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The map label for this gene is iscS [H]

Identifier: 103486286

GI number: 103486286

Start: 799990

End: 801081

Strand: Direct

Name: iscS [H]

Synonym: Sala_0794

Alternate gene names: 103486286

Gene position: 799990-801081 (Clockwise)

Preceding gene: 103486279

Following gene: 103486287

Centisome position: 23.91

GC content: 68.77

Gene sequence:

>1092_bases
ATGATTTACCTCGATTATCAAGCCACTACGCCGCTCGCCCCCGAGGCGCGCGATGCGATGTTGCGCTGGCTCGACGGACC
GGGAGAGGGCGACGGTTTCGCCAACCCTTCGAGTACGCACAAGGCGGGCCGTGCCGCCGCCGCGGCGGTCGAGGTCGCGC
GCGATCAGGTTGCGGCGCTGCTGCCAGGGGGGGGGCGCGTCTTCTTCACCTCGGGCGCGACCGAGGCGCTCAACTGGGCG
CTGCTGCGCGGCGCCGAGGCGATGCCGGGCGGCGTCGCGGGGCTCAGCATCGAACATGCGGCGTCGCTGCAATGCCTTGA
GCGGCTCGATGCGGCGATTTTGCCGGTCGATGGCGCGGGGCTGGCCTTGCCGCCCGATGCGGCGCTGATCCCCGAAAATG
GCATCGTCGCGACGATGCTGGTGAACAATGAGGTCGGCACGATCCAGCCGGTTGCCGACTTCGCTGCGGCCGCGCACGCC
AAGAACAGCCTGCTGCTGTGTGATGCGGTGCAGGGTTTCGGCCGGATCGCGATTCCCGAAGGCCCCGACCTGATCGCCGT
GTCGGCGCACAAGATTCACGGTCCCAAGGGGGTCGGTGCGCTGTGGGTGCGTGACGGGGTCGAGCTTGAACCGCTGATGT
TTGGCGGCGCGCAGGAACAGGGGATGCGTTCGGGCACCGTCTCGCCGGCGCTCTGCGCCGGGTTCGGCGCTGCCGCCGCG
GTCGCGGCCGAGCGCCTGGACAAGGATGCAAGCCATGTCGAGCGCCTCTGGTCGCTCGCGCGCGATATGCTGCCCGAATG
GACGATCAACGGCGCCGAAAGCCCGCGCTATCACGGCAATCTCAATATACGTCGCGAGGGCGTGAACGGCCTGCGCCTGA
TGTCCGACGCGCGCGATGTCGCCTTTTCGCTCGGCAGCGCGTGCGGCAGCGGATCGGGCAAGGTCAGCCATGTGCTGCGC
GCAATGGGGGTGAGCGAGGCCGACGCGCGCGCCTCGCTCCGCCTCGGCTGGGGGCGCTATACCAGCGAACAGGAGTTGCG
CGACGGCCTGAACGCGATCAAGGACGCTGCCAGGCTTCAAGGGGTTAACTGA

Upstream 100 bases:

>100_bases
CATGGGGCGGGGTGGCGGAGCGAAGACACGCGCCTATATAGAAAAAAGGTCGCAACTTGCAACTTTTGCGAATTGTTCGC
AATAAGGACTCCGTCGCCGA

Downstream 100 bases:

>100_bases
TGCGCGTCACTTTCATCCACGCTGACGGCAAGGGGCGCACCGAGGCCGAAGCCGAGCCGGGCTCGACCCTGCTCGACGTC
GCGCAGGCGCATCTGATACC

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MIYLDYQATTPLAPEARDAMLRWLDGPGEGDGFANPSSTHKAGRAAAAAVEVARDQVAALLPGGGRVFFTSGATEALNWA
LLRGAEAMPGGVAGLSIEHAASLQCLERLDAAILPVDGAGLALPPDAALIPENGIVATMLVNNEVGTIQPVADFAAAAHA
KNSLLLCDAVQGFGRIAIPEGPDLIAVSAHKIHGPKGVGALWVRDGVELEPLMFGGAQEQGMRSGTVSPALCAGFGAAAA
VAAERLDKDASHVERLWSLARDMLPEWTINGAESPRYHGNLNIRREGVNGLRLMSDARDVAFSLGSACGSGSGKVSHVLR
AMGVSEADARASLRLGWGRYTSEQELRDGLNAIKDAARLQGVN

Sequences:

>Translated_363_residues
MIYLDYQATTPLAPEARDAMLRWLDGPGEGDGFANPSSTHKAGRAAAAAVEVARDQVAALLPGGGRVFFTSGATEALNWA
LLRGAEAMPGGVAGLSIEHAASLQCLERLDAAILPVDGAGLALPPDAALIPENGIVATMLVNNEVGTIQPVADFAAAAHA
KNSLLLCDAVQGFGRIAIPEGPDLIAVSAHKIHGPKGVGALWVRDGVELEPLMFGGAQEQGMRSGTVSPALCAGFGAAAA
VAAERLDKDASHVERLWSLARDMLPEWTINGAESPRYHGNLNIRREGVNGLRLMSDARDVAFSLGSACGSGSGKVSHVLR
AMGVSEADARASLRLGWGRYTSEQELRDGLNAIKDAARLQGVN
>Mature_363_residues
MIYLDYQATTPLAPEARDAMLRWLDGPGEGDGFANPSSTHKAGRAAAAAVEVARDQVAALLPGGGRVFFTSGATEALNWA
LLRGAEAMPGGVAGLSIEHAASLQCLERLDAAILPVDGAGLALPPDAALIPENGIVATMLVNNEVGTIQPVADFAAAAHA
KNSLLLCDAVQGFGRIAIPEGPDLIAVSAHKIHGPKGVGALWVRDGVELEPLMFGGAQEQGMRSGTVSPALCAGFGAAAA
VAAERLDKDASHVERLWSLARDMLPEWTINGAESPRYHGNLNIRREGVNGLRLMSDARDVAFSLGSACGSGSGKVSHVLR
AMGVSEADARASLRLGWGRYTSEQELRDGLNAIKDAARLQGVN

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=38.0577427821522, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI156713448, Length=416, Percent_Identity=29.5673076923077, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI48994898, Length=377, Percent_Identity=34.2175066312997, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25143064, Length=386, Percent_Identity=37.3056994818653, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17533177, Length=315, Percent_Identity=26.3492063492064, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=38.0952380952381, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI20129463, Length=382, Percent_Identity=38.2198952879581, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 37662; Mature: 37662

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDYQATTPLAPEARDAMLRWLDGPGEGDGFANPSSTHKAGRAAAAAVEVARDQVAAL
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
LPGGGRVFFTSGATEALNWALLRGAEAMPGGVAGLSIEHAASLQCLERLDAAILPVDGAG
CCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
LALPPDAALIPENGIVATMLVNNEVGTIQPVADFAAAAHAKNSLLLCDAVQGFGRIAIPE
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECHHCCCEEECCC
GPDLIAVSAHKIHGPKGVGALWVRDGVELEPLMFGGAQEQGMRSGTVSPALCAGFGAAAA
CCCEEEEEEEEECCCCCCCEEEEECCCEECCEEECCCHHHCCCCCCCCHHHHHHHHHHHH
VAAERLDKDASHVERLWSLARDMLPEWTINGAESPRYHGNLNIRREGVNGLRLMSDARDV
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
AFSLGSACGSGSGKVSHVLRAMGVSEADARASLRLGWGRYTSEQELRDGLNAIKDAARLQ
HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
GVN
CCC
>Mature Secondary Structure
MIYLDYQATTPLAPEARDAMLRWLDGPGEGDGFANPSSTHKAGRAAAAAVEVARDQVAAL
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
LPGGGRVFFTSGATEALNWALLRGAEAMPGGVAGLSIEHAASLQCLERLDAAILPVDGAG
CCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCC
LALPPDAALIPENGIVATMLVNNEVGTIQPVADFAAAAHAKNSLLLCDAVQGFGRIAIPE
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECHHCCCEEECCC
GPDLIAVSAHKIHGPKGVGALWVRDGVELEPLMFGGAQEQGMRSGTVSPALCAGFGAAAA
CCCEEEEEEEEECCCCCCCEEEEECCCEECCEEECCCHHHCCCCCCCCHHHHHHHHHHHH
VAAERLDKDASHVERLWSLARDMLPEWTINGAESPRYHGNLNIRREGVNGLRLMSDARDV
HHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
AFSLGSACGSGSGKVSHVLRAMGVSEADARASLRLGWGRYTSEQELRDGLNAIKDAARLQ
HHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHC
GVN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]