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The map label for this gene is acdA [H]

Identifier: 103487014

GI number: 103487014

Start: 1595795

End: 1596964

Strand: Direct

Name: acdA [H]

Synonym: Sala_1529

Alternate gene names: 103487014

Gene position: 1595795-1596964 (Clockwise)

Preceding gene: 103487009

Following gene: 103487015

Centisome position: 47.7

GC content: 65.3

Gene sequence:

>1170_bases
ATGCGCGCCACCCCCGATTTCGACTTTGCGCTCGGCGAAACCGCCGACATGATCCGCGAAACCACCGCCCGCTTCGCCGA
CGAGCAGATTGCGCCGCTCGCCGCCAGGGCCGATGCGGAGGACTGGTTCCCGCGCGACGAGCTGTGGACGGCGATGGGCG
CACTCGGCCTCCATGGCATCACCGTCGAGGAGGAGTTCGGAGGGCTCGGCCTCGGCTATCTCGAACATGTCATCGCGGTT
GAAGAGGTTTCGCGCGCCAGCGCCGCGATCGGCCTCTCCTACGGCGCGCACTCGAACCTTTGCGTCAATCAGATCCGCCG
CTGGGGCAACGCCGAGCAGAAAGCGAAATATCTGCCGAAACTGATCTCGGGCGAGCATGTCGGCAGTCTCGCCATGTCCG
AAGCCGGGGCGGGCAGCGATGTGGTGTCGATGAAGCTGAAGGCCGACAAGGTGCAGGGCGGCTATGTCCTCAACGGCACG
AAGTTCTGGATCACCAACGCGAGCCACGCCGACACGCTGGTCGTCTATGCCAAGACCTCACCCGACGCGGGATCGCGGGG
AATTACGGCCTTTTTGATCGAAAAGGACATGCCGGGGTTCAGCATCGGGCAAAAGATCGACAAGGTCGGGATGCGCGGCA
GCCCGACCGCCGAACTGGTTTTCACCGATTGTGAAGTGTCCGAAGAGCAGGTGATGGGGCCGGAGAACGGCGGCGTCGGC
GTGCTGATGTCGGGGCTCGATTATGAGCGCGTCGTGCTCGCCGGGCTCCAGCTCGGCATCATGCAGGCGTGCCTCGACAC
GGTCATCCCTTACGTGCGCGAGCGCAAGCAGTTCGGCAAGCCGATCGGCGCGTTCCAGCTGATGCAGGCCAAGGTCGCCG
ACATGTATGTCATGCTCCAGTCGGCGCGCTCCTATGTCTATAACGTCGCCAAGGCGTGCGACGCAGGCCAGACGACGCGC
TTCGACGCCGCGGGCGCGATCCTGCTCGCGAGCGAGAGCGCGGTAAAGGTTGCGGGCGAGGCGATTCAGGCCCTCGGCGG
CGCGGGCTATACGAAGGACTGGCCGGTCGAGCGTTACTGGCGCGACGCCAAGCTGCTCGACATCGGCGCGGGCACCAACG
AAATCCGCCGGATGCTGATCGGCCGCGAACTGATCGGCGCCGGCGCGTGA

Upstream 100 bases:

>100_bases
AGATTTTGTTTATGCCGAACTGCGATCTCTTTCAATTTCCATATGCTGGGTTTTTGGGGCACTATCCCCTCCCGTCCGGC
CCTCGATCGACAGGTACTCC

Downstream 100 bases:

>100_bases
TCTGGCTCTGGCTGTCGGCGGCGGGCATGACGACGACGGCCGCGATCCACGCCATTCTTGGCGAGCGGCGGTTGATGGGG
CCGGTGATGATGCTCGATCA

Product: acyl-CoA dehydrogenase-like protein

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MRATPDFDFALGETADMIRETTARFADEQIAPLAARADAEDWFPRDELWTAMGALGLHGITVEEEFGGLGLGYLEHVIAV
EEVSRASAAIGLSYGAHSNLCVNQIRRWGNAEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLKADKVQGGYVLNGT
KFWITNASHADTLVVYAKTSPDAGSRGITAFLIEKDMPGFSIGQKIDKVGMRGSPTAELVFTDCEVSEEQVMGPENGGVG
VLMSGLDYERVVLAGLQLGIMQACLDTVIPYVRERKQFGKPIGAFQLMQAKVADMYVMLQSARSYVYNVAKACDAGQTTR
FDAAGAILLASESAVKVAGEAIQALGGAGYTKDWPVERYWRDAKLLDIGAGTNEIRRMLIGRELIGAGA

Sequences:

>Translated_389_residues
MRATPDFDFALGETADMIRETTARFADEQIAPLAARADAEDWFPRDELWTAMGALGLHGITVEEEFGGLGLGYLEHVIAV
EEVSRASAAIGLSYGAHSNLCVNQIRRWGNAEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLKADKVQGGYVLNGT
KFWITNASHADTLVVYAKTSPDAGSRGITAFLIEKDMPGFSIGQKIDKVGMRGSPTAELVFTDCEVSEEQVMGPENGGVG
VLMSGLDYERVVLAGLQLGIMQACLDTVIPYVRERKQFGKPIGAFQLMQAKVADMYVMLQSARSYVYNVAKACDAGQTTR
FDAAGAILLASESAVKVAGEAIQALGGAGYTKDWPVERYWRDAKLLDIGAGTNEIRRMLIGRELIGAGA
>Mature_389_residues
MRATPDFDFALGETADMIRETTARFADEQIAPLAARADAEDWFPRDELWTAMGALGLHGITVEEEFGGLGLGYLEHVIAV
EEVSRASAAIGLSYGAHSNLCVNQIRRWGNAEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLKADKVQGGYVLNGT
KFWITNASHADTLVVYAKTSPDAGSRGITAFLIEKDMPGFSIGQKIDKVGMRGSPTAELVFTDCEVSEEQVMGPENGGVG
VLMSGLDYERVVLAGLQLGIMQACLDTVIPYVRERKQFGKPIGAFQLMQAKVADMYVMLQSARSYVYNVAKACDAGQTTR
FDAAGAILLASESAVKVAGEAIQALGGAGYTKDWPVERYWRDAKLLDIGAGTNEIRRMLIGRELIGAGA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=59.2, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=58.6486486486486, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=40, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=39.6739130434783, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI7656849, Length=384, Percent_Identity=33.59375, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=32.258064516129, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=34.0314136125654, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=34.0314136125654, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI21361497, Length=369, Percent_Identity=36.0433604336043, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=34.9740932642487, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=34.9740932642487, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=30.4785894206549, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI7669494, Length=367, Percent_Identity=31.0626702997275, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI48976061, Length=291, Percent_Identity=28.8659793814433, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI211971008, Length=291, Percent_Identity=28.8659793814433, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38505218, Length=318, Percent_Identity=21.6981132075472, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=32.2077922077922, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=28.7958115183246, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=24.031007751938, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=56.3157894736842, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.4086021505376, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=32.0209973753281, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.4330708661417, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=34.2105263157895, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.1207349081365, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=38.0434782608696, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=32.972972972973, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=31.25, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=34.2007434944238, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=33.9130434782609, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=28.8828337874659, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=28.7634408602151, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=364, Percent_Identity=26.9230769230769, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=287, Percent_Identity=30.6620209059233, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=28.8702928870293, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=285, Percent_Identity=23.5087719298246, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI86563381, Length=283, Percent_Identity=26.5017667844523, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=283, Percent_Identity=26.5017667844523, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=56.6929133858268, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=39.8921832884097, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=37.3015873015873, Blast_Score=260, Evalue=9e-70,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=38.9920424403183, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=34.8167539267016, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=35.4929577464789, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=27.8061224489796, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41701; Mature: 41701

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRATPDFDFALGETADMIRETTARFADEQIAPLAARADAEDWFPRDELWTAMGALGLHGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHCCCHHHHHHHHHHHCCCCE
TVEEEFGGLGLGYLEHVIAVEEVSRASAAIGLSYGAHSNLCVNQIRRWGNAEQKAKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
LISGEHVGSLAMSEAGAGSDVVSMKLKADKVQGGYVLNGTKFWITNASHADTLVVYAKTS
HHCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCEEEEEEECC
PDAGSRGITAFLIEKDMPGFSIGQKIDKVGMRGSPTAELVFTDCEVSEEQVMGPENGGVG
CCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCE
VLMSGLDYERVVLAGLQLGIMQACLDTVIPYVRERKQFGKPIGAFQLMQAKVADMYVMLQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SARSYVYNVAKACDAGQTTRFDAAGAILLASESAVKVAGEAIQALGGAGYTKDWPVERYW
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
RDAKLLDIGAGTNEIRRMLIGRELIGAGA
CCCEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRATPDFDFALGETADMIRETTARFADEQIAPLAARADAEDWFPRDELWTAMGALGLHGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHCCCHHHHHHHHHHHCCCCE
TVEEEFGGLGLGYLEHVIAVEEVSRASAAIGLSYGAHSNLCVNQIRRWGNAEQKAKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
LISGEHVGSLAMSEAGAGSDVVSMKLKADKVQGGYVLNGTKFWITNASHADTLVVYAKTS
HHCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCEEECCEEEEEECCCCCCEEEEEEECC
PDAGSRGITAFLIEKDMPGFSIGQKIDKVGMRGSPTAELVFTDCEVSEEQVMGPENGGVG
CCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCCCE
VLMSGLDYERVVLAGLQLGIMQACLDTVIPYVRERKQFGKPIGAFQLMQAKVADMYVMLQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SARSYVYNVAKACDAGQTTRFDAAGAILLASESAVKVAGEAIQALGGAGYTKDWPVERYW
HHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHH
RDAKLLDIGAGTNEIRRMLIGRELIGAGA
CCCEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]