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The map label for this gene is rnr [H]

Identifier: 103486718

GI number: 103486718

Start: 1279381

End: 1281681

Strand: Direct

Name: rnr [H]

Synonym: Sala_1231

Alternate gene names: 103486718

Gene position: 1279381-1281681 (Clockwise)

Preceding gene: 103486717

Following gene: 103486720

Centisome position: 38.25

GC content: 67.49

Gene sequence:

>2301_bases
TTGGCGAAACGGCAACAGCCTGCTGGTCTTCCCAGCCCGGAACAGATCCTGCGTTTCATCGAAGAAAGCAGGGACGCGGT
CGGCAAGCGCGAGATCGCGAGACATTTCGGCCTGCGCGGCGCCGACAAGATTGCGCTCAAGGCGCTGCTCAAGGACATGA
CCGATGAGGGGCTGGTCGACCTGGCGCCCGGACGCGCCTTCCACAAGCATGGCGGGCTGCCCAAGGTAATGGTTCTGCGG
GTTGCGGCGGTCGAGGGCGATGTCGTCTGGGCGGTCCCCGACCGCTGGGAGGGGGCCGGGGCGCCGCCGCGCCTTCGGAT
CATGGAAAAAGGGCGCAAGGGCGCGCTTGGACTCGGCGACCGCATCCTCGCGCGCACCGAGGAACGCGGCAGCGGCCATG
TCGCGCACCCGATGAAAAAATTGCAGGCGGGCGGCGAGACGATCATCGGCGTGCTCGTGACCGATACCGGCCCCGGCGGC
AAGCCGGTGACCTGGCTGCGCCCTGCCGACAAGCGCGCGCGGTTCGACTTCGCGGTGGCGGACATGGGCGACGCGGCGAT
CGGCGACCTGGTGCGCGCCGAGCTGTCGGGGCGCGGTCCGGCGACGAGGGCGCGCGTGATCGACCGCATCGGTGATCCCT
TTGCGCCGCGCTCGCTCAGCATGATCGCGATCGCGAAGCATGAGATCCCGCACATCTTCGGCGACGAGGTGATCGACGAG
GCCGAGCGCGCGGCAAAATTGCCGCTCACCACCGACGGGCGCGAGGATCTGCGCGACCTGCCGATCCTTGCGATCGACCC
CGCCGACGCGCGCGACCATGACGACGCTGTGTGGGCGGTCCCCGACGACGATCCCGGCAACAAGGGCGGTTTCCGCGCCA
TCGTCGCGATCGCCGACGTCAGCTATTATGTCCGTCCCGACGGCGCGCTTGACCGCGAGGCGCGGCGGCGCGGCAACAGC
GTCTATTTCCCCGACCGGGTCGTGCCGATGCTGCCCGAAACGCTGTCGGCGGGCGTCTGCTCGCTCAAAGCGGGGCAGGA
TCGCGCCGCGATGGCATGTCATCTGGTGATCGACAAGCATGGCAAGGTGACGTCATGGCGCTTCACGCGCGCGCTGGTGC
GACTGCGCGCGAACATTGCCTATGAGCGCGCGCAGACGGCCTATGACGCCGGCGCGCCCGACGCGGGATGGGACGACGAT
GTGCTGTCGGCGCTCCGCCATCTTTGGGCCTGCTGGACGCTGCTCGCCAAGGCGCGCGCGGCGCGGGCGCCGCTCGACCT
CGACCTGCCCGAACGGCAGGTGATCCTCGACGAACAGGGCGGCATCGCTGAAATCCGCGTGCGCGAACGGCTCGACGCGC
ACCGGCTGATCGAGGATTATATGATCGCGGCGAATGTCGCGGCGGCCAAGGCGCTCGAAGCGAAAAAATCGCCCGTCATG
TACCGCATCCACGAACCGCCGAGCCGCGAGAAGCTCGTCAGCCTCAAGGATTATCTGGAGACGTTCGAGCAGGGCTTTGC
GCTGGGGCAGGTCATTACGCCCGCGGTGTTCAACCGGCTGATCGATGGTTTTTCAGGCGACGACCGCTTGCCCGAAATCA
TGGAGGCGATTTTGCGCAGCCAGACGCAGGCCTATTACGGCCCCGCCAATGCGGGGCATTTCGGGCTGGCGCTCGGCTCC
TATGCGCATTTCACTTCACCGATCCGCCGCTATGCCGATTTGATCGTTCACCGTGCGCTGGTCGATTCATACCGGCTCGA
AGTGCCGGGCAAGCCGAAAGGCCTGCCCGCGAAGACCGGGCTGGGCGAGGCCGATGCCAAGGGCCTTTCGCGCATCGGCG
AGGCGATCAGCGCGCTCGAACGCCGCGCAATGGAGGCCGAGCGCGAAACGGTCGACCGCTATGTCGCCGCCTATCTCGCG
GGCAAGGTCGGCGAGATCGTCGCCGCGCGGATCACCGGGGTGCAGCCGTTCGGATTCTTTGCTACGGTCGACGGGCTGGG
CGGCGACGGGTTGGTGCCCGTCTCGACCCTGGGCAGCGAGCGTTTCTTTTATGACGAGGCGGCGCGGACGCTCGACAGCG
AACATGGCCGCGTCAGTTTTTCGGTCGGTCAGCGGCTCGACCTCAGGCTGGTGGACGCCAATCCGGTCAGCGGCGCGCTC
CGCTTTGAATTGCCCGATGCGCCCGAAGGCGGATACCGGAACCGCCCGCCGCGGCGCGACGGGGTGAAGAAAGCGGGCAA
GCCTATGGTCGGCAAACGCGGGCGGCCTGCGAACATCAAGCATAAGGGGCGGAAGCGTTGA

Upstream 100 bases:

>100_bases
GATGCGCAACACCCCGCTCGACGCCGCGCCCGCGGACAGCGCGTGCATCTTCACCGGCGAACCCGCGGTCGAGCGCGTGT
TGATCGGGCGGACCTATTAA

Downstream 100 bases:

>100_bases
ACCATTTCAGCCCTCCCCTTCAGGGGAGGGCAGCGAGACTTGCCGGCTTGCCGGCTTAGTCGCAGCGGGTGGGGGCCATC
GGCCTTGCGCAAGGCCGATG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MAKRQQPAGLPSPEQILRFIEESRDAVGKREIARHFGLRGADKIALKALLKDMTDEGLVDLAPGRAFHKHGGLPKVMVLR
VAAVEGDVVWAVPDRWEGAGAPPRLRIMEKGRKGALGLGDRILARTEERGSGHVAHPMKKLQAGGETIIGVLVTDTGPGG
KPVTWLRPADKRARFDFAVADMGDAAIGDLVRAELSGRGPATRARVIDRIGDPFAPRSLSMIAIAKHEIPHIFGDEVIDE
AERAAKLPLTTDGREDLRDLPILAIDPADARDHDDAVWAVPDDDPGNKGGFRAIVAIADVSYYVRPDGALDREARRRGNS
VYFPDRVVPMLPETLSAGVCSLKAGQDRAAMACHLVIDKHGKVTSWRFTRALVRLRANIAYERAQTAYDAGAPDAGWDDD
VLSALRHLWACWTLLAKARAARAPLDLDLPERQVILDEQGGIAEIRVRERLDAHRLIEDYMIAANVAAAKALEAKKSPVM
YRIHEPPSREKLVSLKDYLETFEQGFALGQVITPAVFNRLIDGFSGDDRLPEIMEAILRSQTQAYYGPANAGHFGLALGS
YAHFTSPIRRYADLIVHRALVDSYRLEVPGKPKGLPAKTGLGEADAKGLSRIGEAISALERRAMEAERETVDRYVAAYLA
GKVGEIVAARITGVQPFGFFATVDGLGGDGLVPVSTLGSERFFYDEAARTLDSEHGRVSFSVGQRLDLRLVDANPVSGAL
RFELPDAPEGGYRNRPPRRDGVKKAGKPMVGKRGRPANIKHKGRKR

Sequences:

>Translated_766_residues
MAKRQQPAGLPSPEQILRFIEESRDAVGKREIARHFGLRGADKIALKALLKDMTDEGLVDLAPGRAFHKHGGLPKVMVLR
VAAVEGDVVWAVPDRWEGAGAPPRLRIMEKGRKGALGLGDRILARTEERGSGHVAHPMKKLQAGGETIIGVLVTDTGPGG
KPVTWLRPADKRARFDFAVADMGDAAIGDLVRAELSGRGPATRARVIDRIGDPFAPRSLSMIAIAKHEIPHIFGDEVIDE
AERAAKLPLTTDGREDLRDLPILAIDPADARDHDDAVWAVPDDDPGNKGGFRAIVAIADVSYYVRPDGALDREARRRGNS
VYFPDRVVPMLPETLSAGVCSLKAGQDRAAMACHLVIDKHGKVTSWRFTRALVRLRANIAYERAQTAYDAGAPDAGWDDD
VLSALRHLWACWTLLAKARAARAPLDLDLPERQVILDEQGGIAEIRVRERLDAHRLIEDYMIAANVAAAKALEAKKSPVM
YRIHEPPSREKLVSLKDYLETFEQGFALGQVITPAVFNRLIDGFSGDDRLPEIMEAILRSQTQAYYGPANAGHFGLALGS
YAHFTSPIRRYADLIVHRALVDSYRLEVPGKPKGLPAKTGLGEADAKGLSRIGEAISALERRAMEAERETVDRYVAAYLA
GKVGEIVAARITGVQPFGFFATVDGLGGDGLVPVSTLGSERFFYDEAARTLDSEHGRVSFSVGQRLDLRLVDANPVSGAL
RFELPDAPEGGYRNRPPRRDGVKKAGKPMVGKRGRPANIKHKGRKR
>Mature_765_residues
AKRQQPAGLPSPEQILRFIEESRDAVGKREIARHFGLRGADKIALKALLKDMTDEGLVDLAPGRAFHKHGGLPKVMVLRV
AAVEGDVVWAVPDRWEGAGAPPRLRIMEKGRKGALGLGDRILARTEERGSGHVAHPMKKLQAGGETIIGVLVTDTGPGGK
PVTWLRPADKRARFDFAVADMGDAAIGDLVRAELSGRGPATRARVIDRIGDPFAPRSLSMIAIAKHEIPHIFGDEVIDEA
ERAAKLPLTTDGREDLRDLPILAIDPADARDHDDAVWAVPDDDPGNKGGFRAIVAIADVSYYVRPDGALDREARRRGNSV
YFPDRVVPMLPETLSAGVCSLKAGQDRAAMACHLVIDKHGKVTSWRFTRALVRLRANIAYERAQTAYDAGAPDAGWDDDV
LSALRHLWACWTLLAKARAARAPLDLDLPERQVILDEQGGIAEIRVRERLDAHRLIEDYMIAANVAAAKALEAKKSPVMY
RIHEPPSREKLVSLKDYLETFEQGFALGQVITPAVFNRLIDGFSGDDRLPEIMEAILRSQTQAYYGPANAGHFGLALGSY
AHFTSPIRRYADLIVHRALVDSYRLEVPGKPKGLPAKTGLGEADAKGLSRIGEAISALERRAMEAERETVDRYVAAYLAG
KVGEIVAARITGVQPFGFFATVDGLGGDGLVPVSTLGSERFFYDEAARTLDSEHGRVSFSVGQRLDLRLVDANPVSGALR
FELPDAPEGGYRNRPPRRDGVKKAGKPMVGKRGRPANIKHKGRKR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=490, Percent_Identity=27.3469387755102, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI190014625, Length=480, Percent_Identity=27.9166666666667, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI134288890, Length=354, Percent_Identity=31.3559322033898, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI19115966, Length=571, Percent_Identity=27.6707530647986, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI219521928, Length=568, Percent_Identity=27.6408450704225, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI156105693, Length=375, Percent_Identity=26.9333333333333, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI156105695, Length=375, Percent_Identity=26.9333333333333, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI87082383, Length=743, Percent_Identity=33.2436069986541, Blast_Score=338, Evalue=7e-94,
Organism=Escherichia coli, GI1787542, Length=516, Percent_Identity=27.5193798449612, Blast_Score=133, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI212645896, Length=472, Percent_Identity=31.3559322033898, Blast_Score=182, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=397, Percent_Identity=31.4861460957179, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324552, Length=464, Percent_Identity=29.5258620689655, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320499, Length=297, Percent_Identity=22.8956228956229, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24649634, Length=383, Percent_Identity=33.420365535248, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI19922976, Length=390, Percent_Identity=29.4871794871795, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24654597, Length=390, Percent_Identity=29.4871794871795, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24654592, Length=390, Percent_Identity=29.4871794871795, Blast_Score=132, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.13.1

Molecular weight: Translated: 83504; Mature: 83373

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRQQPAGLPSPEQILRFIEESRDAVGKREIARHFGLRGADKIALKALLKDMTDEGLVD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
LAPGRAFHKHGGLPKVMVLRVAAVEGDVVWAVPDRWEGAGAPPRLRIMEKGRKGALGLGD
CCCCCHHHHCCCCCHHHHEEEEEECCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCH
RILARTEERGSGHVAHPMKKLQAGGETIIGVLVTDTGPGGKPVTWLRPADKRARFDFAVA
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCEEEEEC
DMGDAAIGDLVRAELSGRGPATRARVIDRIGDPFAPRSLSMIAIAKHEIPHIFGDEVIDE
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHH
AERAAKLPLTTDGREDLRDLPILAIDPADARDHDDAVWAVPDDDPGNKGGFRAIVAIADV
HHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECC
SYYVRPDGALDREARRRGNSVYFPDRVVPMLPETLSAGVCSLKAGQDRAAMACHLVIDKH
EEEECCCCCCCHHHHHCCCCEECCCCCHHHCHHHHHCCCEEECCCCCCHHEEEEEEEECC
GKVTSWRFTRALVRLRANIAYERAQTAYDAGAPDAGWDDDVLSALRHLWACWTLLAKARA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARAPLDLDLPERQVILDEQGGIAEIRVRERLDAHRLIEDYMIAANVAAAKALEAKKSPVM
HCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YRIHEPPSREKLVSLKDYLETFEQGFALGQVITPAVFNRLIDGFSGDDRLPEIMEAILRS
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QTQAYYGPANAGHFGLALGSYAHFTSPIRRYADLIVHRALVDSYRLEVPGKPKGLPAKTG
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCC
LGEADAKGLSRIGEAISALERRAMEAERETVDRYVAAYLAGKVGEIVAARITGVQPFGFF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ATVDGLGGDGLVPVSTLGSERFFYDEAARTLDSEHGRVSFSVGQRLDLRLVDANPVSGAL
EEECCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEE
RFELPDAPEGGYRNRPPRRDGVKKAGKPMVGKRGRPANIKHKGRKR
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKRQQPAGLPSPEQILRFIEESRDAVGKREIARHFGLRGADKIALKALLKDMTDEGLVD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
LAPGRAFHKHGGLPKVMVLRVAAVEGDVVWAVPDRWEGAGAPPRLRIMEKGRKGALGLGD
CCCCCHHHHCCCCCHHHHEEEEEECCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCH
RILARTEERGSGHVAHPMKKLQAGGETIIGVLVTDTGPGGKPVTWLRPADKRARFDFAVA
HHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCEEEEEC
DMGDAAIGDLVRAELSGRGPATRARVIDRIGDPFAPRSLSMIAIAKHEIPHIFGDEVIDE
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHH
AERAAKLPLTTDGREDLRDLPILAIDPADARDHDDAVWAVPDDDPGNKGGFRAIVAIADV
HHHHHCCCCCCCCHHHHHHCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECC
SYYVRPDGALDREARRRGNSVYFPDRVVPMLPETLSAGVCSLKAGQDRAAMACHLVIDKH
EEEECCCCCCCHHHHHCCCCEECCCCCHHHCHHHHHCCCEEECCCCCCHHEEEEEEEECC
GKVTSWRFTRALVRLRANIAYERAQTAYDAGAPDAGWDDDVLSALRHLWACWTLLAKARA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARAPLDLDLPERQVILDEQGGIAEIRVRERLDAHRLIEDYMIAANVAAAKALEAKKSPVM
HCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
YRIHEPPSREKLVSLKDYLETFEQGFALGQVITPAVFNRLIDGFSGDDRLPEIMEAILRS
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QTQAYYGPANAGHFGLALGSYAHFTSPIRRYADLIVHRALVDSYRLEVPGKPKGLPAKTG
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCC
LGEADAKGLSRIGEAISALERRAMEAERETVDRYVAAYLAGKVGEIVAARITGVQPFGFF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ATVDGLGGDGLVPVSTLGSERFFYDEAARTLDSEHGRVSFSVGQRLDLRLVDANPVSGAL
EEECCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCEE
RFELPDAPEGGYRNRPPRRDGVKKAGKPMVGKRGRPANIKHKGRKR
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]