Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 99082368

GI number: 99082368

Start: 2668364

End: 2669401

Strand: Reverse

Name: hemE

Synonym: TM1040_2528

Alternate gene names: 99082368

Gene position: 2669401-2668364 (Counterclockwise)

Preceding gene: 99082370

Following gene: 99082366

Centisome position: 83.39

GC content: 60.98

Gene sequence:

>1038_bases
ATGGGCCAACAGAAGACGATCCTACGCGCATTGGCAGGCGAAACGCAGGCCGTGCCGCCGATTTGGATGATGCGTCAGGC
CGGGCGTTACCTGCCCGAATACCGCGCGACCCGGGCACAGGCCGGGGATTTTCTGAGTCTATGCTACAATCCCGAACTGG
CGGCAGAGGTGACACTGCAGCCCATTCGTCGCTATGGCTTTGATGCGGCTATCCTGTTTGCCGATATTCTTCTGGTGCCA
CAGGCGCTGGGGGCAGACCTTTGGTTTGTCACCGGCGAGGGGCCGCGCCTCTCCACGATCACGACAGATGCGGATTTTGC
CAAGCTGGGGCCAGCCAGTGATGTGCACGAAACCCTGAGCCCGATTTACGAGACGGTGCGAATTCTGTCGAAAGAGCTGC
CGTCGGAGACCACCTTGATCGGGTTTGCGGGCGCGCCATGGACGGTTGCGACCTATATGATCGCAGGACGTGGAACGCCG
GATCAGGGACCGGCGCATGCCTTGATGCAGGAAAACACCCCCCTGTTCGAGGCGCTTTTGGCACGGATTACCGAGGCGAC
CATCAGCTATCTCTCAGCCCAGATCGAAGCTGGCGCAGAGGTTGTGAAGATCTTTGACAGCTGGGCGGGATCGCTCAAGG
GAGAGGCATTTGACAAATACGCGCTCGAGCCGGCACGTCAGATCACCGCGGCCCTGAAGGCGCGCCACCCGCATGTCCCC
GTAATCGGCTTTCCGCGCGAGGCCGGCGAGAAGTACATCGGTTTTCACGCAGCGACAGGTGTGGATTGTGTTGCGCTCGA
CAACTCCGTCGACCCGGAATGGGCGGCGGAGCATGTGCAGGTCGCAGGCTGCGTGCAAGGCAACCTTGCATCGCGGCACA
TGGTCAGCGGTGGAGAGGCGCTCGTTCAGGACACCCGCCGGATCGTCAAGGCGTTCTCGAAGGGGCCGCATATTTTCAAC
CTCGGACATGGTATCACGCCGGATGCGGATCCCGACAACGTGCAACGAATGATCGATACCGTACGCGAAGGCGCTTAG

Upstream 100 bases:

>100_bases
CATTATGCCGTGGCAAGCGCTTGGATGCGCAGGTTGGCAAGCCTTGACAATTTGCCGCTGAGGCTAGACCTCAGGGGGAC
CGCAATGAGAGGGGCAGAGC

Downstream 100 bases:

>100_bases
GCGCGCAGGATTGCACGCTACAAAGATCTGGTCATTCCGATGAGGGGGCGCTGCCCCCTCAAACACCCCCGGGGTATTTC
TCGTTGGAAGAGGGGGAGAC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGQQKTILRALAGETQAVPPIWMMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLVP
QALGADLWFVTGEGPRLSTITTDADFAKLGPASDVHETLSPIYETVRILSKELPSETTLIGFAGAPWTVATYMIAGRGTP
DQGPAHALMQENTPLFEALLARITEATISYLSAQIEAGAEVVKIFDSWAGSLKGEAFDKYALEPARQITAALKARHPHVP
VIGFPREAGEKYIGFHAATGVDCVALDNSVDPEWAAEHVQVAGCVQGNLASRHMVSGGEALVQDTRRIVKAFSKGPHIFN
LGHGITPDADPDNVQRMIDTVREGA

Sequences:

>Translated_345_residues
MGQQKTILRALAGETQAVPPIWMMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLVP
QALGADLWFVTGEGPRLSTITTDADFAKLGPASDVHETLSPIYETVRILSKELPSETTLIGFAGAPWTVATYMIAGRGTP
DQGPAHALMQENTPLFEALLARITEATISYLSAQIEAGAEVVKIFDSWAGSLKGEAFDKYALEPARQITAALKARHPHVP
VIGFPREAGEKYIGFHAATGVDCVALDNSVDPEWAAEHVQVAGCVQGNLASRHMVSGGEALVQDTRRIVKAFSKGPHIFN
LGHGITPDADPDNVQRMIDTVREGA
>Mature_344_residues
GQQKTILRALAGETQAVPPIWMMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLVPQ
ALGADLWFVTGEGPRLSTITTDADFAKLGPASDVHETLSPIYETVRILSKELPSETTLIGFAGAPWTVATYMIAGRGTPD
QGPAHALMQENTPLFEALLARITEATISYLSAQIEAGAEVVKIFDSWAGSLKGEAFDKYALEPARQITAALKARHPHVPV
IGFPREAGEKYIGFHAATGVDCVALDNSVDPEWAAEHVQVAGCVQGNLASRHMVSGGEALVQDTRRIVKAFSKGPHIFNL
GHGITPDADPDNVQRMIDTVREGA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=347, Percent_Identity=38.328530259366, Blast_Score=228, Evalue=6e-60,
Organism=Escherichia coli, GI2367337, Length=338, Percent_Identity=42.603550295858, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320252, Length=350, Percent_Identity=34.2857142857143, Blast_Score=203, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=36.0230547550432, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=36.0230547550432, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SILST (Q1GDK6)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614522.1
- ProteinModelPortal:   Q1GDK6
- SMR:   Q1GDK6
- STRING:   Q1GDK6
- GeneID:   4076530
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2528
- NMPDR:   fig|292414.1.peg.755
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q1GDK6
- ProtClustDB:   PRK00115
- BioCyc:   SSP292414:TM1040_2528-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37261; Mature: 37130

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 75-75 BINDING 152-152 BINDING 207-207 BINDING 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQQKTILRALAGETQAVPPIWMMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQ
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRYGFDAAILFADILLVPQALGADLWFVTGEGPRLSTITTDADFAKLGPASDVHETLS
HHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHCCCCHHHHHHHH
PIYETVRILSKELPSETTLIGFAGAPWTVATYMIAGRGTPDQGPAHALMQENTPLFEALL
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHH
ARITEATISYLSAQIEAGAEVVKIFDSWAGSLKGEAFDKYALEPARQITAALKARHPHVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VIGFPREAGEKYIGFHAATGVDCVALDNSVDPEWAAEHVQVAGCVQGNLASRHMVSGGEA
EEECCHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHH
LVQDTRRIVKAFSKGPHIFNLGHGITPDADPDNVQRMIDTVREGA
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GQQKTILRALAGETQAVPPIWMMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQ
CCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
PIRRYGFDAAILFADILLVPQALGADLWFVTGEGPRLSTITTDADFAKLGPASDVHETLS
HHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCHHHHCCCCHHHHHHHH
PIYETVRILSKELPSETTLIGFAGAPWTVATYMIAGRGTPDQGPAHALMQENTPLFEALL
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHH
ARITEATISYLSAQIEAGAEVVKIFDSWAGSLKGEAFDKYALEPARQITAALKARHPHVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VIGFPREAGEKYIGFHAATGVDCVALDNSVDPEWAAEHVQVAGCVQGNLASRHMVSGGEA
EEECCHHHCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHH
LVQDTRRIVKAFSKGPHIFNLGHGITPDADPDNVQRMIDTVREGA
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA