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The map label for this gene is dsdC [H]

Identifier: 99081898

GI number: 99081898

Start: 2161695

End: 2162609

Strand: Direct

Name: dsdC [H]

Synonym: TM1040_2058

Alternate gene names: 99081898

Gene position: 2161695-2162609 (Clockwise)

Preceding gene: 99081894

Following gene: 99081899

Centisome position: 67.53

GC content: 65.36

Gene sequence:

>915_bases
ATGTCTCGCCGCCACTACAATCTGCCCCCCCTGACCACGCTCACCGCCTTTGAAGCGGCGGCGCGCCACCTCAGCTTCAA
GGACGCCGCCAAGGAGCTCTCGGTGACACCGGGCGCGGTCAGCCACCAAGTCAAAGCGCTGGAGGGGGAATTGGGCGTGG
CGCTGTTTCGCCGCAAGCATCGCGGCGTGGATCTGACGGTGCCGGGGCAGACCCTCTACGACACGCTGGCGGGGTCCCTG
ACCCGCATCTCACAAAGCCTGCAGTCCATCCGCGACCAGAGCAGCGCAGGCGTGGTGACGGTGGGCTCCACCACGGCGAT
GGCGGCCATGTGGCTATCGCCTGCCGTGATCCGGTTCTGGCGCGACCACCCGGAGATCAACATCAACCAGGTGGTGCGCG
ACCGGGCTTTCACCACCTCGGCAGAACTTGATCTCTATATCTGGTATGGCCGCGAAAAGGATCAGCGGCTGGATCAGTTT
CCGCTCTATCGCGATCGCCTGCTGCCTGTTGCCGCCCCGGAGCGGGCCGCCGAGTTGGCAGGCGCGGATCTGGACGTGCT
GGCCAGCCAGCGCCTGATCCATCTGGAGGGCGACGACATCAGTTGGACCAAATGGCACGACTGGTTCCGCCAGCTTGGCT
ACAGCGGTCCGGTGGCTTCGGGCATCCGGGTCAACAACTACTCTATCGCGCTGCAGGCGGCGCGCGATGGCGCCGGGCTG
ACGCTGGGTTGGGAGCGGCTGATCTCGCCGCTCATCACACAGGGCGACCTAGCGATCATCGGCCCGCATGTCCTGCCCGC
ACCAGAGCGGTTTTTCCTCGTCAGCAAACCCGACGAGGAGCTGACGCCCAGCGCCAGATTGCTGCGCGACTGGATCATCG
AAGAGGCCAGCCAGATCACGGATGAGCCCTGCTAA

Upstream 100 bases:

>100_bases
ACCCAAATGTCGGTAGCGGCCGGGCTTTTGTCGGGAAGCCTCTCGCCAAGTGCCTGCGCGAAGCCCATAGTCACATCACC
CCTAGCCATGAGCCGCCCGC

Downstream 100 bases:

>100_bases
CGTGTGAGTGAGATTTTCTGATATTGAGGGCGCCCGCGCTGCGCCACATCCTCGGCTCAAGATCCTTGCCACATCCGTTC
AAAGGAGCGCCGGATGACCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSRRHYNLPPLTTLTAFEAAARHLSFKDAAKELSVTPGAVSHQVKALEGELGVALFRRKHRGVDLTVPGQTLYDTLAGSL
TRISQSLQSIRDQSSAGVVTVGSTTAMAAMWLSPAVIRFWRDHPEININQVVRDRAFTTSAELDLYIWYGREKDQRLDQF
PLYRDRLLPVAAPERAAELAGADLDVLASQRLIHLEGDDISWTKWHDWFRQLGYSGPVASGIRVNNYSIALQAARDGAGL
TLGWERLISPLITQGDLAIIGPHVLPAPERFFLVSKPDEELTPSARLLRDWIIEEASQITDEPC

Sequences:

>Translated_304_residues
MSRRHYNLPPLTTLTAFEAAARHLSFKDAAKELSVTPGAVSHQVKALEGELGVALFRRKHRGVDLTVPGQTLYDTLAGSL
TRISQSLQSIRDQSSAGVVTVGSTTAMAAMWLSPAVIRFWRDHPEININQVVRDRAFTTSAELDLYIWYGREKDQRLDQF
PLYRDRLLPVAAPERAAELAGADLDVLASQRLIHLEGDDISWTKWHDWFRQLGYSGPVASGIRVNNYSIALQAARDGAGL
TLGWERLISPLITQGDLAIIGPHVLPAPERFFLVSKPDEELTPSARLLRDWIIEEASQITDEPC
>Mature_303_residues
SRRHYNLPPLTTLTAFEAAARHLSFKDAAKELSVTPGAVSHQVKALEGELGVALFRRKHRGVDLTVPGQTLYDTLAGSLT
RISQSLQSIRDQSSAGVVTVGSTTAMAAMWLSPAVIRFWRDHPEININQVVRDRAFTTSAELDLYIWYGREKDQRLDQFP
LYRDRLLPVAAPERAAELAGADLDVLASQRLIHLEGDDISWTKWHDWFRQLGYSGPVASGIRVNNYSIALQAARDGAGLT
LGWERLISPLITQGDLAIIGPHVLPAPERFFLVSKPDEELTPSARLLRDWIIEEASQITDEPC

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=279, Percent_Identity=32.258064516129, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789173, Length=300, Percent_Identity=33.6666666666667, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786448, Length=291, Percent_Identity=28.1786941580756, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789440, Length=242, Percent_Identity=25.2066115702479, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787128, Length=126, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786401, Length=285, Percent_Identity=23.1578947368421, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33815; Mature: 33684

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRHYNLPPLTTLTAFEAAARHLSFKDAAKELSVTPGAVSHQVKALEGELGVALFRRKH
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGVDLTVPGQTLYDTLAGSLTRISQSLQSIRDQSSAGVVTVGSTTAMAAMWLSPAVIRFW
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHH
RDHPEININQVVRDRAFTTSAELDLYIWYGREKDQRLDQFPLYRDRLLPVAAPERAAELA
HCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCHHHHCCCCCCCHHHHHHC
GADLDVLASQRLIHLEGDDISWTKWHDWFRQLGYSGPVASGIRVNNYSIALQAARDGAGL
CCCHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEECCEEEEEEECCCCCCC
TLGWERLISPLITQGDLAIIGPHVLPAPERFFLVSKPDEELTPSARLLRDWIIEEASQIT
EECHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHC
DEPC
CCCC
>Mature Secondary Structure 
SRRHYNLPPLTTLTAFEAAARHLSFKDAAKELSVTPGAVSHQVKALEGELGVALFRRKH
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGVDLTVPGQTLYDTLAGSLTRISQSLQSIRDQSSAGVVTVGSTTAMAAMWLSPAVIRFW
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHH
RDHPEININQVVRDRAFTTSAELDLYIWYGREKDQRLDQFPLYRDRLLPVAAPERAAELA
HCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCHHHHCCCCCCCHHHHHHC
GADLDVLASQRLIHLEGDDISWTKWHDWFRQLGYSGPVASGIRVNNYSIALQAARDGAGL
CCCHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEEECCEEEEEEECCCCCCC
TLGWERLISPLITQGDLAIIGPHVLPAPERFFLVSKPDEELTPSARLLRDWIIEEASQIT
EECHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCHHCCHHHHHHHHHHHHHHHHHC
DEPC
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]