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The map label for this gene is serA [H]

Identifier: 103485842

GI number: 103485842

Start: 352006

End: 352950

Strand: Reverse

Name: serA [H]

Synonym: Sala_0347

Alternate gene names: 103485842

Gene position: 352950-352006 (Counterclockwise)

Preceding gene: 103485843

Following gene: 103485835

Centisome position: 10.55

GC content: 65.61

Gene sequence:

>945_bases
ATGACCAAAACCGTCACCGTCCTGTCGGGCCTCATCCGCCCCCTCGTCGAAAGCCGCCTCCCCGAATGGGTCGAGCCGCG
CTTTTTTCAGTCAAAGGACGAGGCCCTCGAACTCGCGCCGCACGCCGAAATCGGCTGGTTCGACATGTATGACAAGAAGG
ACATGGCCGCGGTCATCACCGCGGCGACCAAGCTCAAATGGCTGAACTCGATCTACGCCGGCGTCGACGGCATGCCGCTC
GATCTGCTCGCGACACGCGGCACCATCGTCACCAACGGCGCGGGGATCAACGCGATCACCATCGCCGAATATGTCGTGAT
GGGGATGCTCACCGTCGCCAAGGGTTACCGTGAGGTCGTGCGCGCGCAGGAGCGGCGCGAGTGGCTGACGGACTCGCCGG
GCAAGGTTGAACTGTTCGGATCGAAGGCGCTGCTCCTCGGCTATGGCGCGATCGGCAAGCTGATCGAGGAGCGGCTGAAG
GGTTTTGCGGTCGAGGTCACCGTCGTCCGCCGCACGCCGGGCGAACATACGCTGACCCCCGACCAGTGGCGCGCGCGGCT
TGGCGATTTCGACTGGGTGATCCTGGCGGTCCCGGCGACCCCCGAAACCGATGGCATGATCGGCGCCGCCGAACTCGCCA
CGATGAAGCCGAGCGCGACGCTCATCAACATCGCGCGCGGCAGCGTCGTCGATCAGGACGCGCTCGTCGCCGCGCTCGAT
GCGCAGCAGATCGCCGCGGCCTTCCTCGACGTCACGACGCCCGAACCGCTTCCCGCCGACAATCCGCTGTGGAGCCTCGA
CAATGCGCATATCACCATGCATCTGTCGGGCCGCGCGCAGGACAAGATGTTCGTGCGCTCGGCAGAGCGGTTTCTGGAGA
ATCTGGCGCGGTGGCACCGGGGCGAGGCGGTCGAGCCACGGGTGAACCTCACTTTAGGCTACTGA

Upstream 100 bases:

>100_bases
TCGAAGACCGCTTGAACAGCTTCGGCAAGGCCCCTCCGTCATCGCTTCGCGATGCCACCTCCCCATCGCAAGTCGATGGG
GAGGATCAGAAAGATCGAAT

Downstream 100 bases:

>100_bases
CATCTGATTTCGTCATCCCGGCGAAGGCCGGGATGACGATTCAAAGGGTGTTGCAATAGCACTTACCCCGGCCGCTCGGC
CTTCAATTCGCGGACCAGCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTKTVTVLSGLIRPLVESRLPEWVEPRFFQSKDEALELAPHAEIGWFDMYDKKDMAAVITAATKLKWLNSIYAGVDGMPL
DLLATRGTIVTNGAGINAITIAEYVVMGMLTVAKGYREVVRAQERREWLTDSPGKVELFGSKALLLGYGAIGKLIEERLK
GFAVEVTVVRRTPGEHTLTPDQWRARLGDFDWVILAVPATPETDGMIGAAELATMKPSATLINIARGSVVDQDALVAALD
AQQIAAAFLDVTTPEPLPADNPLWSLDNAHITMHLSGRAQDKMFVRSAERFLENLARWHRGEAVEPRVNLTLGY

Sequences:

>Translated_314_residues
MTKTVTVLSGLIRPLVESRLPEWVEPRFFQSKDEALELAPHAEIGWFDMYDKKDMAAVITAATKLKWLNSIYAGVDGMPL
DLLATRGTIVTNGAGINAITIAEYVVMGMLTVAKGYREVVRAQERREWLTDSPGKVELFGSKALLLGYGAIGKLIEERLK
GFAVEVTVVRRTPGEHTLTPDQWRARLGDFDWVILAVPATPETDGMIGAAELATMKPSATLINIARGSVVDQDALVAALD
AQQIAAAFLDVTTPEPLPADNPLWSLDNAHITMHLSGRAQDKMFVRSAERFLENLARWHRGEAVEPRVNLTLGY
>Mature_313_residues
TKTVTVLSGLIRPLVESRLPEWVEPRFFQSKDEALELAPHAEIGWFDMYDKKDMAAVITAATKLKWLNSIYAGVDGMPLD
LLATRGTIVTNGAGINAITIAEYVVMGMLTVAKGYREVVRAQERREWLTDSPGKVELFGSKALLLGYGAIGKLIEERLKG
FAVEVTVVRRTPGEHTLTPDQWRARLGDFDWVILAVPATPETDGMIGAAELATMKPSATLINIARGSVVDQDALVAALDA
QQIAAAFLDVTTPEPLPADNPLWSLDNAHITMHLSGRAQDKMFVRSAERFLENLARWHRGEAVEPRVNLTLGY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=31.8996415770609, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=26.865671641791, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1789279, Length=231, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=31.203007518797, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081824, Length=175, Percent_Identity=32, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=24.113475177305, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=251, Percent_Identity=29.4820717131474, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=249, Percent_Identity=28.9156626506024, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=175, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=130, Percent_Identity=31.5384615384615, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28571528, Length=149, Percent_Identity=43.6241610738255, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=28.0632411067194, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=26.4591439688716, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI19921140, Length=269, Percent_Identity=25.2788104089219, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34520; Mature: 34389

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTVTVLSGLIRPLVESRLPEWVEPRFFQSKDEALELAPHAEIGWFDMYDKKDMAAVIT
CCCHHHHHHHHHHHHHHHHCCHHCCCCHHCCCCHHEEECCCCCCCEEECCCCCHHHHHHH
AATKLKWLNSIYAGVDGMPLDLLATRGTIVTNGAGINAITIAEYVVMGMLTVAKGYREVV
HHHHHHHHHHHHHCCCCCCHHHEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAQERREWLTDSPGKVELFGSKALLLGYGAIGKLIEERLKGFAVEVTVVRRTPGEHTLTP
HHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCH
DQWRARLGDFDWVILAVPATPETDGMIGAAELATMKPSATLINIARGSVVDQDALVAALD
HHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHH
AQQIAAAFLDVTTPEPLPADNPLWSLDNAHITMHLSGRAQDKMFVRSAERFLENLARWHR
HHHHHHHHHHCCCCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GEAVEPRVNLTLGY
CCCCCCEEEEEECC
>Mature Secondary Structure 
TKTVTVLSGLIRPLVESRLPEWVEPRFFQSKDEALELAPHAEIGWFDMYDKKDMAAVIT
CCHHHHHHHHHHHHHHHHCCHHCCCCHHCCCCHHEEECCCCCCCEEECCCCCHHHHHHH
AATKLKWLNSIYAGVDGMPLDLLATRGTIVTNGAGINAITIAEYVVMGMLTVAKGYREVV
HHHHHHHHHHHHHCCCCCCHHHEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAQERREWLTDSPGKVELFGSKALLLGYGAIGKLIEERLKGFAVEVTVVRRTPGEHTLTP
HHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCH
DQWRARLGDFDWVILAVPATPETDGMIGAAELATMKPSATLINIARGSVVDQDALVAALD
HHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHH
AQQIAAAFLDVTTPEPLPADNPLWSLDNAHITMHLSGRAQDKMFVRSAERFLENLARWHR
HHHHHHHHHHCCCCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GEAVEPRVNLTLGY
CCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]