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The map label for this gene is map [H]

Identifier: 99082309

GI number: 99082309

Start: 2609508

End: 2610323

Strand: Direct

Name: map [H]

Synonym: TM1040_2469

Alternate gene names: 99082309

Gene position: 2609508-2610323 (Clockwise)

Preceding gene: 99082308

Following gene: 99082312

Centisome position: 81.52

GC content: 59.56

Gene sequence:

>816_bases
ATGAGATCCAAGACCGGCCGCACCACCAAAGACGGCATCCGCATCTATGAGCAAGCCGACTTTGCTGGCATGCACAAGGC
AGGTGCGCTTGCGGCCAAGATTTTGGACGACATCGCGGCGCATGTGTTTCCGAGCCAGACCACAGGCGAGATCGACCGGA
TCATCACCCAGATGGTCGAGGATGCCGGCGCGACCTCGGCCACCATCGGCTACAAAGGTTACCAGCACGCAAGCTGCATT
TCGATCAACCACGTGGTGTGCCACGGCATTCCCGGGGACAAAAAGCTCAAGGACGGGGACATCCTCAATATCGACGTCAC
GGTGATCGTCGATGGCTGGTTTGGGGATACCAGCCGCATGTATGTGGCAGGCAAGCTGCCCCGCAAGGCGGAACGCCTGA
TCCAGATTACCCATGATGCCCTGATGAAGGGGATCGAAGTGGTCAAGCCCGGCAATACCTTCGGTGACATCGGTCACGCG
ATCCAGTCCTATGCGGAGAGCCAGCGCGTGAGCGTGGTGCGCGATTTCTGCGGTCACGGCCTAGGTCAGGTCTTTCACGC
CCCGCCAAACGTACTGCACTACGGCCGCCCGGGTACTGGGCCGGTGCTCGAAGAGGGCATGTTCTTCACCATCGAACCGA
TGCTGAACCTTGGCCGGGCCGAAACCAAGGTCTTGGCCGACGACTGGACGGCTGTGACACGCGATAAATCGCTGTCGGCA
CAGTTTGAACATTCTGTTGGCGTGACATCTGACGGGGTGGACATATTCACGCTCTCGCCCGCAGGCCGGTTTCACCCGAC
GTACGACAAAGACTGA

Upstream 100 bases:

>100_bases
ATTTCGGTCCTCGGGGCAGCGAAAGAGGCACCGCTGCCTCTGGCTCTTTGGCGATGAAACCCCTAAATAGCAGTCAAACA
AACGTGATGGAGCACGCCCA

Downstream 100 bases:

>100_bases
CCCTGACGGGGCAAGGGGCGCTGCCCCTCTGGCCCTTACGGGCCATTCACCCCGGGATACTTGAGGTTAGAAGAAAGCCA
AGCCTGCACCCCAGTGCAGG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MRSKTGRTTKDGIRIYEQADFAGMHKAGALAAKILDDIAAHVFPSQTTGEIDRIITQMVEDAGATSATIGYKGYQHASCI
SINHVVCHGIPGDKKLKDGDILNIDVTVIVDGWFGDTSRMYVAGKLPRKAERLIQITHDALMKGIEVVKPGNTFGDIGHA
IQSYAESQRVSVVRDFCGHGLGQVFHAPPNVLHYGRPGTGPVLEEGMFFTIEPMLNLGRAETKVLADDWTAVTRDKSLSA
QFEHSVGVTSDGVDIFTLSPAGRFHPTYDKD

Sequences:

>Translated_271_residues
MRSKTGRTTKDGIRIYEQADFAGMHKAGALAAKILDDIAAHVFPSQTTGEIDRIITQMVEDAGATSATIGYKGYQHASCI
SINHVVCHGIPGDKKLKDGDILNIDVTVIVDGWFGDTSRMYVAGKLPRKAERLIQITHDALMKGIEVVKPGNTFGDIGHA
IQSYAESQRVSVVRDFCGHGLGQVFHAPPNVLHYGRPGTGPVLEEGMFFTIEPMLNLGRAETKVLADDWTAVTRDKSLSA
QFEHSVGVTSDGVDIFTLSPAGRFHPTYDKD
>Mature_271_residues
MRSKTGRTTKDGIRIYEQADFAGMHKAGALAAKILDDIAAHVFPSQTTGEIDRIITQMVEDAGATSATIGYKGYQHASCI
SINHVVCHGIPGDKKLKDGDILNIDVTVIVDGWFGDTSRMYVAGKLPRKAERLIQITHDALMKGIEVVKPGNTFGDIGHA
IQSYAESQRVSVVRDFCGHGLGQVFHAPPNVLHYGRPGTGPVLEEGMFFTIEPMLNLGRAETKVLADDWTAVTRDKSLSA
QFEHSVGVTSDGVDIFTLSPAGRFHPTYDKD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=38.3673469387755, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=37.2, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=51.004016064257, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=38.0952380952381, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=257, Percent_Identity=39.2996108949416, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=40.8163265306122, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=38.9344262295082, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29409; Mature: 29409

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSKTGRTTKDGIRIYEQADFAGMHKAGALAAKILDDIAAHVFPSQTTGEIDRIITQMVE
CCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DAGATSATIGYKGYQHASCISINHVVCHGIPGDKKLKDGDILNIDVTVIVDGWFGDTSRM
HCCCCEEEECCCCCCCCCEEEECEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCE
YVAGKLPRKAERLIQITHDALMKGIEVVKPGNTFGDIGHAIQSYAESQRVSVVRDFCGHG
EEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGQVFHAPPNVLHYGRPGTGPVLEEGMFFTIEPMLNLGRAETKVLADDWTAVTRDKSLSA
HHHHHCCCCCEEECCCCCCCCHHHCCCEEEEHHHHCCCCHHHEEECCCCHHHHCCCCCCH
QFEHSVGVTSDGVDIFTLSPAGRFHPTYDKD
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRSKTGRTTKDGIRIYEQADFAGMHKAGALAAKILDDIAAHVFPSQTTGEIDRIITQMVE
CCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DAGATSATIGYKGYQHASCISINHVVCHGIPGDKKLKDGDILNIDVTVIVDGWFGDTSRM
HCCCCEEEECCCCCCCCCEEEECEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCE
YVAGKLPRKAERLIQITHDALMKGIEVVKPGNTFGDIGHAIQSYAESQRVSVVRDFCGHG
EEEECCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGQVFHAPPNVLHYGRPGTGPVLEEGMFFTIEPMLNLGRAETKVLADDWTAVTRDKSLSA
HHHHHCCCCCEEECCCCCCCCHHHCCCEEEEHHHHCCCCHHHEEECCCCHHHHCCCCCCH
QFEHSVGVTSDGVDIFTLSPAGRFHPTYDKD
HHHHCCCCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]