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The map label for this gene is ahcY

Identifier: 103485659

GI number: 103485659

Start: 163757

End: 165175

Strand: Reverse

Name: ahcY

Synonym: Sala_0163

Alternate gene names: 103485659

Gene position: 165175-163757 (Counterclockwise)

Preceding gene: 103485661

Following gene: 103485658

Centisome position: 4.94

GC content: 62.3

Gene sequence:

>1419_bases
GTGGCCACTCTCGCCGCCGATACCCGCGATTATGTCGTTGCCGACATCGGCCTCGCCGATTTCGGGCGCAAGGAAATCAA
CATCGCCGAAACCGAAATGCCGGGCCTGATGGCGCTACGCGCCGAATATGGCGCATCGCAGCCGCTGAAGGGTGCGCGCA
TCACCGGGTCGCTGCACATGACCATCCAGACCGCGGTGCTGATCGAGACGCTGACCGCGCTTGGCGCCGAAGTGCGCTGG
GCGACATGCAACATTTTCTCGACGCAGAACCATGCCGCCGCCGCGATCGCCGCGTCGGGCGTGCCGGTGTTCGCGGTGAA
GGGCGAAAGCCTCGCCGATTATTGGGACTATGTCGGCCGCATTTTCGACTGGGAAAGCGACAATGACGGCCGGACCGCGA
ACCTGATCCTCGACGATGGCGGCGACGCCACCATGTTCGCGCTGTGGGGCGCGAAGCTGGAGGCCGGCGAAACCATGCCG
CCGCCCGAAAATGAGGAAGAGGTCGAGATGCAGCGCGCGCTGAAGGCGTTCATCGCCGCAAAACCCGGCTATCTCACCAA
AACCGTCAAGGCGATCAAGGGCGTGTCGGAAGAAACGACCACCGGTGTCCACCGCCTCTATCACATCGCCAAGAAGGGCG
AACTGCCCTTCCCCGCGATCAACGTCAACGACAGCGTCACCAAGTCGAAGTTCGACAATCTTTATGGCTGCAAGGAATCG
CTCGTCGACGCGATCCGTCGCGGCACCGACGTGATGCTGGCGGGCAAGGTTGCGACAGTCGCCGGCTTCGGCGACGTCGG
CAAGGGCAGCGCGCAAAGCCTGCGCAACGGCGGCGCGCGCGTCCTCGTCACCGAAATCGACCCGATCTGCGCGCTGCAGG
CGGCGATGGAGGGTTTCGAGGTCGTGACGATGGACGAAGCCGTCAAGCGCTCGGACATCTTCGTCACCGCGACCGGCAAC
GCCGACGTCATCACCGCCGAACATATGGCGGCGATGAAGAATATGGCGATCGTCTGCAACATCGGCCATTTCGACAGCGA
GATCCAGATCGCGGCGCTCGCCAACTACAAGTGGACCGAAGTGAAGCCGCAGGTCGACCTGGTCGAGTTTCCCGACGGCA
AGCAGATCATCATCCTGTCGAAGGGTCGCCTGGTCAATCTCGGCAATGCGACGGGCCATCCAAGCTTCGTGATGTCGGCG
AGCTTCACCAACCAGACGCTCGCGCAGATCGAACTGTGGACGCGCAGCGAGCAGTATCAGAACGACGTCTATGTCCTGCC
CAAGCATCTCGACGAAAAGGTCGCGGCGCTGCATCTGGAAAAGCTGGGCGTGAAGCTGACCAAGCTCACGCAGAAGCAGG
CCGATTATATCGGCGTGCCGGTCGAGGGCCCGTTCAAGCCCGACCATTATCGTTATTGA

Upstream 100 bases:

>100_bases
ATTTGATCGGCGGCGCGCTTTCGGCTAGGACGCGCAAGAAAATTACACAGTTTTCGTGGCCGCTCGCCTGCGGTCGTTCC
TGCCATATATGGAGAATCCC

Downstream 100 bases:

>100_bases
CCGTTTCGCCTGCGGCGAAGGCGGCATCGGCCCGCTTCCGCTTGACGGAACCGGGATAAAATGTGGACGGCGCGCCCATC
GGACGATGCGGCGCGCCGAT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MATLAADTRDYVVADIGLADFGRKEINIAETEMPGLMALRAEYGASQPLKGARITGSLHMTIQTAVLIETLTALGAEVRW
ATCNIFSTQNHAAAAIAASGVPVFAVKGESLADYWDYVGRIFDWESDNDGRTANLILDDGGDATMFALWGAKLEAGETMP
PPENEEEVEMQRALKAFIAAKPGYLTKTVKAIKGVSEETTTGVHRLYHIAKKGELPFPAINVNDSVTKSKFDNLYGCKES
LVDAIRRGTDVMLAGKVATVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMEGFEVVTMDEAVKRSDIFVTATGN
ADVITAEHMAAMKNMAIVCNIGHFDSEIQIAALANYKWTEVKPQVDLVEFPDGKQIIILSKGRLVNLGNATGHPSFVMSA
SFTNQTLAQIELWTRSEQYQNDVYVLPKHLDEKVAALHLEKLGVKLTKLTQKQADYIGVPVEGPFKPDHYRY

Sequences:

>Translated_472_residues
MATLAADTRDYVVADIGLADFGRKEINIAETEMPGLMALRAEYGASQPLKGARITGSLHMTIQTAVLIETLTALGAEVRW
ATCNIFSTQNHAAAAIAASGVPVFAVKGESLADYWDYVGRIFDWESDNDGRTANLILDDGGDATMFALWGAKLEAGETMP
PPENEEEVEMQRALKAFIAAKPGYLTKTVKAIKGVSEETTTGVHRLYHIAKKGELPFPAINVNDSVTKSKFDNLYGCKES
LVDAIRRGTDVMLAGKVATVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMEGFEVVTMDEAVKRSDIFVTATGN
ADVITAEHMAAMKNMAIVCNIGHFDSEIQIAALANYKWTEVKPQVDLVEFPDGKQIIILSKGRLVNLGNATGHPSFVMSA
SFTNQTLAQIELWTRSEQYQNDVYVLPKHLDEKVAALHLEKLGVKLTKLTQKQADYIGVPVEGPFKPDHYRY
>Mature_471_residues
ATLAADTRDYVVADIGLADFGRKEINIAETEMPGLMALRAEYGASQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWA
TCNIFSTQNHAAAAIAASGVPVFAVKGESLADYWDYVGRIFDWESDNDGRTANLILDDGGDATMFALWGAKLEAGETMPP
PENEEEVEMQRALKAFIAAKPGYLTKTVKAIKGVSEETTTGVHRLYHIAKKGELPFPAINVNDSVTKSKFDNLYGCKESL
VDAIRRGTDVMLAGKVATVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMEGFEVVTMDEAVKRSDIFVTATGNA
DVITAEHMAAMKNMAIVCNIGHFDSEIQIAALANYKWTEVKPQVDLVEFPDGKQIIILSKGRLVNLGNATGHPSFVMSAS
FTNQTLAQIELWTRSEQYQNDVYVLPKHLDEKVAALHLEKLGVKLTKLTQKQADYIGVPVEGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=469, Percent_Identity=57.7825159914712, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=57.6923076923077, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=49.1452991452991, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=49.1452991452991, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=49.1452991452991, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=49.1452991452991, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=468, Percent_Identity=47.8632478632479, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=59.7430406852248, Blast_Score=537, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=57.201646090535, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=61.8534482758621, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24656245, Length=469, Percent_Identity=48.6140724946695, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=48.7124463519313, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=48.6021505376344, Blast_Score=426, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_SPHAL (Q1GWT5)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615220.1
- ProteinModelPortal:   Q1GWT5
- SMR:   Q1GWT5
- GeneID:   4082921
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0163
- NMPDR:   fig|317655.9.peg.142
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BioCyc:   SALA317655:SALA_0163-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51174; Mature: 51043

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 61-61 BINDING 139-139 BINDING 198-198 BINDING 228-228 BINDING 232-232 BINDING 233-233 BINDING 285-285 BINDING 320-320 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLAADTRDYVVADIGLADFGRKEINIAETEMPGLMALRAEYGASQPLKGARITGSLHM
CCCCCCCCCCEEEEECCHHHCCCCCCEEECCCCCCCEEEEHHCCCCCCCCCCEEEEEEEE
TIQTAVLIETLTALGAEVRWATCNIFSTQNHAAAAIAASGVPVFAVKGESLADYWDYVGR
EEHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEEECCCEEEEECCCHHHHHHHHHCE
IFDWESDNDGRTANLILDDGGDATMFALWGAKLEAGETMPPPENEEEVEMQRALKAFIAA
EECCCCCCCCCEEEEEEECCCCEEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHC
KPGYLTKTVKAIKGVSEETTTGVHRLYHIAKKGELPFPAINVNDSVTKSKFDNLYGCKES
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCHHHH
LVDAIRRGTDVMLAGKVATVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMEGFE
HHHHHHCCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCE
VVTMDEAVKRSDIFVTATGNADVITAEHMAAMKNMAIVCNIGHFDSEIQIAALANYKWTE
EEEHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEE
VKPQVDLVEFPDGKQIIILSKGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTRSEQYQ
CCCCEEEEECCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCCEEEEEEEECCHHHC
NDVYVLPKHLDEKVAALHLEKLGVKLTKLTQKQADYIGVPVEGPFKPDHYRY
CCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
ATLAADTRDYVVADIGLADFGRKEINIAETEMPGLMALRAEYGASQPLKGARITGSLHM
CCCCCCCCCEEEEECCHHHCCCCCCEEECCCCCCCEEEEHHCCCCCCCCCCEEEEEEEE
TIQTAVLIETLTALGAEVRWATCNIFSTQNHAAAAIAASGVPVFAVKGESLADYWDYVGR
EEHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEEECCCEEEEECCCHHHHHHHHHCE
IFDWESDNDGRTANLILDDGGDATMFALWGAKLEAGETMPPPENEEEVEMQRALKAFIAA
EECCCCCCCCCEEEEEEECCCCEEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHC
KPGYLTKTVKAIKGVSEETTTGVHRLYHIAKKGELPFPAINVNDSVTKSKFDNLYGCKES
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCHHHH
LVDAIRRGTDVMLAGKVATVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMEGFE
HHHHHHCCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHCCCE
VVTMDEAVKRSDIFVTATGNADVITAEHMAAMKNMAIVCNIGHFDSEIQIAALANYKWTE
EEEHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCEEEEEEECCCCCCEEEEEECCCEEEE
VKPQVDLVEFPDGKQIIILSKGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTRSEQYQ
CCCCEEEEECCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCCEEEEEEEECCHHHC
NDVYVLPKHLDEKVAALHLEKLGVKLTKLTQKQADYIGVPVEGPFKPDHYRY
CCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA