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The map label for this gene is lpd [H]

Identifier: 103486724

GI number: 103486724

Start: 1285570

End: 1286967

Strand: Direct

Name: lpd [H]

Synonym: Sala_1237

Alternate gene names: 103486724

Gene position: 1285570-1286967 (Clockwise)

Preceding gene: 103486723

Following gene: 103486725

Centisome position: 38.43

GC content: 63.81

Gene sequence:

>1398_bases
ATGGCTGACACCAACTATGACCTCATCGTCCTCGGCTCGGGCCCCGGCGGCTATGTCGCCGCGATCCGCGCGGCGCAGCT
GGGGATGAAGACCGCGATTGTCGAACGCGAACTGCTCGGCGGCATCTGCCTCAACTGGGGCTGCATCCCGACCAAGGCGC
TGCTGCGGTCGGCGGAAATCTATCACTACATGCAACATGCGGGCGCCTATGGGCTGAAAGCCGCCGAGATCAGCGCCGAC
ATCGACGCGGTGGTGAAGCGGTCGCGCGGGGTCGCGTCGCAGCTGAACAAGGGCGTGACCGGCCTGATGAAGAAGCACAA
GATCACCGTCCATATGGGCGAGGGCAAGCTGACCGCGCCGGGCAAGCTGGAAGTGAAGGGGGAGAAAGGGACCGAAACCC
TTTCCGCGAAAAACATCATCGTCGCGACCGGCGCCCGCGCCCGCGACCTGCCCTTCGCGCCTGCCGACGGCAAGCGCATC
TGGACCTATCGCCACGCGCTCGTGCCGTCCGAAATGCCGAAGAAATTGCTCGTCATCGGATCGGGTGCTATCGGGATCGA
GTTTGCGAGCTTTTACAGTGATATGGGGGCCGAGGTTACGGTGGTGGAGATGCTCGATCGCCTCGTTCCCGTCGAGGATG
CCGACATCTCCGCCTTCCTCGAAAAACAGCTCAAAAAACAGGGCATGACGATCCACACCGGCGCCGGGGTCGAGGAGCTG
AAGACGACCGCGAACGGCGTCATCGCAAAGATCAAGGACAAGGACGGCAAGACCCAGAGCGCCGAGTTCAGTCACGCGAT
TGTCGCGATCGGCATCGTCCCGAACACCGAGAATATCGGGCTGGAGGCGCTCGGCGTGAAGACGACCAGGGGCCATATCG
ACACCGACGCGATGTGCCGCACCAACGTCCCCGGCGTCTGGGCGATCGGCGACGTCACCGCGCCGCCGTGGCTCGCGCAC
AAGGCGATGCACGAATCGATCATCGCGGTCGAGGCGATCGCGGGCAATCACCCGCACGCGATGGACGTGCGCAACATCCC
CGGCTGCACCTATTGCCGCCCGCAGATCGCCAGCGTCGGCCTGACCGAAGCGAAGGCGAAGGAGCTGGGGTATGAGGTCA
AGGTCGGCACCTTCCCCTTCATCGGCAATGGCAAGGCGATTGCGCTGGGCGAATCCGAAGGCTTCACCAAGACCGTGTTC
GACGCCAGGACCGGCGAACTCTTGGGCGCGCACATGATCGGCGCCGAGGTCACCGAACTGATTCAGGGCTATACGATCGG
CAAGACCGCCGAGCTGGTCGAGGATGATTTCATCGGCACCGTCTTTCCGCACCCGACGCTCAGCGAAACGATGCACGAGG
GCGTACTGGCGGCGTTCGGACGGCCGCTGCACATCTGA

Upstream 100 bases:

>100_bases
ATCCTCGATGCCATCGATTCTCTTGGCGCGCAGACGCGCGCCGACCCCACACCCCAACCCCTCTCCCGCAAGGGGAGAGG
GGCTTTTGAAGGAGCCCATA

Downstream 100 bases:

>100_bases
GCCTCGATCGCTCCCGCGATTTTCCGCTGTCCTAATCGGTGCTCCTTTGCCATCTAGGCAAAGGGCACCAACAAGGGACG
GTCGCGATATGCAATCCAGA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MADTNYDLIVLGSGPGGYVAAIRAAQLGMKTAIVERELLGGICLNWGCIPTKALLRSAEIYHYMQHAGAYGLKAAEISAD
IDAVVKRSRGVASQLNKGVTGLMKKHKITVHMGEGKLTAPGKLEVKGEKGTETLSAKNIIVATGARARDLPFAPADGKRI
WTYRHALVPSEMPKKLLVIGSGAIGIEFASFYSDMGAEVTVVEMLDRLVPVEDADISAFLEKQLKKQGMTIHTGAGVEEL
KTTANGVIAKIKDKDGKTQSAEFSHAIVAIGIVPNTENIGLEALGVKTTRGHIDTDAMCRTNVPGVWAIGDVTAPPWLAH
KAMHESIIAVEAIAGNHPHAMDVRNIPGCTYCRPQIASVGLTEAKAKELGYEVKVGTFPFIGNGKAIALGESEGFTKTVF
DARTGELLGAHMIGAEVTELIQGYTIGKTAELVEDDFIGTVFPHPTLSETMHEGVLAAFGRPLHI

Sequences:

>Translated_465_residues
MADTNYDLIVLGSGPGGYVAAIRAAQLGMKTAIVERELLGGICLNWGCIPTKALLRSAEIYHYMQHAGAYGLKAAEISAD
IDAVVKRSRGVASQLNKGVTGLMKKHKITVHMGEGKLTAPGKLEVKGEKGTETLSAKNIIVATGARARDLPFAPADGKRI
WTYRHALVPSEMPKKLLVIGSGAIGIEFASFYSDMGAEVTVVEMLDRLVPVEDADISAFLEKQLKKQGMTIHTGAGVEEL
KTTANGVIAKIKDKDGKTQSAEFSHAIVAIGIVPNTENIGLEALGVKTTRGHIDTDAMCRTNVPGVWAIGDVTAPPWLAH
KAMHESIIAVEAIAGNHPHAMDVRNIPGCTYCRPQIASVGLTEAKAKELGYEVKVGTFPFIGNGKAIALGESEGFTKTVF
DARTGELLGAHMIGAEVTELIQGYTIGKTAELVEDDFIGTVFPHPTLSETMHEGVLAAFGRPLHI
>Mature_464_residues
ADTNYDLIVLGSGPGGYVAAIRAAQLGMKTAIVERELLGGICLNWGCIPTKALLRSAEIYHYMQHAGAYGLKAAEISADI
DAVVKRSRGVASQLNKGVTGLMKKHKITVHMGEGKLTAPGKLEVKGEKGTETLSAKNIIVATGARARDLPFAPADGKRIW
TYRHALVPSEMPKKLLVIGSGAIGIEFASFYSDMGAEVTVVEMLDRLVPVEDADISAFLEKQLKKQGMTIHTGAGVEELK
TTANGVIAKIKDKDGKTQSAEFSHAIVAIGIVPNTENIGLEALGVKTTRGHIDTDAMCRTNVPGVWAIGDVTAPPWLAHK
AMHESIIAVEAIAGNHPHAMDVRNIPGCTYCRPQIASVGLTEAKAKELGYEVKVGTFPFIGNGKAIALGESEGFTKTVFD
ARTGELLGAHMIGAEVTELIQGYTIGKTAELVEDDFIGTVFPHPTLSETMHEGVLAAFGRPLHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=37.1002132196162, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=29.1576673866091, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI22035672, Length=478, Percent_Identity=27.4058577405858, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI33519430, Length=478, Percent_Identity=25.7322175732218, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI33519428, Length=478, Percent_Identity=25.7322175732218, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI33519426, Length=478, Percent_Identity=25.7322175732218, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI148277071, Length=478, Percent_Identity=25.7322175732218, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI148277065, Length=478, Percent_Identity=25.7322175732218, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=26.4705882352941, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI291045268, Length=326, Percent_Identity=27.6073619631902, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786307, Length=448, Percent_Identity=38.8392857142857, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87082354, Length=472, Percent_Identity=29.4491525423729, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=28.8018433179723, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.3522975929978, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081763, Length=326, Percent_Identity=28.8343558282209, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788892, Length=191, Percent_Identity=30.8900523560209, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=37.3362445414847, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=25.5274261603376, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=465, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=465, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=23.9085239085239, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=191, Percent_Identity=29.8429319371728, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=36.7647058823529, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=27.4841437632135, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=28.0590717299578, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=39.5299145299145, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24640549, Length=468, Percent_Identity=25.4273504273504, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24640553, Length=468, Percent_Identity=25.4273504273504, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24640551, Length=468, Percent_Identity=25.4273504273504, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=25.6842105263158, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49406; Mature: 49274

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTNYDLIVLGSGPGGYVAAIRAAQLGMKTAIVERELLGGICLNWGCIPTKALLRSAEI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHH
YHYMQHAGAYGLKAAEISADIDAVVKRSRGVASQLNKGVTGLMKKHKITVHMGEGKLTAP
HHHHHHCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHHCEEEEEECCCEECCC
GKLEVKGEKGTETLSAKNIIVATGARARDLPFAPADGKRIWTYRHALVPSEMPKKLLVIG
CEEEEECCCCCCEECCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEE
SGAIGIEFASFYSDMGAEVTVVEMLDRLVPVEDADISAFLEKQLKKQGMTIHTGAGVEEL
CCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHH
KTTANGVIAKIKDKDGKTQSAEFSHAIVAIGIVPNTENIGLEALGVKTTRGHIDTDAMCR
HHHCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCEEC
TNVPGVWAIGDVTAPPWLAHKAMHESIIAVEAIAGNHPHAMDVRNIPGCTYCRPQIASVG
CCCCCEEEECCCCCCHHHHHHHHHHHHEEEEEECCCCCCEECCCCCCCCCCCCCHHHHCC
LTEAKAKELGYEVKVGTFPFIGNGKAIALGESEGFTKTVFDARTGELLGAHMIGAEVTEL
CCHHHHHHCCCEEEECCEEEECCCCEEEEECCCCCEEHHHCCCCCHHHHHHHHHHHHHHH
IQGYTIGKTAELVEDDFIGTVFPHPTLSETMHEGVLAAFGRPLHI
HCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ADTNYDLIVLGSGPGGYVAAIRAAQLGMKTAIVERELLGGICLNWGCIPTKALLRSAEI
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHH
YHYMQHAGAYGLKAAEISADIDAVVKRSRGVASQLNKGVTGLMKKHKITVHMGEGKLTAP
HHHHHHCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHCCHHHHHHHCEEEEEECCCEECCC
GKLEVKGEKGTETLSAKNIIVATGARARDLPFAPADGKRIWTYRHALVPSEMPKKLLVIG
CEEEEECCCCCCEECCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEE
SGAIGIEFASFYSDMGAEVTVVEMLDRLVPVEDADISAFLEKQLKKQGMTIHTGAGVEEL
CCCHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHH
KTTANGVIAKIKDKDGKTQSAEFSHAIVAIGIVPNTENIGLEALGVKTTRGHIDTDAMCR
HHHCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCEEEEEEEECCCCCCCCCEEC
TNVPGVWAIGDVTAPPWLAHKAMHESIIAVEAIAGNHPHAMDVRNIPGCTYCRPQIASVG
CCCCCEEEECCCCCCHHHHHHHHHHHHEEEEEECCCCCCEECCCCCCCCCCCCCHHHHCC
LTEAKAKELGYEVKVGTFPFIGNGKAIALGESEGFTKTVFDARTGELLGAHMIGAEVTEL
CCHHHHHHCCCEEEECCEEEECCCCEEEEECCCCCEEHHHCCCCCHHHHHHHHHHHHHHH
IQGYTIGKTAELVEDDFIGTVFPHPTLSETMHEGVLAAFGRPLHI
HCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]