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The map label for this gene is pbpC [H]

Identifier: 99082612

GI number: 99082612

Start: 2923147

End: 2925219

Strand: Reverse

Name: pbpC [H]

Synonym: TM1040_2772

Alternate gene names: 99082612

Gene position: 2925219-2923147 (Counterclockwise)

Preceding gene: 99082613

Following gene: 99082611

Centisome position: 91.39

GC content: 63.87

Gene sequence:

>2073_bases
GTGGCAGGCCCTCACAGGCGCTGGCGCTCACCGCTCAGGCTTCCACTTCTGGGCCTGCTGATTGCAGCGGTCATTGCGGG
AAAAGCGCTGGATCAATGGGTTGAGGACACGCGCCTACCACAGACCTTGGCCGAAACTTCGGTTGAAGTGCGGGACCGCC
ATGGTCGGCTCCTGCGCGCTTTTCCGGTAGAAGATGGCATCTGGCGCATGGCGGTCCGCTCTGAAGAAGTGGACCCCACG
TATCTGCGCATGTTGCGCGCCTATGAAGACAAACGGTTCGACACCCACTTCGGAGTAGATCCGGTCGCGATGCTGCGCGC
CTTTGGGCAGGCCGTGTGGAATGGACGGACCGTCTCGGGGGGCTCCACTCTCACGATGCAGGTCGCACGGTTGCTCGAGG
ATGGGCCGACCGGGCGCTGGTCTGGAAAGCTGCGCCAGATCCGTGTCGCGCTGGCTCTGGAACGCAAGCTCTCCAAGACC
GAGATCCTCAATCTCTACCTCATTCACGCACCATTTGGTGGGAATCTCGAAGGGGTGCGCGCCGCAAGTCTTTCCTGGTT
TGGCAAGGAGCCACATCGCTTGACCGCTGCGGAAGCTGCGCTTCTGGTGGCACTGCCGCAATCACCAGAGACACGCCGTC
CTGACCGATCGGTAAGTGCGGCGCGAGAGGCACGGAGACGCGTGCTCAATCGCAGCCAAGACGCAGGCGTACTGACGACG
GAAGTGGCACATCTCGCCGCCGTTGCGCCGCTACCTGACAGGCGGCGGGCGTTCCCCCTGCTGGCACCTCATCTGAGCGA
TCAACTCCGCGCGACAGCCCCGGCACAGGCGCGGTTTGACACCACATTGGATGCGATGCTTCAGGCGCGGCTTCAGGCGG
TGCTATCGCGCAGGGTCAAGGTCTCTGGTGCACGGCTGAGCGCAGCGATGATTGTTGCCGATCACCAAAGCGGGGAGATA
TTGGTGCGGATCGGGGCGCCCGATTACACGGATACCGCGCGGCGGAGTTACGTCGATATGGCGCGCGCGGTGCGTTCGCC
GGGCTCTACTCTGAAACCGCTGGTCTACGGTCTCGCCTTTGACGATGGGCTTGCGCATCCTGATACGCTGATCCGCGATG
CGCCCGTGTCCTTTGGTGGCTACGCACCTCAGAACTTTGATGGTGCATTTCGCGGAGATGTGCGGGTGCGCGACGCGTTG
CAGATGTCTTTGAACACCCCGGTCGTCACCTTGACCGAGGCGCTTGGACCGTCGCGGCTGATGGCCGCAATGCGGCAGGT
CGGCATGCGACCCCAACTCCCTAGCGGAAAGCCGGGGCTGGCGGTCAGCCTCGGCGGTGTTGGTGTGAGTCTTCATGATC
TGGTGCAAATGTATGCGGTCGTTGCTGCCGGCGGAACGGCACCGAGGCTTACCTCCGAGACCGGAGCTGCGCGGGAAAAG
ACCCCAAGGGTAATGTCGCCGGTTGCAGCTTGGTATCTTGGGGACATCCTGCGCGATGCTCCGGCGCCCGCCGGGGCGCG
CGGTGGTATGTTGCCCTACAAGACAGGCACGTCTTACGGGCACCGAGATGCTTGGGCTGTGGGCTGGGACGGGCGGCATG
TGATCGGAGTCTGGCTCGGACGAGCGGACGGCACGCCGGTGCCGGGTGTCTTTGGCGCGGAGCTGGCGGCACCGGTGCTG
TTCGAAGCCTTTGCCGTTTTAAAACCGGAGATTGATCCTCTGTCCCCGCCCCCTTCGAACGCACTGGTGTTGGAGACCGC
AGAGCTCCCGGCCCCTCTGCAACGGTTTCGCGCCCGGTCAGAGACTTTTTCAGAGGCCGGCGCCGGGGCGCCAGAGGTGC
TTTTCCCACCCACCCATGCCCGGCTTTCGTTGGTGGAGGGGCGGATGGCGTTGAAATTGCGGGGAGGTCGGTTGCCCTTT
ACCGTGCTGGCCAATGGCGTGCCGGTGGCCCAAGGCCTGAGGTCACGCGACCTCGACCTTCCGAGCCCCGGGCCGGGCCA
TGCAACGCTTGTGGTGATCGATGCAGACGGGCAATCTGCACGGGTGACCGTTGAAATCGAGGAGACCGGCTAA

Upstream 100 bases:

>100_bases
GCCGGATTGGCTTCGCCTGCAAAGGGCGCCCGCTGAGCGGCGGGCGCATCAGACTTCTGCTGCGCCCGGGCGTGTCCTTA
CCGATCGGTCAGTTGGCAGT

Downstream 100 bases:

>100_bases
TGCGCTGGCTTGAGGAGAAAAGAGGCATTTCGTTGAGAACATCGGGTCTGGTTGGAATCCTGACGATGAGCGTAGCTCTG
ACCCTTGGAACAGATATTGC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MAGPHRRWRSPLRLPLLGLLIAAVIAGKALDQWVEDTRLPQTLAETSVEVRDRHGRLLRAFPVEDGIWRMAVRSEEVDPT
YLRMLRAYEDKRFDTHFGVDPVAMLRAFGQAVWNGRTVSGGSTLTMQVARLLEDGPTGRWSGKLRQIRVALALERKLSKT
EILNLYLIHAPFGGNLEGVRAASLSWFGKEPHRLTAAEAALLVALPQSPETRRPDRSVSAAREARRRVLNRSQDAGVLTT
EVAHLAAVAPLPDRRRAFPLLAPHLSDQLRATAPAQARFDTTLDAMLQARLQAVLSRRVKVSGARLSAAMIVADHQSGEI
LVRIGAPDYTDTARRSYVDMARAVRSPGSTLKPLVYGLAFDDGLAHPDTLIRDAPVSFGGYAPQNFDGAFRGDVRVRDAL
QMSLNTPVVTLTEALGPSRLMAAMRQVGMRPQLPSGKPGLAVSLGGVGVSLHDLVQMYAVVAAGGTAPRLTSETGAAREK
TPRVMSPVAAWYLGDILRDAPAPAGARGGMLPYKTGTSYGHRDAWAVGWDGRHVIGVWLGRADGTPVPGVFGAELAAPVL
FEAFAVLKPEIDPLSPPPSNALVLETAELPAPLQRFRARSETFSEAGAGAPEVLFPPTHARLSLVEGRMALKLRGGRLPF
TVLANGVPVAQGLRSRDLDLPSPGPGHATLVVIDADGQSARVTVEIEETG

Sequences:

>Translated_690_residues
MAGPHRRWRSPLRLPLLGLLIAAVIAGKALDQWVEDTRLPQTLAETSVEVRDRHGRLLRAFPVEDGIWRMAVRSEEVDPT
YLRMLRAYEDKRFDTHFGVDPVAMLRAFGQAVWNGRTVSGGSTLTMQVARLLEDGPTGRWSGKLRQIRVALALERKLSKT
EILNLYLIHAPFGGNLEGVRAASLSWFGKEPHRLTAAEAALLVALPQSPETRRPDRSVSAAREARRRVLNRSQDAGVLTT
EVAHLAAVAPLPDRRRAFPLLAPHLSDQLRATAPAQARFDTTLDAMLQARLQAVLSRRVKVSGARLSAAMIVADHQSGEI
LVRIGAPDYTDTARRSYVDMARAVRSPGSTLKPLVYGLAFDDGLAHPDTLIRDAPVSFGGYAPQNFDGAFRGDVRVRDAL
QMSLNTPVVTLTEALGPSRLMAAMRQVGMRPQLPSGKPGLAVSLGGVGVSLHDLVQMYAVVAAGGTAPRLTSETGAAREK
TPRVMSPVAAWYLGDILRDAPAPAGARGGMLPYKTGTSYGHRDAWAVGWDGRHVIGVWLGRADGTPVPGVFGAELAAPVL
FEAFAVLKPEIDPLSPPPSNALVLETAELPAPLQRFRARSETFSEAGAGAPEVLFPPTHARLSLVEGRMALKLRGGRLPF
TVLANGVPVAQGLRSRDLDLPSPGPGHATLVVIDADGQSARVTVEIEETG
>Mature_689_residues
AGPHRRWRSPLRLPLLGLLIAAVIAGKALDQWVEDTRLPQTLAETSVEVRDRHGRLLRAFPVEDGIWRMAVRSEEVDPTY
LRMLRAYEDKRFDTHFGVDPVAMLRAFGQAVWNGRTVSGGSTLTMQVARLLEDGPTGRWSGKLRQIRVALALERKLSKTE
ILNLYLIHAPFGGNLEGVRAASLSWFGKEPHRLTAAEAALLVALPQSPETRRPDRSVSAAREARRRVLNRSQDAGVLTTE
VAHLAAVAPLPDRRRAFPLLAPHLSDQLRATAPAQARFDTTLDAMLQARLQAVLSRRVKVSGARLSAAMIVADHQSGEIL
VRIGAPDYTDTARRSYVDMARAVRSPGSTLKPLVYGLAFDDGLAHPDTLIRDAPVSFGGYAPQNFDGAFRGDVRVRDALQ
MSLNTPVVTLTEALGPSRLMAAMRQVGMRPQLPSGKPGLAVSLGGVGVSLHDLVQMYAVVAAGGTAPRLTSETGAAREKT
PRVMSPVAAWYLGDILRDAPAPAGARGGMLPYKTGTSYGHRDAWAVGWDGRHVIGVWLGRADGTPVPGVFGAELAAPVLF
EAFAVLKPEIDPLSPPPSNALVLETAELPAPLQRFRARSETFSEAGAGAPEVLFPPTHARLSLVEGRMALKLRGGRLPFT
VLANGVPVAQGLRSRDLDLPSPGPGHATLVVIDADGQSARVTVEIEETG

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=545, Percent_Identity=43.6697247706422, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786343, Length=569, Percent_Identity=26.5377855887522, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87082258, Length=283, Percent_Identity=28.9752650176678, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1789601, Length=140, Percent_Identity=33.5714285714286, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 74269; Mature: 74138

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPHRRWRSPLRLPLLGLLIAAVIAGKALDQWVEDTRLPQTLAETSVEVRDRHGRLLRA
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
FPVEDGIWRMAVRSEEVDPTYLRMLRAYEDKRFDTHFGVDPVAMLRAFGQAVWNGRTVSG
ECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECC
GSTLTMQVARLLEDGPTGRWSGKLRQIRVALALERKLSKTEILNLYLIHAPFGGNLEGVR
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHEEEEEEEEECCCCCCCCCEE
AASLSWFGKEPHRLTAAEAALLVALPQSPETRRPDRSVSAAREARRRVLNRSQDAGVLTT
EEHHHHCCCCCCHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
EVAHLAAVAPLPDRRRAFPLLAPHLSDQLRATAPAQARFDTTLDAMLQARLQAVLSRRVK
HHHHHHHHCCCCCCCCCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VSGARLSAAMIVADHQSGEILVRIGAPDYTDTARRSYVDMARAVRSPGSTLKPLVYGLAF
CCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEEC
DDGLAHPDTLIRDAPVSFGGYAPQNFDGAFRGDVRVRDALQMSLNTPVVTLTEALGPSRL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCEEEEHHHCCHHHH
MAAMRQVGMRPQLPSGKPGLAVSLGGVGVSLHDLVQMYAVVAAGGTAPRLTSETGAAREK
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHC
TPRVMSPVAAWYLGDILRDAPAPAGARGGMLPYKTGTSYGHRDAWAVGWDGRHVIGVWLG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEE
RADGTPVPGVFGAELAAPVLFEAFAVLKPEIDPLSPPPSNALVLETAELPAPLQRFRARS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
ETFSEAGAGAPEVLFPPTHARLSLVEGRMALKLRGGRLPFTVLANGVPVAQGLRSRDLDL
HHHHHHCCCCCCEECCCCCHHHEECCCEEEEEEECCCCCEEEEECCCCHHHCHHHCCCCC
PSPGPGHATLVVIDADGQSARVTVEIEETG
CCCCCCCEEEEEEECCCCCEEEEEEEECCC
>Mature Secondary Structure 
AGPHRRWRSPLRLPLLGLLIAAVIAGKALDQWVEDTRLPQTLAETSVEVRDRHGRLLRA
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEE
FPVEDGIWRMAVRSEEVDPTYLRMLRAYEDKRFDTHFGVDPVAMLRAFGQAVWNGRTVSG
ECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECC
GSTLTMQVARLLEDGPTGRWSGKLRQIRVALALERKLSKTEILNLYLIHAPFGGNLEGVR
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHEEEEEEEEECCCCCCCCCEE
AASLSWFGKEPHRLTAAEAALLVALPQSPETRRPDRSVSAAREARRRVLNRSQDAGVLTT
EEHHHHCCCCCCHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
EVAHLAAVAPLPDRRRAFPLLAPHLSDQLRATAPAQARFDTTLDAMLQARLQAVLSRRVK
HHHHHHHHCCCCCCCCCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VSGARLSAAMIVADHQSGEILVRIGAPDYTDTARRSYVDMARAVRSPGSTLKPLVYGLAF
CCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEEC
DDGLAHPDTLIRDAPVSFGGYAPQNFDGAFRGDVRVRDALQMSLNTPVVTLTEALGPSRL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCEEEEHHHCCHHHH
MAAMRQVGMRPQLPSGKPGLAVSLGGVGVSLHDLVQMYAVVAAGGTAPRLTSETGAAREK
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHC
TPRVMSPVAAWYLGDILRDAPAPAGARGGMLPYKTGTSYGHRDAWAVGWDGRHVIGVWLG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEEE
RADGTPVPGVFGAELAAPVLFEAFAVLKPEIDPLSPPPSNALVLETAELPAPLQRFRARS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
ETFSEAGAGAPEVLFPPTHARLSLVEGRMALKLRGGRLPFTVLANGVPVAQGLRSRDLDL
HHHHHHCCCCCCEECCCCCHHHEECCCEEEEEEECCCCCEEEEECCCCHHHCHHHCCCCC
PSPGPGHATLVVIDADGQSARVTVEIEETG
CCCCCCCEEEEEEECCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]