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The map label for this gene is fadH [H]

Identifier: 103486355

GI number: 103486355

Start: 872154

End: 873035

Strand: Direct

Name: fadH [H]

Synonym: Sala_0865

Alternate gene names: 103486355

Gene position: 872154-873035 (Clockwise)

Preceding gene: 103486347

Following gene: 103486356

Centisome position: 26.07

GC content: 65.31

Gene sequence:

>882_bases
TTGCCAATACCGGCCCATCATATTGTGGCGACCCCGCCGCCATTCGAAGCGCCCCCCTATCCGGGCGACATTTTTGCCGG
TCAGACGGTGCTGGTCACCGGCGGCGGGTCGGGCATGGGTCTCGCGATGGCAAAGGCCTTTGCGCAGGGCGGGGCCGATG
TCGCGGTGCTGGGACGGAACCTCGACCGGGCACGGGACGGCGCCGAACAGATCGCCGCGCTGGGCGTGCGCAGTCATGCG
ATAAGCTGTGACGTTCGCAATCCCGATGCCGTGGCGGCAGCCTTTGACGAAGCCGAGGAGGCGCTCGGGCCCATCGGCCT
GCTCGCCAACAATGCCGGCGCCAATTTCCCGATCCTGGCAGAAGATATATCGCGCAATGCCTGGAACGCGGTCACGCGGA
TCGCGATCGACGGGACGTTCCTTTGCTCCAGCGAATTCGCCCGGCGCCGCATCGCGCGCGGTGAGGGCGGGGCGATCGTC
AACAACAGCGCCCAATATATCTGGACCGGCTTTCCGGGCGATGCCCATAGCGCCGCCGCCAAGACCGCGCAGGCGACGAT
GACGAAGCGTCTGGCCGCCGATTGGGCGCCATATGGCATTCGCGTCAATGCAATAGCGGCGGGTTTCTTCCCCCATGCCG
ATTCGGTTTCGGGTCGCAGCGAGGATGGCGTGGAGCCGTTGCAGGCGATGATCCCCGCGGGCCGCACGGGCAGCATATGG
GAGTTTGGCTGGTTGTCCGCGATGACCTGTACCCCGTTTTTCGGTGAAATGACCGGACAGGTGATCGTGCAGGACGGTGG
CGAAAGCCTGCGTAGATCGCTGATCATGCCCGACTTCATTCCGCCGCGTGAGCGGGCTGACGGCCCGTGGGGTTGGCAAT
GA

Upstream 100 bases:

>100_bases
CATCCGCAACGATTTCCATGTCGGCTCCTATATAACCTAGTTAGTCATGTCTTGACATGCAGAGGGTCAAGGCGCAACCC
TTGGCGCGAGGGAGAGAGCC

Downstream 100 bases:

>100_bases
ACGGCTGGCTTGCCGGAAAACGCGCCCGGATCGAAGGGGACGCGCCTGCCATTACGGCGGCGATCGAGGCCGCCGGGGCG
GTGCTGGTCGCCGATGGCGA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPIPAHHIVATPPPFEAPPYPGDIFAGQTVLVTGGGSGMGLAMAKAFAQGGADVAVLGRNLDRARDGAEQIAALGVRSHA
ISCDVRNPDAVAAAFDEAEEALGPIGLLANNAGANFPILAEDISRNAWNAVTRIAIDGTFLCSSEFARRRIARGEGGAIV
NNSAQYIWTGFPGDAHSAAAKTAQATMTKRLAADWAPYGIRVNAIAAGFFPHADSVSGRSEDGVEPLQAMIPAGRTGSIW
EFGWLSAMTCTPFFGEMTGQVIVQDGGESLRRSLIMPDFIPPRERADGPWGWQ

Sequences:

>Translated_293_residues
MPIPAHHIVATPPPFEAPPYPGDIFAGQTVLVTGGGSGMGLAMAKAFAQGGADVAVLGRNLDRARDGAEQIAALGVRSHA
ISCDVRNPDAVAAAFDEAEEALGPIGLLANNAGANFPILAEDISRNAWNAVTRIAIDGTFLCSSEFARRRIARGEGGAIV
NNSAQYIWTGFPGDAHSAAAKTAQATMTKRLAADWAPYGIRVNAIAAGFFPHADSVSGRSEDGVEPLQAMIPAGRTGSIW
EFGWLSAMTCTPFFGEMTGQVIVQDGGESLRRSLIMPDFIPPRERADGPWGWQ
>Mature_292_residues
PIPAHHIVATPPPFEAPPYPGDIFAGQTVLVTGGGSGMGLAMAKAFAQGGADVAVLGRNLDRARDGAEQIAALGVRSHAI
SCDVRNPDAVAAAFDEAEEALGPIGLLANNAGANFPILAEDISRNAWNAVTRIAIDGTFLCSSEFARRRIARGEGGAIVN
NSAQYIWTGFPGDAHSAAAKTAQATMTKRLAADWAPYGIRVNAIAAGFFPHADSVSGRSEDGVEPLQAMIPAGRTGSIWE
FGWLSAMTCTPFFGEMTGQVIVQDGGESLRRSLIMPDFIPPRERADGPWGWQ

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=280, Percent_Identity=32.8571428571429, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=32.4626865671642, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=33.8709677419355, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=31.9502074688797, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI209862901, Length=168, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI19923983, Length=168, Percent_Identity=27.3809523809524, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=27.2, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=31.25, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789208, Length=215, Percent_Identity=33.0232558139535, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=33.201581027668, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367175, Length=216, Percent_Identity=34.2592592592593, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790717, Length=192, Percent_Identity=27.6041666666667, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=26.171875, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=28.1632653061224, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=275, Percent_Identity=32.7272727272727, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17536025, Length=275, Percent_Identity=31.6363636363636, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=34.7639484978541, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=28.4644194756554, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=284, Percent_Identity=26.4084507042254, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=190, Percent_Identity=30, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=277, Percent_Identity=26.7148014440433, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=26.4925373134328, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=27.5590551181102, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=28, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=279, Percent_Identity=28.3154121863799, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=29.6992481203008, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=28.3636363636364, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=27.8810408921933, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=29.1338582677165, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=27.2, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=28.1746031746032, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007234, Length=135, Percent_Identity=36.2962962962963, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI116007232, Length=135, Percent_Identity=36.2962962962963, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=28.6274509803922, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=28.7958115183246, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 30742; Mature: 30611

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPAHHIVATPPPFEAPPYPGDIFAGQTVLVTGGGSGMGLAMAKAFAQGGADVAVLGRN
CCCCCCCEEECCCCCCCCCCCCCEECCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCC
LDRARDGAEQIAALGVRSHAISCDVRNPDAVAAAFDEAEEALGPIGLLANNAGANFPILA
HHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEH
EDISRNAWNAVTRIAIDGTFLCSSEFARRRIARGEGGAIVNNSAQYIWTGFPGDAHSAAA
HHHCCHHHHHEEEEEECCEEEECHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHH
KTAQATMTKRLAADWAPYGIRVNAIAAGFFPHADSVSGRSEDGVEPLQAMIPAGRTGSIW
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEE
EFGWLSAMTCTPFFGEMTGQVIVQDGGESLRRSLIMPDFIPPRERADGPWGWQ
ECCCHHHHHCCCCHHCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIPAHHIVATPPPFEAPPYPGDIFAGQTVLVTGGGSGMGLAMAKAFAQGGADVAVLGRN
CCCCCCEEECCCCCCCCCCCCCEECCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCC
LDRARDGAEQIAALGVRSHAISCDVRNPDAVAAAFDEAEEALGPIGLLANNAGANFPILA
HHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEH
EDISRNAWNAVTRIAIDGTFLCSSEFARRRIARGEGGAIVNNSAQYIWTGFPGDAHSAAA
HHHCCHHHHHEEEEEECCEEEECHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCHHHHH
KTAQATMTKRLAADWAPYGIRVNAIAAGFFPHADSVSGRSEDGVEPLQAMIPAGRTGSIW
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEE
EFGWLSAMTCTPFFGEMTGQVIVQDGGESLRRSLIMPDFIPPRERADGPWGWQ
ECCCHHHHHCCCCHHCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]