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The map label for this gene is zmpB [H]

Identifier: 99082206

GI number: 99082206

Start: 2488085

End: 2489236

Strand: Reverse

Name: zmpB [H]

Synonym: TM1040_2366

Alternate gene names: 99082206

Gene position: 2489236-2488085 (Counterclockwise)

Preceding gene: 99082207

Following gene: 99082205

Centisome position: 77.77

GC content: 64.84

Gene sequence:

>1152_bases
GTGCAAACCGGCACAAAGATCTCTCTCGCGGGGCATGGCCTCCTGATCACCTGGGCGCTGGCTGGCGGGTGGCTCAATCC
TGAGCCGCTACCCTTCCAGAGCCAGGATGTGTCGATCATTTCGGCAGAAGAGTTTGCACGACTGAGCGAGCAATATGCTG
CTCCCGAGGTCTCTGACGCCCCTGAGGCGCCACAGGAACCGGCGATCACCGAGACGACCCCGTCGATCCCCGAGCGCCCG
AGCCAGACGCCCGAGACCCCCGCAACACCTGCGCCGATTGAAACGCCGGTCGCAGACACGGCGGCAGAGCCTCCCGCGCC
AGAGCCTGATCCCGAGGTGCCAAGCCGTGTGCCTGATGCACCAGAGCTGCCCGAAATCGTGACGGACCTGCCGCAAACCG
CAGAGCCTCAGACTGCTCAGCAGACGGACCGTGTCGCGCCCGAGCCGGTGCGCGCGCCCGAGCCGGACACACAGATTGGC
GATGTGGTGCAGGAAGAGGTTGCACCCGATGCCGAGGCAGAGGCCAATCAGCCCGTGCAGGAAGCCACGGCACCCGAGGC
CGCAAGTGACCGTATCGTCACCGAGGCCGAAGCAGATGATGCCGAGCCCACAGCGCCTCTGGCGAGTGTTCGTCCGCGCG
CGCGCCCGGCGCGACCCGCTCCGGAACCAGAGCCTGACCCTGAACCACAGACCCAAACCGCCGCCCGCGACGAAGAGCCC
GCCCCGGATGCGGAGCAAAACCCCGAGGTCGAGCGTTCCGCTGTCAACGATGCGCTTGCAGAAGCGCTGAGTGGCGCGGG
GGAGGTGGAGGCGCCCGAACCCTCCGGCCCGCCGATGACACGAGGAGAAAAAGATGCCCTTCGGATTGCGGTGTCGCAAT
GCTGGAACCTCGGCTCTTTGTCGAGCGAGGCGCTGCTTACGGAGGTTGTCGTGGGGGTCACCCTCTCGCGCGAGGGCGTG
CCGGATATTGGTTCCATTCGCCTGCTGTCGAGCACTGGTGGGTCCGACAGCTCTGCCAAACAGGCCTATGAGGCCGCGCG
CCGTGCAATCATCCGCTGTGGATCAAGAGGATTTGATCTTCCGGCTGACAAATACGCTCAGTGGCGTGATATTGAGATGA
CATTTAACCCCGAAGGAATGCGGATCAGATGA

Upstream 100 bases:

>100_bases
AATGCGGGTGGGTTTGCCAATGTGGGGCTTGTGACCGACCAGGGCGGCCCTGCACTCGACGGGCGGTCTGCCGCCCCGGC
AGAGTAACACGGGTGCGGAT

Downstream 100 bases:

>100_bases
GAAACGCAATTGCGACAGTACTCCTTGGCCTTGCAATGCTGCTGCCCGTTGGGGCGGTGCAGGCACAGGATGGGCCGCTC
CGGATCGAGATCACGGATGG

Product: TonB domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQTGTKISLAGHGLLITWALAGGWLNPEPLPFQSQDVSIISAEEFARLSEQYAAPEVSDAPEAPQEPAITETTPSIPERP
SQTPETPATPAPIETPVADTAAEPPAPEPDPEVPSRVPDAPELPEIVTDLPQTAEPQTAQQTDRVAPEPVRAPEPDTQIG
DVVQEEVAPDAEAEANQPVQEATAPEAASDRIVTEAEADDAEPTAPLASVRPRARPARPAPEPEPDPEPQTQTAARDEEP
APDAEQNPEVERSAVNDALAEALSGAGEVEAPEPSGPPMTRGEKDALRIAVSQCWNLGSLSSEALLTEVVVGVTLSREGV
PDIGSIRLLSSTGGSDSSAKQAYEAARRAIIRCGSRGFDLPADKYAQWRDIEMTFNPEGMRIR

Sequences:

>Translated_383_residues
MQTGTKISLAGHGLLITWALAGGWLNPEPLPFQSQDVSIISAEEFARLSEQYAAPEVSDAPEAPQEPAITETTPSIPERP
SQTPETPATPAPIETPVADTAAEPPAPEPDPEVPSRVPDAPELPEIVTDLPQTAEPQTAQQTDRVAPEPVRAPEPDTQIG
DVVQEEVAPDAEAEANQPVQEATAPEAASDRIVTEAEADDAEPTAPLASVRPRARPARPAPEPEPDPEPQTQTAARDEEP
APDAEQNPEVERSAVNDALAEALSGAGEVEAPEPSGPPMTRGEKDALRIAVSQCWNLGSLSSEALLTEVVVGVTLSREGV
PDIGSIRLLSSTGGSDSSAKQAYEAARRAIIRCGSRGFDLPADKYAQWRDIEMTFNPEGMRIR
>Mature_383_residues
MQTGTKISLAGHGLLITWALAGGWLNPEPLPFQSQDVSIISAEEFARLSEQYAAPEVSDAPEAPQEPAITETTPSIPERP
SQTPETPATPAPIETPVADTAAEPPAPEPDPEVPSRVPDAPELPEIVTDLPQTAEPQTAQQTDRVAPEPVRAPEPDTQIG
DVVQEEVAPDAEAEANQPVQEATAPEAASDRIVTEAEADDAEPTAPLASVRPRARPARPAPEPEPDPEPQTQTAARDEEP
APDAEQNPEVERSAVNDALAEALSGAGEVEAPEPSGPPMTRGEKDALRIAVSQCWNLGSLSSEALLTEVVVGVTLSREGV
PDIGSIRLLSSTGGSDSSAKQAYEAARRAIIRCGSRGFDLPADKYAQWRDIEMTFNPEGMRIR

Specific function: Is a virulence factor capable of inducing inflammation in the lower respiratory tract, by increasing tumor necrosis factor alpha (TNF-alpha) concentration in the lungs. Also appears to have other functions important in virulence in models of pneumonia and

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall. Membrane; Multi-pass membrane protein. Secreted, cell wall; Peptidoglycan-anchor [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019948
- InterPro:   IPR019931
- InterPro:   IPR008006
- InterPro:   IPR011505 [H]

Pfam domain/function: PF00746 Gram_pos_anchor; PF07580 Peptidase_M26_C; PF05342 Peptidase_M26_N [H]

EC number: NA

Molecular weight: Translated: 40533; Mature: 40533

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTGTKISLAGHGLLITWALAGGWLNPEPLPFQSQDVSIISAEEFARLSEQYAAPEVSDA
CCCCCEEEECCCCEEEEEEHHCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCC
PEAPQEPAITETTPSIPERPSQTPETPATPAPIETPVADTAAEPPAPEPDPEVPSRVPDA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PELPEIVTDLPQTAEPQTAQQTDRVAPEPVRAPEPDTQIGDVVQEEVAPDAEAEANQPVQ
CCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCHH
EATAPEAASDRIVTEAEADDAEPTAPLASVRPRARPARPAPEPEPDPEPQTQTAARDEEP
HHCCCCHHCCCEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
APDAEQNPEVERSAVNDALAEALSGAGEVEAPEPSGPPMTRGEKDALRIAVSQCWNLGSL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
SSEALLTEVVVGVTLSREGVPDIGSIRLLSSTGGSDSSAKQAYEAARRAIIRCGSRGFDL
CHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PADKYAQWRDIEMTFNPEGMRIR
CHHHCCCCEEEEEEECCCCCEEC
>Mature Secondary Structure
MQTGTKISLAGHGLLITWALAGGWLNPEPLPFQSQDVSIISAEEFARLSEQYAAPEVSDA
CCCCCEEEECCCCEEEEEEHHCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCCC
PEAPQEPAITETTPSIPERPSQTPETPATPAPIETPVADTAAEPPAPEPDPEVPSRVPDA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PELPEIVTDLPQTAEPQTAQQTDRVAPEPVRAPEPDTQIGDVVQEEVAPDAEAEANQPVQ
CCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCCHH
EATAPEAASDRIVTEAEADDAEPTAPLASVRPRARPARPAPEPEPDPEPQTQTAARDEEP
HHCCCCHHCCCEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
APDAEQNPEVERSAVNDALAEALSGAGEVEAPEPSGPPMTRGEKDALRIAVSQCWNLGSL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
SSEALLTEVVVGVTLSREGVPDIGSIRLLSSTGGSDSSAKQAYEAARRAIIRCGSRGFDL
CHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PADKYAQWRDIEMTFNPEGMRIR
CHHHCCCCEEEEEEECCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10792723; 11463916 [H]