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The map label for this gene is tmk [H]

Identifier: 103486743

GI number: 103486743

Start: 1309822

End: 1310445

Strand: Direct

Name: tmk [H]

Synonym: Sala_1257

Alternate gene names: 103486743

Gene position: 1309822-1310445 (Clockwise)

Preceding gene: 103486742

Following gene: 103486744

Centisome position: 39.16

GC content: 70.51

Gene sequence:

>624_bases
GTGATCCGCGGACGCTTCATCACGCTTGAGGGCGGCGAGGGTGTCGGCAAATCGACGCAGTTGCGCGCCTTGTCGGAGGC
ACTCGCCGCGCGATCGATCGAGGTTGTGGCAACGCGTGAACCCGGCGGCAGCGTGGGCGCCGAGGCAATCCGGACGCTGC
TGATGGAAGGCAGCGACGACCGCTGGGATGCGCGCAGCGAGGCGCTGCTGTTCGCCGCCGCGCGCGCCGACCATGTTGCG
CGCACGATCCGCCCGGCGCTTGCGCGTGGCGCATGGGTATTGTGCGACCGATTCGTCGATTCGAGCCGCGCCTATCAGGG
CGGCGGGGGGGGGATCACCGACGCCGATATCCTGGCGCTCCACCGTTTCGGATCCAGGGGGCTGCTGCCCGACCGCACCT
TCCTGTTGACCGTGCGCCCCGATGAAGCGGCGCGCCGACTGGCAGCGCGCGGTGATCGCGACCGCATGGGCAGCAAGCCC
GCGGACTATCAGGCGCGCCTCGCCGCGCGATTCGCCGAAATGGCCGCGACCGAGCCGCAGCGCTGGCGGTTGATCGACGC
CGACCTGCCCGCCGCCGACGTCACCGCGGCCATGCTTGCGGAGCTGATCGAATGGCTGCCATGA

Upstream 100 bases:

>100_bases
GCCGCGGGCGCGACGCATAGATGACAAAGCCGGCGGGGCAGTTTACCTCCCGTGCCATGTCTCGACACCAGCCCATCCTC
CCGTCGTCCGGTCTGACGCC

Downstream 100 bases:

>100_bases
TCGGCCATCAGGAGGCCGAAAAGGCGTTTCTGGACGGCTGGCAGGGCGGCCGCCTGCACCATGCCTGGCTGCTCGCCGGG
CCACAGGGGATGGGGAAGGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MIRGRFITLEGGEGVGKSTQLRALSEALAARSIEVVATREPGGSVGAEAIRTLLMEGSDDRWDARSEALLFAAARADHVA
RTIRPALARGAWVLCDRFVDSSRAYQGGGGGITDADILALHRFGSRGLLPDRTFLLTVRPDEAARRLAARGDRDRMGSKP
ADYQARLAARFAEMAATEPQRWRLIDADLPAADVTAAMLAELIEWLP

Sequences:

>Translated_207_residues
MIRGRFITLEGGEGVGKSTQLRALSEALAARSIEVVATREPGGSVGAEAIRTLLMEGSDDRWDARSEALLFAAARADHVA
RTIRPALARGAWVLCDRFVDSSRAYQGGGGGITDADILALHRFGSRGLLPDRTFLLTVRPDEAARRLAARGDRDRMGSKP
ADYQARLAARFAEMAATEPQRWRLIDADLPAADVTAAMLAELIEWLP
>Mature_207_residues
MIRGRFITLEGGEGVGKSTQLRALSEALAARSIEVVATREPGGSVGAEAIRTLLMEGSDDRWDARSEALLFAAARADHVA
RTIRPALARGAWVLCDRFVDSSRAYQGGGGGITDADILALHRFGSRGLLPDRTFLLTVRPDEAARRLAARGDRDRMGSKP
ADYQARLAARFAEMAATEPQRWRLIDADLPAADVTAAMLAELIEWLP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=38.5714285714286, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22398; Mature: 22398

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGRFITLEGGEGVGKSTQLRALSEALAARSIEVVATREPGGSVGAEAIRTLLMEGSDD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCC
RWDARSEALLFAAARADHVARTIRPALARGAWVLCDRFVDSSRAYQGGGGGITDADILAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
HRFGSRGLLPDRTFLLTVRPDEAARRLAARGDRDRMGSKPADYQARLAARFAEMAATEPQ
HHCCCCCCCCCCEEEEEECCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCC
RWRLIDADLPAADVTAAMLAELIEWLP
CEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRGRFITLEGGEGVGKSTQLRALSEALAARSIEVVATREPGGSVGAEAIRTLLMEGSDD
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCCCC
RWDARSEALLFAAARADHVARTIRPALARGAWVLCDRFVDSSRAYQGGGGGITDADILAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
HRFGSRGLLPDRTFLLTVRPDEAARRLAARGDRDRMGSKPADYQARLAARFAEMAATEPQ
HHCCCCCCCCCCEEEEEECCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCC
RWRLIDADLPAADVTAAMLAELIEWLP
CEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA