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The map label for this gene is trxA [H]

Identifier: 99082687

GI number: 99082687

Start: 3019090

End: 3019410

Strand: Direct

Name: trxA [H]

Synonym: TM1040_2847

Alternate gene names: 99082687

Gene position: 3019090-3019410 (Clockwise)

Preceding gene: 99082686

Following gene: 99082689

Centisome position: 94.32

GC content: 60.12

Gene sequence:

>321_bases
ATGTCCACCGTAGCCGTTACCGACGCCACCTTCGACGCCGAAGTCAAGAATTCCGATGTCCCCGTTGTGGTGGACTTCTG
GGCCGAATGGTGTGGCCCGTGCAAACAGATCGGCCCCGCTCTGGAAGAGCTGGCAGCCGAGTATGGCGACAAGGTAAAAA
TCGCCAAGGTTGATGTCGACAGCAACCCGAATGCCGCTGCTGCCATGGGTGTGCGCGGCATTCCAGCTCTGTTCGTGTTC
AAGGATGGTCAGGTGGTTTCCAACCGCGCCGGCGCCGCTCCCAAGGCCGCGCTCAAGAGCTGGATCGACGAATCCATCTG
A

Upstream 100 bases:

>100_bases
GCCCGTGAACGGGCGGGTTTCCAGCGACTGGAACCTTGACGCCATGTCTGAGCGTCCATAGGTTTCGCTCCAGTTGCCAA
TCTTCTCAGGAGACATATCC

Downstream 100 bases:

>100_bases
TCTGAGACCCAGATAAACATAGAAAAGGCGCGTCCCTCGGGAGGCGCCTTTTTTCATGAGAATGTGGAGAGCCACCCCAC
AAAAGGAAAAGCCGCCCTGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSTVAVTDATFDAEVKNSDVPVVVDFWAEWCGPCKQIGPALEELAAEYGDKVKIAKVDVDSNPNAAAAMGVRGIPALFVF
KDGQVVSNRAGAAPKAALKSWIDESI

Sequences:

>Translated_106_residues
MSTVAVTDATFDAEVKNSDVPVVVDFWAEWCGPCKQIGPALEELAAEYGDKVKIAKVDVDSNPNAAAAMGVRGIPALFVF
KDGQVVSNRAGAAPKAALKSWIDESI
>Mature_105_residues
STVAVTDATFDAEVKNSDVPVVVDFWAEWCGPCKQIGPALEELAAEYGDKVKIAKVDVDSNPNAAAAMGVRGIPALFVFK
DGQVVSNRAGAAPKAALKSWIDESI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=107, Percent_Identity=38.3177570093458, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=46.6019417475728, Blast_Score=115, Evalue=4e-28,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=42.7184466019417, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI87081747, Length=87, Percent_Identity=36.7816091954023, Blast_Score=75, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=39.3617021276596, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=37.5, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=38.8888888888889, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=104, Percent_Identity=33.6538461538462, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=103, Percent_Identity=38.8349514563107, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=106, Percent_Identity=37.7358490566038, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=102, Percent_Identity=40.1960784313725, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=38, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=37.6344086021505, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639826, Length=75, Percent_Identity=42.6666666666667, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358065, Length=92, Percent_Identity=38.0434782608696, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=43.2432432432432, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=43.2432432432432, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=42.6229508196721, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24658597, Length=108, Percent_Identity=37.962962962963, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11152; Mature: 11020

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAVTDATFDAEVKNSDVPVVVDFWAEWCGPCKQIGPALEELAAEYGDKVKIAKVDVD
CCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
SNPNAAAAMGVRGIPALFVFKDGQVVSNRAGAAPKAALKSWIDESI
CCCCHHHHCCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
STVAVTDATFDAEVKNSDVPVVVDFWAEWCGPCKQIGPALEELAAEYGDKVKIAKVDVD
CCEEECCCCCCCCCCCCCCCEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
SNPNAAAAMGVRGIPALFVFKDGQVVSNRAGAAPKAALKSWIDESI
CCCCHHHHCCCCCCCEEEEEECCEEECCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2137818; 3280308 [H]