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The map label for this gene is trxA [H]

Identifier: 103485652

GI number: 103485652

Start: 152009

End: 152329

Strand: Reverse

Name: trxA [H]

Synonym: Sala_0156

Alternate gene names: 103485652

Gene position: 152329-152009 (Counterclockwise)

Preceding gene: 103485653

Following gene: 103485648

Centisome position: 4.55

GC content: 62.93

Gene sequence:

>321_bases
ATGGGTACCAAAGCCATCACCGACGCGAGCTTCCAGGCCGACGTGCTCGACAGCGAGACCCCCGTCCTCGTCGATTTCTG
GGCCGAATGGTGTGGCCCGTGCAAGATGATCGGCCCCGCGCTCGAAGAGATTTCGGACGAGCTCGCCGGCAAGGTCGTGA
TCGCAAAGCTCAACATCGACGACCATCCCGACGCGCCGAGCAAATATGGCGTGCGCGGCATCCCGACGATGATCCTGTTC
AAGAACGGCGAGATCGCCGACACCAAGGTCGGCGCGGCGCCCAAAAGCGCGCTCAAGGGTTGGCTTGAGGGCGCGCTTTA
A

Upstream 100 bases:

>100_bases
GGGCTTGCTGGCAACCAAGGCGAATTTGCCGGGTTCGGCCCTTGAGCCGGACGCGCCGACGCCTTAGCTTGGGGATAACC
GAGTTTCAGGAGTGCAGATC

Downstream 100 bases:

>100_bases
TTCTTCCCCCCCGTCATTGCGAGGAGCGAAGCGACGCGGCAATCCACAATGTGCAGCCTTGTGCTGGCCTGATAGCCGGT
GATTGCATCAGATATACAGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MGTKAITDASFQADVLDSETPVLVDFWAEWCGPCKMIGPALEEISDELAGKVVIAKLNIDDHPDAPSKYGVRGIPTMILF
KNGEIADTKVGAAPKSALKGWLEGAL

Sequences:

>Translated_106_residues
MGTKAITDASFQADVLDSETPVLVDFWAEWCGPCKMIGPALEEISDELAGKVVIAKLNIDDHPDAPSKYGVRGIPTMILF
KNGEIADTKVGAAPKSALKGWLEGAL
>Mature_105_residues
GTKAITDASFQADVLDSETPVLVDFWAEWCGPCKMIGPALEEISDELAGKVVIAKLNIDDHPDAPSKYGVRGIPTMILFK
NGEIADTKVGAAPKSALKGWLEGAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=48.3870967741936, Blast_Score=100, Evalue=2e-22,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=40.9638554216867, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI21361657, Length=94, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI20070125, Length=96, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=61.3861386138614, Blast_Score=134, Evalue=9e-34,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=41.304347826087, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI87081747, Length=87, Percent_Identity=35.632183908046, Blast_Score=70, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=40.625, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=44.2857142857143, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=44.2857142857143, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=85, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=76, Percent_Identity=38.1578947368421, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=78, Percent_Identity=39.7435897435897, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=70, Percent_Identity=44.2857142857143, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=45.2054794520548, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=30.5263157894737, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=36, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=37.5, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=35.4166666666667, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=42.6229508196721, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921434, Length=78, Percent_Identity=38.4615384615385, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11257; Mature: 11126

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTKAITDASFQADVLDSETPVLVDFWAEWCGPCKMIGPALEEISDELAGKVVIAKLNID
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
DHPDAPSKYGVRGIPTMILFKNGEIADTKVGAAPKSALKGWLEGAL
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GTKAITDASFQADVLDSETPVLVDFWAEWCGPCKMIGPALEEISDELAGKVVIAKLNID
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
DHPDAPSKYGVRGIPTMILFKNGEIADTKVGAAPKSALKGWLEGAL
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2137818; 3280308 [H]