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The map label for this gene is pqqL [C]

Identifier: 99082169

GI number: 99082169

Start: 2449051

End: 2450313

Strand: Reverse

Name: pqqL [C]

Synonym: TM1040_2329

Alternate gene names: 99082169

Gene position: 2450313-2449051 (Counterclockwise)

Preceding gene: 99082170

Following gene: 99082168

Centisome position: 76.55

GC content: 61.2

Gene sequence:

>1263_bases
TTGACCGTTAAACAAGACACCCTGCCCAACGGGTTTCGTATTGTCACCGAGTATATGCCGGGGCTGCAATCCGCAGCCCT
CGGCATCTGGGTTTCGGCAGGGGGCCGCCATGAGCGGCTCGAACAGAATGGGGTGGCCCATTTCCTTGAACATATGGCGT
TCAAAGGCACCAAGCGGCGCAGCGCGTTGCAGATCGCCGAAGCCATCGAGGATGTGGGCGGCTACATCAACGCCTATACC
AGCCGCGAAGTGACCGCCTATTACGCGCGTATTCTCAAGGACGACGTGGATCTCGCCCTTGATGTGATCGGCGACATCGT
TCTGAACTCGGTCTTTGATGAACGCGAGATCGAAGTGGAACGCGGGGTCATCCTGCAGGAAATCGGTCAGGCGCTTGATA
CGCCGGACGACATCATTTTTGACTGGCTGCAGGAAGAGAGCTATCGCGAACAGGCGATTGGCCGCTCGATCCTCGGCCCC
GCAGAACGGGTTCGCAGCTTCAACAAGGAAGATCTGACCCGGTTTGTGGCCGAACACTATGGTCCCGGTCAGATGATCCT
CTCAGCCGCTGGTGCGGTCGACCACGATCGGTTGGTGAAGGCCGCTACAGAAATGTTTGGTCATCTGGAACCCAAACAGC
AGGACGTGATCGAATGTGCTCGCTTTACCGGCGGTGAAGCGCGCCACGACAAAGCGCTGGAGCAGGCCCATGTGGCGCTG
GCCTTTGAAAGCCCAAGCTACCGCGCCGATGACATCTATGCCGCGCAGATCTATGCGGCGGCGCTCGGCGGCGGCATGTC
CTCTCGGTTGTTTCAGGAAGTGCGCGAAAAGCGCGGGCTTTGCTACACGATCTTTGCGCAGGCAGGGGCCTATGAGGACA
CCGGCATGATGACCATCTACGCGGGCACCTCCGGGGCGCAGGTTTCGGATCTTCTGGGCATCACGGTTGATGAGCTCAAG
CGCTCCGCAGATGACATGTCCGACGCCGAGGTGGAGCGTGCCCGCGCGCAGATGAAGGCCGGTATGCTGATGGGGCTTGA
GAGCCCTTCGAACCGGGCGGAACGTCTGGCGCGCCTCGTCCAGATCTGGGACCGGGTGCCAAGCCTTGAGGACACGGTTG
CAAAGATTGATGCGGTAACCACCGCGGATGTGCGCGCCATGGCGGCGCGGATTTCTCGCGAGGCACCGGCTGCGCTAGCA
CTCTATGGCCCGGTCGCCGAAGCGCCGCGCCTTGAGGAGATCGCCCGGAGGCGCGCTGCCTGA

Upstream 100 bases:

>100_bases
CCCCTCGCATGGCAGACCTGTATGACAGATCGGAGCGCGTGACCCGGATCGCCAATGATCTCGGCGCGATTGAAGATCAT
ATCAGAAAGCACATCGCCAA

Downstream 100 bases:

>100_bases
TGCTTTTGGCCCGGCGGACGGTGAAACTGGAGACGGAGCGCCTGACGCTCCGCCCTCCCGTGCATGCCGATTTCCGGTAC
TGGGCCTTCCTGCGCCAGCA

Product: peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTVKQDTLPNGFRIVTEYMPGLQSAALGIWVSAGGRHERLEQNGVAHFLEHMAFKGTKRRSALQIAEAIEDVGGYINAYT
SREVTAYYARILKDDVDLALDVIGDIVLNSVFDEREIEVERGVILQEIGQALDTPDDIIFDWLQEESYREQAIGRSILGP
AERVRSFNKEDLTRFVAEHYGPGQMILSAAGAVDHDRLVKAATEMFGHLEPKQQDVIECARFTGGEARHDKALEQAHVAL
AFESPSYRADDIYAAQIYAAALGGGMSSRLFQEVREKRGLCYTIFAQAGAYEDTGMMTIYAGTSGAQVSDLLGITVDELK
RSADDMSDAEVERARAQMKAGMLMGLESPSNRAERLARLVQIWDRVPSLEDTVAKIDAVTTADVRAMAARISREAPAALA
LYGPVAEAPRLEEIARRRAA

Sequences:

>Translated_420_residues
MTVKQDTLPNGFRIVTEYMPGLQSAALGIWVSAGGRHERLEQNGVAHFLEHMAFKGTKRRSALQIAEAIEDVGGYINAYT
SREVTAYYARILKDDVDLALDVIGDIVLNSVFDEREIEVERGVILQEIGQALDTPDDIIFDWLQEESYREQAIGRSILGP
AERVRSFNKEDLTRFVAEHYGPGQMILSAAGAVDHDRLVKAATEMFGHLEPKQQDVIECARFTGGEARHDKALEQAHVAL
AFESPSYRADDIYAAQIYAAALGGGMSSRLFQEVREKRGLCYTIFAQAGAYEDTGMMTIYAGTSGAQVSDLLGITVDELK
RSADDMSDAEVERARAQMKAGMLMGLESPSNRAERLARLVQIWDRVPSLEDTVAKIDAVTTADVRAMAARISREAPAALA
LYGPVAEAPRLEEIARRRAA
>Mature_419_residues
TVKQDTLPNGFRIVTEYMPGLQSAALGIWVSAGGRHERLEQNGVAHFLEHMAFKGTKRRSALQIAEAIEDVGGYINAYTS
REVTAYYARILKDDVDLALDVIGDIVLNSVFDEREIEVERGVILQEIGQALDTPDDIIFDWLQEESYREQAIGRSILGPA
ERVRSFNKEDLTRFVAEHYGPGQMILSAAGAVDHDRLVKAATEMFGHLEPKQQDVIECARFTGGEARHDKALEQAHVALA
FESPSYRADDIYAAQIYAAALGGGMSSRLFQEVREKRGLCYTIFAQAGAYEDTGMMTIYAGTSGAQVSDLLGITVDELKR
SADDMSDAEVERARAQMKAGMLMGLESPSNRAERLARLVQIWDRVPSLEDTVAKIDAVTTADVRAMAARISREAPAALAL
YGPVAEAPRLEEIARRRAA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=424, Percent_Identity=35.1415094339623, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI46593007, Length=422, Percent_Identity=30.3317535545024, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI24308013, Length=443, Percent_Identity=27.5395033860045, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI50592988, Length=418, Percent_Identity=24.8803827751196, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1787770, Length=202, Percent_Identity=25.7425742574257, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=423, Percent_Identity=31.6784869976359, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17553678, Length=400, Percent_Identity=28.5, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17510601, Length=446, Percent_Identity=23.0941704035874, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17569737, Length=391, Percent_Identity=23.5294117647059, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555260, Length=413, Percent_Identity=22.2760290556901, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323192, Length=430, Percent_Identity=35.1162790697674, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6321813, Length=412, Percent_Identity=24.5145631067961, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319426, Length=403, Percent_Identity=24.8138957816377, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357875, Length=418, Percent_Identity=36.1244019138756, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24646943, Length=418, Percent_Identity=36.1244019138756, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI19921772, Length=448, Percent_Identity=26.1160714285714, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24665395, Length=394, Percent_Identity=23.6040609137056, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46217; Mature: 46086

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKQDTLPNGFRIVTEYMPGLQSAALGIWVSAGGRHERLEQNGVAHFLEHMAFKGTKRR
CCCCCCCCCCHHHHHHHHHCCHHHHHHEEEEECCCCHHHHHHCCHHHHHHHHHHCCCHHH
SALQIAEAIEDVGGYINAYTSREVTAYYARILKDDVDLALDVIGDIVLNSVFDEREIEVE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVILQEIGQALDTPDDIIFDWLQEESYREQAIGRSILGPAERVRSFNKEDLTRFVAEHY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHC
GPGQMILSAAGAVDHDRLVKAATEMFGHLEPKQQDVIECARFTGGEARHDKALEQAHVAL
CCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEEE
AFESPSYRADDIYAAQIYAAALGGGMSSRLFQEVREKRGLCYTIFAQAGAYEDTGMMTIY
EECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
AGTSGAQVSDLLGITVDELKRSADDMSDAEVERARAQMKAGMLMGLESPSNRAERLARLV
ECCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QIWDRVPSLEDTVAKIDAVTTADVRAMAARISREAPAALALYGPVAEAPRLEEIARRRAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TVKQDTLPNGFRIVTEYMPGLQSAALGIWVSAGGRHERLEQNGVAHFLEHMAFKGTKRR
CCCCCCCCCHHHHHHHHHCCHHHHHHEEEEECCCCHHHHHHCCHHHHHHHHHHCCCHHH
SALQIAEAIEDVGGYINAYTSREVTAYYARILKDDVDLALDVIGDIVLNSVFDEREIEVE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGVILQEIGQALDTPDDIIFDWLQEESYREQAIGRSILGPAERVRSFNKEDLTRFVAEHY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHC
GPGQMILSAAGAVDHDRLVKAATEMFGHLEPKQQDVIECARFTGGEARHDKALEQAHVAL
CCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEEE
AFESPSYRADDIYAAQIYAAALGGGMSSRLFQEVREKRGLCYTIFAQAGAYEDTGMMTIY
EECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEE
AGTSGAQVSDLLGITVDELKRSADDMSDAEVERARAQMKAGMLMGLESPSNRAERLARLV
ECCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QIWDRVPSLEDTVAKIDAVTTADVRAMAARISREAPAALALYGPVAEAPRLEEIARRRAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]