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The map label for this gene is bhbA [H]

Identifier: 103486708

GI number: 103486708

Start: 1263607

End: 1265754

Strand: Direct

Name: bhbA [H]

Synonym: Sala_1221

Alternate gene names: 103486708

Gene position: 1263607-1265754 (Clockwise)

Preceding gene: 103486707

Following gene: 103486709

Centisome position: 37.77

GC content: 64.99

Gene sequence:

>2148_bases
ATGAGCGACAAACCAACCATCGCCGACTGGCAGGCCGCCGCCGAGAAGGAAGTGAAGGGCAAGGACCTCACCTGGCACAC
GCCCGAGGGGATCGACGTCAAGCCGCTCTATACGGCCGAGGACGTGCGCGAAGACCCCGGCCTGCCCGGCTTCGCGCCCT
TCACGCGCGGGGTGCGCGCGTCGATGTATGCGGGGCGGCCGTGGACGATCCGGCAATATGCGGGGTTTTCGACCGCCGAG
GAATCGAACGCCTTTTACCGCCGCAACCTCGCGGCGGGGCAGAAGGGGCTGTCGGTCGCCTTCGACCTCGCCACCCACCG
CGGCTATGACAGCGACCATCCGCGCGTCGTCGGCGACGTCGGCAAGGCGGGGGTCGCGATCGACACGGTCGAGGACATGA
AGATCCTGTTCGACGGCATCCCGCTCGATCAGATGTCGGTCAGCATGACGATGAACGGGGCGGTGATCCCCATACTCGCC
TTCTTCATCGTTGCGGGCGAGGAGCAGGGGGTCGATCGCAAATTGCTCGACGGGACGATCCAGAACGACATTCTGAAGGA
GTTCATGGTCCGCAACACCTACATCTACCCGCCCGAACCGAGCATGCGGATCATCTCGGACATTTTCGGCTACACCAGCC
GCGAGATGCCGAAGTTCAACAGCATCTCGATCTCCGGCTATCATATGCAGGAAGCCGGCGCGACGCAGGTGCAGGAGCTG
GCCTTCACCATTGCCGACGGCGCCGAATATGTGCGCTACGGCGTCGCGTCGGGGCTCGACATCGACAAGTTTGCGGGGCG
CCTGTCCTTCTTCTTCGCGATCGGCATGAACTTTTTCATGGAGATCGCCAAGCTGCGCGCAGCGCGCGTGCTGTGGCACC
GGGTGATGACCAACCTCGGCGCCAAGGACGAGCGCAGCAAGATGCTGCGCACCCACTGCCAGACGTCGGGCGTGTCGCTG
ACCGAGCAGGACCCCTATAACAATGTCATCCGGACGACGATCGAGGCGATGGCGGCGATGCTCGGCGGGACGCAGAGCCT
GCACACCAACGCGCTCGACGAAGCGATCGCGCTGCCGACCGATTTTTCGGCACGCATCGCGCGCAATACGCAGATCGTCA
TCCAGGAAGAAACGGGGATGACCAAGGTCGTCGATCCGCTTGGCGGCTCCTACTATGTCGAAGCGCTGACACAGGAACTG
GTCGACAAGGCGTGGGAGATCATCGAGCGCGTCGAGAGGGAGGGCGGCATGGCCAAAGCCGTCGCCGCCGGCTGGCCCAA
GGCGATGATCGAGGAAGCCGCCGCCGCCCGGCAGGCGCGCGTCGACCGCGGCGAAGACGTGATCGTCGGCGTGAACAAAT
ATCGCCTCAAGGACGAGGATCTGCTCGAAACGCTGGAGGTCGACAACACCAAGGTCCGCGAAGCGCAGGTCGCGCGGATC
AATCGCGTGAAGGCGAGCCGTGACGAGGCGGCGTGCCGGGCGGCGCTCGATGCGCTGCGGAGGGCGGCGGCGGCACCGCA
ATCGATCGAAACGAACCTGCTGGCGCACGCCGTTGAAGCCGCGCGTGCGCGTGCGACGCTGGGAGAAATCTCGTCGGCGA
TGGAGGAAAGCTTCCAGCGTTACGCCACCCAGCCGACCCCGGTGAAGGGCGTCTATGCCGCGCCTTATGCGGGCGACGAC
CGCTGGCAACAGGTGCTCGACGGGGTGAAGGCGGTCGAACGCCGGATGGGCCGCAAACCGAAGCTGCTCGTCGCCAAGAT
GGGGCAGGACGGGCACGACCGCGGCGCCAATGTCATCGCCTCGGCGTTCGGCGACATGGGCTTTGACGTCGTGTCGGGAC
CGCTGTTCCAGACGCCCGAAGAGACGGTGGTGCTGGCGCTCGAAAACGAGGTCGATGTCGTCGGCGCATCGAGCCTCGCG
GCGGGTCACAAGACGCTTATCCCCGAACTTATCCACAAGCTGAAAGAAGCGGGGCGCGGCGACATCAAGGTGATCGCGGG
CGGGGTGATCCCGCCGCAGGATTATCAATATCTGCGCGACGCGGGGGTGCAGGGGATTTACGGCCCCGGCTCGAACGTCG
TGGAATGCGCGGCCGATGTGCTGCGCTTGCTGGGGCATAATATGCCGCCGATTGGAGAAGCTGCGTGA

Upstream 100 bases:

>100_bases
GCTCGCGACCCCTCTCCCAGCTACGACTAGGCGGCAAAGCCGCCAGGTCTTCGCATCCCTCCCCCGCAAGGGGGGAGGGA
GTTAGGGACTGACACGAATT

Downstream 100 bases:

>100_bases
CCAATGTGAATCTCTCTACCCCGCTCGTGTCGAGCGAAGTCGAGACACCCATCAACCGTAAGCCCAGCCCGAGGGGCATC
TCGACTTCGCTCGATGCGAA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MSDKPTIADWQAAAEKEVKGKDLTWHTPEGIDVKPLYTAEDVREDPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAE
ESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDTVEDMKILFDGIPLDQMSVSMTMNGAVIPILA
FFIVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQEL
AFTIADGAEYVRYGVASGLDIDKFAGRLSFFFAIGMNFFMEIAKLRAARVLWHRVMTNLGAKDERSKMLRTHCQTSGVSL
TEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMTKVVDPLGGSYYVEALTQEL
VDKAWEIIERVEREGGMAKAVAAGWPKAMIEEAAAARQARVDRGEDVIVGVNKYRLKDEDLLETLEVDNTKVREAQVARI
NRVKASRDEAACRAALDALRRAAAAPQSIETNLLAHAVEAARARATLGEISSAMEESFQRYATQPTPVKGVYAAPYAGDD
RWQQVLDGVKAVERRMGRKPKLLVAKMGQDGHDRGANVIASAFGDMGFDVVSGPLFQTPEETVVLALENEVDVVGASSLA
AGHKTLIPELIHKLKEAGRGDIKVIAGGVIPPQDYQYLRDAGVQGIYGPGSNVVECAADVLRLLGHNMPPIGEAA

Sequences:

>Translated_715_residues
MSDKPTIADWQAAAEKEVKGKDLTWHTPEGIDVKPLYTAEDVREDPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAE
ESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDTVEDMKILFDGIPLDQMSVSMTMNGAVIPILA
FFIVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQEL
AFTIADGAEYVRYGVASGLDIDKFAGRLSFFFAIGMNFFMEIAKLRAARVLWHRVMTNLGAKDERSKMLRTHCQTSGVSL
TEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMTKVVDPLGGSYYVEALTQEL
VDKAWEIIERVEREGGMAKAVAAGWPKAMIEEAAAARQARVDRGEDVIVGVNKYRLKDEDLLETLEVDNTKVREAQVARI
NRVKASRDEAACRAALDALRRAAAAPQSIETNLLAHAVEAARARATLGEISSAMEESFQRYATQPTPVKGVYAAPYAGDD
RWQQVLDGVKAVERRMGRKPKLLVAKMGQDGHDRGANVIASAFGDMGFDVVSGPLFQTPEETVVLALENEVDVVGASSLA
AGHKTLIPELIHKLKEAGRGDIKVIAGGVIPPQDYQYLRDAGVQGIYGPGSNVVECAADVLRLLGHNMPPIGEAA
>Mature_714_residues
SDKPTIADWQAAAEKEVKGKDLTWHTPEGIDVKPLYTAEDVREDPGLPGFAPFTRGVRASMYAGRPWTIRQYAGFSTAEE
SNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDTVEDMKILFDGIPLDQMSVSMTMNGAVIPILAF
FIVAGEEQGVDRKLLDGTIQNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQELA
FTIADGAEYVRYGVASGLDIDKFAGRLSFFFAIGMNFFMEIAKLRAARVLWHRVMTNLGAKDERSKMLRTHCQTSGVSLT
EQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPTDFSARIARNTQIVIQEETGMTKVVDPLGGSYYVEALTQELV
DKAWEIIERVEREGGMAKAVAAGWPKAMIEEAAAARQARVDRGEDVIVGVNKYRLKDEDLLETLEVDNTKVREAQVARIN
RVKASRDEAACRAALDALRRAAAAPQSIETNLLAHAVEAARARATLGEISSAMEESFQRYATQPTPVKGVYAAPYAGDDR
WQQVLDGVKAVERRMGRKPKLLVAKMGQDGHDRGANVIASAFGDMGFDVVSGPLFQTPEETVVLALENEVDVVGASSLAA
GHKTLIPELIHKLKEAGRGDIKVIAGGVIPPQDYQYLRDAGVQGIYGPGSNVVECAADVLRLLGHNMPPIGEAA

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=703, Percent_Identity=61.5931721194879, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=714, Percent_Identity=62.0448179271709, Blast_Score=880, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=713, Percent_Identity=62.6928471248247, Blast_Score=898, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77948; Mature: 77816

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPTIADWQAAAEKEVKGKDLTWHTPEGIDVKPLYTAEDVREDPGLPGFAPFTRGVRA
CCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCHHHHCCHH
SMYAGRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDV
HHCCCCCEEEHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEEECC
GKAGVAIDTVEDMKILFDGIPLDQMSVSMTMNGAVIPILAFFIVAGEEQGVDRKLLDGTI
CCCCEEEECHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHH
QNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQEL
HHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECEEECCCCHHHHHHH
AFTIADGAEYVRYGVASGLDIDKFAGRLSFFFAIGMNFFMEIAKLRAARVLWHRVMTNLG
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKDERSKMLRTHCQTSGVSLTEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPT
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DFSARIARNTQIVIQEETGMTKVVDPLGGSYYVEALTQELVDKAWEIIERVEREGGMAKA
CCHHHHCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VAAGWPKAMIEEAAAARQARVDRGEDVIVGVNKYRLKDEDLLETLEVDNTKVREAQVARI
HHHCCHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
NRVKASRDEAACRAALDALRRAAAAPQSIETNLLAHAVEAARARATLGEISSAMEESFQR
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YATQPTPVKGVYAAPYAGDDRWQQVLDGVKAVERRMGRKPKLLVAKMGQDGHDRGANVIA
HCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
SAFGDMGFDVVSGPLFQTPEETVVLALENEVDVVGASSLAAGHKTLIPELIHKLKEAGRG
HHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCEECCHHHHCCHHHHHHHHHHHHHHCCCC
DIKVIAGGVIPPQDYQYLRDAGVQGIYGPGSNVVECAADVLRLLGHNMPPIGEAA
CEEEEECCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SDKPTIADWQAAAEKEVKGKDLTWHTPEGIDVKPLYTAEDVREDPGLPGFAPFTRGVRA
CCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCHHHHCCHH
SMYAGRPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDV
HHCCCCCEEEHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEEEECC
GKAGVAIDTVEDMKILFDGIPLDQMSVSMTMNGAVIPILAFFIVAGEEQGVDRKLLDGTI
CCCCEEEECHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHH
QNDILKEFMVRNTYIYPPEPSMRIISDIFGYTSREMPKFNSISISGYHMQEAGATQVQEL
HHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEECEEECCCCHHHHHHH
AFTIADGAEYVRYGVASGLDIDKFAGRLSFFFAIGMNFFMEIAKLRAARVLWHRVMTNLG
HHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKDERSKMLRTHCQTSGVSLTEQDPYNNVIRTTIEAMAAMLGGTQSLHTNALDEAIALPT
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DFSARIARNTQIVIQEETGMTKVVDPLGGSYYVEALTQELVDKAWEIIERVEREGGMAKA
CCHHHHCCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VAAGWPKAMIEEAAAARQARVDRGEDVIVGVNKYRLKDEDLLETLEVDNTKVREAQVARI
HHHCCHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
NRVKASRDEAACRAALDALRRAAAAPQSIETNLLAHAVEAARARATLGEISSAMEESFQR
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YATQPTPVKGVYAAPYAGDDRWQQVLDGVKAVERRMGRKPKLLVAKMGQDGHDRGANVIA
HCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
SAFGDMGFDVVSGPLFQTPEETVVLALENEVDVVGASSLAAGHKTLIPELIHKLKEAGRG
HHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCEECCHHHHCCHHHHHHHHHHHHHHCCCC
DIKVIAGGVIPPQDYQYLRDAGVQGIYGPGSNVVECAADVLRLLGHNMPPIGEAA
CEEEEECCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]