Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 99082233

GI number: 99082233

Start: 2516031

End: 2517155

Strand: Reverse

Name: gcvT [H]

Synonym: TM1040_2393

Alternate gene names: 99082233

Gene position: 2517155-2516031 (Counterclockwise)

Preceding gene: 99082238

Following gene: 99082232

Centisome position: 78.64

GC content: 62.31

Gene sequence:

>1125_bases
ATGTCGGATCTGAAGACCACTCCCCTTACTGAATTGCACGAGAGCCTCGGGGCCAAGATGGTGCCCTTTGCTGGCTACTC
CATGCCTGTGCAATACCCGCTCGGGATCATGAAAGAACACACGCACACCCGCGAGAAAGCCGGGCTCTTTGATGTGAGCC
ACATGGGGCAAGTGATTCTGCGTGGAGAGAGCTATGAGGCCTTGGCCGCTGCGTTTGAAAAGCTGGTGCCGATGGATGTA
CTCGGGCTGTCCGAGGGGCGCCAACGCTACGGGCTGTTCACCAACGATACGGGCGGCATCGAGGACGACCTGATGTTCGC
CAACCGCGGTGATCACCTGTTTGTGGTTGTGAACGCAGCCTGCAAGGACGCTGACATCGCCCGCATGAAGGCCGCGCTTG
AACCCGAAGTAACAGTCGAGCCTGTCACCGATCGCGCGCTTCTGGCCCTTCAGGGCCCTGCCGCTGAGGCGGCGCTGGAG
GCGTTGGTGCCTGGCGTTGCGGCGATGAAGTTCATGGATGTGGCAACCTTCGCATATGAAGGCGGAGAGCTCTGGATCTC
CCGCTCTGGTTATACCGGAGAGGATGGCTATGAGATCTCCGTCGCCGAAGCCGGCGCAGAGGCCTTTGCCAAGGCTCTGC
TGGCACATGCCGACGTTGAGGCCATTGGCCTCGGCGCACGAGATTCCCTGCGCCTTGAGGGCGGGCTTTGCCTTTATGGA
CACGACATCGACACTGAGACCCGCCCGTTTGAGGCCGCTCTTGGCTGGGCGATCCAAAAAGTACGCCGCCCGGGTGGCGA
CCGCGCGGGCGGCTTTCCCGGTGCGGATGCGATCTTTGCTGATCTCGGTGGCAAGGCCCCGCGCAAACGTGTGGGTCTGA
AGCCCGAGGGCCGTGCGCCGATGCGCGAGGGTGTTGTGCTTTACGCAAGTGCCGAAGGTGGCGACCCTATCGGCACCATC
ACGTCTGGTGGCTTTGGTCCGACCGTTGGCGGCCCGGTCGCCATGGGCTACGTCACCGCAGAGCATGCTGCTCTGGACAC
ACAGGTCTTTGGCGAGCTGCGCGGCAAGCGCGTGCCCGTCACTGTTGCAAAGCTGCCCTTCGTGGCGGCCAACTTCAAAC
GCTAA

Upstream 100 bases:

>100_bases
AGGCTCAGCCTGCGCAAAACCTTGGATGCCGGATGCCAATCGACGCGTTGACATGTTATGATTTGACCGCACCGGCCGCA
GACGCGGAAGGCAGGCCGAT

Downstream 100 bases:

>100_bases
AACCGGTCCCCGCTAAAGCGGCCAACACAGGAAGAGAACCCATGAAATACACCGAAGAACACGAATGGCTGCAGGTCGAA
GGCGACGTTGTGACTGTTGG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSDLKTTPLTELHESLGAKMVPFAGYSMPVQYPLGIMKEHTHTREKAGLFDVSHMGQVILRGESYEALAAAFEKLVPMDV
LGLSEGRQRYGLFTNDTGGIEDDLMFANRGDHLFVVVNAACKDADIARMKAALEPEVTVEPVTDRALLALQGPAAEAALE
ALVPGVAAMKFMDVATFAYEGGELWISRSGYTGEDGYEISVAEAGAEAFAKALLAHADVEAIGLGARDSLRLEGGLCLYG
HDIDTETRPFEAALGWAIQKVRRPGGDRAGGFPGADAIFADLGGKAPRKRVGLKPEGRAPMREGVVLYASAEGGDPIGTI
TSGGFGPTVGGPVAMGYVTAEHAALDTQVFGELRGKRVPVTVAKLPFVAANFKR

Sequences:

>Translated_374_residues
MSDLKTTPLTELHESLGAKMVPFAGYSMPVQYPLGIMKEHTHTREKAGLFDVSHMGQVILRGESYEALAAAFEKLVPMDV
LGLSEGRQRYGLFTNDTGGIEDDLMFANRGDHLFVVVNAACKDADIARMKAALEPEVTVEPVTDRALLALQGPAAEAALE
ALVPGVAAMKFMDVATFAYEGGELWISRSGYTGEDGYEISVAEAGAEAFAKALLAHADVEAIGLGARDSLRLEGGLCLYG
HDIDTETRPFEAALGWAIQKVRRPGGDRAGGFPGADAIFADLGGKAPRKRVGLKPEGRAPMREGVVLYASAEGGDPIGTI
TSGGFGPTVGGPVAMGYVTAEHAALDTQVFGELRGKRVPVTVAKLPFVAANFKR
>Mature_373_residues
SDLKTTPLTELHESLGAKMVPFAGYSMPVQYPLGIMKEHTHTREKAGLFDVSHMGQVILRGESYEALAAAFEKLVPMDVL
GLSEGRQRYGLFTNDTGGIEDDLMFANRGDHLFVVVNAACKDADIARMKAALEPEVTVEPVTDRALLALQGPAAEAALEA
LVPGVAAMKFMDVATFAYEGGELWISRSGYTGEDGYEISVAEAGAEAFAKALLAHADVEAIGLGARDSLRLEGGLCLYGH
DIDTETRPFEAALGWAIQKVRRPGGDRAGGFPGADAIFADLGGKAPRKRVGLKPEGRAPMREGVVLYASAEGGDPIGTIT
SGGFGPTVGGPVAMGYVTAEHAALDTQVFGELRGKRVPVTVAKLPFVAANFKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=43.9153439153439, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=44.2896935933148, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI257796254, Length=374, Percent_Identity=39.8395721925134, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI257796256, Length=313, Percent_Identity=44.0894568690096, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=36, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560118, Length=384, Percent_Identity=40.8854166666667, Blast_Score=237, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6320222, Length=390, Percent_Identity=38.4615384615385, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI20129441, Length=384, Percent_Identity=41.40625, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39523; Mature: 39391

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKTTPLTELHESLGAKMVPFAGYSMPVQYPLGIMKEHTHTREKAGLFDVSHMGQVIL
CCCCCCCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCEEEE
RGESYEALAAAFEKLVPMDVLGLSEGRQRYGLFTNDTGGIEDDLMFANRGDHLFVVVNAA
CCCCHHHHHHHHHHHCCHHEECCCCCHHHCCEEECCCCCCCCCEEEECCCCEEEEEEECC
CKDADIARMKAALEPEVTVEPVTDRALLALQGPAAEAALEALVPGVAAMKFMDVATFAYE
CCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHEEEC
GGELWISRSGYTGEDGYEISVAEAGAEAFAKALLAHADVEAIGLGARDSLRLEGGLCLYG
CCEEEEEECCCCCCCCCEEEHHHCCHHHHHHHHHHHCCHHHEECCCCCCEEECCCEEEEE
HDIDTETRPFEAALGWAIQKVRRPGGDRAGGFPGADAIFADLGGKAPRKRVGLKPEGRAP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCC
MREGVVLYASAEGGDPIGTITSGGFGPTVGGPVAMGYVTAEHAALDTQVFGELRGKRVPV
HHCCEEEEEECCCCCCCEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCE
TVAKLPFVAANFKR
EEECCCEEECCCCC
>Mature Secondary Structure 
SDLKTTPLTELHESLGAKMVPFAGYSMPVQYPLGIMKEHTHTREKAGLFDVSHMGQVIL
CCCCCCCHHHHHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCEEEE
RGESYEALAAAFEKLVPMDVLGLSEGRQRYGLFTNDTGGIEDDLMFANRGDHLFVVVNAA
CCCCHHHHHHHHHHHCCHHEECCCCCHHHCCEEECCCCCCCCCEEEECCCCEEEEEEECC
CKDADIARMKAALEPEVTVEPVTDRALLALQGPAAEAALEALVPGVAAMKFMDVATFAYE
CCCCHHHHHHHHCCCCCEEECCCCCEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHEEEC
GGELWISRSGYTGEDGYEISVAEAGAEAFAKALLAHADVEAIGLGARDSLRLEGGLCLYG
CCEEEEEECCCCCCCCCEEEHHHCCHHHHHHHHHHHCCHHHEECCCCCCEEECCCEEEEE
HDIDTETRPFEAALGWAIQKVRRPGGDRAGGFPGADAIFADLGGKAPRKRVGLKPEGRAP
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHCCCCCCCCCC
MREGVVLYASAEGGDPIGTITSGGFGPTVGGPVAMGYVTAEHAALDTQVFGELRGKRVPV
HHCCEEEEEECCCCCCCEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCE
TVAKLPFVAANFKR
EEECCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA