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The map label for this gene is prs [H]

Identifier: 99081915

GI number: 99081915

Start: 2178130

End: 2179152

Strand: Direct

Name: prs [H]

Synonym: TM1040_2075

Alternate gene names: 99081915

Gene position: 2178130-2179152 (Clockwise)

Preceding gene: 99081912

Following gene: 99081916

Centisome position: 68.05

GC content: 60.22

Gene sequence:

>1023_bases
ATGCCGACCTTGAACGAACCCAAGTTGATCTCTGGGAACGCCAATCTTCCGCTCGCTAAATCGATCTCGCGCCGCATGAG
CATGCACCGTGGTGTCGACCAAGACCTCGTGAACGCCCGTGTCGAGCGTTTCAACGATGGCGAGATCTTTGTCGAAGTCT
ACGAGAACGTGCGCGGCGAGGATATGTTTATCATCCAGCCGACCTCGAACCCGGCCAATGATAATCTGATGGAGCTGTTG
ATCATCGCCGATGCGCTGCGCCGTTCCTCGGCCCAGCGGATCACCGCAGTGATCCCTTACTTCGGCTACGCCCGTCAGGA
CCGCCGCACCAAGGCGCGCACACCGATTTCAGCCAAGATGGTCGCCAATATGCTGACCGGCGCGGGCATCGAGCGGGTTC
TGACCATGGATCTGCACGCCGCTCAGATCCAGGGTTTCTTCGATATTCCGGTGGACAACCTCTATGCCAGCCCGATCTTT
GCGCTGGACGTGAAGGCGCAGTTCAAGGACCAGATGGACGACCTGATGGTGGTTTCGCCCGATGTGGGTGGCGTGGCGCG
TGCCCGCGAGCTCGCGAAACGCATCAACGCCCCCCTGTCGATCGTCGACAAGCGCCGCGAAAAGGCGGGCGAGATTGCCG
AGATGACCGTCATCGGTGACGTCAAAGACAAGATCTGCCTGATCGTCGATGACATCTGCGACACCGCCGGCACCCTCTGC
AAGGCCGCGCAGATCCTGCTCGACAATGGCGCCAAGGAAGTCCACGCCTACATCAGCCACGGCGTGATGTCCGGCCCCGC
CGTGGAACGTGTGACCAATTCGGTGATGAAATCGCTGGTGCTGACGGACTCGATCCAGCCCACTCAGCCGATCCTCGACG
CGCCCAATATCCGCATCGTGCCCACCGCGCCGCTCTTTACGCAGGCGATCCTCAACATCTGGCACGGCACCTCGGTGTCC
TCGCTGTTTGAGGATAAGACCCTGATCCCGATCTACGAGTCGCTCTACAACAGCCAGAGCTAA

Upstream 100 bases:

>100_bases
AGAATTCCTCGTGCTTAGAACTAGGCCTGACCCTATGTGCGTGTTAAGCGGGGTTCAATATCACGAATCTGTCACATTGC
TGCCTGGGGAAAAACAGCCA

Downstream 100 bases:

>100_bases
GATCGCTCGGATTTCACCAAAACACCCCGCGAGATGTCGTGGGGTGTTTTTTTGTGGGCGTCGAAAAAATGCACCGCACA
TGGCCACGTCTGTTCAATGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPTLNEPKLISGNANLPLAKSISRRMSMHRGVDQDLVNARVERFNDGEIFVEVYENVRGEDMFIIQPTSNPANDNLMELL
IIADALRRSSAQRITAVIPYFGYARQDRRTKARTPISAKMVANMLTGAGIERVLTMDLHAAQIQGFFDIPVDNLYASPIF
ALDVKAQFKDQMDDLMVVSPDVGGVARARELAKRINAPLSIVDKRREKAGEIAEMTVIGDVKDKICLIVDDICDTAGTLC
KAAQILLDNGAKEVHAYISHGVMSGPAVERVTNSVMKSLVLTDSIQPTQPILDAPNIRIVPTAPLFTQAILNIWHGTSVS
SLFEDKTLIPIYESLYNSQS

Sequences:

>Translated_340_residues
MPTLNEPKLISGNANLPLAKSISRRMSMHRGVDQDLVNARVERFNDGEIFVEVYENVRGEDMFIIQPTSNPANDNLMELL
IIADALRRSSAQRITAVIPYFGYARQDRRTKARTPISAKMVANMLTGAGIERVLTMDLHAAQIQGFFDIPVDNLYASPIF
ALDVKAQFKDQMDDLMVVSPDVGGVARARELAKRINAPLSIVDKRREKAGEIAEMTVIGDVKDKICLIVDDICDTAGTLC
KAAQILLDNGAKEVHAYISHGVMSGPAVERVTNSVMKSLVLTDSIQPTQPILDAPNIRIVPTAPLFTQAILNIWHGTSVS
SLFEDKTLIPIYESLYNSQS
>Mature_339_residues
PTLNEPKLISGNANLPLAKSISRRMSMHRGVDQDLVNARVERFNDGEIFVEVYENVRGEDMFIIQPTSNPANDNLMELLI
IADALRRSSAQRITAVIPYFGYARQDRRTKARTPISAKMVANMLTGAGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFA
LDVKAQFKDQMDDLMVVSPDVGGVARARELAKRINAPLSIVDKRREKAGEIAEMTVIGDVKDKICLIVDDICDTAGTLCK
AAQILLDNGAKEVHAYISHGVMSGPAVERVTNSVMKSLVLTDSIQPTQPILDAPNIRIVPTAPLFTQAILNIWHGTSVSS
LFEDKTLIPIYESLYNSQS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=323, Percent_Identity=42.7244582043344, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=42.8571428571429, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=42.4528301886792, Blast_Score=274, Evalue=7e-74,
Organism=Homo sapiens, GI28557709, Length=323, Percent_Identity=41.1764705882353, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI194018537, Length=349, Percent_Identity=33.5243553008596, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI4506133, Length=351, Percent_Identity=31.9088319088319, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=31.9727891156463, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=31.9727891156463, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=31.9727891156463, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=31.9727891156463, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1787458, Length=319, Percent_Identity=50.4702194357367, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17554704, Length=317, Percent_Identity=41.6403785488959, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI17554702, Length=323, Percent_Identity=41.4860681114551, Blast_Score=266, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI25149168, Length=323, Percent_Identity=41.4860681114551, Blast_Score=266, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=323, Percent_Identity=41.4860681114551, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=30.2593659942363, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321776, Length=329, Percent_Identity=43.4650455927052, Blast_Score=275, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319403, Length=323, Percent_Identity=43.6532507739938, Blast_Score=263, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6320946, Length=322, Percent_Identity=42.8571428571429, Blast_Score=255, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=38.6473429951691, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=37.2727272727273, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355239, Length=325, Percent_Identity=44.6153846153846, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI45551540, Length=348, Percent_Identity=41.6666666666667, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24651458, Length=363, Percent_Identity=30.8539944903581, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24651456, Length=363, Percent_Identity=30.8539944903581, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281362873, Length=363, Percent_Identity=30.8539944903581, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24651454, Length=363, Percent_Identity=30.8539944903581, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24651462, Length=200, Percent_Identity=36.5, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24651464, Length=200, Percent_Identity=36.5, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI45552010, Length=206, Percent_Identity=36.4077669902913, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 37435; Mature: 37303

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLNEPKLISGNANLPLAKSISRRMSMHRGVDQDLVNARVERFNDGEIFVEVYENVRGE
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHEEHHCCCCC
DMFIIQPTSNPANDNLMELLIIADALRRSSAQRITAVIPYFGYARQDRRTKARTPISAKM
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHH
VANMLTGAGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFALDVKAQFKDQMDDLMVVSP
HHHHHHCCCHHHHHHHHHHHHHHCCEEECCHHHHHCCCEEEEECHHHHHHCCCCEEEECC
DVGGVARARELAKRINAPLSIVDKRREKAGEIAEMTVIGDVKDKICLIVDDICDTAGTLC
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHH
KAAQILLDNGAKEVHAYISHGVMSGPAVERVTNSVMKSLVLTDSIQPTQPILDAPNIRIV
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
PTAPLFTQAILNIWHGTSVSSLFEDKTLIPIYESLYNSQS
ECCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
PTLNEPKLISGNANLPLAKSISRRMSMHRGVDQDLVNARVERFNDGEIFVEVYENVRGE
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHEEHHCCCCC
DMFIIQPTSNPANDNLMELLIIADALRRSSAQRITAVIPYFGYARQDRRTKARTPISAKM
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHH
VANMLTGAGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFALDVKAQFKDQMDDLMVVSP
HHHHHHCCCHHHHHHHHHHHHHHCCEEECCHHHHHCCCEEEEECHHHHHHCCCCEEEECC
DVGGVARARELAKRINAPLSIVDKRREKAGEIAEMTVIGDVKDKICLIVDDICDTAGTLC
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEHHHHHHHHHHH
KAAQILLDNGAKEVHAYISHGVMSGPAVERVTNSVMKSLVLTDSIQPTQPILDAPNIRIV
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
PTAPLFTQAILNIWHGTSVSSLFEDKTLIPIYESLYNSQS
ECCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA