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The map label for this gene is ldc [H]

Identifier: 103486685

GI number: 103486685

Start: 1237642

End: 1238835

Strand: Reverse

Name: ldc [H]

Synonym: Sala_1197

Alternate gene names: 103486685

Gene position: 1238835-1237642 (Counterclockwise)

Preceding gene: 103486686

Following gene: 103486684

Centisome position: 37.03

GC content: 65.08

Gene sequence:

>1194_bases
TTGCACCAGCATCATAGCGCCCACGGGCTGATTCAGGCACTTTCGCCGGTCGAACCTGTTACGCTTGTCCGCCCGCACGC
CGCGCGGCGCGCAGCGCGTTTCTTCATCGAGCGATTTCCCGGCACCACCATGTATGCGGTCAAGGCGAATCCGTCCGCCG
ACCTGTTGCGCGTGCTGTGGGATTCGGGTGTCACGCACTATGACGTCGCCTCGATCGCCGAGGTGCGCCTCGTCGCGCGC
ACGCTGCCGCAAGCGACTCTCTGCTTCATGCACCCGGTAAAGGCCGAGGAAGCGATTTCCGAAGCCTATTGGAAGCATGG
CGTGCGCACCTTCTCGCTCGATACGCTCGACGAGCTCGAAAAGATCGTCCGCGCGACCGAAGGCGCGCAGGATCTGAACC
TGCTCGTCCGGCTCAGGGTCTCGTCCGATCATTCGAAGCTCAGCCTCGCCGCCAAGTTCGGCGCCGAGCCGGAGGATGTG
GCCGAACTGCTGATGGCGACGCGGCAGGCGGCCGACGCGCTTGGCATCTGCTTCCACGTCGGCAGCCAGGCGATGACCCC
GCACGCCTATGCGCAGGCGATGGAGCGTGTCCGCGCGGCGATCGTCGCGGCGTCGGTCACCGTCGACATCATCGATGTCG
GCGGCGGCTTTCCGTCCTCCTATCCGGGCATGGAGCCGCCGCCGCTCGATGCCTATTTCGACACCATCCACCGCAGCTTC
GAAAGCCTGCCGATCAGCTATTCGGCCGAGCTTTGGTGCGAACCGGGCCGTGCGCTGTCGGCCGAGTACAGCTCGCTGAT
CGTCCGCGTCGAAAAGCGCCGCGGCGAGGAGCTGTACATCAACGATGGCGCTTACGGCGCGCTGTTCGACGCCGCGCATG
TCGGCTGGCGCTTCCCGGTGTCGCTGCAACGCGATGCGGAAAGCGGCGCTGAACTGCTGCCGTTCAGCTTCTACGGCCCG
ACGTGCGACGATCTCGACCATATGGCGGGCCCCTTCTTCCTGCCGGCGGACATCAAGGCGGGCGACTTCATCGAGATCGG
GATGCTTGGCGCTTATGGCTGCGCGATGCGGACGAAGTTCAACGGCTTCGGCGCGGACGAAACCCACGTCGTCAGCGACG
AACCAATGACCAGCCTCTACACCGGCGAAGTCGAACAGGAACGCCGCAGCGCGACGGTGACCAAGCTGTTCTGA

Upstream 100 bases:

>100_bases
GACCCCCCGCCATATATGCGCTCCCCGCTGCCCCAGGGGGACTTCCAATAACCGCAAGGCAGCCTTGGATGTTTCACTTA
ACCTTTGGGGGTCCCTTGCA

Downstream 100 bases:

>100_bases
TCGCGTTCGAATAACAAGATTGAAAGGGTCGGCGCAGCGATGCGATCGGCCCTTTCGCTTTTGGTTCAAGGCGCTAGAGC
GGCACCCATGTCTCCCTTCC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MHQHHSAHGLIQALSPVEPVTLVRPHAARRAARFFIERFPGTTMYAVKANPSADLLRVLWDSGVTHYDVASIAEVRLVAR
TLPQATLCFMHPVKAEEAISEAYWKHGVRTFSLDTLDELEKIVRATEGAQDLNLLVRLRVSSDHSKLSLAAKFGAEPEDV
AELLMATRQAADALGICFHVGSQAMTPHAYAQAMERVRAAIVAASVTVDIIDVGGGFPSSYPGMEPPPLDAYFDTIHRSF
ESLPISYSAELWCEPGRALSAEYSSLIVRVEKRRGEELYINDGAYGALFDAAHVGWRFPVSLQRDAESGAELLPFSFYGP
TCDDLDHMAGPFFLPADIKAGDFIEIGMLGAYGCAMRTKFNGFGADETHVVSDEPMTSLYTGEVEQERRSATVTKLF

Sequences:

>Translated_397_residues
MHQHHSAHGLIQALSPVEPVTLVRPHAARRAARFFIERFPGTTMYAVKANPSADLLRVLWDSGVTHYDVASIAEVRLVAR
TLPQATLCFMHPVKAEEAISEAYWKHGVRTFSLDTLDELEKIVRATEGAQDLNLLVRLRVSSDHSKLSLAAKFGAEPEDV
AELLMATRQAADALGICFHVGSQAMTPHAYAQAMERVRAAIVAASVTVDIIDVGGGFPSSYPGMEPPPLDAYFDTIHRSF
ESLPISYSAELWCEPGRALSAEYSSLIVRVEKRRGEELYINDGAYGALFDAAHVGWRFPVSLQRDAESGAELLPFSFYGP
TCDDLDHMAGPFFLPADIKAGDFIEIGMLGAYGCAMRTKFNGFGADETHVVSDEPMTSLYTGEVEQERRSATVTKLF
>Mature_397_residues
MHQHHSAHGLIQALSPVEPVTLVRPHAARRAARFFIERFPGTTMYAVKANPSADLLRVLWDSGVTHYDVASIAEVRLVAR
TLPQATLCFMHPVKAEEAISEAYWKHGVRTFSLDTLDELEKIVRATEGAQDLNLLVRLRVSSDHSKLSLAAKFGAEPEDV
AELLMATRQAADALGICFHVGSQAMTPHAYAQAMERVRAAIVAASVTVDIIDVGGGFPSSYPGMEPPPLDAYFDTIHRSF
ESLPISYSAELWCEPGRALSAEYSSLIVRVEKRRGEELYINDGAYGALFDAAHVGWRFPVSLQRDAESGAELLPFSFYGP
TCDDLDHMAGPFFLPADIKAGDFIEIGMLGAYGCAMRTKFNGFGADETHVVSDEPMTSLYTGEVEQERRSATVTKLF

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=30.5851063829787, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI16506287, Length=359, Percent_Identity=25.9052924791086, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562780, Length=359, Percent_Identity=29.2479108635098, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322664, Length=371, Percent_Identity=29.1105121293801, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24586472, Length=362, Percent_Identity=25.6906077348066, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24586474, Length=340, Percent_Identity=26.7647058823529, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43553; Mature: 43553

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQHHSAHGLIQALSPVEPVTLVRPHAARRAARFFIERFPGTTMYAVKANPSADLLRVLW
CCCCCCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
DSGVTHYDVASIAEVRLVARTLPQATLCFMHPVKAEEAISEAYWKHGVRTFSLDTLDELE
HCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
KIVRATEGAQDLNLLVRLRVSSDHSKLSLAAKFGAEPEDVAELLMATRQAADALGICFHV
HHHHHHCCCCCEEEEEEEEECCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GSQAMTPHAYAQAMERVRAAIVAASVTVDIIDVGGGFPSSYPGMEPPPLDAYFDTIHRSF
CCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
ESLPISYSAELWCEPGRALSAEYSSLIVRVEKRRGEELYINDGAYGALFDAAHVGWRFPV
HHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCEECCC
SLQRDAESGAELLPFSFYGPTCDDLDHMAGPFFLPADIKAGDFIEIGMLGAYGCAMRTKF
EECCCCCCCCCCCEEECCCCCCCCHHHHCCCEEEECCCCCCCEEEECCHHHHHHHHEEEC
NGFGADETHVVSDEPMTSLYTGEVEQERRSATVTKLF
CCCCCCCCEEECCCCCHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MHQHHSAHGLIQALSPVEPVTLVRPHAARRAARFFIERFPGTTMYAVKANPSADLLRVLW
CCCCCCHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
DSGVTHYDVASIAEVRLVARTLPQATLCFMHPVKAEEAISEAYWKHGVRTFSLDTLDELE
HCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCHHHHH
KIVRATEGAQDLNLLVRLRVSSDHSKLSLAAKFGAEPEDVAELLMATRQAADALGICFHV
HHHHHHCCCCCEEEEEEEEECCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GSQAMTPHAYAQAMERVRAAIVAASVTVDIIDVGGGFPSSYPGMEPPPLDAYFDTIHRSF
CCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
ESLPISYSAELWCEPGRALSAEYSSLIVRVEKRRGEELYINDGAYGALFDAAHVGWRFPV
HHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCEECCC
SLQRDAESGAELLPFSFYGPTCDDLDHMAGPFFLPADIKAGDFIEIGMLGAYGCAMRTKF
EECCCCCCCCCCCEEECCCCCCCCHHHHCCCEEEECCCCCCCEEEECCHHHHHHHHEEEC
NGFGADETHVVSDEPMTSLYTGEVEQERRSATVTKLF
CCCCCCCCEEECCCCCHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]