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The map label for this gene is accC [H]

Identifier: 103486924

GI number: 103486924

Start: 1486896

End: 1488260

Strand: Direct

Name: accC [H]

Synonym: Sala_1439

Alternate gene names: 103486924

Gene position: 1486896-1488260 (Clockwise)

Preceding gene: 103486923

Following gene: 103486925

Centisome position: 44.45

GC content: 63.3

Gene sequence:

>1365_bases
ATGACCATCGAAAAACTGCTCATCGCCAACCGCGGCGAGATTGCGCTGCGTATCCACCGCGCGTGCCACGAAATGGGCAT
CAGGACGGTTGCGGTCCACTCGACCGCCGACACCGACGCGATGCACGTCCGTCTCGCCGACGAGGCGGTGTGCATCGGCC
CGCCCGCGGCGAAGGACAGCTATCTCAATATCCCCGCCATCATCTCGGCGGCCGAGATCACCGGCGCCGACGCGATCCAT
CCGGGCTATGGCTTCCTCTCCGAAAACGAGCGCTTCGCCGAGATCATCGAAGCGCATGACATGATCTTCGTCGGGCCGAA
GCCCGAACATATCCGGACGATGGGCGACAAGGTCGAGGCAAAGCGCACCGCGGTCGCGCTGGGTCTTCCCGTCGTTCCGG
GCTCGCCCGGCGCGGTGACGTTCGGCGAGGAAACGAAAAAGCTCGCGCGCGAGATCGGCTATCCGGTGCTGATCAAGGCG
GCGTCGGGCGGCGGCGGGCGCGGCATGAAGGTGGTGCCCGACGAGGACAGCCTCGAAAGCCTGATGGGTCAGGCGTCGAG
CGAAGCGGCGGCGGCATTCGGCGATCCCACCGTTTACATGGAAAAATATCTCGGCAACCCGCGCCACATCGAGTTTCAGG
TGTTCGGCGACGGCAAGGGTAATGCGATCCATCTGGGCGAGCGCGACTGTTCGCTCCAGCGCCGCCACCAGAAGGTGCTT
GAAGAAGCGCCGTCGCCGATCATTTCGGCCGAGGAACGCGCGCGCATGGGCAAGGTCTGCGCCGATGCGATGGCCACAAT
GGGCTATCGCGGCGCTGGCACGATCGAGTTCCTGTGGGAAAATGGTGAGTTCTTCTTCATCGAAATGAACACGCGCATCC
AGGTCGAGCATCCGGTGACCGAGATGATCACCGGCTTCGACCTTGTGCGCGAACAGATTCGCATCGCGGGCGGCGCCGGG
CTTTCGGTGAAACAGGAAGAGCTGGAGTTTCGCGGCCATGCGATCGAATGCCGCATCAATGCGGAGGATCCGCGCACCTT
CATGCCCTCACCGGGCAAGGTGACCGCCTATCATCCGGCAGGCGGGATGCACGTCCGCGTCGATAGCGGGCTTTACGCCG
GCTATTCGATCCCGCCCTATTACGACAGCATGATCGGCAAGCTGATCGTCTATGGCCGCAGCCGCGAAAGCTGCATGATG
CGGATGCGCCGCGCGCTCGAGGAAATGGTGATCGCGGGCGTCAAGACGAACATCCCGCTCCACCAGGCGCTGCTCGCCGA
CCCCGACGTCATCAACGGCGATTATACGATCAAATGGCTGGAGGAATGGCTGGCGAAGCAGGATGCGGAGGAAAGCGCGG
CATAA

Upstream 100 bases:

>100_bases
GATCACCGCGCCCGCCGCGGGCACGCTCAAGGCCGTGCATGTCGAAAACAGCCAGCCGGTCGAGTTCGACCAGCCGCTGT
TCACCATCGGGTAAGTACCC

Downstream 100 bases:

>100_bases
AGGCAATGCGTCACCCCGGCGAAGGCCGGGGAGTCAAGGCGCCTTACAATCCGGCGCGGAGATTCCGGCCTTCGCAGGAA
TGACGAAGCCGCTTTTAATC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTIEKLLIANRGEIALRIHRACHEMGIRTVAVHSTADTDAMHVRLADEAVCIGPPAAKDSYLNIPAIISAAEITGADAIH
PGYGFLSENERFAEIIEAHDMIFVGPKPEHIRTMGDKVEAKRTAVALGLPVVPGSPGAVTFGEETKKLAREIGYPVLIKA
ASGGGGRGMKVVPDEDSLESLMGQASSEAAAAFGDPTVYMEKYLGNPRHIEFQVFGDGKGNAIHLGERDCSLQRRHQKVL
EEAPSPIISAEERARMGKVCADAMATMGYRGAGTIEFLWENGEFFFIEMNTRIQVEHPVTEMITGFDLVREQIRIAGGAG
LSVKQEELEFRGHAIECRINAEDPRTFMPSPGKVTAYHPAGGMHVRVDSGLYAGYSIPPYYDSMIGKLIVYGRSRESCMM
RMRRALEEMVIAGVKTNIPLHQALLADPDVINGDYTIKWLEEWLAKQDAEESAA

Sequences:

>Translated_454_residues
MTIEKLLIANRGEIALRIHRACHEMGIRTVAVHSTADTDAMHVRLADEAVCIGPPAAKDSYLNIPAIISAAEITGADAIH
PGYGFLSENERFAEIIEAHDMIFVGPKPEHIRTMGDKVEAKRTAVALGLPVVPGSPGAVTFGEETKKLAREIGYPVLIKA
ASGGGGRGMKVVPDEDSLESLMGQASSEAAAAFGDPTVYMEKYLGNPRHIEFQVFGDGKGNAIHLGERDCSLQRRHQKVL
EEAPSPIISAEERARMGKVCADAMATMGYRGAGTIEFLWENGEFFFIEMNTRIQVEHPVTEMITGFDLVREQIRIAGGAG
LSVKQEELEFRGHAIECRINAEDPRTFMPSPGKVTAYHPAGGMHVRVDSGLYAGYSIPPYYDSMIGKLIVYGRSRESCMM
RMRRALEEMVIAGVKTNIPLHQALLADPDVINGDYTIKWLEEWLAKQDAEESAA
>Mature_453_residues
TIEKLLIANRGEIALRIHRACHEMGIRTVAVHSTADTDAMHVRLADEAVCIGPPAAKDSYLNIPAIISAAEITGADAIHP
GYGFLSENERFAEIIEAHDMIFVGPKPEHIRTMGDKVEAKRTAVALGLPVVPGSPGAVTFGEETKKLAREIGYPVLIKAA
SGGGGRGMKVVPDEDSLESLMGQASSEAAAAFGDPTVYMEKYLGNPRHIEFQVFGDGKGNAIHLGERDCSLQRRHQKVLE
EAPSPIISAEERARMGKVCADAMATMGYRGAGTIEFLWENGEFFFIEMNTRIQVEHPVTEMITGFDLVREQIRIAGGAGL
SVKQEELEFRGHAIECRINAEDPRTFMPSPGKVTAYHPAGGMHVRVDSGLYAGYSIPPYYDSMIGKLIVYGRSRESCMMR
MRRALEEMVIAGVKTNIPLHQALLADPDVINGDYTIKWLEEWLAKQDAEESAA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=49.2134831460674, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=49.2134831460674, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=49.2134831460674, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=436, Percent_Identity=46.7889908256881, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.413870246085, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=30.8447937131631, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=30.8447937131631, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=30.8447937131631, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=30.8447937131631, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=30.4854368932039, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=30.9055118110236, Blast_Score=215, Evalue=8e-56,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=61.2975391498881, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=23.7704918032787, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=45.945945945946, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=438, Percent_Identity=46.1187214611872, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=44.0265486725664, Blast_Score=358, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=497, Percent_Identity=28.7726358148893, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=28.0392156862745, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=28.0392156862745, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319695, Length=455, Percent_Identity=45.4945054945055, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.2053571428571, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=42.2897196261682, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=30.5182341650672, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=471, Percent_Identity=31.4225053078556, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.5478841870824, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651757, Length=431, Percent_Identity=45.4756380510441, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=393, Percent_Identity=44.7837150127226, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=30.0395256916996, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076407, Length=507, Percent_Identity=29.9802761341223, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=507, Percent_Identity=29.9802761341223, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=30.0395256916996, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49591; Mature: 49460

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEKLLIANRGEIALRIHRACHEMGIRTVAVHSTADTDAMHVRLADEAVCIGPPAAKDS
CCHHHEEECCCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCC
YLNIPAIISAAEITGADAIHPGYGFLSENERFAEIIEAHDMIFVGPKPEHIRTMGDKVEA
CCCCHHHEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
KRTAVALGLPVVPGSPGAVTFGEETKKLAREIGYPVLIKAASGGGGRGMKVVPDEDSLES
HHEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHH
LMGQASSEAAAAFGDPTVYMEKYLGNPRHIEFQVFGDGKGNAIHLGERDCSLQRRHQKVL
HHCCCCCCHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPIISAEERARMGKVCADAMATMGYRGAGTIEFLWENGEFFFIEMNTRIQVEHPVT
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGFDLVREQIRIAGGAGLSVKQEELEFRGHAIECRINAEDPRTFMPSPGKVTAYHPA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEECCC
GGMHVRVDSGLYAGYSIPPYYDSMIGKLIVYGRSRESCMMRMRRALEEMVIAGVKTNIPL
CCEEEEECCCEEECCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
HQALLADPDVINGDYTIKWLEEWLAKQDAEESAA
HHHHHCCCCEECCCEEHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
TIEKLLIANRGEIALRIHRACHEMGIRTVAVHSTADTDAMHVRLADEAVCIGPPAAKDS
CHHHEEECCCCCEEEHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEECCCCCCCC
YLNIPAIISAAEITGADAIHPGYGFLSENERFAEIIEAHDMIFVGPKPEHIRTMGDKVEA
CCCCHHHEEEHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
KRTAVALGLPVVPGSPGAVTFGEETKKLAREIGYPVLIKAASGGGGRGMKVVPDEDSLES
HHEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCHHHHH
LMGQASSEAAAAFGDPTVYMEKYLGNPRHIEFQVFGDGKGNAIHLGERDCSLQRRHQKVL
HHCCCCCCHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPSPIISAEERARMGKVCADAMATMGYRGAGTIEFLWENGEFFFIEMNTRIQVEHPVT
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGFDLVREQIRIAGGAGLSVKQEELEFRGHAIECRINAEDPRTFMPSPGKVTAYHPA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEECCC
GGMHVRVDSGLYAGYSIPPYYDSMIGKLIVYGRSRESCMMRMRRALEEMVIAGVKTNIPL
CCEEEEECCCEEECCCCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
HQALLADPDVINGDYTIKWLEEWLAKQDAEESAA
HHHHHCCCCEECCCEEHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]