Click here to switch to the map view.

The map label for this gene is ade

Identifier: 99082639

GI number: 99082639

Start: 2960323

End: 2962128

Strand: Direct

Name: ade

Synonym: TM1040_2799

Alternate gene names: 99082639

Gene position: 2960323-2962128 (Clockwise)

Preceding gene: 99082637

Following gene: 99082640

Centisome position: 92.48

GC content: 60.02

Gene sequence:

>1806_bases
ATGACACATAAGACCTTCCCAAGCTGGCCCGACGTCGCCCCCCAACTGATCGAAACTGCTGCCGGACGCAGCCCCGCCGA
TACCGTGATCCGTAACGGTAAATGGGTGAACGTGCACACGCGCGAGGTTCTTGAGGGACATGACATCGCGATCAAGGCAG
GCAGGATCGCCTATGTCGGACCGGATGCCTCCTATTGCACGGGGCCAGAGACCGAGGTGATCGACGCTGAGGGGCGCTAC
ATGATGCCTGGGCTCTGCGATGGACATATGCACATCGAATCCGGGATGCTGACCCCCGCAGAATTCGCCCGCGCCGTTAT
CCCGCATGGCACAACGACCATGTTCACTGACCCGCATGAGATCGCAAATGTCCTGGGACTTGAGGGCGTGCGCTTGATGC
ATGACGAGGCGCTGTTGCAGCCGGTCAATATCTACACGCAGATGCCGTCCTGCGCCCCCTCTGCGCCGGGGCTGGAGACC
ACCGGCTATGAGATCTCCGCCGAGGATGTCGCTGAGGCCATGACCTGGCCGGGGATCATCGGCCTCGGTGAAATGATGAA
TTTTCCGGGTGTCGCTCATGGTGATCCAAAGATGCTAGCGGAAATCGCCGCAACCCAGCGCTCCGGCAAAACTGTAGGCG
GCCACTATGCCTCGCCAGATCTTGGACCGGATTTTGCAGCCTATGTGGCAGGCGGCCCCGCAGATGACCACGAAGGCACC
TGTGAGGCGGACGCCATCACACGGATGCGACAGGGCATGCGGGCAATGGTGCGCCTCGGATCCGCCTGGTATGACGTCGA
GGCCCAGATCACAGCGATCACCGAGAAGGGCCTTGATCCGCGCAATTTCATCCTTTGCACCGATGACTGCCACTCCGGAA
CGTTGGTCAATGAGGGTCATATGAACCGCGCAGTGCGTCACGCAATCGACTGCGGCTGCGATCCGCTGATCGCGATCCAG
ATGGCGACGATCAACACCGCAACACACTTTGGGCTCGAGCGCGAAATTGGCTCCATCACCCCCGGTCGACGGGCCGATAT
CATCCTGACATCTGACCTGAAAACGCTGCCCATCGAAGTGGTGATCGCGCGTGGGCAGATTGTGGCTGAATCAGGCTCTA
TTAAGGTGGAATGCCCCCATCTTGATTGGCCAGAAAGCGCTCGCGGTACGGTGCACCTGGGCCACACGCTCGCTGCGACG
GACTTTGAACTGGCAGCACCAGAAGGGGCAAATGCCGTCACCGCAAATGTGATTGGCGTGGTGGAGAACCAAGCCCCGAC
CAAAGCGCTCAAAGCGGAGCTGCCGGTGCGCGATGGTCTGGTTGAGGGTGAAGGCGATGTCTGCCAGATCGCCCTGGTTG
AGCGTCACCGGGCCACAGGCGGCGTGACCAACGCCTTCGTGTCGGGTTTCGGCTACGAAGGGAAAATGGCGATGGCCTCG
ACCGTGGCGCATGACAGCCATCACATGATTGTGGTCGGCACTGACCGCACCCAAATGGCCCTTGCCGCCAACCGTCTGGC
CGAGGTCGGCGGTGGCATCACGATTTTCCGGGATGGCGCAGAGCTGGCGTTGGTGGAGCTGCCTATTGCCGGTCTGATGT
CTGACAGCCCTGCCTCAGAGGTCGCCGCCAATGCACAGAAACTCGTGGAGGCCATGCAGGCCTGCGGCTGCACTCTGAAC
AATGCCTATATGCAACACTCTCTCTTGGCACTTGTGGTGATCCCGGAACTGCGGATCAGCGATCTTGGCCTTGTAGACGT
GCGTAGTTTCAAGAAAATTCCAGTAATCGAGCCGTTCAATGAATGA

Upstream 100 bases:

>100_bases
TGACGATATCCAAGGGCGTGCTCCGGCATGAGGTCATGAGGCTGTTATGAACTCGGATTACGGGTCTTGCACCCATCTGC
GCAATCAATAACAGTAGGCC

Downstream 100 bases:

>100_bases
TGTAAAAACACCCGACCTGCCCGCTGCCGAAAGCTTTACCGACGCCAAAGCGGCCGTAGCGCGCCTGATTGAGCTCTACG
ATAGCGCAACCAATTTTCTC

Product: adenine deaminase

Products: NA

Alternate protein names: Adenase; Adenine aminase

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MTHKTFPSWPDVAPQLIETAAGRSPADTVIRNGKWVNVHTREVLEGHDIAIKAGRIAYVGPDASYCTGPETEVIDAEGRY
MMPGLCDGHMHIESGMLTPAEFARAVIPHGTTTMFTDPHEIANVLGLEGVRLMHDEALLQPVNIYTQMPSCAPSAPGLET
TGYEISAEDVAEAMTWPGIIGLGEMMNFPGVAHGDPKMLAEIAATQRSGKTVGGHYASPDLGPDFAAYVAGGPADDHEGT
CEADAITRMRQGMRAMVRLGSAWYDVEAQITAITEKGLDPRNFILCTDDCHSGTLVNEGHMNRAVRHAIDCGCDPLIAIQ
MATINTATHFGLEREIGSITPGRRADIILTSDLKTLPIEVVIARGQIVAESGSIKVECPHLDWPESARGTVHLGHTLAAT
DFELAAPEGANAVTANVIGVVENQAPTKALKAELPVRDGLVEGEGDVCQIALVERHRATGGVTNAFVSGFGYEGKMAMAS
TVAHDSHHMIVVGTDRTQMALAANRLAEVGGGITIFRDGAELALVELPIAGLMSDSPASEVAANAQKLVEAMQACGCTLN
NAYMQHSLLALVVIPELRISDLGLVDVRSFKKIPVIEPFNE

Sequences:

>Translated_601_residues
MTHKTFPSWPDVAPQLIETAAGRSPADTVIRNGKWVNVHTREVLEGHDIAIKAGRIAYVGPDASYCTGPETEVIDAEGRY
MMPGLCDGHMHIESGMLTPAEFARAVIPHGTTTMFTDPHEIANVLGLEGVRLMHDEALLQPVNIYTQMPSCAPSAPGLET
TGYEISAEDVAEAMTWPGIIGLGEMMNFPGVAHGDPKMLAEIAATQRSGKTVGGHYASPDLGPDFAAYVAGGPADDHEGT
CEADAITRMRQGMRAMVRLGSAWYDVEAQITAITEKGLDPRNFILCTDDCHSGTLVNEGHMNRAVRHAIDCGCDPLIAIQ
MATINTATHFGLEREIGSITPGRRADIILTSDLKTLPIEVVIARGQIVAESGSIKVECPHLDWPESARGTVHLGHTLAAT
DFELAAPEGANAVTANVIGVVENQAPTKALKAELPVRDGLVEGEGDVCQIALVERHRATGGVTNAFVSGFGYEGKMAMAS
TVAHDSHHMIVVGTDRTQMALAANRLAEVGGGITIFRDGAELALVELPIAGLMSDSPASEVAANAQKLVEAMQACGCTLN
NAYMQHSLLALVVIPELRISDLGLVDVRSFKKIPVIEPFNE
>Mature_600_residues
THKTFPSWPDVAPQLIETAAGRSPADTVIRNGKWVNVHTREVLEGHDIAIKAGRIAYVGPDASYCTGPETEVIDAEGRYM
MPGLCDGHMHIESGMLTPAEFARAVIPHGTTTMFTDPHEIANVLGLEGVRLMHDEALLQPVNIYTQMPSCAPSAPGLETT
GYEISAEDVAEAMTWPGIIGLGEMMNFPGVAHGDPKMLAEIAATQRSGKTVGGHYASPDLGPDFAAYVAGGPADDHEGTC
EADAITRMRQGMRAMVRLGSAWYDVEAQITAITEKGLDPRNFILCTDDCHSGTLVNEGHMNRAVRHAIDCGCDPLIAIQM
ATINTATHFGLEREIGSITPGRRADIILTSDLKTLPIEVVIARGQIVAESGSIKVECPHLDWPESARGTVHLGHTLAATD
FELAAPEGANAVTANVIGVVENQAPTKALKAELPVRDGLVEGEGDVCQIALVERHRATGGVTNAFVSGFGYEGKMAMAST
VAHDSHHMIVVGTDRTQMALAANRLAEVGGGITIFRDGAELALVELPIAGLMSDSPASEVAANAQKLVEAMQACGCTLNN
AYMQHSLLALVVIPELRISDLGLVDVRSFKKIPVIEPFNE

Specific function: Unknown

COG id: COG1001

COG function: function code F; Adenine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenine deaminase family

Homologues:

Organism=Escherichia coli, GI1790098, Length=578, Percent_Identity=32.6989619377163, Blast_Score=271, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADEC_SILST (Q1GCT5)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614793.1
- ProteinModelPortal:   Q1GCT5
- STRING:   Q1GCT5
- GeneID:   4076567
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2799
- NMPDR:   fig|292414.1.peg.1703
- eggNOG:   COG1001
- HOGENOM:   HBG725357
- OMA:   VGLGEMM
- PhylomeDB:   Q1GCT5
- ProtClustDB:   CLSK862922
- BioCyc:   SSP292414:TM1040_2799-MONOMER
- HAMAP:   MF_01518
- InterPro:   IPR006679
- InterPro:   IPR006680
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01178

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.2

Molecular weight: Translated: 63890; Mature: 63758

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHKTFPSWPDVAPQLIETAAGRSPADTVIRNGKWVNVHTREVLEGHDIAIKAGRIAYVG
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCEEEEEEHHHHHCCCCEEEECCEEEEEC
PDASYCTGPETEVIDAEGRYMMPGLCDGHMHIESGMLTPAEFARAVIPHGTTTMFTDPHE
CCCCCCCCCCCEEEECCCCEECCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEECHHH
IANVLGLEGVRLMHDEALLQPVNIYTQMPSCAPSAPGLETTGYEISAEDVAEAMTWPGII
HHHHHCCCCEEEECHHHHHCHHHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCE
GLGEMMNFPGVAHGDPKMLAEIAATQRSGKTVGGHYASPDLGPDFAAYVAGGPADDHEGT
EHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCC
CEADAITRMRQGMRAMVRLGSAWYDVEAQITAITEKGLDPRNFILCTDDCHSGTLVNEGH
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCEEEECCCCCCCCEECCCH
MNRAVRHAIDCGCDPLIAIQMATINTATHFGLEREIGSITPGRRADIILTSDLKTLPIEV
HHHHHHHHHHCCCCCEEEEEEEEECHHHHCCHHHHHCCCCCCCCEEEEEECCCCCCCEEE
VIARGQIVAESGSIKVECPHLDWPESARGTVHLGHTLAATDFELAAPEGANAVTANVIGV
EEECCEEEEECCCEEEECCCCCCCCCCCCEEEECCEEEECCCEEECCCCCCEEEEEEEEE
VENQAPTKALKAELPVRDGLVEGEGDVCQIALVERHRATGGVTNAFVSGFGYEGKMAMAS
ECCCCCHHHHHHCCCHHCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHCCCCCCCCHHHH
TVAHDSHHMIVVGTDRTQMALAANRLAEVGGGITIFRDGAELALVELPIAGLMSDSPASE
HHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHHCCCCCHHH
VAANAQKLVEAMQACGCTLNNAYMQHSLLALVVIPELRISDLGLVDVRSFKKIPVIEPFN
HHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEECCCCCCCCCEEEHHCCCCCCCCCCCC
E
C
>Mature Secondary Structure 
THKTFPSWPDVAPQLIETAAGRSPADTVIRNGKWVNVHTREVLEGHDIAIKAGRIAYVG
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCEEEEEEHHHHHCCCCEEEECCEEEEEC
PDASYCTGPETEVIDAEGRYMMPGLCDGHMHIESGMLTPAEFARAVIPHGTTTMFTDPHE
CCCCCCCCCCCEEEECCCCEECCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEECHHH
IANVLGLEGVRLMHDEALLQPVNIYTQMPSCAPSAPGLETTGYEISAEDVAEAMTWPGII
HHHHHCCCCEEEECHHHHHCHHHHHHCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCE
GLGEMMNFPGVAHGDPKMLAEIAATQRSGKTVGGHYASPDLGPDFAAYVAGGPADDHEGT
EHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEECCCCCCCCCCC
CEADAITRMRQGMRAMVRLGSAWYDVEAQITAITEKGLDPRNFILCTDDCHSGTLVNEGH
CCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCEEEECCCCCCCCEECCCH
MNRAVRHAIDCGCDPLIAIQMATINTATHFGLEREIGSITPGRRADIILTSDLKTLPIEV
HHHHHHHHHHCCCCCEEEEEEEEECHHHHCCHHHHHCCCCCCCCEEEEEECCCCCCCEEE
VIARGQIVAESGSIKVECPHLDWPESARGTVHLGHTLAATDFELAAPEGANAVTANVIGV
EEECCEEEEECCCEEEECCCCCCCCCCCCEEEECCEEEECCCEEECCCCCCEEEEEEEEE
VENQAPTKALKAELPVRDGLVEGEGDVCQIALVERHRATGGVTNAFVSGFGYEGKMAMAS
ECCCCCHHHHHHCCCHHCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHCCCCCCCCHHHH
TVAHDSHHMIVVGTDRTQMALAANRLAEVGGGITIFRDGAELALVELPIAGLMSDSPASE
HHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECHHHHCCCCCHHH
VAANAQKLVEAMQACGCTLNNAYMQHSLLALVVIPELRISDLGLVDVRSFKKIPVIEPFN
HHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEECCCCCCCCCEEEHHCCCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA