 (Clockwise)

Preceding gene: 103487077

Following gene: 103487079

Centisome position: 49.9

GC content: 68.99

Gene sequence:

>1074_bases
ATGACCATCATCGTCCCCGTCATCCTTTCCGGCGGCTCCGGCACGCGCCTCTGGCCCGTATCGACCGCCGAGGCTCCCAA
GCAGTTCCAGCCGCTCACAGGCGGCGACAGCATGTTCCGGCACACGGTGGAGCGCGCGAGCGATCGCACCCGCTTCGCCG
CGCCGCTGGTCGTGTGCGGTCCGGCGCACGTCGCGCATGTCGAAGTCGATCTGGCCGCGGCGCGCATCGACGACGCGCGG
ATCATCGTCGAGCCCGCGGCGCGCAACACCGCCCCGGCGATTGCGCTCGCCGCGCTGGCCGCGCGTTCGGACGATCCCGA
CGCGATGATCCTCGTCATGCCAGCCGACCATGTGATGACCGACGTGCCAACCTTCCGCAAAGCGGTCGAGGCGGCGCGCC
CCGCGGTCGAAGGCGGCGCGCTCGCGACCTTCGGCATTGCGCCGTCGCATCCCGAAACCGGCTATGGCTATATCGCGGCG
GGCGATCCGGTGATCGGCGCTCCGGGCGTGCGCATGGTACGCCGCTTCGTCGAAAAGCCGCCGCGCGAGCGCGCAGAAGC
GATGCTGGACGAAGGCAGTCATTACTGGAACGCCGGCATATTCCTGATGCGCGCCGACCGTTTCCTTGCCGAACTGGAGC
GGCAACAGCCCGCAATGGCGTCCGCCTGCACGGCGGCGATGGACGGTGCGCGGTCAGACGGCGCGAAGGTCCATCCGCAC
GCCGACGCCTTCCTCGCCAGCCCGTCGAACTCGGTCGATTATGCGGTGATGGAGGGCGCCAGCCATGTCGTCGTCGTTCC
CGTCGATCCCGGCTGGTCCGACGTCGGCGGCTGGGCCGCGCTTCACGAACTCGGCGACAAGGATATGGCGGGCAATGTCC
GCATCGGCGAGATCATCGCCCTCGACGCGGCCGACAATTATCTGCGCGCGGGCGATGGCAAACGGATCGCCGTCGTCGGT
GTTTCGGACCTTATCGTCGTCGCGCACGGCGATGACATCCTCGTCATCCCGCGCGAGCGGGCGCAGGAGGTCAAGGCGAT
CGTCGAAGCGCTCGCCAAGCGCTCGCCCGGCTGA

Upstream 100 bases:

>100_bases
GAATGCGTGGCCACCGACCGCGCCGACGCCATCGCGCTGGAACCCGGTGCCCGTGCTTTACTGAGTTGGCCCACCTGATT
TCGCGCCCTAAAGCTTGTCC

Downstream 100 bases:

>100_bases
AGGCGCTCGCCCGCCCCTTGCGGCGCCACCCGCCATCGCCCATATCGCGCGGCATGACCCATCCCCACGCGCAAAGTGCC
GCGCCCTGGCACGGAACCAC

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTIIVPVILSGGSGTRLWPVSTAEAPKQFQPLTGGDSMFRHTVERASDRTRFAAPLVVCGPAHVAHVEVDLAAARIDDAR
IIVEPAARNTAPAIALAALAARSDDPDAMILVMPADHVMTDVPTFRKAVEAARPAVEGGALATFGIAPSHPETGYGYIAA
GDPVIGAPGVRMVRRFVEKPPRERAEAMLDEGSHYWNAGIFLMRADRFLAELERQQPAMASACTAAMDGARSDGAKVHPH
ADAFLASPSNSVDYAVMEGASHVVVVPVDPGWSDVGGWAALHELGDKDMAGNVRIGEIIALDAADNYLRAGDGKRIAVVG
VSDLIVVAHGDDILVIPRERAQEVKAIVEALAKRSPG

Sequences:

>Translated_357_residues
MTIIVPVILSGGSGTRLWPVSTAEAPKQFQPLTGGDSMFRHTVERASDRTRFAAPLVVCGPAHVAHVEVDLAAARIDDAR
IIVEPAARNTAPAIALAALAARSDDPDAMILVMPADHVMTDVPTFRKAVEAARPAVEGGALATFGIAPSHPETGYGYIAA
GDPVIGAPGVRMVRRFVEKPPRERAEAMLDEGSHYWNAGIFLMRADRFLAELERQQPAMASACTAAMDGARSDGAKVHPH
ADAFLASPSNSVDYAVMEGASHVVVVPVDPGWSDVGGWAALHELGDKDMAGNVRIGEIIALDAADNYLRAGDGKRIAVVG
VSDLIVVAHGDDILVIPRERAQEVKAIVEALAKRSPG
>Mature_356_residues
TIIVPVILSGGSGTRLWPVSTAEAPKQFQPLTGGDSMFRHTVERASDRTRFAAPLVVCGPAHVAHVEVDLAAARIDDARI
IVEPAARNTAPAIALAALAARSDDPDAMILVMPADHVMTDVPTFRKAVEAARPAVEGGALATFGIAPSHPETGYGYIAAG
DPVIGAPGVRMVRRFVEKPPRERAEAMLDEGSHYWNAGIFLMRADRFLAELERQQPAMASACTAAMDGARSDGAKVHPHA
DAFLASPSNSVDYAVMEGASHVVVVPVDPGWSDVGGWAALHELGDKDMAGNVRIGEIIALDAADNYLRAGDGKRIAVVGV
SDLIVVAHGDDILVIPRERAQEVKAIVEALAKRSPG

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=352, Percent_Identity=44.3181818181818, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 37598; Mature: 37467

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIVPVILSGGSGTRLWPVSTAEAPKQFQPLTGGDSMFRHTVERASDRTRFAAPLVVCG
CEEEEEEEEECCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCHHCCCEEEEC
PAHVAHVEVDLAAARIDDARIIVEPAARNTAPAIALAALAARSDDPDAMILVMPADHVMT
CCEEEEEEEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHHHH
DVPTFRKAVEAARPAVEGGALATFGIAPSHPETGYGYIAAGDPVIGAPGVRMVRRFVEKP
CCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCC
PRERAEAMLDEGSHYWNAGIFLMRADRFLAELERQQPAMASACTAAMDGARSDGAKVHPH
CHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCC
ADAFLASPSNSVDYAVMEGASHVVVVPVDPGWSDVGGWAALHELGDKDMAGNVRIGEIIA
CCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEE
LDAADNYLRAGDGKRIAVVGVSDLIVVAHGDDILVIPRERAQEVKAIVEALAKRSPG
EECCCCCEECCCCCEEEEEEEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIIVPVILSGGSGTRLWPVSTAEAPKQFQPLTGGDSMFRHTVERASDRTRFAAPLVVCG
EEEEEEEEECCCCCEEEECCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCHHCCCEEEEC
PAHVAHVEVDLAAARIDDARIIVEPAARNTAPAIALAALAARSDDPDAMILVMPADHVMT
CCEEEEEEEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHHHH
DVPTFRKAVEAARPAVEGGALATFGIAPSHPETGYGYIAAGDPVIGAPGVRMVRRFVEKP
CCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCC
PRERAEAMLDEGSHYWNAGIFLMRADRFLAELERQQPAMASACTAAMDGARSDGAKVHPH
CHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEECCC
ADAFLASPSNSVDYAVMEGASHVVVVPVDPGWSDVGGWAALHELGDKDMAGNVRIGEIIA
CCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEEE
LDAADNYLRAGDGKRIAVVGVSDLIVVAHGDDILVIPRERAQEVKAIVEALAKRSPG
EECCCCCEECCCCCEEEEEEEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]