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The map label for this gene is msrA2 [H]

Identifier: 103485622

GI number: 103485622

Start: 122439

End: 122954

Strand: Direct

Name: msrA2 [H]

Synonym: Sala_0126

Alternate gene names: 103485622

Gene position: 122439-122954 (Clockwise)

Preceding gene: 103485621

Following gene: 103485623

Centisome position: 3.66

GC content: 63.57

Gene sequence:

>516_bases
ATGACCGAACGTTCCATCCTTGCCGGCGGCTGCTTCTGGGGCATGCAGGACCTGATCCGCAAACTCCCCGGCGTCGTCAG
CACCCGTGTCGGTTACAGCGGCGGCGATGTGCCGAACGCGACCTATCGCAACCACGGCACGCACGCCGAGGCGATCGAGA
TCAATTTCGATCCCGATCAGATCAGCTACCGCCGGATCCTCGAATTTTTCTTCCAGATCCACGATCCGACCACGCGCAAT
CGCCAGGGCAACGACCGCGGCGGGAGCTATCGCTCGGCGATCTATTATGCCGACGAAGCGCAGCGTGAAACCGCGTTGCA
GACGATCGCGGACGTCAACGCATCCGGCCTCTGGCCGGGAAAGGTAGCGAGCGAGTTGGAGCCGATTGGCCCCTTCTGGG
AGGCGGAGCCGGAGCACCAGGATTATCTGGAGCGCCGTCCCAATGGTTACACCTGCCACTTTCCGCGCGCCGCCTGGGTC
CTTCCATCGGCCGGCGAGCGGTCTGAGGCAGCTTGA

Upstream 100 bases:

>100_bases
GCTACTGCATCAACTCGGCTTCACTCCGCTTCGTCCACCGCGATGACATGGAAGCCGAGGGCTATTCCGAATTTCTGAAC
CAGATCGAGGAGAATTGATC

Downstream 100 bases:

>100_bases
TCGGAGACATGAAATGAAACCGAACATAACCCTCTATACCAAGGACTATTGCCCCTTTTGTCACCGGGCCAAGGCGCATC
TTCGCGCCAAGGGGGTGACC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTERSILAGGCFWGMQDLIRKLPGVVSTRVGYSGGDVPNATYRNHGTHAEAIEINFDPDQISYRRILEFFFQIHDPTTRN
RQGNDRGGSYRSAIYYADEAQRETALQTIADVNASGLWPGKVASELEPIGPFWEAEPEHQDYLERRPNGYTCHFPRAAWV
LPSAGERSEAA

Sequences:

>Translated_171_residues
MTERSILAGGCFWGMQDLIRKLPGVVSTRVGYSGGDVPNATYRNHGTHAEAIEINFDPDQISYRRILEFFFQIHDPTTRN
RQGNDRGGSYRSAIYYADEAQRETALQTIADVNASGLWPGKVASELEPIGPFWEAEPEHQDYLERRPNGYTCHFPRAAWV
LPSAGERSEAA
>Mature_170_residues
TERSILAGGCFWGMQDLIRKLPGVVSTRVGYSGGDVPNATYRNHGTHAEAIEINFDPDQISYRRILEFFFQIHDPTTRNR
QGNDRGGSYRSAIYYADEAQRETALQTIADVNASGLWPGKVASELEPIGPFWEAEPEHQDYLERRPNGYTCHFPRAAWVL
PSAGERSEAA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=36.9426751592357, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=36.9426751592357, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=37.3831775700935, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.7631578947368, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=38.3561643835616, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.7469879518072, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=35.9154929577465, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=35.9154929577465, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=34.7222222222222, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19205; Mature: 19074

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERSILAGGCFWGMQDLIRKLPGVVSTRVGYSGGDVPNATYRNHGTHAEAIEINFDPDQ
CCCCCEECCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCH
ISYRRILEFFFQIHDPTTRNRQGNDRGGSYRSAIYYADEAQRETALQTIADVNASGLWPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCC
KVASELEPIGPFWEAEPEHQDYLERRPNGYTCHFPRAAWVLPSAGERSEAA
HHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TERSILAGGCFWGMQDLIRKLPGVVSTRVGYSGGDVPNATYRNHGTHAEAIEINFDPDQ
CCCCEECCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCH
ISYRRILEFFFQIHDPTTRNRQGNDRGGSYRSAIYYADEAQRETALQTIADVNASGLWPG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCC
KVASELEPIGPFWEAEPEHQDYLERRPNGYTCHFPRAAWVLPSAGERSEAA
HHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]