Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 103486794

GI number: 103486794

Start: 1367791

End: 1369047

Strand: Reverse

Name: nuoD [H]

Synonym: Sala_1308

Alternate gene names: 103486794

Gene position: 1369047-1367791 (Counterclockwise)

Preceding gene: 103486795

Following gene: 103486793

Centisome position: 40.93

GC content: 61.89

Gene sequence:

>1257_bases
ATGACCGATGCTCCTCAGGTCAGGCACCACGGCAGCGACATGTTTGAAGGCTATCCGGTCGATACCGCGAACACCGCGGG
CGATCAGGCCGTCACCAATTACACGATCAACTTCGGCCCGCAGCATCCCGCGGCGCACGGCGTGCTGCGCATGGTGATGG
AGCTCGACGGCGAGATCATCGAGCGCGTCGACCCGCACGTCGGGCTGCTCCATCGCGGCACCGAAAAGCTGATCGAATAC
AAGACCTATTTGCAGGCTTTGCCCTATTTCGACCGGCTCGACTATTGCTCGCCGCTCGGCATGGAGCACAGCTATGTGCT
CGCGATCGAGAAATTGCTCGACCTCGAAGTCCCGGCGCGCGCGCAATATCTCCGCACGATGTTCGCCGAGCTGACGCGCA
TCTGCAACCATATGCTCAACATCGGGTCGCACGTCATGGACGTCGGCGCGATGACGCCAAACCTGTGGGTGTTCGAACTG
CGCGAAGATTGCCTGAACTTCTTCGAGCGGGCGTCGGGTGCGCGGATGCACTCGGCGTACTTCCGTCCGGGTGGCGTCCA
TCAGGACGTCCCCGAAAAACTGCTCGTCGACATCGGCGAATGGGTCGAAACGCGGCTGCCGAAGCTGTTCGGCGACGCGA
TGAGCCTGGTCATCGACAACCGCATCTTCAAGCAGCGCAACGTCGACATCGCGACAGTGAGCAAGGAAGACGCGCTGGCG
TGGGGCTTCTCAGGCCCGATGATCCGCGGCAGCGGCATCGCGTGGGATCTGCGCAAATCGCAGCCCTATGACGCCTATGC
CGCGATGGAGTTCGACATTCCCGTCGGCACGCGCGGCGACTGCTATGACCGCTTCATGGTGCGCGTCGAGGAAGTCTATC
AGTCGGCAAAGATCATCAAACAGTGCCTGCGCGACATGCCGACCGGCCCGATCGCCAGCCTCGACCGCAAGGTCGTGCCG
CCGAAGCGCGGCGAGATGAAGCAGTCGATGGAATCGCTGATCCACCACTTCAAACTCTACACCGAGGGTTTCCACGTCCC
CGCGGGCGAGGTTTATGTCGCGACCGAAAGCCCGAAGGGTGAATTCGGCGTCTATCTGGTCAGCGACGGCACCAACAAGC
CGTACCGCTGCAAGATCCGCCCGACGGCGTTTTCGCACCTGCAGGCGATGGACATGATGTCGAAGGGCCATATGCTTGCG
GATACGACCGCGATCATCGGCGCGATCGACGTGGTGTTCGGGGAGTGTGACCGGTGA

Upstream 100 bases:

>100_bases
CGAAGCCTGCTGCAAAGGCCAAGACGCCCGCGACCAAGAAGGCGGAAAAGGCGCCGGCCAGGCCGCGCGCGCCGCGCAAG
CCGAAAACAGGAGGTGACGC

Downstream 100 bases:

>100_bases
GTGTAGGTCTCCGATGTGTGCGGTTTGTCGATTGGGATGTTGCGAATATGCGCGGCGGAATGACGACGTTGCTGGCTACG
ATTCCACCTTTGCTGGCCGT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTDAPQVRHHGSDMFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEIIERVDPHVGLLHRGTEKLIEY
KTYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPARAQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFEL
REDCLNFFERASGARMHSAYFRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALA
WGFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIKQCLRDMPTGPIASLDRKVVP
PKRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLA
DTTAIIGAIDVVFGECDR

Sequences:

>Translated_418_residues
MTDAPQVRHHGSDMFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEIIERVDPHVGLLHRGTEKLIEY
KTYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPARAQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFEL
REDCLNFFERASGARMHSAYFRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALA
WGFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIKQCLRDMPTGPIASLDRKVVP
PKRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLA
DTTAIIGAIDVVFGECDR
>Mature_417_residues
TDAPQVRHHGSDMFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEIIERVDPHVGLLHRGTEKLIEYK
TYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPARAQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFELR
EDCLNFFERASGARMHSAYFRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALAW
GFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIKQCLRDMPTGPIASLDRKVVPP
KRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKGEFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLAD
TTAIIGAIDVVFGECDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=400, Percent_Identity=61, Blast_Score=524, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=60.4060913705584, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.2764857881137, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI1789076, Length=398, Percent_Identity=25.3768844221106, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788832, Length=388, Percent_Identity=26.0309278350515, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17555284, Length=403, Percent_Identity=59.0570719602978, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568379, Length=403, Percent_Identity=57.8163771712159, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24638644, Length=400, Percent_Identity=60, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221459469, Length=391, Percent_Identity=56.2659846547315, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47135; Mature: 47004

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00535 COMPLEX1_49K ; PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAPQVRHHGSDMFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEII
CCCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
ERVDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPAR
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
AQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFELREDCLNFFERASGARMHSAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
FRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
WGFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIK
ECCCCCEEECCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QCLRDMPTGPIASLDRKVVPPKRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKG
HHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
EFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLADTTAIIGAIDVVFGECDR
CEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDAPQVRHHGSDMFEGYPVDTANTAGDQAVTNYTINFGPQHPAAHGVLRMVMELDGEII
CCCCCHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
ERVDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYCSPLGMEHSYVLAIEKLLDLEVPAR
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHH
AQYLRTMFAELTRICNHMLNIGSHVMDVGAMTPNLWVFELREDCLNFFERASGARMHSAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
FRPGGVHQDVPEKLLVDIGEWVETRLPKLFGDAMSLVIDNRIFKQRNVDIATVSKEDALA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
WGFSGPMIRGSGIAWDLRKSQPYDAYAAMEFDIPVGTRGDCYDRFMVRVEEVYQSAKIIK
ECCCCCEEECCCCEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QCLRDMPTGPIASLDRKVVPPKRGEMKQSMESLIHHFKLYTEGFHVPAGEVYVATESPKG
HHHHHCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
EFGVYLVSDGTNKPYRCKIRPTAFSHLQAMDMMSKGHMLADTTAIIGAIDVVFGECDR
CEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA