Click here to switch to the map view.

The map label for this gene is hisA1 [H]

Identifier: 99081879

GI number: 99081879

Start: 2146291

End: 2147013

Strand: Direct

Name: hisA1 [H]

Synonym: TM1040_2039

Alternate gene names: 99081879

Gene position: 2146291-2147013 (Clockwise)

Preceding gene: 99081877

Following gene: 99081880

Centisome position: 67.05

GC content: 63.07

Gene sequence:

>723_bases
ATGATCCTCTACCCTGCCATTGACCTCAAGGACGGCCAGGCCGTGCGACTTCTGCATGGTGACATGGACAAGACCACCGT
ATTCAACGACAACCCCGCCGCGCAGGCGCTGGAGTTTGTGGCGGCGGGCTGCGAATGGCTGCATCTGGTGGATCTCAACG
GAGCCTTTGCGGGCGAGCCTGTAAATGCGGCCCCCGTTGAGGAGATCCTGAGGCAATGCAAGGTGCCCGCGCAGCTGGGT
GGTGGCATTCGGGACATGGCTACGATCGAGCGCTGGCTCGACAAGGGGCTGGCGCGGGTCATCCTTGGCACCGTGGCGGT
GGAAAACCCCGACCTCGTGCGCGAGGCAGCACGCGCCTTTCCGGGCAAGGTCGCCGTAGGGATTGATGCCCGCAATGGCA
AGGTCGCAACCAAGGGCTGGGCCGAGGAAACCGATGTCGAGGTGACCGATCTGGCGAAATCCTTCGAGGACGCGGGCGTT
GCAGCCATCATCTACACCGACATCATGCGCGACGGTGCCATGAAGGGGCCCAATATCGACGCGACAGCAGCGCTGGCCAA
TGCGGTCTCTATCCCGGTGATTGCGTCGGGCGGGGTGTCATCCCTTGAAGATCTGCATGCACTCAAGTCCTGCGGTGCGG
CGCTCAACGGCGCGATCTCTGGTCGGGCGCTTTATGATGGTGCGATTGATCTCGCCGAGGCGCTGGCCGTCCTGAAGGGC
TAA

Upstream 100 bases:

>100_bases
AATTGAGGCGCCAGAAGGCGCGGGCTACGTTGCAATTCACCTGCGGCTTGGGCAAAAGGGCAGCCGAAAGATATTCCACC
ATCACCAAAAGGGCGCACTG

Downstream 100 bases:

>100_bases
ACACGCCAAGGCAAATGGCGCTGCGGTGCCAGTCTTTTCCCACGCTCAGACCGAGATCGACCGCTGAGAGAGAGGGGTTT
CGCTTCGGGCTTCGCCCGAA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 1 [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MILYPAIDLKDGQAVRLLHGDMDKTTVFNDNPAAQALEFVAAGCEWLHLVDLNGAFAGEPVNAAPVEEILRQCKVPAQLG
GGIRDMATIERWLDKGLARVILGTVAVENPDLVREAARAFPGKVAVGIDARNGKVATKGWAEETDVEVTDLAKSFEDAGV
AAIIYTDIMRDGAMKGPNIDATAALANAVSIPVIASGGVSSLEDLHALKSCGAALNGAISGRALYDGAIDLAEALAVLKG

Sequences:

>Translated_240_residues
MILYPAIDLKDGQAVRLLHGDMDKTTVFNDNPAAQALEFVAAGCEWLHLVDLNGAFAGEPVNAAPVEEILRQCKVPAQLG
GGIRDMATIERWLDKGLARVILGTVAVENPDLVREAARAFPGKVAVGIDARNGKVATKGWAEETDVEVTDLAKSFEDAGV
AAIIYTDIMRDGAMKGPNIDATAALANAVSIPVIASGGVSSLEDLHALKSCGAALNGAISGRALYDGAIDLAEALAVLKG
>Mature_240_residues
MILYPAIDLKDGQAVRLLHGDMDKTTVFNDNPAAQALEFVAAGCEWLHLVDLNGAFAGEPVNAAPVEEILRQCKVPAQLG
GGIRDMATIERWLDKGLARVILGTVAVENPDLVREAARAFPGKVAVGIDARNGKVATKGWAEETDVEVTDLAKSFEDAGV
AAIIYTDIMRDGAMKGPNIDATAALANAVSIPVIASGGVSSLEDLHALKSCGAALNGAISGRALYDGAIDLAEALAVLKG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=33.8842975206612, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=22.9838709677419, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 24928; Mature: 24928

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILYPAIDLKDGQAVRLLHGDMDKTTVFNDNPAAQALEFVAAGCEWLHLVDLNGAFAGEP
CEEECCEECCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
VNAAPVEEILRQCKVPAQLGGGIRDMATIERWLDKGLARVILGTVAVENPDLVREAARAF
CCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PGKVAVGIDARNGKVATKGWAEETDVEVTDLAKSFEDAGVAAIIYTDIMRDGAMKGPNID
CCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCCCC
ATAALANAVSIPVIASGGVSSLEDLHALKSCGAALNGAISGRALYDGAIDLAEALAVLKG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILYPAIDLKDGQAVRLLHGDMDKTTVFNDNPAAQALEFVAAGCEWLHLVDLNGAFAGEP
CEEECCEECCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
VNAAPVEEILRQCKVPAQLGGGIRDMATIERWLDKGLARVILGTVAVENPDLVREAARAF
CCCHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PGKVAVGIDARNGKVATKGWAEETDVEVTDLAKSFEDAGVAAIIYTDIMRDGAMKGPNID
CCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCCCCC
ATAALANAVSIPVIASGGVSSLEDLHALKSCGAALNGAISGRALYDGAIDLAEALAVLKG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA