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The map label for this gene is nhaC [H]

Identifier: 99081999

GI number: 99081999

Start: 2268651

End: 2270105

Strand: Direct

Name: nhaC [H]

Synonym: TM1040_2159

Alternate gene names: 99081999

Gene position: 2268651-2270105 (Clockwise)

Preceding gene: 99081996

Following gene: 99082000

Centisome position: 70.87

GC content: 61.37

Gene sequence:

>1455_bases
ATGCCATTGCAGAAAACGGACATCCGTCCCTCCATCGGCCTAGCGCTGCTGCCGATCGTGCTGACGCTCGCCATTCTTGG
GGTGCAGATCTTTTACTTTGGGGATTTCACCCCCCATATCCCACTTGCAATCGGGATCGCCCTCACCGCGGTGGTGGGCC
TGATCGAAGGGCTGAGCTGGGATGAGATCGAAAAAGGCGCCTTTCATGTGATCGCAGTGTCTTTCCCGGCGGTGTCGGTG
CTGATCCTTGTCGGCATGATCGTTGGCACATGGATCGCCTCCGGCACCGTTCCCACGCTGATCTATTACGGGCTGTCGCT
GCTTTCGCCAGAGCTGTTTCTCGCGGCGGGGATGATCCTCTGCTCCATCGTCTCGCTTGCCCTCGGGACATCCTGGGGCA
CGGTCGGCACAGTGGGTCTCGCGCTGATGGGCATCGGCGAAGGCTTTGGCATCCCGGCCTACTGGACTGCAGGCGCGGTG
GTTTCAGGCGCCTTCTTTGGCGACAAGATCTCGCCCCTTTCGGATACCACCAACCTGGCCCCGGCCGTGACTGATACGCA
GCTATTTGACCACATCCGCAACATGTTGCCGACCACTGTTCCCGCGATGCTGATCGCGCTGGCGATCTACACTGTGATGG
GGTTCAACCTTGGTGACGGCGCGCCCTCCTTTGAACGCATCGAGAGCTTCAAGGGCGCGCTGGAGGGGTCGTTTGACATC
ACGCCCTGGCTGCTATTGCCCGCGCTTTTGGTGGTCGGGCTTGCAATGATGCGCATGCCGGCGATCCCGACTCTGTTCAT
CGGTGTCGTGGTAGCGTCTCTGATTGCGATCTTTGTGCAGGGCGCATCGCTGCATGACGTTTTCACCTATGCCAACTACG
GCTATTCGGTCGAAACCGGCGTCGCCGCAATGGACTCGCTGATGAACCGGGGCGGGATCCAGTCGATGATGTGGACCATC
TCTCTGATCCTGATCGCGCTTGGCTTTGGCGGCGCGTTGGAGCGCACGGGCTGCCTTGCGGCCATCATCGAGCTTTTGAC
CAAGCGGGTGAAAACCATCGCGGGTGTGCAGACCTCGGCGATCCTGTCCTCCATGGCGACCAACACCGTGGCGGGCGATC
CCTATCTCTCGATCGCGCTGCCTGGGCGGATGTTCAAGCCGGTCTACGACCGTATCGGCTATTCGCGCCTGAACCTGGCA
CGCGCCACCGAGGAAGGCGGCACCATCATCTCGCCGCTGATCCCGTGGAACGCCGGTGGCGCCTTTGTGATCTCGGCCCT
CGCGCTGGGTGTCTCGGACGGCAAGATCGAAAACCTGCTCTACATCCCGCTGTCCTTTGCCTGCTGGCTGGCCCCGGTCT
TTGGGATCTTCTACGCATGGACCGGCCTTTTTACACCCAAGGCCGAAGCGGCTGACACCGTGCGCGCAGAAGCCGCGCAG
CACCCCGCAGAGTAA

Upstream 100 bases:

>100_bases
ACCCACCCTCCCACGTACTCACCAACGGCCAGCCCCTTTTTTTTGGCGGATCACAGCGCCCTGGGGGTCGGCCTTCTTCA
CGATAAAGAGGACATCTTTT

Downstream 100 bases:

>100_bases
TACTCACAAGGATATGCGCCTGACTACAAATCGGGCGCATATCACCCTGCATTCCTGCACAGACGCAGTGAGCCAGTGCA
GATTTTCCTAATCCGACATC

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MPLQKTDIRPSIGLALLPIVLTLAILGVQIFYFGDFTPHIPLAIGIALTAVVGLIEGLSWDEIEKGAFHVIAVSFPAVSV
LILVGMIVGTWIASGTVPTLIYYGLSLLSPELFLAAGMILCSIVSLALGTSWGTVGTVGLALMGIGEGFGIPAYWTAGAV
VSGAFFGDKISPLSDTTNLAPAVTDTQLFDHIRNMLPTTVPAMLIALAIYTVMGFNLGDGAPSFERIESFKGALEGSFDI
TPWLLLPALLVVGLAMMRMPAIPTLFIGVVVASLIAIFVQGASLHDVFTYANYGYSVETGVAAMDSLMNRGGIQSMMWTI
SLILIALGFGGALERTGCLAAIIELLTKRVKTIAGVQTSAILSSMATNTVAGDPYLSIALPGRMFKPVYDRIGYSRLNLA
RATEEGGTIISPLIPWNAGGAFVISALALGVSDGKIENLLYIPLSFACWLAPVFGIFYAWTGLFTPKAEAADTVRAEAAQ
HPAE

Sequences:

>Translated_484_residues
MPLQKTDIRPSIGLALLPIVLTLAILGVQIFYFGDFTPHIPLAIGIALTAVVGLIEGLSWDEIEKGAFHVIAVSFPAVSV
LILVGMIVGTWIASGTVPTLIYYGLSLLSPELFLAAGMILCSIVSLALGTSWGTVGTVGLALMGIGEGFGIPAYWTAGAV
VSGAFFGDKISPLSDTTNLAPAVTDTQLFDHIRNMLPTTVPAMLIALAIYTVMGFNLGDGAPSFERIESFKGALEGSFDI
TPWLLLPALLVVGLAMMRMPAIPTLFIGVVVASLIAIFVQGASLHDVFTYANYGYSVETGVAAMDSLMNRGGIQSMMWTI
SLILIALGFGGALERTGCLAAIIELLTKRVKTIAGVQTSAILSSMATNTVAGDPYLSIALPGRMFKPVYDRIGYSRLNLA
RATEEGGTIISPLIPWNAGGAFVISALALGVSDGKIENLLYIPLSFACWLAPVFGIFYAWTGLFTPKAEAADTVRAEAAQ
HPAE
>Mature_483_residues
PLQKTDIRPSIGLALLPIVLTLAILGVQIFYFGDFTPHIPLAIGIALTAVVGLIEGLSWDEIEKGAFHVIAVSFPAVSVL
ILVGMIVGTWIASGTVPTLIYYGLSLLSPELFLAAGMILCSIVSLALGTSWGTVGTVGLALMGIGEGFGIPAYWTAGAVV
SGAFFGDKISPLSDTTNLAPAVTDTQLFDHIRNMLPTTVPAMLIALAIYTVMGFNLGDGAPSFERIESFKGALEGSFDIT
PWLLLPALLVVGLAMMRMPAIPTLFIGVVVASLIAIFVQGASLHDVFTYANYGYSVETGVAAMDSLMNRGGIQSMMWTIS
LILIALGFGGALERTGCLAAIIELLTKRVKTIAGVQTSAILSSMATNTVAGDPYLSIALPGRMFKPVYDRIGYSRLNLAR
ATEEGGTIISPLIPWNAGGAFVISALALGVSDGKIENLLYIPLSFACWLAPVFGIFYAWTGLFTPKAEAADTVRAEAAQH
PAE

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50897; Mature: 50765

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLQKTDIRPSIGLALLPIVLTLAILGVQIFYFGDFTPHIPLAIGIALTAVVGLIEGLSW
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCH
DEIEKGAFHVIAVSFPAVSVLILVGMIVGTWIASGTVPTLIYYGLSLLSPELFLAAGMIL
HHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHH
CSIVSLALGTSWGTVGTVGLALMGIGEGFGIPAYWTAGAVVSGAFFGDKISPLSDTTNLA
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PAVTDTQLFDHIRNMLPTTVPAMLIALAIYTVMGFNLGDGAPSFERIESFKGALEGSFDI
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
TPWLLLPALLVVGLAMMRMPAIPTLFIGVVVASLIAIFVQGASLHDVFTYANYGYSVETG
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHH
VAAMDSLMNRGGIQSMMWTISLILIALGFGGALERTGCLAAIIELLTKRVKTIAGVQTSA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ILSSMATNTVAGDPYLSIALPGRMFKPVYDRIGYSRLNLARATEEGGTIISPLIPWNAGG
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCH
AFVISALALGVSDGKIENLLYIPLSFACWLAPVFGIFYAWTGLFTPKAEAADTVRAEAAQ
HHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
HPAE
CCCC
>Mature Secondary Structure 
PLQKTDIRPSIGLALLPIVLTLAILGVQIFYFGDFTPHIPLAIGIALTAVVGLIEGLSW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCH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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]