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The map label for this gene is aceA [C]

Identifier: 103486433

GI number: 103486433

Start: 962080

End: 963672

Strand: Reverse

Name: aceA [C]

Synonym: Sala_0943

Alternate gene names: 103486433

Gene position: 963672-962080 (Counterclockwise)

Preceding gene: 103486435

Following gene: 103486431

Centisome position: 28.81

GC content: 62.4

Gene sequence:

>1593_bases
ATGGGTTATCAGGAAGACATGGCGCAGGCCGGCCGCCTCATCCGCGACCATGACGGCGCATGGGATGCCATCAGCGGCGA
AAGCGTCGCCCGGATGCGCGCCCAGAACAGGTTCAGGACCGGCCTCGACATCGCCCGCTACACCGCGCGCATCATGCGCG
CCGACATGGCCGCCTACGACGCCGATCCCGCCAACTACACCCAGTCGCTCGGCTGCTGGCACGGCTTCATCGCGCAGCAG
AAGATGATCGCGATCAAGAAGCATTTCGGCACGACCAAGCGCCGCTACATCTATCTGTCGGGCTGGATGATCGCCGCGCT
GCGCAGCGAGTTCGGCCCGCTCCCCGACCAGTCGATGCACGAAAAGACCAGCGTTCCGGCGCTGATCGAGGAAATCTACA
CCTTCCTGCGTCAGGCCGACGCCCGCGAACTGGGGATGCTCTTCCGCGACCTCGACGCCGCGCGCGCCGAGGGCGACGAA
CTCAAGGCCAAGCAGGTGCAGGCCGCGATCGACAATCACGAAACGCACGTCGTGCCGATCATCGCCGACATCGACGCAGG
CTTCGGCAATGCCGAGGCGACCTACCTGCTCGCCAAGAAGATGATCGAGGCCGGCGCCTGCGCGCTCCAGGTCGAGAACC
AGGTTTCCGACGAAAAGCAGTGCGGTCACCAGGACGGCAAGGTCACGGTTCCGCATGAAGATTTTCTTCAGAAGATCCGC
GCCATTCGCTACGCCTTCATGGAACTGGGGGTCGAGGACGGCATCATCGTCGCGCGCACCGACAGCCTCGGCGCGGGCCT
GACCAAGCAGATCGCCTATTCGAAACAGCCCGGCGATCTTGGCGACCAGTATAACAGCTTCCTCGATTGCGAAGAGGTTC
CGGGCGCGGGCAACCCCGGCGATGTCCTCATTAACCGCAACGGCAAGCTGATGCGCCCAAAGCGCCTGCCCTCCAACCTT
TATCAGTTCCGTCCCGGAACCGGCGAGGACCGCTGCGTGCTCGACTGCATTACCTCGCTCCAGAATGGCGCCGACCTGAT
CTGGATCGAGACGGAAAAGCCGCACATCGAACAGATTGCCGGCATGGTCGACCGCATCCGCGAGGTCGTGCCCAATGCGA
AGCTCGCCTACAATAACTCGCCGAGCTTCAACTGGACGCTCAATTTCCGCCAGCAGGTCTATGACAGCTGGGCAGAGGAG
GGCCGCGACCTGTCGGCATATGACCGCGCCAAGCTGATGAGCGCCGAATATGATGACAGCGAACTTTCCAGCGAAGCCGA
CAACCGCATCCGCAACTTCCAGCGCGACGCGGCGAAACGGGCGGGCATCTTCCATCACCTGATCACGCTGCCGACCTATC
ACACGGCCGCGCTCAGCACCGACAATCTCGCCAGGGAGTATTTTGGCGACGAAGCGATGCTCGGCTATGTCAAGGGCGTC
CAGCGCAAGGAAATCCGCGAGGGCATCGCCTGTGTGAAGCACCAGAATATGAGCGGAAGCGACATCGGTGACGATCACAA
GGAGTATTTCGCCGGCGAAGCGGCCCTGAAAGCCGCCGGCAAAGACAATACGATGAACCAGTTCGCGGCTTGA

Upstream 100 bases:

>100_bases
CCTATCGGCGGTATTTCACAAATATTATTGACAAATCTTTTCCCTTTCCGCGACACCTTCGCCAACATCCACCCATCACC
TCCGCACAAGGACAAAGACG

Downstream 100 bases:

>100_bases
CCGAGCTCGGCGCGAGGGATCCGTTGCAACCCTCGCGCCAACCCGCTCGGCGCGGGACGCCTTGCACAATCGTCCCGCGC
CTCCCGCGCTTTCCTGGGGA

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MGYQEDMAQAGRLIRDHDGAWDAISGESVARMRAQNRFRTGLDIARYTARIMRADMAAYDADPANYTQSLGCWHGFIAQQ
KMIAIKKHFGTTKRRYIYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGMLFRDLDAARAEGDE
LKAKQVQAAIDNHETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQVENQVSDEKQCGHQDGKVTVPHEDFLQKIR
AIRYAFMELGVEDGIIVARTDSLGAGLTKQIAYSKQPGDLGDQYNSFLDCEEVPGAGNPGDVLINRNGKLMRPKRLPSNL
YQFRPGTGEDRCVLDCITSLQNGADLIWIETEKPHIEQIAGMVDRIREVVPNAKLAYNNSPSFNWTLNFRQQVYDSWAEE
GRDLSAYDRAKLMSAEYDDSELSSEADNRIRNFQRDAAKRAGIFHHLITLPTYHTAALSTDNLAREYFGDEAMLGYVKGV
QRKEIREGIACVKHQNMSGSDIGDDHKEYFAGEAALKAAGKDNTMNQFAA

Sequences:

>Translated_530_residues
MGYQEDMAQAGRLIRDHDGAWDAISGESVARMRAQNRFRTGLDIARYTARIMRADMAAYDADPANYTQSLGCWHGFIAQQ
KMIAIKKHFGTTKRRYIYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGMLFRDLDAARAEGDE
LKAKQVQAAIDNHETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQVENQVSDEKQCGHQDGKVTVPHEDFLQKIR
AIRYAFMELGVEDGIIVARTDSLGAGLTKQIAYSKQPGDLGDQYNSFLDCEEVPGAGNPGDVLINRNGKLMRPKRLPSNL
YQFRPGTGEDRCVLDCITSLQNGADLIWIETEKPHIEQIAGMVDRIREVVPNAKLAYNNSPSFNWTLNFRQQVYDSWAEE
GRDLSAYDRAKLMSAEYDDSELSSEADNRIRNFQRDAAKRAGIFHHLITLPTYHTAALSTDNLAREYFGDEAMLGYVKGV
QRKEIREGIACVKHQNMSGSDIGDDHKEYFAGEAALKAAGKDNTMNQFAA
>Mature_529_residues
GYQEDMAQAGRLIRDHDGAWDAISGESVARMRAQNRFRTGLDIARYTARIMRADMAAYDADPANYTQSLGCWHGFIAQQK
MIAIKKHFGTTKRRYIYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEEIYTFLRQADARELGMLFRDLDAARAEGDEL
KAKQVQAAIDNHETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACALQVENQVSDEKQCGHQDGKVTVPHEDFLQKIRA
IRYAFMELGVEDGIIVARTDSLGAGLTKQIAYSKQPGDLGDQYNSFLDCEEVPGAGNPGDVLINRNGKLMRPKRLPSNLY
QFRPGTGEDRCVLDCITSLQNGADLIWIETEKPHIEQIAGMVDRIREVVPNAKLAYNNSPSFNWTLNFRQQVYDSWAEEG
RDLSAYDRAKLMSAEYDDSELSSEADNRIRNFQRDAAKRAGIFHHLITLPTYHTAALSTDNLAREYFGDEAMLGYVKGVQ
RKEIREGIACVKHQNMSGSDIGDDHKEYFAGEAALKAAGKDNTMNQFAA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=412, Percent_Identity=28.8834951456311, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982926, Length=412, Percent_Identity=29.3689320388349, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17561814, Length=412, Percent_Identity=29.3689320388349, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320908, Length=175, Percent_Identity=32, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325263, Length=104, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59196; Mature: 59065

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYQEDMAQAGRLIRDHDGAWDAISGESVARMRAQNRFRTGLDIARYTARIMRADMAAYD
CCCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADPANYTQSLGCWHGFIAQQKMIAIKKHFGTTKRRYIYLSGWMIAALRSEFGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEEIYTFLRQADARELGMLFRDLDAARAEGDELKAKQVQAAIDNHETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQVENQVSDEKQCGHQDGKVTVPHEDFLQKIR
EEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
AIRYAFMELGVEDGIIVARTDSLGAGLTKQIAYSKQPGDLGDQYNSFLDCEEVPGAGNPG
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHHCCCHHHCCCCCCCC
DVLINRNGKLMRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGADLIWIETEKPHIEQIA
CEEECCCCCEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
GMVDRIREVVPNAKLAYNNSPSFNWTLNFRQQVYDSWAEEGRDLSAYDRAKLMSAEYDDS
HHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCH
ELSSEADNRIRNFQRDAAKRAGIFHHLITLPTYHTAALSTDNLAREYFGDEAMLGYVKGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCHHHHHHHHCH
QRKEIREGIACVKHQNMSGSDIGDDHKEYFAGEAALKAAGKDNTMNQFAA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
GYQEDMAQAGRLIRDHDGAWDAISGESVARMRAQNRFRTGLDIARYTARIMRADMAAYD
CCHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADPANYTQSLGCWHGFIAQQKMIAIKKHFGTTKRRYIYLSGWMIAALRSEFGPLPDQSMH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHH
EKTSVPALIEEIYTFLRQADARELGMLFRDLDAARAEGDELKAKQVQAAIDNHETHVVPI
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEE
IADIDAGFGNAEATYLLAKKMIEAGACALQVENQVSDEKQCGHQDGKVTVPHEDFLQKIR
EEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHH
AIRYAFMELGVEDGIIVARTDSLGAGLTKQIAYSKQPGDLGDQYNSFLDCEEVPGAGNPG
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHHHCCCHHHCCCCCCCC
DVLINRNGKLMRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGADLIWIETEKPHIEQIA
CEEECCCCCEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
GMVDRIREVVPNAKLAYNNSPSFNWTLNFRQQVYDSWAEEGRDLSAYDRAKLMSAEYDDS
HHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCH
ELSSEADNRIRNFQRDAAKRAGIFHHLITLPTYHTAALSTDNLAREYFGDEAMLGYVKGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCHHHHHHHHCH
QRKEIREGIACVKHQNMSGSDIGDDHKEYFAGEAALKAAGKDNTMNQFAA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]