| Definition | Sphingopyxis alaskensis RB2256, complete genome. |
|---|---|
| Accession | NC_008048 |
| Length | 3,345,170 |
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The map label for this gene is hdhA [C]
Identifier: 103486360
GI number: 103486360
Start: 876798
End: 877586
Strand: Reverse
Name: hdhA [C]
Synonym: Sala_0870
Alternate gene names: 103486360
Gene position: 877586-876798 (Counterclockwise)
Preceding gene: 103486361
Following gene: 103486354
Centisome position: 26.23
GC content: 65.65
Gene sequence:
>789_bases ATGCCGGATTTCACCAATGCCCGGTTCGATCTGGACGGCAAGGTCGCCATCGTCACCGGCGCGGGCGGGCGCGGCAACAG CATCGGACGCGCCTATGCCGTCGGCCTCGCCAATGCCGGGGCGAGCGTCGTGGTCGCCGATCTGAACAAGGAAGGCGCCG AGCGCGTCGCGGCCGAAATCAACGATGGCGGCGGCACCGCGCTCGCGATTCAGGTCGATATCGCCGACGAAGCATCGGTT GCGGCAATGATGGAGGCAACCCGGTCGGCTTTTGGCGGACTGGACATTCTGGTCAACAATGCGGCGTTGATGGTCGAAGC CGTCGGGACGCCCGCGATCCAGACGAGCATCGCCGATTTCGAACGCTTGATGCGCGTGAACCTTACCGGTGCGCTGATCT GTTCAAAGGCCGCCGTCCCGCTGTTTCAGGCGCGCGGCGGCGGCAAGATCGTCAACCAGCTGTCCGCTGGCGCTTTTCCC GCGCAAACGCCCTATGGCATCAGCAAGGTCGCCCTGTTGGGGCTGACCACGACGCTTGCCACCGAACTCGGACGGATGAA CATCAACGTCAATGCGATTGCGCCGGGCATGACCATGTCGGACGCGGGCAAGGCACTGACCCCCGAGGACAGCCCCTTCG TCCAGGCCGCGATGGCGCGCGTCGTCAAACAGCCGCGCGGCGAGCCCCAGGATCTGGTCGGCGCCCTCCTGCTCCTTTGC TCGCCCGCGGGCGACTGGATCACGGGGCAGGCGCTGAACGTCGATGGCGGCTTCATCATGCGGAATTGA
Upstream 100 bases:
>100_bases GCAAGGAAGGCGGCAAGGCCGGGATCGACGAGTTCCTTCACTACAAGACCGTGACCATCGGCGTCGGCGCCCCGATTTTT CCGAAGCAGGAGGCGTAAGC
Downstream 100 bases:
>100_bases CGCTCGATGGCGCCGGTTCAGGAACAGCGGCGCAATTCATGCTTCAACACCTTGCCCGATGCATTGCGCGGAAGCTCGGG CAGGATGGTCAGCCGTTCGG
Product: short chain dehydrogenase
Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 262; Mature: 261
Protein sequence:
>262_residues MPDFTNARFDLDGKVAIVTGAGGRGNSIGRAYAVGLANAGASVVVADLNKEGAERVAAEINDGGGTALAIQVDIADEASV AAMMEATRSAFGGLDILVNNAALMVEAVGTPAIQTSIADFERLMRVNLTGALICSKAAVPLFQARGGGKIVNQLSAGAFP AQTPYGISKVALLGLTTTLATELGRMNINVNAIAPGMTMSDAGKALTPEDSPFVQAAMARVVKQPRGEPQDLVGALLLLC SPAGDWITGQALNVDGGFIMRN
Sequences:
>Translated_262_residues MPDFTNARFDLDGKVAIVTGAGGRGNSIGRAYAVGLANAGASVVVADLNKEGAERVAAEINDGGGTALAIQVDIADEASV AAMMEATRSAFGGLDILVNNAALMVEAVGTPAIQTSIADFERLMRVNLTGALICSKAAVPLFQARGGGKIVNQLSAGAFP AQTPYGISKVALLGLTTTLATELGRMNINVNAIAPGMTMSDAGKALTPEDSPFVQAAMARVVKQPRGEPQDLVGALLLLC SPAGDWITGQALNVDGGFIMRN >Mature_261_residues PDFTNARFDLDGKVAIVTGAGGRGNSIGRAYAVGLANAGASVVVADLNKEGAERVAAEINDGGGTALAIQVDIADEASVA AMMEATRSAFGGLDILVNNAALMVEAVGTPAIQTSIADFERLMRVNLTGALICSKAAVPLFQARGGGKIVNQLSAGAFPA QTPYGISKVALLGLTTTLATELGRMNINVNAIAPGMTMSDAGKALTPEDSPFVQAAMARVVKQPRGEPQDLVGALLLLCS PAGDWITGQALNVDGGFIMRN
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=32.6771653543307, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=30.1960784313725, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI126723750, Length=257, Percent_Identity=30.3501945525292, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI4504505, Length=263, Percent_Identity=31.9391634980989, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=33.6, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI15277342, Length=266, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=32.5490196078431, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI126723191, Length=189, Percent_Identity=32.2751322751323, Blast_Score=78, Evalue=6e-15, Organism=Homo sapiens, GI210032110, Length=194, Percent_Identity=29.3814432989691, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=31.2796208530806, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI209862901, Length=201, Percent_Identity=30.8457711442786, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI19923983, Length=201, Percent_Identity=30.8457711442786, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI40254986, Length=204, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI142976729, Length=185, Percent_Identity=28.1081081081081, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=29.7979797979798, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI7706318, Length=260, Percent_Identity=28.4615384615385, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=29.1497975708502, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI302344755, Length=106, Percent_Identity=39.622641509434, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI59889578, Length=234, Percent_Identity=29.4871794871795, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=32.4022346368715, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI10190704, Length=255, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI1787905, Length=258, Percent_Identity=39.1472868217054, Blast_Score=144, Evalue=4e-36, Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=34.8484848484849, Blast_Score=122, Evalue=2e-29, Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=32.1705426356589, Blast_Score=122, Evalue=3e-29, Organism=Escherichia coli, GI1789208, Length=259, Percent_Identity=33.976833976834, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=33.0739299610895, Blast_Score=104, Evalue=6e-24, Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=31.3953488372093, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=30.2325581395349, Blast_Score=101, Evalue=5e-23, Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=30.0380228136882, Blast_Score=88, Evalue=7e-19, Organism=Escherichia coli, GI2367175, Length=256, Percent_Identity=31.640625, Blast_Score=84, Evalue=8e-18, Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=28.2945736434109, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=28.1124497991968, Blast_Score=69, Evalue=3e-13, Organism=Escherichia coli, GI1787820, Length=220, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=7e-13, Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=30, Blast_Score=68, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=31.496062992126, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=34.375, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=31.9391634980989, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=33.210332103321, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17561402, Length=276, Percent_Identity=31.5217391304348, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=29.7297297297297, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=31.9852941176471, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=31.3653136531365, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=34.2307692307692, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17568967, Length=200, Percent_Identity=34.5, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=31.0861423220974, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=30.8880308880309, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI25147288, Length=264, Percent_Identity=31.0606060606061, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=29.2490118577075, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=28.6764705882353, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17555612, Length=208, Percent_Identity=34.6153846153846, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=28.0632411067194, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI115534694, Length=257, Percent_Identity=30.3501945525292, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=30.2325581395349, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=29.2592592592593, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI71982365, Length=195, Percent_Identity=29.2307692307692, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17564282, Length=260, Percent_Identity=25.3846153846154, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.1368821292776, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=28.4615384615385, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=29.6153846153846, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71997099, Length=251, Percent_Identity=29.8804780876494, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=27.5471698113208, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17558628, Length=195, Percent_Identity=30.2564102564103, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17561272, Length=240, Percent_Identity=27.9166666666667, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=27.3076923076923, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538182, Length=262, Percent_Identity=29.7709923664122, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=26.0377358490566, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17567345, Length=184, Percent_Identity=29.3478260869565, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=27.3764258555133, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=194, Percent_Identity=36.0824742268041, Blast_Score=99, Evalue=6e-22, Organism=Saccharomyces cerevisiae, GI6323882, Length=200, Percent_Identity=29, Blast_Score=69, Evalue=9e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=27.2373540856031, Blast_Score=67, Evalue=4e-12, Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=32.9365079365079, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI18859837, Length=204, Percent_Identity=35.2941176470588, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=30.7086614173228, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=30.2325581395349, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI21357041, Length=268, Percent_Identity=30.5970149253731, Blast_Score=87, Evalue=8e-18, Organism=Drosophila melanogaster, GI17737361, Length=261, Percent_Identity=31.8007662835249, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI21357673, Length=237, Percent_Identity=28.6919831223629, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=28.125, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=29.277566539924, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24644337, Length=266, Percent_Identity=28.1954887218045, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI24643142, Length=259, Percent_Identity=28.957528957529, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI24665243, Length=233, Percent_Identity=29.1845493562232, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI221331218, Length=225, Percent_Identity=30.2222222222222, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24665247, Length=234, Percent_Identity=29.0598290598291, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI221331216, Length=226, Percent_Identity=30.0884955752212, Blast_Score=66, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100
Molecular weight: Translated: 26684; Mature: 26553
Theoretical pI: Translated: 4.58; Mature: 4.58
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.8 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.4 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPDFTNARFDLDGKVAIVTGAGGRGNSIGRAYAVGLANAGASVVVADLNKEGAERVAAEI CCCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHEE NDGGGTALAIQVDIADEASVAAMMEATRSAFGGLDILVNNAALMVEAVGTPAIQTSIADF CCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHH ERLMRVNLTGALICSKAAVPLFQARGGGKIVNQLSAGAFPAQTPYGISKVALLGLTTTLA HHHHHHCCCHHEEECCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH TELGRMNINVNAIAPGMTMSDAGKALTPEDSPFVQAAMARVVKQPRGEPQDLVGALLLLC HHHHHEEEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH SPAGDWITGQALNVDGGFIMRN CCCCCCEECEEEECCCCEEECC >Mature Secondary Structure PDFTNARFDLDGKVAIVTGAGGRGNSIGRAYAVGLANAGASVVVADLNKEGAERVAAEI CCCCCCEEECCCCEEEEECCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHEE NDGGGTALAIQVDIADEASVAAMMEATRSAFGGLDILVNNAALMVEAVGTPAIQTSIADF CCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCHHHHHHHHH ERLMRVNLTGALICSKAAVPLFQARGGGKIVNQLSAGAFPAQTPYGISKVALLGLTTTLA HHHHHHCCCHHEEECCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH TELGRMNINVNAIAPGMTMSDAGKALTPEDSPFVQAAMARVVKQPRGEPQDLVGALLLLC HHHHHEEEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH SPAGDWITGQALNVDGGFIMRN CCCCCCEECEEEECCCCEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+
Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]